Oncolytic Activities of Host Defense Peptides

Suppression of Soft Tissue Sarcoma Growth by a Host Defense-Like Lytic Peptide

(2011) Lars Steinstraesser et al.   PLoS One

Effect of loop structure of bovine lactoferricin on apoptosis in Jurkat cells

(2010) Tie-nan Zhang et al.   BIOMETALS

Host defense peptides and their antimicrobial-immunomodulatory duality

(2010) Lars Steinstraesser et al.   IMMUNOBIOLOGY

Oncolytic designer host defense peptide suppresses growth of human liposarcoma

(2010) Lars Steinstraesser et al.   INTERNATIONAL JOURNAL OF CANCER

The antimicrobial peptide cecropin A induces caspase-independent cell death in human promyelocytic leukemia cells

(2010) José Mª. Cerón et al.   PEPTIDES

A novel analog of antimicrobial peptide Polybia-MPI, with thioamide bond substitution, exhibits increased therapeutic efficacy against cancer and diminished toxicity in mice

(2010) Wei Zhang et al.   PEPTIDES

The anticancer activity of lytic peptides is inhibited by heparan sulfate on the surface of the tumor cells

(2009) Bodil Fadnes et al.   BMC CANCER

Novel mode of action of polybia-MPI, a novel antimicrobial peptide, in multi-drug resistant leukemic cells

(2009) Kai-rong Wang et al.   CANCER LETTERS

Suppression of Human Solid Tumor Growth in Mice by Intratumor and Systemic Inoculation of Histidine-Rich and pH-Dependent Host Defense-like Lytic Peptides

(2009) A. Makovitzki et al.   CANCER RESEARCH

Intratumoral Expression of Mature Human Neutrophil Peptide-1 Mediates Antitumor Immunity in Mice

(2009) Y.-s. Wang et al.   CLINICAL CANCER RESEARCH

Host Defense Peptides as Effector Molecules of the Innate Immune Response: A Sledgehammer for Drug Resistance?

(2009) Lars Steinstraesser et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Bioengineered Human Skin: Working the Bugs Out

(2009) L Steinstraesser et al.   MOLECULAR THERAPY

Epinecidin-1 peptide induces apoptosis which enhances antitumor effects in human leukemia U937 cells

(2009) Jyh-Yih Chen et al.   PEPTIDES

Structure and function of a custom anticancer peptide, CB1a

(2009) Jiun-Ming Wu et al.   PEPTIDES

Magainin 2 in Action: Distinct Modes of Membrane Permeabilization in Living Bacterial and Mammalian Cells

(2008) Yuichi Imura et al.   BIOPHYSICAL JOURNAL

Mechanism of anticancer activity of buforin IIb, a histone H2A-derived peptide

(2008) Hyun Soo Lee et al.   CANCER LETTERS

Organization and promoter analysis of the grouper (Epinephelus coioides) epinecidin-1 gene

(2008) Chia-Yu Pan et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY

Hunter−Killer Peptide (HKP) for Targeted Therapy

(2008) H. Michael Ellerby et al.   JOURNAL OF MEDICINAL CHEMISTRY

Human α-defensin-1 inhibits growth of human lung adenocarcinoma xenograft in nude mice

(2008) Ning Xu et al.   MOLECULAR CANCER THERAPEUTICS

Antitumor effects, cell selectivity and structure–activity relationship of a novel antimicrobial peptide polybia-MPI

(2008) Kai-rong Wang et al.   PEPTIDES

Selective cancer cell cytotoxicity of enantiomeric 9-mer peptides derived from beetle defensins depends on negatively charged phosphatidylserine on the cell surface

(2008) Takashi Iwasaki et al.   PEPTIDES

Epinecidin-1, an antimicrobial peptide from fish (Epinephelus coioides) which has an antitumor effect like lytic peptides in human fibrosarcoma cells

(2008) Wei-Ju Lin et al.   PEPTIDES

Antimicrobial peptides of the Cecropin-family show potent antitumor activity against bladder cancer cells

(2008) Henrik Suttmann et al.   BMC Urology

Functional analysis of the host defense peptide Human Beta Defensin-1: New insight into its potential role in cancer

(2007) Rebecca S. Bullard et al.   MOLECULAR IMMUNOLOGY