Ligustilide attenuates nitric oxide-induced apoptosis in rat chondrocytes and cartilage degradation via inhibiting JNK and p38 MAPK pathways

Surfactant protein D attenuates nitric oxide-stimulated apoptosis in rat chondrocyte by suppressing p38 MAPK signaling

(2018) Yan Zhou et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Wood-cultivated ginseng exerts anti-inflammatory effect in LPS-stimulated RAW264.7 cells

(2018) Su Bin Park et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Effects of microRNA-24 targeting C-myc on apoptosis, proliferation, and cytokine expressions in chondrocytes of rats with osteoarthritis via MAPK signaling pathway

(2018) Yuan-Hao Wu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Myricetin treatment induces apoptosis in canine osteosarcoma cells by inducing DNA fragmentation, disrupting redox homeostasis, and mediating loss of mitochondrial membrane potential

(2018) Hahyun Park et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Osteoarthritis as a disease of the cartilage pericellular matrix

(2018) Farshid Guilak et al.   MATRIX BIOLOGY

Ligustilide attenuates vascular inflammation and activates Nrf2/HO-1 induction and, NO synthesis in HUVECs

(2018) Eun Sik Choi et al.   PHYTOMEDICINE

Hydroxysafflor yellow A (HSYA) targeting NF-κB and MAPK pathways ameliorates the development of osteoarthritis

(2018) Zhichao Hu et al.   Food & Function

The Protective Effect of Ligustilide in Osteoarthritis: An in Vitro and in Vivo Study

(2018) Xiaobin Li et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Modern-day environmental factors in the pathogenesis of osteoarthritis

(2018) Francis Berenbaum et al.   Nature Reviews Rheumatology

Disease-Modifying Osteoarthritis Treatment With Interleukin-1 Receptor Antagonist Gene Therapy in Small and Large Animal Models

(2018) Alan J. Nixon et al.   Arthritis & Rheumatology

Clinical Perspective on Pain and Pain Phenotypes in Osteoarthritis

(2018) Feng Pan et al.   Current Rheumatology Reports

Cudraflavone C Induces Apoptosis of A375.S2 Melanoma Cells through Mitochondrial ROS Production and MAPK Activation

(2017) Chiang-Wen Lee et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

MiR-29b-3p promotes chondrocyte apoptosis and facilitates the occurrence and development of osteoarthritis by targeting PGRN

(2017) Lingqiang Chen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Chondrogenic progenitor cells promote vascular endothelial growth factor expression through stromal-derived factor-1

(2017) S. Wang et al.   OSTEOARTHRITIS AND CARTILAGE

MicroRNA-145 attenuates TNF-α-driven cartilage matrix degradation in osteoarthritis via direct suppression of MKK4

(2017) Guoli Hu et al.   Cell Death & Disease

Neuroprotective Effect of Ligustilide through Induction of α-Secretase Processing of Both APP and Klotho in a Mouse Model of Alzheimer’s Disease

(2017) Xi Kuang et al.   Frontiers in Aging Neuroscience

Protection of carboxymethylated chitosan on chondrocytes from nitric oxide-induced apoptosis by regulating phosphatidylinositol 3-kinase/Akt signaling pathway

(2016) Bin He et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Therapeutic Effect of Ligustilide-Stimulated Adipose-Derived Stem Cells in a Mouse Thromboembolic Stroke Model

(2016) Kang Chi et al.   CELL TRANSPLANTATION

(Z)-ligustilide increases ferroportin1 expression and ferritin content in ischemic SH-SY5Y cells

(2016) Yun-Ting Zhang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Locally and traditionally used Ligusticum species – A review of their phytochemistry, pharmacology and pharmacokinetics

(2016) Paul Owusu Donkor et al.   JOURNAL OF ETHNOPHARMACOLOGY

Protection against β-amyloid-induced neurotoxicity by naturally occurring Z-ligustilide through the concurrent regulation of p38 and PI3-K/Akt pathways

(2016) Wei Xu et al.   NEUROCHEMISTRY INTERNATIONAL

Berberine prevents nitric oxide-induced rat chondrocyte apoptosis and cartilage degeneration in a rat osteoarthritis model via AMPK and p38 MAPK signaling

(2015) Yan Zhou et al.   APOPTOSIS

Compromised MAPK signaling in human diseases: an update

(2015) Eun Kyung Kim et al.   ARCHIVES OF TOXICOLOGY

Ligustilide inhibits tumour necrosis factor-alpha-induced autophagy during C2C12 cells differentiation

(2015) Ying Shi et al.   BIOMEDICINE & PHARMACOTHERAPY

Targets, models and challenges in osteoarthritis research

(2015) S. Thysen et al.   Disease Models & Mechanisms

In vivo anti-apoptosis activity of novel berberine-loaded chitosan nanoparticles effectively ameliorates osteoarthritis

(2015) Yan Zhou et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Chondrosenescence: Definition, hallmarks and potential role in the pathogenesis of osteoarthritis

(2015) Ali Mobasheri et al.   MATURITAS

Effect of ligustilide on Ang II-induced hypertrophy in cardiomyocytes and the potential mechanisms

(2014) QUN LU et al.   Experimental and Therapeutic Medicine

The expression of p-ATF2 involved in the chondeocytes apoptosis of an endemic osteoarthritis, Kashin-Beck disease

(2013) Jing Han et al.   BMC MUSCULOSKELETAL DISORDERS

Epigenetic Reactivation of Nrf2 in Murine Prostate Cancer TRAMP C1 Cells by Natural Phytochemicals Z-Ligustilide and Radix Angelica Sinensis via Promoter CpG Demethylation

(2013) Zheng-Yuan Su et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Nitric oxide compounds have different effects profiles on human articular chondrocyte metabolism

(2013) María C de Andrés et al.   ARTHRITIS RESEARCH & THERAPY

Ligustilide alleviates brain damage and improves cognitive function in rats of chronic cerebral hypoperfusion

(2012) Zhanbo Feng et al.   JOURNAL OF ETHNOPHARMACOLOGY

Rebamipide attenuates pain severity and cartilage degeneration in a rat model of osteoarthritis by downregulating oxidative damage and catabolic activity in chondrocytes

(2012) S.-J. Moon et al.   OSTEOARTHRITIS AND CARTILAGE

An in vivo investigation of the initiation and progression of subchondral cysts in a rodent model of secondary osteoarthritis

(2012) David D McErlain et al.   ARTHRITIS RESEARCH & THERAPY

17β-Estradiol Regulates Rat Growth Plate Chondrocyte Apoptosis Through a Mitochondrial Pathway Not Involving Nitric Oxide or MAPKs

(2010) M. Zhong et al.   ENDOCRINOLOGY

Vimentin contributes to changes in chondrocyte stiffness in osteoarthritis

(2010) Dominik R. Haudenschild et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Mitochondrial DNA damage is involved in apoptosis caused by pro-inflammatory cytokines in human OA chondrocytes

(2009) J. Kim et al.   OSTEOARTHRITIS AND CARTILAGE