The potential role of necroptosis in inflammaging and aging

Redox regulation by NRF2 in aging and disease

(2019) Cody J. Schmidlin et al.   FREE RADICAL BIOLOGY AND MEDICINE

MLKL deficiency inhibits DSS-induced colitis independent of intestinal microbiota

(2019) Jie Zhang et al.   MOLECULAR IMMUNOLOGY

Receptor-Interacting Serine/Threonine-Protein Kinase 3 (RIPK3)–Mixed Lineage Kinase Domain-Like Protein (MLKL)–Mediated Necroptosis Contributes to Ischemia-Reperfusion Injury of Steatotic Livers

(2019) Hong-Min Ni et al.   AMERICAN JOURNAL OF PATHOLOGY

Inhibition of mixed lineage kinase domain like pseudokinase decreases fat de novo synthesis and chemokine ligand expression in non‐alcoholic fatty liver disease

(2019) Waqar Khalid Saeed et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer’s disease model

(2019) Peisu Zhang et al.   NATURE NEUROSCIENCE

Necroptosis increases with age and is reduced by dietary restriction

(2018) Sathyaseelan S. Deepa et al.   AGING CELL

RIP3 deficiency protects against traumatic brain injury (TBI) through suppressing oxidative stress, inflammation and apoptosis: Dependent on AMPK pathway

(2018) Zai-Ming Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Oxidative stress induced necroptosis activation is involved in the pathogenesis of hyperoxic acute lung injury

(2018) C.H. Han et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Necrostatin-1 Protects Against Paraquat-Induced Cardiac Contractile Dysfunction via RIP1-RIP3-MLKL-Dependent Necroptosis Pathway

(2018) Liping Zhang et al.   Cardiovascular Toxicology

RIPK3/MLKL-Mediated Neuronal Necroptosis Modulates the M1/M2 Polarization of Microglia/Macrophages in the Ischemic Cortex

(2018) Jiping Yang et al.   CEREBRAL CORTEX

Accelerated sarcopenia in Cu/Zn superoxide dismutase knockout mice

(2018) Sathyaseelan S. Deepa et al.   FREE RADICAL BIOLOGY AND MEDICINE

Pharmacological Inhibition of Necroptosis Protects from Dopaminergic Neuronal Cell Death in Parkinson’s Disease Models

(2018) Angelo Iannielli et al.   Cell Reports

Inhibiting RIPK1 Limits Neuroinflammation and Alleviates Postoperative Cognitive Impairments in D-Galactose-Induced Aged Mice

(2018) Shangchun Duan et al.   Frontiers in Behavioral Neuroscience

Ageing: from inflammation to cancer

(2018) Giulia C. Leonardi et al.   Immunity & Ageing

Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline

(2018) Tyler J. Bussian et al.   NATURE

Author Correction: Necroptosis microenvironment directs lineage commitment in liver cancer

(2018) Marco Seehawer et al.   NATURE

Necroptosis and RIPK1-mediated neuroinflammation in CNS diseases

(2018) Junying Yuan et al.   NATURE REVIEWS NEUROSCIENCE

Microglia in Alzheimer's Disease: Risk Factors and Inflammation

(2018) Atsuko Katsumoto et al.   Frontiers in Neurology

Microglia in Alzheimer’s disease

(2017) Heela Sarlus et al.   JOURNAL OF CLINICAL INVESTIGATION

Necroptosis activation in Alzheimer's disease

(2017) Antonella Caccamo et al.   NATURE NEUROSCIENCE

RIPK1 mediates a disease-associated microglial response in Alzheimer’s disease

(2017) Dimitry Ofengeim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RIPK1-RIPK3-MLKL-dependent necrosis promotes the aging of mouse male reproductive system

(2017) Dianrong Li et al.   eLife

MLKL Mediated Necroptosis Accelerates JEV-Induced Neuroinflammation in Mice

(2017) Peiyu Bian et al.   Frontiers in Microbiology

Aged Gut Microbiota Contributes to Systemical Inflammaging after Transfer to Germ-Free Mice

(2017) Floris Fransen et al.   Frontiers in Immunology

Influence of Nrf2 activators on subcellular skeletal muscle protein and DNA synthesis rates after 6 weeks of milk protein feeding in older adults

(2017) Adam R. Konopka et al.   GeroScience

Microglia activation and phagocytosis: relationship with aging and cognitive impairment in the rhesus monkey

(2017) Eli Shobin et al.   GeroScience

Cigarette smoke-induced necroptosis and DAMP release trigger neutrophilic airway inflammation in mice

(2016) Simon D. Pouwels et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Necroptosis: A Novel Cell Death Modality and Its Potential Relevance for Critical Care Medicine

(2016) Gabriel Moreno-Gonzalez et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Necroptosis and Inflammation

(2016) Kim Newton et al.   Annual Review of Biochemistry

Rapamycin inhibits lipopolysaccharide-induced neuroinflammation in vitro and in vivo

(2016) Na-Shun Mengke et al.   Molecular Medicine Reports

KU0063794, a Dual mTORC1 and mTORC2 Inhibitor, Reduces Neural Tissue Damage and Locomotor Impairment After Spinal Cord Injury in Mice

(2016) Marika Cordaro et al.   MOLECULAR NEUROBIOLOGY

The necrosome promotes pancreatic oncogenesis via CXCL1 and Mincle-induced immune suppression

(2016) Lena Seifert et al.   NATURE

Tumour-cell-induced endothelial cell necroptosis via death receptor 6 promotes metastasis

(2016) Boris Strilic et al.   NATURE

mTOR pathway inhibition prevents neuroinflammation and neuronal death in a mouse model of cerebral palsy

(2016) Isha N. Srivastava et al.   NEUROBIOLOGY OF DISEASE

RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS

(2016) Yasushi Ito et al.   SCIENCE

An evolutionary perspective on the necroptotic pathway

(2016) Yves Dondelinger et al.   TRENDS IN CELL BIOLOGY

Interleukin-6 and C-reactive protein, successful aging, and mortality: the PolSenior study

(2016) Monika Puzianowska-Kuźnicka et al.   Immunity & Ageing

DAMPs as mediators of sterile inflammation in aging-related pathologies

(2015) Noa Feldman et al.   AGEING RESEARCH REVIEWS

RPE necroptosis in response to oxidative stress and in AMD

(2015) Jakub Hanus et al.   AGEING RESEARCH REVIEWS

Sex- and tissue-specific changes in mTOR signaling with age in C57BL/6J mice

(2015) Emma L. Baar et al.   AGING CELL

Glutathione peroxidase 4 prevents necroptosis in mouse erythroid precursors

(2015) O. Canli et al.   BLOOD

Necroptosis is a key pathogenic event in human and experimental murine models of non-alcoholic steatohepatitis

(2015) Marta B. Afonso et al.   CLINICAL SCIENCE

How longevity research can lead to therapies for Alzheimer's disease: The rapamycin story

(2015) Arlan Richardson et al.   EXPERIMENTAL GERONTOLOGY

Oxidative stress response and Nrf2 signaling in aging

(2015) Hongqiao Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Drivers of age-related inflammation and strategies for healthspan extension

(2015) Emily L. Goldberg et al.   IMMUNOLOGICAL REVIEWS

Necroptosis and its role in inflammation

(2015) Manolis Pasparakis et al.   NATURE

Nrf2 Signaling and the Slowed Aging Phenotype: Evidence from Long-Lived Models

(2015) Danielle R. Bruns et al.   Oxidative Medicine and Cellular Longevity

Regulation of Nrf2 signaling and longevity in naturally long-lived rodents

(2015) Kaitlyn N. Lewis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RIP3-mediated necrotic cell death accelerates systematic inflammation and mortality

(2015) Lingjun Meng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Restriction of dietary protein decreases mTORC1 in tumors and somatic tissues of a tumor-bearing mouse xenograft model

(2015) Dudley W. Lamming et al.   Oncotarget

Activation of Necroptosis in Multiple Sclerosis

(2015) Dimitry Ofengeim et al.   Cell Reports

Induction of a common microglia gene expression signature by aging and neurodegenerative conditions: a co-expression meta-analysis

(2015) Inge R Holtman et al.   Acta Neuropathologica Communications

Activation of the PI3K-Akt-mTOR signaling pathway promotes necrotic cell death via suppression of autophagy

(2014) You-Tong Wu et al.   Autophagy

Geroscience: Linking Aging to Chronic Disease

(2014) Brian K. Kennedy et al.   CELL

The Ratio of Macronutrients, Not Caloric Intake, Dictates Cardiometabolic Health, Aging, and Longevity in Ad Libitum-Fed Mice

(2014) Samantha M. Solon-Biet et al.   Cell Metabolism

Circulating mitochondrial DNA increases with age and is a familiar trait: Implications for “inflamm-aging”

(2014) Marcello Pinti et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Retinal ganglion cell (RGC) programmed necrosis contributes to ischemia–reperfusion-induced retinal damage

(2014) Galina Dvoriantchikova et al.   EXPERIMENTAL EYE RESEARCH

Complexity of Danger: The Diverse Nature of Damage-associated Molecular Patterns

(2014) Liliana Schaefer   JOURNAL OF BIOLOGICAL CHEMISTRY

mTOR Signaling Inhibition Modulates Macrophage/Microglia-Mediated Neuroinflammation and Secondary Injury via Regulatory T Cells after Focal Ischemia

(2014) L. Xie et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: RIPK1 Kinase Inactive Mice Are Viable and Protected from TNF-Induced Necroptosis In Vivo

(2014) Apostolos Polykratis et al.   JOURNAL OF IMMUNOLOGY

Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases

(2014) C. Franceschi et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Mixed Lineage Kinase Domain-like Protein MLKL Causes Necrotic Membrane Disruption upon Phosphorylation by RIP3

(2014) Huayi Wang et al.   MOLECULAR CELL

Necroptosis

(2014) Andreas Linkermann et al.   NEW ENGLAND JOURNAL OF MEDICINE

Activity of Protein Kinase RIPK3 Determines Whether Cells Die by Necroptosis or Apoptosis

(2014) K. Newton et al.   SCIENCE

Akt and mTOR mediate programmed necrosis in neurons

(2014) Q Liu et al.   Cell Death & Disease

A Diverse Array of Cancer-Associated MTOR Mutations Are Hyperactivating and Can Predict Rapamycin Sensitivity

(2014) B. C. Grabiner et al.   Cancer Discovery

MLKL Compromises Plasma Membrane Integrity by Binding to Phosphatidylinositol Phosphates

(2014) Yves Dondelinger et al.   Cell Reports

Necrostatin-1 protects against reactive oxygen species (ROS)-induced hepatotoxicity in acetaminophen-induced acute liver failure

(2014) Kenji Takemoto et al.   FEBS Open Bio

Programmed necrosis, not apoptosis, is a key mediator of cell loss and DAMP-mediated inflammation in dsRNA-induced retinal degeneration

(2013) Y Murakami et al.   CELL DEATH AND DIFFERENTIATION

Canonical Nlrp3 Inflammasome Links Systemic Low-Grade Inflammation to Functional Decline in Aging

(2013) Yun-Hee Youm et al.   Cell Metabolism

The role of inflammation in sporadic and familial Parkinson’s disease

(2013) Michela Deleidi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

PRAS40 prevents development of diabetic cardiomyopathy and improves hepatic insulin sensitivity in obesity

(2013) Mirko Völkers et al.   EMBO Molecular Medicine

Seventeen year risk of all-cause and cause-specific mortality associated with C-reactive protein, fibrinogen and leukocyte count in men and women: the EPIC-Norfolk study

(2013) Sara Ahmadi-Abhari et al.   EUROPEAN JOURNAL OF EPIDEMIOLOGY

Dietary restriction attenuates the accelerated aging phenotype of Sod1−/− mice

(2013) Yiqiang Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Necroptosis: The Release of Damage-Associated Molecular Patterns and Its Physiological Relevance

(2013) Agnieszka Kaczmarek et al.   IMMUNITY

The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism

(2013) James M. Murphy et al.   IMMUNITY

p53-dependent release of Alarmin HMGB1 is a central mediator of senescent phenotypes

(2013) Albert R. Davalos et al.   JOURNAL OF CELL BIOLOGY

Hypothalamic programming of systemic ageing involving IKK-β, NF-κB and GnRH

(2013) Guo Zhang et al.   NATURE

A Tumor Suppressor Complex with GAP Activity for the Rag GTPases That Signal Amino Acid Sufficiency to mTORC1

(2013) L. Bar-Peled et al.   SCIENCE

Structural Basis of RIP1 Inhibition by Necrostatins

(2013) Tian Xie et al.   STRUCTURE

Activity and specificity of necrostatin-1, small-molecule inhibitor of RIP1 kinase

(2012) A Degterev et al.   CELL DEATH AND DIFFERENTIATION

DAI/ZBP1/DLM-1 Complexes with RIP3 to Mediate Virus-Induced Programmed Necrosis that Is Targeted by Murine Cytomegalovirus vIRA

(2012) Jason W. Upton et al.   Cell Host & Microbe

TOR Signaling and Rapamycin Influence Longevity by Regulating SKN-1/Nrf and DAF-16/FoxO

(2012) Stacey Robida-Stubbs et al.   Cell Metabolism

Aging and Atherosclerosis

(2012) Julie C. Wang et al.   CIRCULATION RESEARCH

Involvement of Immune Response in the Pathogenesis of Amyotrophic Lateral Sclerosis: A Therapeutic Opportunity?

(2012) A. Calvo et al.   CNS & Neurological Disorders-Drug Targets

Microglia and Inflammation in Alzheimers Disease

(2012) Shweta Mandrekar-Colucci et al.   CNS & Neurological Disorders-Drug Targets

Non-apoptotic functions of apoptosis-regulatory proteins

(2012) Lorenzo Galluzzi et al.   EMBO REPORTS

Absence of receptor interacting protein kinase 3 prevents ethanol-induced liver injury

(2012) Sanjoy Roychowdhury et al.   HEPATOLOGY

Aging and Declining Testosterone: Past, Present, and Hopes for the Future

(2012) B. R. Zirkin et al.   JOURNAL OF ANDROLOGY

Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study

(2012) David H Cribbs et al.   Journal of Neuroinflammation

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

Review: Microglia of the aged brain: primed to be activated and resistant to regulation

(2012) D. M. Norden et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Immune correlates of aging in outdoor-housed captive rhesus macaques (Macaca mulatta)

(2012) Elizabeth S Didier et al.   Immunity & Ageing

The aging gut microbiota: New perspectives

(2011) Elena Biagi et al.   AGEING RESEARCH REVIEWS

Neuronal cell death in neonatal hypoxia-ischemia

(2011) Frances J. Northington et al.   ANNALS OF NEUROLOGY

Elimination of the NLRP3-ASC Inflammasome Protects against Chronic Obesity-Induced Pancreatic Damage

(2011) Yun-Hee Youm et al.   ENDOCRINOLOGY

RIP Kinase-Dependent Necrosis Drives Lethal Systemic Inflammatory Response Syndrome

(2011) Linde Duprez et al.   IMMUNITY

mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in mice

(2011) Ken Inoki et al.   JOURNAL OF CLINICAL INVESTIGATION

Cigarette Smoking and Inflammation

(2011) J. Lee et al.   JOURNAL OF DENTAL RESEARCH

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

HIV Infection, Inflammation, Immunosenescence, and Aging

(2010) Steven G. Deeks   Annual Review of Medicine

Inflammation: A driving force speeds cancer metastasis

(2010) Yadi Wu et al.   CELL CYCLE

Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster

(2010) Ivana Bjedov et al.   Cell Metabolism

Molecular Interplay between Mammalian Target of Rapamycin (mTOR), Amyloid-β, and Tau

(2010) Antonella Caccamo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice

(2010) Richard A. Miller et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Molecular mechanisms of necroptosis: an ordered cellular explosion

(2010) Peter Vandenabeele et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A Human-Like Senescence-Associated Secretory Phenotype Is Conserved in Mouse Cells Dependent on Physiological Oxygen

(2010) Jean-Philippe Coppé et al.   PLoS One

Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation

(2009) YoungSik Cho et al.   CELL

Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α

(2009) Sudan He et al.   CELL

Immunosenescence: what does it mean to health outcomes in older adults?

(2009) Janet E McElhaney et al.   CURRENT OPINION IN IMMUNOLOGY

Radioisotopic Imaging of Neuroinflammation

(2009) A. Winkeler et al.   JOURNAL OF NUCLEAR MEDICINE

RIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis

(2009) D.-W. Zhang et al.   SCIENCE

Identification of RIP1 kinase as a specific cellular target of necrostatins

(2008) Alexei Degterev et al.   Nature Chemical Biology

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY