Critical contribution of RIPK1 mediated mitochondrial dysfunction and oxidative stress to compression-induced rat nucleus pulposus cells necroptosis and apoptosis

Hydrogen peroxide induces programmed necrosis in rat nucleus pulposus cells through the RIP1/RIP3-PARP-AIF pathway

(2017) Lei Zhao et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Hydrogen sulfide protects against endoplasmic reticulum stress and mitochondrial injury in nucleus pulposus cells and ameliorates intervertebral disc degeneration

(2017) Daoliang Xu et al.   PHARMACOLOGICAL RESEARCH

Regulation of RIPK1 activation by TAK1-mediated phosphorylation dictates apoptosis and necroptosis

(2017) Jiefei Geng et al.   Nature Communications

Ripk3 induces mitochondrial apoptosis via inhibition of FUNDC1 mitophagy in cardiac IR injury

(2017) Hao Zhou et al.   Redox Biology

The ROS derived mitochondrial respirstion not from NADPH oxidase plays key role in Celastrol against angiotensin II-mediated HepG2 cell proliferation

(2016) Xin Liu et al.   APOPTOSIS

MicroRNA-377 Mediates Cardiomyocyte Apoptosis Induced by Cyclosporin A

(2016) Xiao-Duo Zhu et al.   CANADIAN JOURNAL OF CARDIOLOGY

FGF-2 Transcriptionally Down-Regulates the Expression of BNIP3L via PI3K/Akt/FoxO3a Signaling and Inhibits Necrosis and Mitochondrial Dysfunction Induced by High Concentrations of Hydrogen Peroxide in H9c2 Cells

(2016) Qian Chen et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Geniposide Prevents Hypoxia/Reoxygenation-Induced Apoptosis in H9c2 Cells: Improvement of Mitochondrial Dysfunction and Activation of GLP-1R and the PI3K/AKT Signaling Pathway

(2016) You-Qin Jiang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Mitochondrial Cyclophilin D in Vascular Oxidative Stress and HypertensionNovelty and Significance

(2016) Hana A. Itani et al.   HYPERTENSION

Dynamin-related Protein 1 Inhibition Mitigates Bisphenol A-mediated Alterations in Mitochondrial Dynamics and Neural Stem Cell Proliferation and Differentiation

(2016) Swati Agarwal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prevention of Cyclophilin D-Mediated mPTP Opening Using Cyclosporine-A Alleviates the Elevation of Necroptosis, Autophagy and Apoptosis-Related Markers Following Global Cerebral Ischemia-Reperfusion

(2016) Farinoosh Fakharnia et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Aging and age related stresses: a senescence mechanism of intervertebral disc degeneration

(2016) F. Wang et al.   OSTEOARTHRITIS AND CARTILAGE

Parthenolide and DMAPT exert cytotoxic effects on breast cancer stem-like cells by inducing oxidative stress, mitochondrial dysfunction and necrosis

(2016) D Carlisi et al.   Cell Death & Disease

Phosphocreatine protects endothelial cells from oxidized low-density lipoprotein-induced apoptosis by modulating the PI3K/Akt/eNOS pathway

(2015) Anil Ahsan et al.   APOPTOSIS

Mitochondrial permeability transition and its regulatory components are implicated in apoptosis of primary cultures of rat proximal tubular cells exposed to lead

(2015) Gang Liu et al.   ARCHIVES OF TOXICOLOGY

Activation of autophagy via Ca2+-dependent AMPK/mTOR pathway in rat notochordal cells is a cellular adaptation under hyperosmotic stress

(2015) Li-Bo Jiang et al.   CELL CYCLE

Valproic acid-induced hepatotoxicity in alpers syndrome is associated with mitochondrial permeability transition pore opening-dependent apoptotic sensitivity in an induced pluripotent stem cell model

(2015) Shengbiao Li et al.   HEPATOLOGY

The Mitochondrial Phosphatase PGAM5 Is Dispensable for Necroptosis but Promotes Inflammasome Activation in Macrophages

(2015) Kenta Moriwaki et al.   JOURNAL OF IMMUNOLOGY

Differential roles of RIPK1 and RIPK3 in TNF-induced necroptosis and chemotherapeutic agent-induced cell death

(2015) K Moriwaki et al.   Cell Death & Disease

Notochordal cell disappearance and modes of apoptotic cell death in a rat tail static compression-induced disc degeneration model

(2014) Takashi Yurube et al.   ARTHRITIS RESEARCH & THERAPY

Inhibition of cyclophilin D by cyclosporin A promotes retinal ganglion cell survival by preventing mitochondrial alteration in ischemic injury

(2014) S Y Kim et al.   Cell Death & Disease

A rat tail temporary static compression model reproduces different stages of intervertebral disc degeneration with decreased notochordal cell phenotype

(2013) Hiroaki Hirata et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Autophagy is activated in compression-induced cell degeneration and is mediated by reactive oxygen species in nucleus pulposus cells exposed to compression

(2013) K.-G. Ma et al.   OSTEOARTHRITIS AND CARTILAGE

Eleostearic acid induces RIP1-mediated atypical apoptosis in a kinase-independent manner via ERK phosphorylation, ROS generation and mitochondrial dysfunction

(2013) S Obitsu et al.   Cell Death & Disease

Widespread Mitochondrial Depletion via Mitophagy Does Not Compromise Necroptosis

(2013) Stephen W.G. Tait et al.   Cell Reports

Role of mitochondrial pathway in compression-induced apoptosis of nucleus pulposus cells

(2012) Fan Ding et al.   APOPTOSIS

RIP1-mediated mitochondrial dysfunction and ROS production contributed to tumor necrosis factor alpha-induced L929 cell necroptosis and autophagy

(2012) Yuan-Chao Ye et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Hyperbaric oxygen treatment suppresses MAPK signaling and mitochondrial apoptotic pathway in degenerated human intervertebral disc cells

(2012) Chi-Chien Niu et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Doxorubicin induced myocardial injury is exacerbated following ischaemic stress via opening of the mitochondrial permeability transition pore

(2012) M. Gharanei et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Rat tail static compression model mimics extracellular matrix metabolic imbalances of matrix metalloproteinases, aggrecanases, and tissue inhibitors of metalloproteinases in intervertebral disc degeneration

(2012) Takashi Yurube et al.   ARTHRITIS RESEARCH & THERAPY

TLR3/TICAM-1 signaling in tumor cell RIP3-dependent necroptosis

(2012) Tsukasa Seya et al.   OncoImmunology

Caspase 3 as a therapeutic target for regulation of intervertebral disc degeneration in rabbits

(2011) Hideki Sudo et al.   ARTHRITIS AND RHEUMATISM

Necroptosis as an alternative form of programmed cell death

(2010) Dana E Christofferson et al.   CURRENT OPINION IN CELL BIOLOGY

Regulation of apoptosis in nucleus pulposus cells by optimized exogenous Bcl-2 overexpression

(2010) Hideki Sudo et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Molecular mechanisms of necroptosis: an ordered cellular explosion

(2010) Peter Vandenabeele et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cyclic Tensile Stress Exerts a Protective Effect on Intervertebral Disc Cells

(2009) Gwendolyn Sowa et al.   AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION

Necroptosis, necrosis and secondary necrosis converge on similar cellular disintegration features

(2009) T Vanden Berghe et al.   CELL DEATH AND DIFFERENTIATION

Mechanisms underlying the loss of mitochondrial membrane potential in glutamate excitotoxicity

(2008) Andrey Y. Abramov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS