Notch Signaling in Skeletal Development, Homeostasis and Pathogenesis

NOTCH Signaling Is Activated through Mechanical Strain in Human Bone Marrow-Derived Mesenchymal Stromal Cells

(2019) Fani Ziouti et al.   Stem Cells International

Notch in skeletal physiology and disease

(2018) E. Canalis   OSTEOPOROSIS INTERNATIONAL

Notch signaling suppresses glucose metabolism in mesenchymal progenitors to restrict osteoblast differentiation

(2018) Seung-Yon Lee et al.   JOURNAL OF CLINICAL INVESTIGATION

Sustained Notch2 signaling in osteoblasts, but not in osteoclasts, is linked to osteopenia in a mouse model of Hajdu-Cheney syndrome

(2017) Stefano Zanotti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Osteoblast-Derived Extracellular Vesicles Are Biological Tools for the Delivery of Active Molecules to Bone

(2017) Alfredo Cappariello et al.   JOURNAL OF BONE AND MINERAL RESEARCH

The Notch Ligand Jagged1 Regulates the Osteoblastic Lineage by Maintaining the Osteoprogenitor Pool

(2017) Rialnat A Lawal et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Maintenance of Bone Homeostasis by DLL1-Mediated Notch Signaling

(2017) Yukari Muguruma et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Notch activation enhances mesenchymal stem cell sheet osteogenic potential by inhibition of cellular senescence

(2017) Ye Tian et al.   Cell Death & Disease

Canonical Notch activation in osteocytes causes osteopetrosis

(2016) Ernesto Canalis et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

HES factors regulate specific aspects of chondrogenesis and chondrocyte hypertrophy during cartilage development

(2016) Timothy P. Rutkowski et al.   JOURNAL OF CELL SCIENCE

NOTCH signaling in skeletal progenitors is critical for fracture repair

(2016) Cuicui Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

NOTCH1 Inhibits Activation of ATM by Impairing the Formation of an ATM-FOXO3a-KAT5/Tip60 Complex

(2016) Marek Adamowicz et al.   Cell Reports

Heterozygous Loss-of-Function Mutations in DLL4 Cause Adams-Oliver Syndrome

(2015) Josephina A.N. Meester et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The Osteogenic Niche Promotes Early-Stage Bone Colonization of Disseminated Breast Cancer Cells

(2015) Hai Wang et al.   CANCER CELL

Hajdu Cheney Mouse Mutants Exhibit Osteopenia, Increased Osteoclastogenesis, and Bone Resorption

(2015) Ernesto Canalis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Notch Signaling Promotes Osteoclast Maturation and Resorptive Activity

(2015) Jason W. Ashley et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Notch inhibits chondrogenic differentiation of mesenchymal progenitor cells by targeting Twist1

(2015) Ye Tian et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Notch is a direct negative regulator of the DNA-damage response

(2015) Jelena Vermezovic et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A dual role for NOTCH signaling in joint cartilage maintenance and osteoarthritis

(2015) Zhaoyang Liu et al.   Science Signaling

Notch is a direct negative regulator of the DNA-damage response

(2015) Jelena Vermezovic et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A dual role for NOTCH signaling in joint cartilage maintenance and osteoarthritis

(2015) Zhaoyang Liu et al.   Science Signaling

Mutations in NOTCH1 Cause Adams-Oliver Syndrome

(2014) Anna-Barbara Stittrich et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Truncating mutations in the last exon ofNOTCH3cause lateral meningocele syndrome

(2014) Karen W. Gripp et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Integrating new discoveries into the “vicious cycle” paradigm of prostate to bone metastases

(2014) Leah M. Cook et al.   CANCER AND METASTASIS REVIEWS

Notch Activation as a Driver of Osteogenic Sarcoma

(2014) Jianning Tao et al.   CANCER CELL

Endothelial Notch activity promotes angiogenesis and osteogenesis in bone

(2014) Saravana K. Ramasamy et al.   NATURE

Notch Signaling in Skeletal Stem Cells

(2013) Shan Chen et al.   CALCIFIED TISSUE INTERNATIONAL

Notch as a hub for signaling in angiogenesis

(2013) Rui Benedito et al.   EXPERIMENTAL CELL RESEARCH

Notch Signaling in Osteocytes Differentially Regulates Cancellous and Cortical Bone Remodeling

(2013) Ernesto Canalis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Analysis of αSMA-Labeled Progenitor Cell Commitment Identifies Notch Signaling as an Important Pathway in Fracture Healing

(2013) Brya G Matthews et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Systemic Inhibition of Canonical Notch Signaling Results in Sustained Callus Inflammation and Alters Multiple Phases of Fracture Healing

(2013) Michael I. Dishowitz et al.   PLoS One

Notch signaling in chondrocytes modulates endochondral ossification and osteoarthritis development

(2013) Y. Hosaka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RBPJ Mutations Identified in Two Families Affected by Adams-Oliver Syndrome

(2012) Susan J. Hassed et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Cartilage-specific RBPj -dependent and -independent Notch signals regulate cartilage and bone development

(2012) A. Kohn et al.   DEVELOPMENT

Osteoblast Lineage-Specific Effects of Notch Activation in the Skeleton

(2012) Ernesto Canalis et al.   ENDOCRINOLOGY

Notch gain of function inhibits chondrocyte differentiation via Rbpj-dependent suppression ofSox9

(2012) Shan Chen et al.   JOURNAL OF BONE AND MINERAL RESEARCH

TNF-induced osteoclastogenesis and inflammatory bone resorption are inhibited by transcription factor RBP-J

(2012) Baohong Zhao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Etiology of osteoarthritis: genetics and synovial joint development

(2012) Linda J. Sandell   Nature Reviews Rheumatology

Differential regulation of osteoclastogenesis by Notch2/Delta-like 1 and Notch1/Jagged1 axes

(2012) Chiyoko Sekine et al.   ARTHRITIS RESEARCH & THERAPY

Lfng regulates the synchronized oscillation of the mouse segmentation clock via trans-repression of Notch signalling

(2012) Yusuke Okubo et al.   Nature Communications

Physiological Notch Signaling Maintains Bone Homeostasis via RBPjk and Hey Upstream of NFATc1

(2012) Xiaolin Tu et al.   PLoS Genetics

Notch signaling: simplicity in design, versatility in function

(2011) E. R. Andersson et al.   DEVELOPMENT

Mutations in NOTCH2 in families with Hajdu-Cheney syndrome

(2011) Jacek Majewski et al.   HUMAN MUTATION

NOTCH2mutations in Alagille syndrome

(2011) Binita Maya Kamath et al.   JOURNAL OF MEDICAL GENETICS

Notch signaling components are upregulated during both endochondral and intramembranous bone regeneration

(2011) Michael I. Dishowitz et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

The relationship between fibrogenic TGFβ1 signaling in the joint and cartilage degradation in post-injury osteoarthritis

(2011) A. Plaas et al.   OSTEOARTHRITIS AND CARTILAGE

Alteration of Notch signaling in skeletal development and disease

(2010) Jianning Tao et al.   Annals of the New York Academy of Sciences

Signaling Pathways in Human Skeletal Dysplasias

(2010) Dustin Baldridge et al.   Annual Review of Genomics and Human Genetics

HES1 and HES5 Are Dispensable for Cartilage and Endochondral Bone Formation

(2010) C. Karlsson et al.   CELLS TISSUES ORGANS

RBPj -dependent Notch signaling regulates mesenchymal progenitor cell proliferation and differentiation during skeletal development

(2010) Y. Dong et al.   DEVELOPMENT

Two novel missense mutations in HAIRY-AND-ENHANCER-OF-SPLIT-7 in a family with spondylocostal dysostosis

(2010) Duncan B Sparrow et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Jagged1 (JAG1) mutations in patients with tetralogy of fallot or pulmonic stenosis

(2010) Robert C. Bauer et al.   HUMAN MUTATION

HES1 (Hairy and Enhancer of Split 1) Is a Determinant of Bone Mass

(2010) Stefano Zanotti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fibroblast Growth Factor Receptor Signaling Crosstalk in Skeletogenesis

(2010) H. Miraoui et al.   Science Signaling

NOTCHing the bone: Insights into multi-functionality

(2009) Feyza Engin et al.   BONE

Inhibition of Notch pathway prevents osteosarcoma growth by cell cycle regulation

(2009) M Tanaka et al.   BRITISH JOURNAL OF CANCER

Notch signaling contributes to the pathogenesis of human osteosarcomas

(2009) F. Engin et al.   HUMAN MOLECULAR GENETICS

Transcriptional networks controlling chondrocyte proliferation and differentiation during endochondral ossification

(2009) Manuela Wuelling et al.   PEDIATRIC NEPHROLOGY

Notch pathway regulation of chondrocyte differentiation and proliferation during appendicular and axial skeleton development

(2009) T. J. Mead et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cartilage homeostasis in health and rheumatic diseases

(2009) Mary B Goldring et al.   ARTHRITIS RESEARCH & THERAPY

The immunohistochemical localization of notch receptors and ligands in human articular cartilage, chondroprogenitor culture and ultrastructural characteristics of these progenitor cells

(2008) Ismail Ustunel et al.   ACTA HISTOCHEMICA

Repression of chondrogenesis through binding of notch signaling proteins HES-1 and HEY-1 to N-box domains in the COL2A1 enhancer site

(2008) Shawn P. Grogan et al.   ARTHRITIS AND RHEUMATISM

Notch1, Jagged1, and HES5 Are Abundantly Expressed in Osteoarthritis

(2008) C. Karlsson et al.   CELLS TISSUES ORGANS

Notch Inhibits Osteoblast Differentiation and Causes Osteopenia

(2008) Stefano Zanotti et al.   ENDOCRINOLOGY

Mutation of HAIRY-AND-ENHANCER-OF-SPLIT-7 in humans causes spondylocostal dysostosis

(2008) D. B. Sparrow et al.   HUMAN MOLECULAR GENETICS

The Association of Notch2 and NF- B Accelerates RANKL-Induced Osteoclastogenesis

(2008) H. Fukushima et al.   MOLECULAR AND CELLULAR BIOLOGY

Dimorphic effects of Notch signaling in bone homeostasis

(2008) Feyza Engin et al.   NATURE MEDICINE

Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation

(2008) Matthew J Hilton et al.   NATURE MEDICINE