Regulation of Autophagy by Kinases

Inhibition of mammalian S6 kinase by resveratrol suppresses autophagy

(2016) Sean M. Armour et al.   Aging-US

Mitochondrially localized ERK2 regulates mitophagy and autophagic cell stress

(2014) Ruben K. Dagda et al.   Autophagy

PERK-dependent regulation of HSP70 expression and the regulation of autophagy

(2014) Margaret A. Park et al.   Autophagy

Autophagic cell death unraveled: Pharmacological inhibition of apoptosis and autophagy enables necrosis

(2014) Eileen White   Autophagy

Rottlerin induces autophagy and apoptotic cell death through a PKC-delta-independent pathway in HT1080 human fibrosarcoma cells: The protective role of autophagy in apoptosis

(2014) Kyoung-Sub Song et al.   Autophagy

Dual Role of JNK1-mediated phosphorylation of Bcl-2 in autophagy and apoptosis regulation

(2014) Yongjie Wei et al.   Autophagy

Evolution of Atg1 function and regulation

(2014) Edmond Y. Chan et al.   Autophagy

Silibinin Activated p53 and Induced Autophagic Death in Human Fibrosarcoma HT1080 Cells via Reactive Oxygen Species-p38 and c-Jun N-Terminal Kinase Pathways

(2011) Wen-Jun Duan et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

JNK regulates FoxO-dependent autophagy in neurons

(2011) P. Xu et al.   GENES & DEVELOPMENT

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Two Faces of Protein Kinase Cδ: The Contrasting Roles of PKCδ in Cell Survival and Cell Death

(2011) Alakananda Basu et al.   TheScientificWorldJOURNAL

Evidence for the interplay between JNK and p53-DRAM signaling pathways in the regulation of autophagy

(2010) Séverine Lorin et al.   Autophagy

Mammalian Atg18 (WIPI2) localizes to omegasome-anchored phagophores and positively regulates LC3 lipidation

(2010) Hannah E.J. Polson et al.   Autophagy

Protein kinase C inhibits autophagy and phosphorylates LC3

(2010) Houbo Jiang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Pineapple bromelain induces autophagy, facilitating apoptotic response in mammary carcinoma cells

(2010) Kulpreet Bhui et al.   BIOFACTORS

p38 Mitogen-Activated Protein Kinase is Involved in Endoplasmic Reticulum Stress-Induced Cell Death and Autophagy in Human Gingival Fibroblasts

(2010) Do-Sung Kim et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

DJ-1, a cancer and Parkinson’s disease associated protein, regulates autophagy through JNK pathway in cancer cells

(2010) Haigang Ren et al.   CANCER LETTERS

mTORC1 signaling requires proteasomal function and the involvement of CUL4-DDB1 ubiquitin E3 ligase

(2010) Papia Ghosh et al.   CELL CYCLE

A Diacylglycerol-Dependent Signaling Pathway Contributes to Regulation of Antibacterial Autophagy

(2010) Shahab Shahnazari et al.   Cell Host & Microbe

Removal or masking of phosphatidylinositol(4,5)bisphosphate from the outer mitochondrial membrane causes mitochondrial fragmentation

(2010) Erika Rosivatz et al.   CELLULAR SIGNALLING

DAP1, a Novel Substrate of mTOR, Negatively Regulates Autophagy

(2010) Itay Koren et al.   CURRENT BIOLOGY

The role of the Atg1/ULK1 complex in autophagy regulation

(2010) Noboru Mizushima   CURRENT OPINION IN CELL BIOLOGY

Autophagy regulation by p53

(2010) Maria Chiara Maiuri et al.   CURRENT OPINION IN CELL BIOLOGY

Macroautophagy modulates cellular response to proteasome inhibitors in cancer therapy

(2010) William K.K. Wu et al.   DRUG RESISTANCE UPDATES

Modulation of Bax mitochondrial insertion and induced cell death in yeast by mammalian protein kinase Cα

(2010) Rui D. Silva et al.   EXPERIMENTAL CELL RESEARCH

New insights into the function of Atg9

(2010) Jemma L. Webber et al.   FEBS LETTERS

Chromosome band 17q21 in breast cancer: Significant association between beclin 1 loss and HER2/NEU amplification

(2010) Tiziana Negri et al.   GENES CHROMOSOMES & CANCER

Selective Transport of α-Mannosidase by Autophagic Pathways

(2010) Yasunori Watanabe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Late Phase of the Endoplasmic Reticulum Stress Response Pathway Is Regulated by Hog1 MAP Kinase

(2010) Alicia A. Bicknell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Starvation-induced Hyperacetylation of Tubulin Is Required for the Stimulation of Autophagy by Nutrient Deprivation

(2010) Camille Geeraert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Resveratrol Arrests Cell Cycle and Induces Apoptosis in Human Hepatocellular Carcinoma Huh-7 Cells

(2010) Pei-Chi Liao et al.   JOURNAL OF MEDICINAL FOOD

The mechanism for the neuroprotective effect of melatonin against methamphetamine-induced autophagy

(2010) Chutikorn Nopparat et al.   JOURNAL OF PINEAL RESEARCH

Protein Phosphatase 2A Reactivates FOXO3a through a Dynamic Interplay with 14-3-3 and AKT

(2010) Amrik Singh et al.   MOLECULAR BIOLOGY OF THE CELL

Autophagy and the Integrated Stress Response

(2010) Guido Kroemer et al.   MOLECULAR CELL

Autophagy Induction by Capsaicin in Malignant Human Breast Cells Is Modulated by p38 and Extracellular Signal-Regulated Mitogen-Activated Protein Kinases and Retards Cell Death by Suppressing Endoplasmic Reticulum Stress-Mediated Apoptosis

(2010) C.-H. Choi et al.   MOLECULAR PHARMACOLOGY

Termination of autophagy and reformation of lysosomes regulated by mTOR

(2010) Li Yu et al.   NATURE

Triterpenes FromGanoderma LucidumInduce Autophagy in Colon Cancer Through the Inhibition of p38 Mitogen-Activated Kinase (p38 MAPK)

(2010) Anita Thyagarajan et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Endoplasmic reticulum stress mediates radiation-induced autophagy by perk-eIF2α in caspase-3/7-deficient cells

(2010) K W Kim et al.   ONCOGENE

Simultaneous Induction of Non-Canonical Autophagy and Apoptosis in Cancer Cells by ROS-Dependent ERK and JNK Activation

(2010) Chew Hooi Wong et al.   PLoS One

The Association of AMPK with ULK1 Regulates Autophagy

(2010) Jong Woo Lee et al.   PLoS One

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

(2010) D. F. Egan et al.   SCIENCE

Autophagy involvement in cadmium resistance through induction of multidrug resistance-associated protein and counterbalance of endoplasmic reticulum stress WI38 lung epithelial fibroblast cells

(2010) Sung-Chul Lim et al.   TOXICOLOGY

Regulation Mechanisms and Signaling Pathways of Autophagy

(2009) Congcong He et al.   Annual Review of Genetics

Inhibition of p38α unveils an AMPK-FoxO3A axis linking autophagy to cancer-specific metabolism

(2009) Fulvio Chiacchiera et al.   Autophagy

Autophagy is an important event for megakaryocytic differentiation of the chronic myelogenous leukemia K562 cell line

(2009) Pascal Colosetti et al.   Autophagy

Safingol (l-threo-sphinganine) induces autophagy in solid tumor cells through inhibition of PKC and the PI3-kinase pathway

(2009) Jesse Coward et al.   Autophagy

The cadmium-induced death of mesangial cells results in nephrotoxicity

(2009) Liang-Yo Yang et al.   Autophagy

Autophagy facilitates the progression of ERα-positive breast cancer cells to antiestrogen resistance

(2009) Patricia V. Schoenlein et al.   Autophagy

PKCδ signaling: A dual role in regulating hypoxic stress-induced autophagy and apoptosis

(2009) Jo-Lin Chen et al.   Autophagy

Upregulation of Beclin-1 expression and phosphorylation of Bcl-2 and p53 are involved in the JNK-mediated autophagic cell death

(2009) Kyung-Jin Park et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

MCP-1 causes cardiomyoblast death via autophagy resulting from ER stress caused by oxidative stress generated by inducing a novel zinc-finger protein, MCPIP

(2009) Craig W. Younce et al.   BIOCHEMICAL JOURNAL

Nutrient-dependent regulation of autophagy through the target of rapamycin pathway: Figure 1

(2009) Yu-Yun Chang et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

A complex interplay between Akt, TSC2 and the two mTOR complexes: Figure 1

(2009) Jingxiang Huang et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Anti- and pro-tumor functions of autophagy

(2009) Eugenia Morselli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The Rac1/MKK7/JNK pathway signals upregulation of Atg5 and subsequent autophagic cell death in response to oncogenic Ras

(2009) Joo-Yun Byun et al.   CARCINOGENESIS

Autophagy Suppresses Tumorigenesis through Elimination of p62

(2009) Robin Mathew et al.   CELL

Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes

(2009) L Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

The role of endoplasmic reticulum in cadmium-induced mesangial cell apoptosis

(2009) Sheng-Hao Wang et al.   CHEMICO-BIOLOGICAL INTERACTIONS

The Double-Edged Sword of Autophagy Modulation in Cancer

(2009) E. White et al.   CLINICAL CANCER RESEARCH

Coordinated regulation of autophagy by p38α MAPK through mAtg9 and p38IP

(2009) Jemma L Webber et al.   EMBO JOURNAL

DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy

(2009) Einat Zalckvar et al.   EMBO REPORTS

Death-associated protein kinase (DAPK) and signal transduction: fine-tuning of autophagy in Caenorhabditis elegans homeostasis

(2009) Chanhee Kang et al.   FEBS Journal

ERK and cell death: Mechanisms of ERK-induced cell death - apoptosis, autophagy and senescence

(2009) Sebastien Cagnol et al.   FEBS Journal

A Non-canonical MEK/ERK Signaling Pathway Regulates Autophagy via Regulating Beclin 1

(2009) Jianrong Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ULK1·ATG13·FIP200 Complex Mediates mTOR Signaling and Is Essential for Autophagy

(2009) Ian G. Ganley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1

(2009) Carson C. Thoreen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tor Directly Controls the Atg1 Kinase Complex To Regulate Autophagy

(2009) Y. Kamada et al.   MOLECULAR AND CELLULAR BIOLOGY

Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy

(2009) Nao Hosokawa et al.   MOLECULAR BIOLOGY OF THE CELL

ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery

(2009) Chang Hwa Jung et al.   MOLECULAR BIOLOGY OF THE CELL

Sorafenib and Vorinostat Kill Colon Cancer Cells by CD95-Dependent and -Independent Mechanisms

(2009) T. Walker et al.   MOLECULAR PHARMACOLOGY

The autophagy effector Beclin 1: a novel BH3-only protein

(2009) S Sinha et al.   ONCOGENE

Acadesine Kills Chronic Myelogenous Leukemia (CML) Cells through PKC-Dependent Induction of Autophagic Cell Death

(2009) Guillaume Robert et al.   PLoS One

Activation of mitochondrial ERK protects cancer cells from death through inhibition of the permeability transition

(2009) A. Rasola et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mTORC1 Phosphorylates the ULK1-mAtg13-FIP200 Autophagy Regulatory Complex

(2009) E. Y. Chan   Science Signaling

ERK and JNK mediate TNFα-induced p53 activation in apoptotic and autophagic L929 cell death

(2008) Yan Cheng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Involvement of PKC signal pathways in oridonin-induced autophagy in HeLa cells: A protective mechanism against apoptosis

(2008) Yahong Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The regulation and function of Class III PI3Ks: novel roles for Vps34

(2008) Jonathan M. Backer   BIOCHEMICAL JOURNAL

Polygonatum cyrtonema lectin induces apoptosis and autophagy in human melanoma A375 cells through a mitochondria-mediated ROS–p38–p53 pathway

(2008) Bo Liu et al.   CANCER LETTERS

Mammalian Target of Rapamycin and S6 Kinase 1 Positively Regulate 6-thioguanine-Induced Autophagy

(2008) X. Zeng et al.   CANCER RESEARCH

Control of autophagy by oncogenes and tumor suppressor genes

(2008) M C Maiuri et al.   CELL DEATH AND DIFFERENTIATION

Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling

(2008) Tsuneo Ikenoue et al.   EMBO JOURNAL

The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C

(2008) Valeria Facchinetti et al.   EMBO JOURNAL

Novel Roles for Protein Kinase Cδ-dependent Signaling Pathways in Acute Hypoxic Stress-induced Autophagy

(2008) Jo-Lin Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DAPK-1 Binding to a Linear Peptide Motif in MAP1B Stimulates Autophagy and Membrane Blebbing

(2008) Ben Harrison et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

S6K Directly Phosphorylates IRS-1 on Ser-270 to Promote Insulin Resistance in Response to TNF-α Signaling through IKK2

(2008) Jin Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of JNK1-dependent Bcl-2 Phosphorylation in Ceramide-induced Macroautophagy

(2008) Sophie Pattingre et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Atg18-Atg2 Complex Is Recruited to Autophagic Membranes via Phosphatidylinositol 3-Phosphate and Exerts an Essential Function

(2008) Keisuke Obara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein Kinase Cθ Is Required for Autophagy in Response to Stress in the Endoplasmic Reticulum

(2008) Kenjiro Sakaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of ERK attenuates autophagy and potentiates tumour necrosis factor-α-induced cell death in MCF-7 cells

(2008) U. Sivaprasad et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells

(2008) Edward D. Plowey et al.   JOURNAL OF NEUROCHEMISTRY

Organization of the Pre-autophagosomal Structure Responsible for Autophagosome Formation

(2008) Tomoko Kawamata et al.   MOLECULAR BIOLOGY OF THE CELL

JNK1-Mediated Phosphorylation of Bcl-2 Regulates Starvation-Induced Autophagy

(2008) Yongjie Wei et al.   MOLECULAR CELL

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL

Structural Basis of Protein Kinase C Isoform Function

(2008) Susan F. Steinberg   PHYSIOLOGICAL REVIEWS

Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase

(2008) Q. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Picky Eater: Exploring the Mechanisms of Selective Autophagy in Human Pathologies

(2008) Aniek van der Vaart et al.   TRAFFIC

Regulation of macroautophagy by mTOR and Beclin 1 complexes

(2007) Sophie Pattingre et al.   BIOCHIMIE

Induction of Autophagy during Extracellular Matrix Detachment Promotes Cell Survival

(2007) Christopher Fung et al.   MOLECULAR BIOLOGY OF THE CELL