A dual role for NOTCH signaling in joint cartilage maintenance and osteoarthritis

G protein-coupled receptors in rheumatology

(2014) Elena Neumann et al.   Nature Reviews Rheumatology

The individual and socioeconomic impact of osteoarthritis

(2014) David J. Hunter et al.   Nature Reviews Rheumatology

Genes Involved in the Osteoarthritis Process Identified through Genome Wide Expression Analysis in Articular Cartilage; the RAAK Study

(2014) Yolande F. M. Ramos et al.   PLoS One

Induction of nerve growth factor expression and release by mechanical and inflammatory stimuli in chondrocytes: possible involvement in osteoarthritis pain

(2014) Emilie Pecchi et al.   ARTHRITIS RESEARCH & THERAPY

A current review of molecular mechanisms regarding osteoarthritis and pain

(2013) Andrew S. Lee et al.   GENE

Notch signaling at a glance

(2013) K. Hori et al.   JOURNAL OF CELL SCIENCE

Insights from human genetic studies into the pathways involved in osteoarthritis

(2013) Louise N. Reynard et al.   Nature Reviews Rheumatology

Interleukin 6 mediates selected effects of Notch in chondrocytes

(2013) S. Zanotti et al.   OSTEOARTHRITIS AND CARTILAGE

Notch signaling in chondrocytes modulates endochondral ossification and osteoarthritis development

(2013) Y. Hosaka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insights on Biology and Pathology of HIF-1α/-2α, TGFβ/BMP, Wnt/β-Catenin, and NF-κB Pathways in Osteoarthritis

(2012) Longhuo Wu et al.   CURRENT PHARMACEUTICAL DESIGN

Interleukin-6, its role in fibrosing conditions

(2012) Steven O’Reilly et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Cartilage-specific RBPj -dependent and -independent Notch signals regulate cartilage and bone development

(2012) A. Kohn et al.   DEVELOPMENT

Notch gain of function inhibits chondrocyte differentiation via Rbpj-dependent suppression ofSox9

(2012) Shan Chen et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Expression patterns of Notch receptors and their ligands in human osteoarthritic and healthy articular cartilage

(2012) M. Mahjoub et al.   TISSUE & CELL

Attenuation of osteoarthritis via blockade of the SDF-1/CXCR4 signaling pathway

(2012) Fangyuan Wei et al.   ARTHRITIS RESEARCH & THERAPY

Recent progress in understanding molecular mechanisms of cartilage degeneration during osteoarthritis

(2011) Meina Wang et al.   Annals of the New York Academy of Sciences

Relationship between placenta growth factor 1 and vascularization, dehydroepiandrosterone sulfate to dehydroepiandrosterone conversion, or aromatase expression in patients with rheumatoid arthritis and patients with osteoarthritis

(2011) Torsten Lowin et al.   ARTHRITIS AND RHEUMATISM

Notch1 signaling regulates chondrogenic lineage determination through Sox9 activation

(2011) R Haller et al.   CELL DEATH AND DIFFERENTIATION

Direct regulation of interleukin-6 expression by Notch signaling in macrophages

(2011) Wipawee Wongchana et al.   Cellular & Molecular Immunology

IL-6/IL-6 receptor system and its role in physiological and pathological conditions

(2011) Masahiko Mihara et al.   CLINICAL SCIENCE

Establishment of an index with increased sensitivity for assessing murine arthritis

(2011) Erik R. Sampson et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

High molecular weight hyaluronic acid inhibits IL-6-induced MMP production from human chondrocytes by up-regulating the ERK inhibitor, MKP-1

(2010) Misato Hashizume et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

RBPj -dependent Notch signaling regulates mesenchymal progenitor cell proliferation and differentiation during skeletal development

(2010) Y. Dong et al.   DEVELOPMENT

The role of the cartilage matrix in osteoarthritis

(2010) Dick Heinegård et al.   Nature Reviews Rheumatology

Role of proinflammatory cytokines in the pathophysiology of osteoarthritis

(2010) Mohit Kapoor et al.   Nature Reviews Rheumatology

Involvement of the notch pathway in the regulation of matrix metalloproteinase 13 and the dedifferentiation of articular chondrocytes in murine cartilage

(2009) Régis Blaise et al.   ARTHRITIS AND RHEUMATISM

Role of placenta growth factor and its receptor flt-1 in rheumatoid inflammation: A link between angiogenesis and inflammation

(2009) Seung-Ah Yoo et al.   ARTHRITIS AND RHEUMATISM

Insurer and out-of-pocket costs of osteoarthritis in the US: Evidence from national survey data

(2009) Harry Kotlarz et al.   ARTHRITIS AND RHEUMATISM

Interleukin-6 is a significant predictor of radiographic knee osteoarthritis: The Chingford study

(2009) Gregory Livshits et al.   ARTHRITIS AND RHEUMATISM

The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

(2009) Raphael Kopan et al.   CELL

Notch pathway regulation of chondrocyte differentiation and proliferation during appendicular and axial skeleton development

(2009) T. J. Mead et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mesenchymal progenitor cell markers in human articular cartilage: normal distribution and changes in osteoarthritis

(2009) Shawn P Grogan et al.   ARTHRITIS RESEARCH & THERAPY

The immunohistochemical localization of notch receptors and ligands in human articular cartilage, chondroprogenitor culture and ultrastructural characteristics of these progenitor cells

(2008) Ismail Ustunel et al.   ACTA HISTOCHEMICA

Notch1, Jagged1, and HES5 Are Abundantly Expressed in Osteoarthritis

(2008) C. Karlsson et al.   CELLS TISSUES ORGANS

New insights into osteoarthritis: early developmental features of an ageing-related disease

(2008) Steffan Daniël Bos et al.   CURRENT OPINION IN RHEUMATOLOGY

The Interleukin 1β Pathway in the Pathogenesis of Osteoarthritis

(2008) Massoud Daheshia et al.   JOURNAL OF RHEUMATOLOGY

Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation

(2008) Matthew J Hilton et al.   NATURE MEDICINE

IL-6 trans-signalling directly induces RANKL on fibroblast-like synovial cells and is involved in RANKL induction by TNF-  and IL-17

(2008) M. Hashizume et al.   RHEUMATOLOGY