Molecular mechanisms regulating NETosis in infection and disease

Histone Deimination As a Response to Inflammatory Stimuli in Neutrophils

(2014) I. Neeli et al.   JOURNAL OF IMMUNOLOGY

Mycobacterium tuberculosis Exploits Human Interferon γ to Stimulate Macrophage Extracellular Trap Formation and Necrosis

(2013) Ka-Wing Wong et al.   JOURNAL OF INFECTIOUS DISEASES

NETs Are a Source of Citrullinated Autoantigens and Stimulate Inflammatory Responses in Rheumatoid Arthritis

(2013) R. Khandpur et al.   Science Translational Medicine

A proposed role for neutrophil extracellular traps in cancer immunoediting

(2013) Sivan Berger-Achituv et al.   Frontiers in Immunology

Opposition between PKC isoforms regulates histone deimination and neutrophil extracellular chromatin release

(2013) Indira Neeli et al.   Frontiers in Immunology

Adenosine A2BReceptor Deficiency Promotes Host Defenses against Gram-Negative Bacterial Pneumonia

(2012) Kathryn E. Barletta et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Neutrophil Function: From Mechanisms to Disease

(2012) Borko Amulic et al.   Annual Review of Immunology

Neutrophil Extracellular Traps Mediate a Host Defense Response to Human Immunodeficiency Virus-1

(2012) Tatsuya Saitoh et al.   Cell Host & Microbe

Afa/Dr Diffusely Adhering Escherichia coli Strain C1845 Induces Neutrophil Extracellular Traps That Kill Bacteria and Damage Human Enterocyte-Like Cells

(2012) Viviana Marin-Esteban et al.   INFECTION AND IMMUNITY

Interplay between Candida albicans and the Mammalian Innate Host Defense

(2012) Shih-Chin Cheng et al.   INFECTION AND IMMUNITY

α-Enolase of Streptococcus pneumoniae Induces Formation of Neutrophil Extracellular Traps

(2012) Yuka Mori et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reactive oxygen species-induced activation of ERK and p38 MAPK mediates PMA-induced NETs release from human neutrophils

(2012) Ravi S. Keshari et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo

(2012) Marie-Luise von Brühl et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neutrophil Extracellular Traps That Are Not Degraded in Systemic Lupus Erythematosus Activate Complement Exacerbating the Disease

(2012) J. Leffler et al.   JOURNAL OF IMMUNOLOGY

Glutathione Reductase Facilitates Host Defense by Sustaining Phagocytic Oxidative Burst and Promoting the Development of Neutrophil Extracellular Traps

(2012) J. Yan et al.   JOURNAL OF IMMUNOLOGY

Infection-induced NETosis is a dynamic process involving neutrophil multitasking in vivo

(2012) Bryan G Yipp et al.   NATURE MEDICINE

Influences of Chloride and Hypochlorite on Neutrophil Extracellular Trap Formation

(2012) Kathryn Akong-Moore et al.   PLoS One

NADPH Oxidase Inhibits the Pathogenesis of Systemic Lupus Erythematosus

(2012) A. M. Campbell et al.   Science Translational Medicine

PAD4 is not essential for disease in the K/BxN murine autoantibody-mediated model of arthritis

(2012) Amanda S Rohrbach et al.   ARTHRITIS RESEARCH & THERAPY

DNase Sda1 Allows Invasive M1T1 Group A Streptococcus to Prevent TLR9-Dependent Recognition

(2012) Satoshi Uchiyama et al.   PLoS Pathogens

Myeloid-Related Protein-14 Contributes to Protective Immunity in Gram-Negative Pneumonia Derived Sepsis

(2012) Ahmed Achouiti et al.   PLoS Pathogens

PAD4 mediated histone hypercitrullination induces heterochromatin decondensation and chromatin unfolding to form neutrophil extracellular trap-like structures

(2012) Marc Leshner et al.   Frontiers in Immunology

Excessive Neutrophils and Neutrophil Extracellular Traps Contribute to Acute Lung Injury of Influenza Pneumonitis

(2011) Teluguakula Narasaraju et al.   AMERICAN JOURNAL OF PATHOLOGY

Neutrophil Myeloperoxidase: Soldier and Statesman

(2011) Zofia Prokopowicz et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Killing by neutrophil extracellular traps: fact or folklore?

(2011) R. Menegazzi et al.   BLOOD

Toxoplasma gondii Triggers Release of Human and Mouse Neutrophil Extracellular Traps

(2011) Delbert S. Abi Abdallah et al.   INFECTION AND IMMUNITY

Restoration of anti-Aspergillus defense by neutrophil extracellular traps in human chronic granulomatous disease after gene therapy is calprotectin-dependent

(2011) Matteo Bianchi et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Regulation of neutrophils by interferon-γ limits lung inflammation during tuberculosis infection

(2011) Bisweswar Nandi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Netting Neutrophils Induce Endothelial Damage, Infiltrate Tissues, and Expose Immunostimulatory Molecules in Systemic Lupus Erythematosus

(2011) E. Villanueva et al.   JOURNAL OF IMMUNOLOGY

Mast Cells and Neutrophils Release IL-17 through Extracellular Trap Formation in Psoriasis

(2011) A. M. Lin et al.   JOURNAL OF IMMUNOLOGY

Extracellular histones increase plasma thrombin generation by impairing thrombomodulin-dependent protein C activation

(2011) C. T. AMMOLLO et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Neutrophil extracellular traps promote deep vein thrombosis in mice

(2011) A. BRILL et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

B cell–helper neutrophils stimulate the diversification and production of immunoglobulin in the marginal zone of the spleen

(2011) Irene Puga et al.   NATURE IMMUNOLOGY

Systemic Lupus Erythematosus

(2011) George C. Tsokos   NEW ENGLAND JOURNAL OF MEDICINE

PAD4-Mediated Neutrophil Extracellular Trap Formation Is Not Required for Immunity against Influenza Infection

(2011) Saskia Hemmers et al.   PLoS One

Neutrophil Extracellular Trap Formation Is Associated with IL-1β and Autophagy-Related Signaling in Gout

(2011) Ioannis Mitroulis et al.   PLoS One

Neutrophil Elastase Enhances Sputum Solubilization in Cystic Fibrosis Patients Receiving DNase Therapy

(2011) Venizelos Papayannopoulos et al.   PLoS One

Neutrophils Activate Plasmacytoid Dendritic Cells by Releasing Self-DNA-Peptide Complexes in Systemic Lupus Erythematosus

(2011) R. Lande et al.   Science Translational Medicine

Myeloperoxidase is required for neutrophil extracellular trap formation: implications for innate immunity

(2010) K. D. Metzler et al.   BLOOD

Activated endothelial cells induce neutrophil extracellular traps and are susceptible to NETosis-mediated cell death

(2010) Anurag Kumar Gupta et al.   FEBS LETTERS

Neutrophils, from Marrow to Microbes

(2010) Niels Borregaard   IMMUNITY

Differential Microbicidal Effects of Human Histone Proteins H2A and H2B onLeishmaniaPromastigotes and Amastigotes

(2010) Yingwei Wang et al.   INFECTION AND IMMUNITY

Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps

(2010) Venizelos Papayannopoulos et al.   JOURNAL OF CELL BIOLOGY

PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps

(2010) Pingxin Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Leishmania donovani Promastigotes Evade the Antimicrobial Activity of Neutrophil Extracellular Traps

(2010) C. Gabriel et al.   JOURNAL OF IMMUNOLOGY

A Novel Mechanism of Rapid Nuclear Neutrophil Extracellular Trap Formation in Response to Staphylococcus aureus

(2010) F. H. Pilsczek et al.   JOURNAL OF IMMUNOLOGY

A Distinct Subset of Proinflammatory Neutrophils Isolated from Patients with Systemic Lupus Erythematosus Induces Vascular Damage and Synthesizes Type I IFNs

(2010) M. F. Denny et al.   JOURNAL OF IMMUNOLOGY

Nuclease Expression by Staphylococcus aureus Facilitates Escape from Neutrophil Extracellular Traps

(2010) Evelien T.M. Berends et al.   Journal of Innate Immunity

NETs formed by human neutrophils inhibit growth of the pathogenic mold Aspergillus fumigatus

(2010) Allison McCormick et al.   MICROBES AND INFECTION

CXCR2 mediates NADPH oxidase–independent neutrophil extracellular trap formation in cystic fibrosis airway inflammation

(2010) Veronica Marcos et al.   NATURE MEDICINE

Neutrophil elastase–mediated degradation of IRS-1 accelerates lung tumor growth

(2010) A McGarry Houghton et al.   NATURE MEDICINE

Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis

(2010) A. Hakkim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Production of Extracellular Traps against Aspergillus fumigatus In Vitro and in Infected Lung Tissue Is Dependent on Invading Neutrophils and Influenced by Hydrophobin RodA

(2010) Sandra Bruns et al.   PLoS Pathogens

Restoration of NET formation by gene therapy in CGD controls aspergillosis

(2009) M. Bianchi et al.   BLOOD

Evidence for a cross-talk between human neutrophils and Th17 cells

(2009) M. Pelletier et al.   BLOOD

Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TAN

(2009) Zvi G. Fridlender et al.   CANCER CELL

Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation

(2009) Yanming Wang et al.   JOURNAL OF CELL BIOLOGY

Characterization of neutrophil extracellular traps in cats naturally infected with feline leukemia virus

(2009) A. B. Wardini et al.   JOURNAL OF GENERAL VIROLOGY

M1 Protein Allows Group A Streptococcal Survival in Phagocyte Extracellular Traps through Cathelicidin Inhibition

(2009) Xavier Lauth et al.   Journal of Innate Immunity

Extracellular neutrophil traps in periodontitis

(2009) L. Vitkov et al.   JOURNAL OF PERIODONTAL RESEARCH

Leishmania amazonensis promastigotes induce and are killed by neutrophil extracellular traps

(2009) A. B. Guimaraes-Costa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathophysiology and Clinical Spectrum of Infections in Systemic Lupus Erythematosus

(2009) Raquel Cuchacovich et al.   RHEUMATIC DISEASE CLINICS OF NORTH AMERICA

NETs: a new strategy for using old weapons

(2009) Venizelos Papayannopoulos et al.   TRENDS IN IMMUNOLOGY

Neutrophil granule proteins tune monocytic cell function

(2009) Oliver Soehnlein et al.   TRENDS IN IMMUNOLOGY

Neutrophil extracellular trap formation as innate immune reactions against the apicomplexan parasite Eimeria bovis

(2009) Jan Hillern Behrendt et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Neutrophil Extracellular Traps Contain Calprotectin, a Cytosolic Protein Complex Involved in Host Defense against Candida albicans

(2009) Constantin F. Urban et al.   PLoS Pathogens

Phagocytosis-independent antimicrobial activity of mast cells by means of extracellular trap formation

(2008) M. von Kockritz-Blickwede et al.   BLOOD

Modern management of chronic granulomatous disease

(2008) Reinhard A. Seger   BRITISH JOURNAL OF HAEMATOLOGY

Genetic and molecular diagnosis of severe congenital neutropenia

(2008) Alister C Ward et al.   CURRENT OPINION IN HEMATOLOGY

Structure–function relationships in the IL-17 receptor: Implications for signal transduction and therapy

(2008) Fang Shen et al.   CYTOKINE

 -Hydroxybutyrate Abrogates Formation of Bovine Neutrophil Extracellular Traps and Bactericidal Activity against Mammary Pathogenic Escherichia coli

(2008) N. Grinberg et al.   INFECTION AND IMMUNITY

Neutrophil Elastase (NE) and NE Inhibitors: Canonical and Noncanonical Functions in Lung Chronic Inflammatory Diseases (Cystic Fibrosis and Chronic Obstructive Pulmonary Disease)

(2008) Ali Roghanian et al.   Journal of Aerosol Medicine and Pulmonary Drug Delivery

Cytokine-associated neutrophil extracellular traps and antinuclear antibodies in Plasmodium falciparum infected children under six years of age

(2008) Virginia S Baker et al.   MALARIA JOURNAL

Catapult-like release of mitochondrial DNA by eosinophils contributes to antibacterial defense

(2008) Shida Yousefi et al.   NATURE MEDICINE

Recent advances in cystic fibrosis

(2008) F. Ratjen   Paediatric Respiratory Reviews

Priming of the neutrophil NADPH oxidase activation: role of p47phox phosphorylation and NOX2 mobilization to the plasma membrane

(2008) Jamel El-Benna et al.   Seminars in Immunopathology

Neutrophil extracellular traps are induced by Mycobacterium tuberculosis

(2008) Victoria Ramos-Kichik et al.   TUBERCULOSIS

An integrated model of the recognition of Candida albicans by the innate immune system

(2007) Mihai G. Netea et al.   NATURE REVIEWS MICROBIOLOGY