Neutrophil extracellular traps: Is immunity the second function of chromatin?

Histone Deimination As a Response to Inflammatory Stimuli in Neutrophils

(2014) I. Neeli et al.   JOURNAL OF IMMUNOLOGY

Host-Derived Extracellular Nucleic Acids Enhance Innate Immune Responses, Induce Coagulation, and Prolong Survival upon Infection in Insects

(2014) B. Altincicek et al.   JOURNAL OF IMMUNOLOGY

Neutrophil Function: From Mechanisms to Disease

(2012) Borko Amulic et al.   Annual Review of Immunology

Neutrophil Extracellular Traps Mediate a Host Defense Response to Human Immunodeficiency Virus-1

(2012) Tatsuya Saitoh et al.   Cell Host & Microbe

Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury

(2012) Axelle Caudrillier et al.   JOURNAL OF CLINICAL INVESTIGATION

Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo

(2012) Marie-Luise von Brühl et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neutrophil Extracellular Traps That Are Not Degraded in Systemic Lupus Erythematosus Activate Complement Exacerbating the Disease

(2012) J. Leffler et al.   JOURNAL OF IMMUNOLOGY

T Lymphocyte Priming by Neutrophil Extracellular Traps Links Innate and Adaptive Immune Responses

(2012) K. Tillack et al.   JOURNAL OF IMMUNOLOGY

Editorial: Nyet to NETs,n? A pause for healthy skepticism

(2012) William M. Nauseef   JOURNAL OF LEUKOCYTE BIOLOGY

Periodontitis, Porphyromonas and the pathogenesis of rheumatoid arthritis

(2012) D Farquharson et al.   Mucosal Immunology

Neutrophil Extracellular Traps Directly Induce Epithelial and Endothelial Cell Death: A Predominant Role of Histones

(2012) Mona Saffarzadeh et al.   PLoS One

Presence of luminal neutrophil extracellular traps in atherosclerosis

(2012) Remco T. A. Megens et al.   THROMBOSIS AND HAEMOSTASIS

Specific post-translational histone modifications of neutrophil extracellular traps as immunogens and potential targets of lupus autoantibodies

(2012) Chih Liu et al.   ARTHRITIS RESEARCH & THERAPY

Felty's syndrome autoantibodies bind to deiminated histones and neutrophil extracellular chromatin traps

(2011) Nishant Dwivedi et al.   ARTHRITIS AND RHEUMATISM

Extracellular histones promote thrombin generation through platelet-dependent mechanisms: involvement of platelet TLR2 and TLR4

(2011) F. Semeraro et al.   BLOOD

Killing by neutrophil extracellular traps: fact or folklore?

(2011) R. Menegazzi et al.   BLOOD

Dying for a cause: NETosis, mechanisms behind an antimicrobial cell death modality

(2011) Q Remijsen et al.   CELL DEATH AND DIFFERENTIATION

Hypochlorous acid regulates neutrophil extracellular trap release in humans

(2011) L. J. Palmer et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Toxoplasma gondii Triggers Release of Human and Mouse Neutrophil Extracellular Traps

(2011) Delbert S. Abi Abdallah et al.   INFECTION AND IMMUNITY

Restoration of anti-Aspergillus defense by neutrophil extracellular traps in human chronic granulomatous disease after gene therapy is calprotectin-dependent

(2011) Matteo Bianchi et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Ultrastructural characterization of cystic fibrosis sputum using atomic force and scanning electron microscopy

(2011) Reinhard Manzenreiter et al.   Journal of Cystic Fibrosis

Netting Neutrophils Induce Endothelial Damage, Infiltrate Tissues, and Expose Immunostimulatory Molecules in Systemic Lupus Erythematosus

(2011) E. Villanueva et al.   JOURNAL OF IMMUNOLOGY

Myeloperoxidase associated with neutrophil extracellular traps is active and mediates bacterial killing in the presence of hydrogen peroxide

(2011) Heather Parker et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Rac2 is required for the formation of neutrophil extracellular traps

(2011) Michael Byung H. Lim et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Innate immunity and coagulation

(2011) C. T. ESMON et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Neutrophil extracellular traps promote deep vein thrombosis in mice

(2011) A. BRILL et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Loss-of-function variant in DNASE1L3 causes a familial form of systemic lupus erythematosus

(2011) Sulaiman M Al-Mayouf et al.   NATURE GENETICS

Extracellular DNA: The tip of root defenses?

(2011) Martha C. Hawes et al.   PLANT SCIENCE

Porphyromonas gingivalis Participates in Pathogenesis of Human Abdominal Aortic Aneurysm by Neutrophil Activation. Proof of Concept in Rats

(2011) Sandrine Delbosc et al.   PLoS One

PAD4-Mediated Neutrophil Extracellular Trap Formation Is Not Required for Immunity against Influenza Infection

(2011) Saskia Hemmers et al.   PLoS One

Neutrophil Elastase Enhances Sputum Solubilization in Cystic Fibrosis Patients Receiving DNase Therapy

(2011) Venizelos Papayannopoulos et al.   PLoS One

Dissecting the Immune Cell Mayhem That Drives Lupus Pathogenesis

(2011) J. E. Craft   Science Translational Medicine

Neutrophils Activate Plasmacytoid Dendritic Cells by Releasing Self-DNA-Peptide Complexes in Systemic Lupus Erythematosus

(2011) R. Lande et al.   Science Translational Medicine

Netting Neutrophils Are Major Inducers of Type I IFN Production in Pediatric Systemic Lupus Erythematosus

(2011) G. S. Garcia-Romo et al.   Science Translational Medicine

Neutrophil clearance: when the party is over, clean-up begins

(2011) Donna L. Bratton et al.   TRENDS IN IMMUNOLOGY

Pus: the Rodney Dangerfield of immunology

(2011) David S Pisetsky   ARTHRITIS RESEARCH & THERAPY

Myeloperoxidase is required for neutrophil extracellular trap formation: implications for innate immunity

(2010) K. D. Metzler et al.   BLOOD

Neutrophil extracellular trap cell death requires both autophagy and superoxide generation

(2010) Quinten Remijsen et al.   CELL RESEARCH

Activated endothelial cells induce neutrophil extracellular traps and are susceptible to NETosis-mediated cell death

(2010) Anurag Kumar Gupta et al.   FEBS LETTERS

Upregulation in response to infection and antibacterial activity of oyster histone H4

(2010) Tarquin Dorrington et al.   FISH & SHELLFISH IMMUNOLOGY

Identification of histones as endogenous antibiotics in fish and quantification in rainbow trout (Oncorhynchus mykiss) skin and gill

(2010) Edward J. Noga et al.   FISH PHYSIOLOGY AND BIOCHEMISTRY

Neutrophils, from Marrow to Microbes

(2010) Niels Borregaard   IMMUNITY

Differential Microbicidal Effects of Human Histone Proteins H2A and H2B onLeishmaniaPromastigotes and Amastigotes

(2010) Yingwei Wang et al.   INFECTION AND IMMUNITY

Mannheimia haemolytica and Its Leukotoxin Cause Neutrophil Extracellular Trap Formation by Bovine Neutrophils

(2010) N. A. Aulik et al.   INFECTION AND IMMUNITY

Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps

(2010) Venizelos Papayannopoulos et al.   JOURNAL OF CELL BIOLOGY

PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps

(2010) Pingxin Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Leishmania donovani Promastigotes Evade the Antimicrobial Activity of Neutrophil Extracellular Traps

(2010) C. Gabriel et al.   JOURNAL OF IMMUNOLOGY

A Novel Mechanism of Rapid Nuclear Neutrophil Extracellular Trap Formation in Response to Staphylococcus aureus

(2010) F. H. Pilsczek et al.   JOURNAL OF IMMUNOLOGY

Nuclease Expression by Staphylococcus aureus Facilitates Escape from Neutrophil Extracellular Traps

(2010) Evelien T.M. Berends et al.   Journal of Innate Immunity

Activation of the Raf-MEK-ERK pathway is required for neutrophil extracellular trap formation

(2010) Abdul Hakkim et al.   Nature Chemical Biology

Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases

(2010) Steffen Massberg et al.   NATURE MEDICINE

Staphylococcus epidermidis Antimicrobial δ-Toxin (Phenol-Soluble Modulin-γ) Cooperates with Host Antimicrobial Peptides to Kill Group A Streptococcus

(2010) Anna L. Cogen et al.   PLoS One

Oligomeric Coiled-Coil Adhesin YadA Is a Double-Edged Sword

(2010) Salome Casutt-Meyer et al.   PLoS One

Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis

(2010) A. Hakkim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extracellular DNA traps promote thrombosis

(2010) T. A. Fuchs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Production of Extracellular Traps against Aspergillus fumigatus In Vitro and in Infected Lung Tissue Is Dependent on Invading Neutrophils and Influenced by Hydrophobin RodA

(2010) Sandra Bruns et al.   PLoS Pathogens

DNA-Bound Lactoferrin Is the Major Target for Antineutrophil Perinuclear Cytoplasmic Antibodies in Ulcerative Colitis

(2009) Bianca Teegen et al.   Annals of the New York Academy of Sciences

Response: Gestational age as a factor in neutrophil extracellular trap formation

(2009) C. C. Yost et al.   BLOOD

Babies born without safety NET

(2009) B. Fadeel   BLOOD

Restoration of NET formation by gene therapy in CGD controls aspergillosis

(2009) M. Bianchi et al.   BLOOD

Impaired neutrophil extracellular trap (NET) formation: a novel innate immune deficiency of human neonates

(2009) C. C. Yost et al.   BLOOD

Fetal calf serum contains heat-stable nucleases that degrade neutrophil extracellular traps

(2009) M. von Kockritz-Blickwede et al.   BLOOD

Viable neutrophils release mitochondrial DNA to form neutrophil extracellular traps

(2009) S Yousefi et al.   CELL DEATH AND DIFFERENTIATION

Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation

(2009) Yanming Wang et al.   JOURNAL OF CELL BIOLOGY

Activation of the Human Contact System on Neutrophil Extracellular Traps

(2009) Sonja Oehmcke et al.   Journal of Innate Immunity

Survival of Bacterial Biofilms within Neutrophil Extracellular Traps Promotes Nontypeable Haemophilus influenzae Persistence in the Chinchilla Model for Otitis Media

(2009) Wenzhou Hong et al.   Journal of Innate Immunity

Mouse Neutrophil Extracellular Traps in Microbial Infections

(2009) David Ermert et al.   Journal of Innate Immunity

Regulation of Extracellular Chromatin Release from Neutrophils

(2009) Indira Neeli et al.   Journal of Innate Immunity

M1 Protein Allows Group A Streptococcal Survival in Phagocyte Extracellular Traps through Cathelicidin Inhibition

(2009) Xavier Lauth et al.   Journal of Innate Immunity

Extracellular neutrophil traps in periodontitis

(2009) L. Vitkov et al.   JOURNAL OF PERIODONTAL RESEARCH

Phagocytosis Independent Extracellular Nanoparticle Clearance by Human Immune Cells

(2009) Matthias Bartneck et al.   NANO LETTERS

Extracellular histones are major mediators of death in sepsis

(2009) Jun Xu et al.   NATURE MEDICINE

Netting neutrophils in autoimmune small-vessel vasculitis

(2009) Kai Kessenbrock et al.   NATURE MEDICINE

Leishmania amazonensis promastigotes induce and are killed by neutrophil extracellular traps

(2009) A. B. Guimaraes-Costa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neutrophil Extracellular Traps Contain Calprotectin, a Cytosolic Protein Complex Involved in Host Defense against Candida albicans

(2009) Constantin F. Urban et al.   PLoS Pathogens

Buforins: Histone H2A-derived antimicrobial peptides from toad stomach

(2008) Ju Hyun Cho et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Antimicrobial action of histone H2B in Escherichia coli: Evidence for membrane translocation and DNA-binding of a histone H2B fragment after proteolytic cleavage by outer membrane proteinase T

(2008) Hiroaki Kawasaki et al.   BIOCHIMIE

Phagocytosis-independent antimicrobial activity of mast cells by means of extracellular trap formation

(2008) M. von Kockritz-Blickwede et al.   BLOOD

Antimicrobial effects of H4-(86-100), histogranin and related compounds - possible involvement of DNA gyrase

(2008) Simon Lemaire et al.   FEBS Journal

 -Hydroxybutyrate Abrogates Formation of Bovine Neutrophil Extracellular Traps and Bactericidal Activity against Mammary Pathogenic Escherichia coli

(2008) N. Grinberg et al.   INFECTION AND IMMUNITY

Catapult-like release of mitochondrial DNA by eosinophils contributes to antibacterial defense

(2008) Shida Yousefi et al.   NATURE MEDICINE

Neutrophil extracellular traps are induced by Mycobacterium tuberculosis

(2008) Victoria Ramos-Kichik et al.   TUBERCULOSIS

Chicken heterophil extracellular traps (HETs): Novel defense mechanism of chicken heterophils

(2008) Phongsakorn Chuammitri et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Single Residue Determines the Specificity of Neutrophil Elastase for Shigella Virulence Factors

(2007) Petra Averhoff et al.   JOURNAL OF MOLECULAR BIOLOGY

Visualization of neutrophil extracellular traps in TEM

(2007) Wolf Dietrich Krautgartner et al.   MICRON