Journal
AUTOPHAGY
Volume 14, Issue 3, Pages 558-559Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/15548627.2018.1425060
Keywords
autophagy; hematopoietic stem cell; monocytic and granulocytic differentiation; temporal expression pattern; transcriptomic analysis
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Funding
- National Natural Science Foundation of China [81770104, 31371322, 81530007, 31471227]
- National Key Research and Development Program of China [2016YFA0100601]
- Natural Science Foundation of Heilongjiang Province [C2015027]
- Weihan Yu Youth Science Fund Project of Harbin Medical University
- CAMS Initiative for Innovative Medicine [2016-12M-3-002, 2017-12M-3-009]
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Macroautophagy/autophagy plays an essential role in hematopoietic stem cell (HSC) differentiation. However, the role of autophagy during monocytic and granulocytic differentiation remains poorly understood. Hence, we first represented global transcriptomic analysis for temporal expression of autophagy genes during monocytic and granulocytic differentiation by combining RNA-Seq data with monocytic and granulocytic induction in CD34(+) hematopoietic stem and progenitor cells. According to a self-organizing map (SOM) algorithm, our results show temporal expression patterns of autophagy genes during monocytic and granulocytic differentiation. More importantly, 22 autophagy genes present significantly divergent roles during monocytic and granulocytic differentiation, indicating these autophagy genes could be important factors involved in the differentiation of myeloid progenitors into monocytes and granulocytes.
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