Homeostatic Mechanisms in Articular Cartilage and Role of Inflammation in Osteoarthritis

Transamidation by Transglutaminase 2 Transforms S100A11 Calgranulin into a Procatabolic Cytokine for Chondrocytes

(2014) D. L. Cecil et al.   JOURNAL OF IMMUNOLOGY

Identification of Soluble 14-3-3∊ as a Novel Subchondral Bone Mediator Involved in Cartilage Degradation in Osteoarthritis

(2013) Sabrina Priam et al.   ARTHRITIS AND RHEUMATISM

In Vivo Cyclic Compression Causes Cartilage Degeneration and Subchondral Bone Changes in Mouse Tibiae

(2013) Frank C. Ko et al.   ARTHRITIS AND RHEUMATISM

Inhibition of TGF-β signaling in mesenchymal stem cells of subchondral bone attenuates osteoarthritis

(2013) Gehua Zhen et al.   NATURE MEDICINE

Stress-induced cartilage degradation does not depend on the NLRP3 inflammasome in human osteoarthritis and mouse models

(2012) Carole Bougault et al.   ARTHRITIS AND RHEUMATISM

Osteoarthritis: A disease of the joint as an organ

(2012) Richard F. Loeser et al.   ARTHRITIS AND RHEUMATISM

Primary cilia elongation in response to interleukin-1 mediates the inflammatory response

(2012) A. K. T. Wann et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Regulation of Chondrocytic Gene Expression by Biomechanical Signals

(2012) Thomas J. Knobloch et al.   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

Induction of the chemokine IL-8/Kc by the articular cartilage: Possible influence on osteoarthritis

(2012) Karine Chauffier et al.   JOINT BONE SPINE

Proinflammatory Actions of Visfatin/Nicotinamide Phosphoribosyltransferase (Nampt) Involve Regulation of Insulin Signaling Pathway and Nampt Enzymatic Activity

(2012) Claire Jacques et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy: A New Therapeutic Target in Cartilage Injury and Osteoarthritis

(2012) Martin Lotz et al.   JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS

Primary cilia attenuate hedgehog signalling in neoplastic chondrocytes

(2012) L Ho et al.   ONCOGENE

Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!)

(2012) F. Berenbaum   OSTEOARTHRITIS AND CARTILAGE

Why subchondral bone in osteoarthritis? The importance of the cartilage bone interface in osteoarthritis

(2012) M. Mahjoub et al.   OSTEOPOROSIS INTERNATIONAL

Adiponectin associates with markers of cartilage degradation in osteoarthritis and induces production of proinflammatory and catabolic factors through mitogen-activated protein kinase pathways

(2012) Anna Koskinen et al.   ARTHRITIS RESEARCH & THERAPY

Plasma proteins present in osteoarthritic synovial fluid can stimulate cytokine production via Toll-like receptor 4

(2012) Dong Sohn et al.   ARTHRITIS RESEARCH & THERAPY

Orientation of Primary Cilia of Articular Chondrocytes in Three-Dimensional Space

(2011) Cornelia E. Farnum et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Mechanotransduction and cartilage integrity

(2011) Daniel J. Leong et al.   Annals of the New York Academy of Sciences

Expanding the adipokine network in cartilage: identification and regulation of novel factors in human and murine chondrocytes

(2011) J. Conde et al.   ANNALS OF THE RHEUMATIC DISEASES

Autophagy activation by rapamycin reduces severity of experimental osteoarthritis

(2011) Beatriz Caramés et al.   ANNALS OF THE RHEUMATIC DISEASES

The impact of knee and hip chondrocalcinosis on disability in older people: the ProVA Study from northeastern Italy

(2011) E. Musacchio et al.   ANNALS OF THE RHEUMATIC DISEASES

Characterization of CCL19 and CCL21 in rheumatoid arthritis

(2011) Sarah R. Pickens et al.   ARTHRITIS AND RHEUMATISM

Contributions of angiogenesis to inflammation, joint damage, and pain in a rat model of osteoarthritis

(2011) Sadaf Ashraf et al.   ARTHRITIS AND RHEUMATISM

Mechanical injury suppresses autophagy regulators and pharmacologic activation of autophagy results in chondroprotection

(2011) Beatriz Caramés et al.   ARTHRITIS AND RHEUMATISM

Proteases involved in cartilage matrix degradation in osteoarthritis

(2011) Linda Troeberg et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Adipokines: Biofactors from white adipose tissue. A complex hub among inflammation, metabolism, and immunity

(2011) Javier Conde et al.   BIOFACTORS

Cilia and Hedgehog: When and how was their marriage solemnized?

(2011) Sudipto Roy   DIFFERENTIATION

Identification of a central role for complement in osteoarthritis

(2011) Qian Wang et al.   NATURE MEDICINE

Depletion of primary cilia in articular chondrocytes results in reduced Gli3 repressor to activator ratio, increased Hedgehog signaling, and symptoms of early osteoarthritis

(2011) C.-F. Chang et al.   OSTEOARTHRITIS AND CARTILAGE

Chondrocyte hypertrophy and osteoarthritis: role in initiation and progression of cartilage degeneration?

(2011) P.M. van der Kraan et al.   OSTEOARTHRITIS AND CARTILAGE

NLRP3 inflammasome plays a critical role in the pathogenesis of hydroxyapatite-associated arthropathy

(2011) C. Jin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adaptive mechanically controlled lubrication mechanism found in articular joints

(2011) G. W. Greene et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Toll-like receptor 4 signalling is specifically TGF-beta-activated kinase 1 independent in synovial fibroblasts

(2011) Jeroen Geurts et al.   RHEUMATOLOGY

Adiponectin is a potential catabolic mediator in osteoarthritis cartilage

(2011) Eun Ha Kang et al.   ARTHRITIS RESEARCH & THERAPY

Cytokine-induced increases in ADAMTS-4 messenger RNA expression do not lead to increased aggrecanase activity in ADAMTS-5-deficient mice

(2010) Fraser M. Rogerson et al.   ARTHRITIS AND RHEUMATISM

Regulation of complement by cartilage oligomeric matrix protein allows for a novel molecular diagnostic principle in rheumatoid arthritis

(2010) Kaisa E. Happonen et al.   ARTHRITIS AND RHEUMATISM

Autophagy is a protective mechanism in normal cartilage, and its aging-related loss is linked with cell death and osteoarthritis

(2010) Beatriz Caramés et al.   ARTHRITIS AND RHEUMATISM

The role of synovial macrophages and macrophage-produced mediators in driving inflammatory and destructive responses in osteoarthritis

(2010) Jan Bondeson et al.   ARTHRITIS AND RHEUMATISM

Synovial inflammation in patients undergoing arthroscopic meniscectomy: Molecular characterization and relationship to symptoms

(2010) Carla R. Scanzello et al.   ARTHRITIS AND RHEUMATISM

NF-κB Signaling: Multiple Angles to Target OA

(2010) Kenneth B. Marcu et al.   CURRENT DRUG TARGETS

Role of extracellular membrane vesicles in the pathogenesis of various diseases, including cancer, renal diseases, atherosclerosis and arthritis

(2010) H Clarke Anderson et al.   LABORATORY INVESTIGATION

Matrix metalloproteinase-3 in articular cartilage is upregulated by joint immobilization and suppressed by passive joint motion

(2010) Daniel J. Leong et al.   MATRIX BIOLOGY

Collagen binding specificity of the discoidin domain receptors: Binding sites on collagens II and III and molecular determinants for collagen IV recognition by DDR1

(2010) Huifang Xu et al.   MATRIX BIOLOGY

Hypoxia-inducible factor-2α is a catabolic regulator of osteoarthritic cartilage destruction

(2010) Siyoung Yang et al.   NATURE MEDICINE

The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis

(2010) Jérémie Sellam et al.   Nature Reviews Rheumatology

The role of the cartilage matrix in osteoarthritis

(2010) Dick Heinegård et al.   Nature Reviews Rheumatology

Chemokine profile of synovial fluid from normal, osteoarthritis and rheumatoid arthritis patients: CCL25, CXCL10 and XCL1 recruit human subchondral mesenchymal progenitor cells

(2010) M. Endres et al.   OSTEOARTHRITIS AND CARTILAGE

Regulation of mechanical stress-induced MMP-13 and ADAMTS-5 expression by RUNX-2 transcriptional factor in SW1353 chondrocyte-like cells

(2010) T. Tetsunaga et al.   OSTEOARTHRITIS AND CARTILAGE

Advanced glycation end products induce the expression of interleukin-6 and interleukin-8 by receptor for advanced glycation end product-mediated activation of mitogen-activated protein kinases and nuclear factor- B in human osteoarthritis chondrocytes

(2010) Z. Rasheed et al.   RHEUMATOLOGY

S100A8 and S100A9 in experimental osteoarthritis

(2010) Hala Zreiqat et al.   ARTHRITIS RESEARCH & THERAPY

High mobility group box 1 potentiates the pro-inflammatory effects of interleukin-1β in osteoarthritic synoviocytes

(2010) Isabel García-Arnandis et al.   ARTHRITIS RESEARCH & THERAPY

Diet-induced obesity differentially regulates behavioral, biomechanical, and molecular risk factors for osteoarthritis in mice

(2010) Timothy M Griffin et al.   ARTHRITIS RESEARCH & THERAPY

Anabolic and catabolic responses of human articular chondrocytes to varying oxygen percentages

(2010) Simon Ströbel et al.   ARTHRITIS RESEARCH & THERAPY

Chondroprotective effects and mechanisms of resveratrol in advanced glycation end products-stimulated chondrocytes

(2010) Feng-Cheng Liu et al.   ARTHRITIS RESEARCH & THERAPY

Extreme obesity due to impaired leptin signaling in mice does not cause knee osteoarthritis

(2009) Timothy M. Griffin et al.   ARTHRITIS AND RHEUMATISM

Matrix metalloproteinase 13–deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development

(2009) C. B. Little et al.   ARTHRITIS AND RHEUMATISM

Hypoxia-inducible factor 1α inhibits the fibroblast-like markers type I and type III collagen during hypoxia-induced chondrocyte redifferentiation: Hypoxia not only induces type II collagen and aggrecan, but it also inhibits type I and type III collagen in the hypoxia-inducible factor 1α-dependent redifferentiation of chondrocytes

(2009) Elise Duval et al.   ARTHRITIS AND RHEUMATISM

Analysing the role of endogenous matrix molecules in the development of osteoarthritis

(2009) Nidhi Sofat   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

Diagnostic Utility of Cytokine Biomarkers in the Evaluation of Acute Knee Pain

(2009) Jason M Cuellar et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

Cartilage abnormalities associated with defects of chondrocytic primary cilia in Bardet-Biedl syndrome mutant mice

(2009) Anjan P. Kaushik et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Syndecan-4 regulates ADAMTS-5 activation and cartilage breakdown in osteoarthritis

(2009) Frank Echtermeyer et al.   NATURE MEDICINE

Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease

(2009) Kim Midwood et al.   NATURE MEDICINE

Stigmasterol: a phytosterol with potential anti-osteoarthritic properties

(2009) O. Gabay et al.   OSTEOARTHRITIS AND CARTILAGE

Risk factors for onset of osteoarthritis of the knee in older adults: a systematic review and meta-analysis

(2009) M. Blagojevic et al.   OSTEOARTHRITIS AND CARTILAGE

Biomechanical Thresholds Regulate Inflammation through the NF-κB Pathway: Experiments and Modeling

(2009) Jin Nam et al.   PLoS One

Aging-related loss of the chromatin protein HMGB2 in articular cartilage is linked to reduced cellularity and osteoarthritis

(2009) N. Taniguchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential Toll-like receptor-dependent collagenase expression in chondrocytes

(2008) Q Zhang et al.   ANNALS OF THE RHEUMATIC DISEASES

Stimulation of chondrocyte-mediated cartilage destruction by S100A8 in experimental murine arthritis

(2008) P. L. E. M. van Lent et al.   ARTHRITIS AND RHEUMATISM

Innate immune system activation in osteoarthritis: is osteoarthritis a chronic wound?

(2008) Carla R Scanzello et al.   CURRENT OPINION IN RHEUMATOLOGY

Primary cilia in osteoarthritic chondrocytes: From chondrons to clusters

(2008) S.R. McGlashan et al.   DEVELOPMENTAL DYNAMICS

Exuberant expression of chemokine genes by adult human articular chondrocytes in response to IL-1β

(2008) L.J. Sandell et al.   OSTEOARTHRITIS AND CARTILAGE

Fragmentation of decorin, biglycan, lumican and keratocan is elevated in degenerate human meniscus, knee and hip articular cartilages compared with age-matched macroscopically normal and control tissues

(2008) James Melrose et al.   ARTHRITIS RESEARCH & THERAPY

Cell death in osteoarthritis

(2008) Marcello Del Carlo et al.   Current Rheumatology Reports

Myeloid-related proteins S100A8/S100A9 regulate joint inflammation and cartilage destruction during antigen-induced arthritis

(2007) P L E M van Lent et al.   ANNALS OF THE RHEUMATIC DISEASES

Proteomic analysis of the LPS-induced stress response in rat chondrocytes reveals induction of innate immune response components in articular cartilage

(2007) Lisbet Haglund et al.   MATRIX BIOLOGY