Review
Biochemistry & Molecular Biology
Andre G. Loxton, Ilana C. van Rensburg
Summary: Tuberculosis is a major health crisis, with patients ranging from latent infection to active disease. B-cells play a significant role in TB by expressing regulatory functions, including FasL.
JOURNAL OF MOLECULAR BIOLOGY
(2021)
Article
Immunology
Ewelina Dobosz, Marta Wadowska, Marta Kaminska, Mateusz Wilamowski, Mohsen Honarpisheh, Danuta Bryzek, Jan Potempa, Jolanta Jura, Maciej Lech, Joanna Koziel
Summary: MCPIP-1 functions as a potent inhibitor of the inflammatory response by regulating apoptosis and retention of neutrophils, with its role in degrading antiapoptotic gene transcripts and interacting with specific miRNAs. This novel anti-inflammatory role of MCPIP-1 is crucial in balancing apoptosis and promoting the resolution of inflammation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Naina Soni, Suchi Gupta, Surender Rawat, Vishnu Krishnakumar, Sujata Mohanty, Arup Banerjee
Summary: This study investigates the effects of exosomes derived from different sources on immune cells. The expression levels of miRNAs varied within different MSCs and exosomes, and most miRNAs had expression profiles different from their respective sources. Exosomes from different sources had different abilities to induce neurogenesis and angiogenesis, as well as varying effects on PBMC proliferation, neutrophil survival, and NET formation.
Article
Cell Biology
Huibin Zhang, Jinglin Wang, Fan Xie, Yangguang Liu, Mengyao Qiu, Zheng Han, Yueyun Ding, Xianrui Zheng, Zongjun Yin, Xiaodong Zhang
Summary: This study investigated the effects of resveratrol (RSV) on the apoptosis of porcine ovarian granulosa cells (POGCs) through miRNA regulation. The results showed that RSV promoted POGCs apoptosis by regulating the expression of miRNAs, and also provided insights into the role of miRNAs combined with RSV in ovarian granulosa cell development in pigs.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Irina Linge, Elena Kondratieva, Alexander Apt
Summary: During tuberculosis infection, B-lymphocytes form B-cell follicles in the lungs near TB granulomata. B-cell depletion in infected primates alters T-lymphocyte responses and increases bacterial burdens. The role of B cells in late-stage TB remained unknown.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Genetics & Heredity
Ting Yang, Lingling Qiu, Shihao Chen, Zhixiu Wang, Yong Jiang, Hao Bai, Yulin Bi, Guohong Chen, Guobin Chang
Summary: This study investigated the role of circ_PIAS1 in ALV-J infection and found that circ_PIAS1 influenced ALV-J infection by promoting cell apoptosis. Additionally, circ_PIAS1 up-regulated the expression of miR-183. This study provides evidence for the role of circRNA in ALV-J infection.
Article
Pharmacology & Pharmacy
Hongwu Meng, Lingfeng Jiang, Pengcheng Jia, Ruowen Niu, Fangtian Bu, Yan Zhu, Xueyin Pan, Juanjuan Li, Jinyu Liu, Yilong Zhang, Cheng Huang, Xiongwen Lv, Jun Li
Summary: This study identified a novel circRNA ASPH (circASPH) that mediates hepatic fibrosis (HF) by targeting the miR-139-5p/Notch1 axis. The expression profile of circASPH in hepatocyte exosomes of mice with HF was found to be upregulated. Downregulation of circASPH expression inhibited hepatic stellate cell (HSC) activation and proliferation, induced apoptosis, and attenuated mouse liver fibrogenic injury. Thus, circASPH may serve as a potential biomarker for HF diagnosis and therapy.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Michael G. McCoy, Daniel Perez-Cremades, Nathan Belkin, Wenhui Peng, Bofang Zhang, Jingshu Chen, Madhur Sachan, A. K. M. Khyrul Wara, Rulin Zhuang, Henry S. Cheng, Mark W. Feinberg
Summary: This study demonstrates that a 4-miRNA cassette can reprogram vascular smooth muscle cells into endothelial cells, and these induced cells exhibit high similarity to native endothelial cells. Injected induced cells even restore blood flow faster than conventional endothelial cells in a mouse model, suggesting the potential of this approach for vascular disease therapy.
Article
Biotechnology & Applied Microbiology
Azar Shams, Ronak Shabani, Hamidreza Asgari, Mahdi Karimi, Mohammad Najafi, Mohammad Asghari-Jafarabadi, Seyed Mohsen Razavi, Seyed Rouhollah Miri, Mehdi Abbasi, Amirhossein Mohammadi, Morteza Koruji
Summary: The study revealed the remarkable apoptotic induction effects of miRNA-143 and -206 in cancer cells, with miRNA-206 showing stronger apoptotic effects compared to miRNA-143 and mixed miRNAs.
Article
Immunology
Heng Xu, Jizhang Yu, Jikai Cui, Zhang Chen, Xi Zhang, Yanqiang Zou, Yifan Du, Yuan Li, Sheng Le, Lang Jiang, Jiahong Xia, Jie Wu
Summary: This study investigated the protective effect and mechanism of conditional knockout of Birc5 in T cells in a mouse model of acute heart allograft rejection. Deletion of Birc5 in T cells attenuated acute heart allograft rejection by reducing the ratio of effector to naive T cells and Th1 to Tregs, without affecting proliferation but impacting apoptosis and IFN-gamma secretion. Treatment with YM155 inhibited acute heart allograft rejection in vivo and increased T-cell apoptosis in healthy human PBMCs in vitro, highlighting a potential therapeutic target for acute transplant rejection prevention and treatment.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Yongbo Wang, Xingyu Liu, Panpan Xia, Zhangwang Li, Xinxi FuChen, Yunfeng Shen, Peng Yu, Jing Zhang
Summary: An effective acute inflammatory response is crucial for eliminating infectious microorganisms and transitioning to the resolution and repair phase. Neutrophils play a key role in antimicrobial defense during inflammation, but their removal is necessary for the subsiding of inflammation. Macrophages help clear neutrophils and promote inflammation towards resolution. Recent attention has been given to the potential of microRNAs (miRNAs) as targeted therapy in chronic diseases by regulating various cellular processes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Food Science & Technology
Yi Sun, Yake Lv, Yuchen Li, Jingwen Li, Jin Liu, Lingfeng Luo, Chenyun Zhang, Wenchang Zhang
Summary: This study investigated the maternal genetic effects of cadmium-induced apoptotic in ovarian granulosa cells (OGCs). The results showed that Cd-induced apoptotic changes were significant in F1 generation, but gradually attenuated and disappeared in F2 and F3 generations. Changes in miRNAs and DNA methylation may play important roles in this process, and the role of transcription factors deserves attention.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Review
Immunology
MingHua Cui, YueHui Liu, Li Cheng, Tao Li, YongZhi Deng, Da Liu
Summary: Ovarian cancer is a highly deadly malignancy among women, and its complex pathogenesis remains largely unknown. The tumor microenvironment plays a crucial role in tumor progression and treatment. MicroRNAs have been shown to regulate ovarian cancer development by affecting the tumor microenvironment. Therefore, identifying new tumor biomarkers and therapeutic targets is of great significance for ovarian cancer treatment.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Ri Zhang, Yujia Wei, Tingmei Wang, Xiaoqi Nie, Zeqi Shi, Yunhua Deng, Dong Li
Summary: Exosomes, small vesicles coated with phospholipids, are released by cells and contain miRNA that plays a significant role in the pathogenesis of autoimmune skin diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Daniel Michaud, Colleen R. Steward, Bhalchandra Mirlekar, Yuliya Pylayeva-Gupta
Summary: Tumorigenesis involves genetic mutations and changes in the microenvironment, with immune cells in tumors playing a role in promoting tumor growth. Recent studies have shed light on the mechanisms of how B cells regulate immune responses, with negative regulation potentially impacting anti-tumor immune function through cytokine production.
IMMUNOLOGICAL REVIEWS
(2021)
Review
Immunology
Osagie A. Eribo, Nelita du Plessis, Novel N. Chegou
Summary: Gut microbiota, especially Bacteroides fragilis, plays a critical role in host health by regulating immune responses. The unique capsular polysaccharides produced by B. fragilis can activate T cells and protect against various diseases, including colitis, cancer, and pulmonary inflammation. Recent studies have explored the immunomodulatory effects of B. fragilis and its polysaccharide-A (PSA) in viral infections and tuberculosis, suggesting their potential application in probiotics and vaccine development.
INFECTION AND IMMUNITY
(2022)
Article
Infectious Diseases
Andriette M. Hiemstra, Candice E. MacDonald, Ilana C. van Rensburg, Kim Stanley, Elizna Maasdorp, Shirley Mc Anda, Susanne Tonsing, Jane Alexandra Shaw, Gerard Tromp, Gian D. van der Spuy, Kevin B. Urdahl, David M. Lewinsohn, Helena Kuivaniemi, Nelita Du Plessis, Stephanus T. Malherbe, Gerhard Walzl
Summary: This study aims to analyze the protective pathways of natural and vaccine-induced immunity against Mycobacterium tuberculosis by collecting data and samples from participants, including lung imaging and laboratory tests.
BMC INFECTIOUS DISEASES
(2022)
Review
Biochemistry & Molecular Biology
Brian S. M. Munansangu, Colin Kenyon, Gerhard Walzl, Andre G. Loxton, Leigh A. Kotze, Nelita du Plessis
Summary: Immunometabolism investigates the interaction between the immune system and metabolic pathways, with small molecules targeting specific pathways to alter immune responses for potential therapeutic interventions. The metabolic reprogramming of MDSC in diseases like cancer contributes to immunosuppression, highlighting the importance of understanding and targeting these pathways in diseases such as tuberculosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Leigh Ann Kotze, Gian van der Spuy, Bryan Leonard, Adam Penn-Nicholson, Munyaradzi Musvosvi, Shirley McAnda, Stephanus T. Malherbe, Mzwandile Erasmus, Thomas Scriba, Coenraad F. N. Koegelenberg, Brian W. Allwood, Gerhard Walzl, Nelita du Plessis
Summary: This study explored the phenotype, function, and immunosuppressive mechanism spectrum of myeloid-derived suppressor cells (MDSC) in patients with tuberculosis (TB). The researchers found that the gene expression patterns of MDSC in TB patients may be similar to those found in cancer. These findings are important for TB research and may guide future studies on repurposing cancer immunotherapies for TB.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Microbiology
Afsatou Ndama Traore, Mpumelelo Casper Rikhotso, Ntshuxeko Thelma Banda, Maphepele Sara Mashilo, Jean Pierre Kabue Ngandu, Vuyo Mavumengwana, Andre G. Loxton, Craig Kinnear, Natasha Potgieter, Scott Heysell, Rob Warren
Summary: This study investigated the effectiveness of adding bedaquiline to the treatment of drug-resistant tuberculosis (DR-TB) infections in Africa. The results showed limited improvement in DR-TB treatment outcomes with the use of bedaquiline. The study highlights the need for better monitoring, reporting, and collaborative research in Africa to understand the usage and clinical impact of bedaquiline.
Article
Immunology
Vinzeigh N. Leukes, Stephanus T. Malherbe, Andriette Hiemstra, Leigh A. Kotze, Kelly Roos, Alana Keyser, Dalene De Swardt, Andrea Gutschmidt, Gerhard Walzl, Nelita du Plessis
Summary: Resistance to common anti-TB drugs is a major challenge in TB treatment, leading to the investigation of host-directed therapies (HDTs). This study found that Sildenafil, when repurposed as an HDT, was unable to reverse the suppressive effects of MDSC on T-cell responsiveness, suggesting the need for further development of MDSC-targeting HDTs for TB.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Munyaradzi Musvosvi, Huang Huang, Chunlin Wang, Qiong Xia, Virginie Rozot, Akshaya Krishnan, Peter Acs, Abhilasha Cheruku, Gerlinde Obermoser, Alasdair Leslie, Samuel M. Behar, Willem A. Hanekom, Nicole Bilek, Michelle Fisher, Stefan H. E. Kaufmann, Gerhard Walzl, Mark Hatherill, Mark M. Davis, Thomas J. Scriba
Summary: In this study, single-cell and bulk T-cell receptor (TCR) sequencing and the GLIPH2 algorithm were used to analyze M. tuberculosis-specific sequences in two longitudinal cohorts. The findings identified T-cell similarity groups associated with control of infection or progression to disease, and proposed antigens recognized by T-cell similarity groups associated with infection control as high-priority targets for future vaccine development.
Article
Multidisciplinary Sciences
Stuart Meier, James A. Seddon, Elizna Maasdorp, Leanie Kleynhans, Nelita du Plessis, Andre G. Loxton, Stephanus T. Malherbe, Daniel E. Zak, Ethan Thompson, Fergal J. Duffy, Stefan H. E. Kaufmann, Tom H. M. Ottenhoff, Thomas J. Scriba, Sara Suliman, Jayne S. Sutherland, Jill Winter, Helena Kuivaniemi, Gerhard Walzl, Gerard Tromp
Summary: This study analyzed RNA sequencing data from TB progressors and TB patients, and identified differential gene expression related to TB progression. The study also revealed that neutrophils and platelets play a critical role in the development of TB.
Article
Multidisciplinary Sciences
Kudzanai Ian Tapfuma, Kudakwashe Nyambo, Francis Adu-Amankwaah, Lucinda Baatjies, Liezel Smith, Nasiema Allie, Marshall Keyster, Andre G. Loxton, Mkhuseli Ngxande, Rehana Malgas-Enus, Vuyo Mavumengwana
Summary: This study investigated the antimicrobial activity of crude secondary metabolites from marine fungi associated with ascidians against Mycobacterium tuberculosis. The results showed that metabolites from marine-derived fungi are potential sources of bioactive metabolites with anti-mycobacterial activity. However, further experimental validation is needed.
Article
Multidisciplinary Sciences
Lucinda Baatjies, Ilana G. van Rensberg, Candice J. Snyders, Andrea Gutschmidt, Andre Loxton, Monique Williams
Summary: Iron is important for Mycobacterium tuberculosis infection and survival. The SufR operon is involved in iron-sulphur biogenesis in M. tuberculosis and is induced during iron limitation and intracellular growth, indicating its relevance during infection. A fluorescent reporter was used to study sufR expression during intracellular growth, and while increased fluorescence was observed in a sub-set of the population, the immune response elicited by SufR in TB-infected individuals was low and did not show a strong immune response.
Article
Multidisciplinary Sciences
Jane Alexandra Shaw, Maynard Meiring, Devon Allies, Lauren Cruywagen, Tarryn-Lee Fisher, Kesheera Kasavan, Kelly Roos, Stefan Marc Botha, Candice MacDonald, Andritte M. Hiemstra, Donald Simon, Ilana M. van Rensburg, Marika A. Flinn, Ayanda B. Shabangu, Helena Kuivaniemi, Gerard Tromp, Stephanus Malherbe, Gerhard Walzl, Nelita du Plessis
Summary: Bronchoalveolar lavage (BAL) is a common procedure for studying infectious disease immunology. This study analyzed the factors that influence the outcomes of BAL and identified associations with participant characteristics such as active tuberculosis (TB) disease, HIV infection, and recent SARS-CoV-2 infection. The results showed correlations between BAL volume and cell count in participants with active TB disease and current smokers. Older participants had lower BAL cell and volume yields, and higher neutrophils. Current smokers had lower volumes, higher cell counts, and black pellets. The findings provide insights for researchers to optimize participant selection and assay for projects involving lung immune cells.
SCIENTIFIC REPORTS
(2023)
Article
Microbiology
Osagie A. Eribo, Charissa C. Naidoo, Grant Theron, Gerhard Walzl, Nelita du Plessis, Novel N. Chegou
Summary: This study aimed to develop a reproducible antibiotic-based model for manipulating the gut microbiota and engrafting B. fragilis into mice. Different combinations of antibiotics were evaluated for their efficacy in depleting the Bacteroides population, and a model involving metronidazole/clindamycin treatment followed by B. fragilis transplantation was found to consistently eliminate Bacteroides and facilitate B. fragilis engraftment. This model has potential use in investigating the role of Bacteroides in specific diseases.
Article
Immunology
Jane Alexandra Shaw, Maynard Meiring, Candice Snyders, Frans Everson, Lovemore Nyasha Sigwadhi, Veranyay Ngah, Gerard Tromp, Brian Allwood, Coenraad F. N. Koegelenberg, Elvis M. Irusen, Usha Lalla, Nicola Baines, Annalise E. Zemlin, Rajiv T. Erasmus, Zivanai C. Chapanduka, Tandi E. Matsha, Gerhard Walzl, Hans Strijdom, Nelita du Plessis, Alimuddin Zumla, Novel Chegou, Stephanus T. Malherbe, Peter S. Nyasulu
Summary: This study collected samples and clinical data from COVID-19 patients in Sub-Saharan African populations and found dysregulation in biomarkers among critical patients. These dysregulations were associated with abnormal cytokine responses, bacterial infections, and endothelial dysfunction, which may contribute to mortality.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Jane Alexandra Shaw, Stephanus T. Malherbe, Gerhard Walzl, Nelita du Plessis
Summary: Epidemiologic data indicate that both current and previous tuberculosis (TB) increase the risk of in-hospital mortality from COVID-19, and a similar trend is observed for poor outcomes from Mtb infection after recent SARS-CoV-2. Dysregulation of immunity explains the dual risk posed by co-infection, with a dysfunctional innate immune response observed in COVID-19. Myeloid-derived suppressor cells (MDSC) play a crucial role in this process by becoming immunosuppressive and impairing pathogen clearance. MDSC are enriched in severe COVID-19 patients and are associated with higher levels of inflammatory cytokines.
FRONTIERS IN IMMUNOLOGY
(2023)
Proceedings Paper
Computer Science, Interdisciplinary Applications
Aleksandra Suwalska, Nelita du Plessis-Burger, Gian van der Spuy, Joanna Polanska
Summary: Mass cytometry, a popular single-cell technology, can measure over 50 markers for millions of cells simultaneously. This study compared two batch correction methods, cyCombine and iMUBAC, on a real dataset and found that cyCombine outperformed iMUBAC in terms of the similarity of marker profiles within cell clusters.
BIOINFORMATICS AND BIOMEDICAL ENGINEERING, PT II
(2022)
Article
Genetics & Heredity
Xiangge Meng, Chengping Li, Yu Hei, Xiang Zhou, Guoli Zhou
Summary: The study used IVT-SAPAS sequencing to analyze the dynamic changes of APA sites during adipogenesis in bovine subcutaneous preadipocytes and intramuscular preadipocytes. The results showed that APA plays an important role in adipocyte differentiation, and UTR-APA switching genes have different trends, with intramuscular preadipocytes tending to use shorter 3'UTR for differentiation. TRIB3, WWTR1, and INSIG1 play important roles in intramuscular preadipocyte differentiation.
Article
Genetics & Heredity
S. Alizadeh, S. Khamse, N. Tajeddin, H. R. Khorram Khorshid, A. Delbari, M. Ohadi
Summary: This study identifies a specific genotype at a CG-rich trinucleotide short tandem repeat (STR) locus that is associated with late-onset neurocognitive disorders such as Alzheimer's disease (AD).
Article
Genetics & Heredity
Shougang Liu, Zhe Zhuang, Fanghua Liu, Xiuqing Yuan, Zeqiao Zhang, Xiaoqian Liang, Xinhui Li, Yongfeng Chen
Summary: This study investigated the effect and mechanism of RPL9 and TIFA in scalp psoriasis, and identified RPL9 as a potential therapeutic target for scalp psoriasis.
Article
Genetics & Heredity
Shiting Wang, Jiaqi Chen, Zhichao Jin, Ying Xing, Ruiping Wang
Summary: This study suggests a causal association between hair color and skin cancers, with light hair colors (red, blonde, and light brown) being associated with an increased risk and dark brown hair being associated with a decreased risk.
Article
Genetics & Heredity
Joseph Hawadak, Loick Pradel Kojom Foko, Rodrigue Roman Dongang Nana, Karmveer Yadav, Veena Pande, Aparup Das, Vineeta Singh
Summary: This study investigates the genetic diversity and natural selection of the Pfama-1 gene in Plasmodium falciparum isolates from Cameroon. The study finds a considerable nucleotide and haplotype diversity, as well as specific mutations in Cameroonian isolates. Positive diversifying selection and the identification of selected codon sites suggest the potential implication of these genetic variations in host immune pressure and parasite-binding complex modulation. The findings provide valuable baseline data for malaria vaccine design.
Article
Genetics & Heredity
Emily Biernat, Mansi Verma, Chhabi K. Govind
Summary: RSC is an essential ATP-dependent chromatin remodeling complex in Saccharomyces cerevisiae. It regulates nucleosome-depleted regions (NDRs) by sliding flanking nucleosomes away from NDRs. Depletion of RSC leads to nucleosome encroachment in NDRs and transcription initiation defects. The study compared the effects of catalytic-dead Sth1 and rapid depletion of Sth1 on transcription. Rapid depletion of Sth1 reduces recruitment of TBP and Pol II, while the catalytic-dead mutant exhibits a severe reduction in TBP binding but accumulates Pol II in coding regions. The results suggest a role for RSC in transcription elongation and termination processes.
Article
Genetics & Heredity
Yunxiao Wei, Yuhan Song, Muhammad Aamir Khan, Chengzhen Liang, Zhigang Meng, Yuan Wang, Sandui Guo, Rui Zhang
Summary: This study analyzed the GhTPP protein family in upland cotton for the first time and identified the important role of GhTPPA_2 in regulating sugar metabolism, improving soluble sugar accumulation, and drought stress tolerance.
Article
Genetics & Heredity
Yannan Geng, Rui Shao, Tiantong Xu, Lilong Zhang
Summary: A novel risk model based on SCUBE3, TNNC1, SPON1, SEPT12 and ULBP1 genes was developed for predicting PMOP risk, with higher risk score indicating higher risk of suffering from PMOP. Significant differences in signaling pathway activities were observed between the high-risk score group and the low-risk score group.
Article
Genetics & Heredity
Randy P. Williams, Corina Lesseur, Haoxiang Cheng, Qian Li, Maya Deyssenroth, Christopher D. Molteno, Ernesta M. Meintjes, Sandra W. Jacobson, Joseph L. Jacobson, Helen Wainwright, Ke Hao, Jia Chen, R. Colin Carter
Summary: The study suggests that heavy alcohol exposure during pregnancy may impact the proportion of fetal placental villi macrophages and increase the expression of inflammatory genes. Further research is needed to explore these effects and evaluate the potential functional roles of placental inflammation in FASD.
Article
Genetics & Heredity
Lvjing Luo, Lishuang Sun, Shu Li, Huiting Liu, Zhengyu Chen, Shi Huang, Yinyin Mo, Genliang Li
Summary: This study analyzed the expression of Ptpn1 and miR-124-3p in testicular tissues of mice and investigated their regulatory relationship. The results showed that Ptpn1 expression was up-regulated in adult mouse testis compared to juvenile mouse testis, while miR-124-3p expression showed an opposite pattern. Further analysis suggested that the down-regulation of miR-124-3p may contribute to the high expression of Ptpn1 in adult mouse testis.
Article
Genetics & Heredity
Gairui Li, Dan Zhao, Xiaolin Peng, Yashuang Zhao
Summary: MiRNA-22 shows potential as a candidate for early diagnosis of colorectal cancer (CRC). The study found higher miR-22 expression levels in the CRC and CRA groups, suggesting its potential as a biomarker for CRC early screening.
Article
Genetics & Heredity
Zhongqiu Zhu, Qianting Yang, Xiaoying Tian, Da Man, Jian Wang, Junfang Zhang, Bingshe Han
Summary: This study constructed a ceRNA network mediated by lncRNAs in cold-acclimated zebrafish ZF4 cells and revealed that upregulation of MSTRG3207 promotes apoptosis by sponging dre-miR-736 during cold acclimation.
Article
Genetics & Heredity
Weitao Chen, Denggao Xiang, Shang Gao, Shuli Zhu, Zhi Wu, Yuefei Li, Jie Li
Summary: Dam construction has negatively impacted the genetic diversity and structure of fish populations. This case study on the endangered Hemibagrus guttatus found low genetic diversity, high levels of inbreeding, and decreasing population size in fragmented populations. Genetic structure and differentiation were also observed, indicating the influence of dams on these fish populations.
Article
Genetics & Heredity
Pooja Singh, Debleena Guin, Bijay Pattnaik, Ritushree Kukreti
Summary: Through systematic literature review and meta-analysis, it was found that idiopathic pulmonary fibrosis is significantly associated with 222 polymorphisms in 118 genes. Four polymorphisms - rs35705950/MUC5B, rs2736100/TERT, rs2076295/DSP, and rs111521887/TOLLIP, exhibited substantial epidemiological evidence supporting their association with IPF risk.
Article
Genetics & Heredity
Jianping Zhang, Zhijun Cai, Fanzhe Feng, Yufeng Peng, Yi Cui, Yongiqing Xu
Summary: This study found that exosomes secreted by young BMSCs can promote the healing of tendon-bone interface after rotator cuff tears. These exosomes can improve extracellular matrix remodeling, osteogenic differentiation, angiogenesis, and stemness of tendon-derived stem cells (TDSCs). The exosomes from young BMSCs have better effects compared to those from aged BMSCs.
