Emerging Mechanisms and Disease Implications of Ferroptosis: Potential Applications of Natural Products
Published 2022 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Emerging Mechanisms and Disease Implications of Ferroptosis: Potential Applications of Natural Products
Authors
Keywords
-
Journal
Frontiers in Cell and Developmental Biology
Volume 9, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2022-01-18
DOI
10.3389/fcell.2021.774957
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Deferiprone Treatment in Aged Transgenic Tau Mice Improves Y-Maze Performance and Alters Tau Pathology
- (2021) Shalini S. Rao et al. Neurotherapeutics
- PEITC triggers multiple forms of cell death by GSH-iron-ROS regulation in K7M2 murine osteosarcoma cells
- (2020) Huan-huan Lv et al. ACTA PHARMACOLOGICA SINICA
- Iron overload as a risk factor for hepatic ischemia‐reperfusion injury in liver transplantation: Potential role of ferroptosis
- (2020) Naoya Yamada et al. AMERICAN JOURNAL OF TRANSPLANTATION
- Anti-cancer effect of gallic acid in presence of low level laser irradiation: ROS production and induction of apoptosis and ferroptosis
- (2020) Khatereh Khorsandi et al. Cancer Cell International
- The role of ferroptosis in ionizing radiation-induced cell death and tumor suppression
- (2020) Guang Lei et al. CELL RESEARCH
- Relieving ferroptosis may partially reverse neurodegeneration of the auditory cortex
- (2020) Xi Chen et al. FEBS Journal
- Simultaneous Study of Anti-Ferroptosis and Antioxidant Mechanisms of Butein and (S)-Butin
- (2020) Liu et al. MOLECULES
- Ferroptosis driven by radical oxidation of n-6 polyunsaturated fatty acids mediates acetaminophen-induced acute liver failure
- (2020) Naoya Yamada et al. Cell Death & Disease
- Inhibitory Effect and Mechanism of Action of Quercetin and Quercetin Diels-Alder anti-Dimer on Erastin-Induced Ferroptosis in Bone Marrow-Derived Mesenchymal Stem Cells
- (2020) Xican Li et al. Antioxidants
- Acetaminophen-induced hepatotoxicity: different mechanisms of acetaminophen-induced ferroptosis and mitochondrial damage
- (2020) Naoya Yamada et al. ARCHIVES OF TOXICOLOGY
- Loss of Cardiac Ferritin H Facilitates Cardiomyopathy via Slc7a11-Mediated Ferroptosis
- (2020) Xuexian Fang et al. CIRCULATION RESEARCH
- Iron Chelation Properties of Green Tea Epigallocatechin-3-Gallate (EGCG) in Colorectal Cancer Cells: Analysis on Tfr/Fth Regulations and Molecular Docking
- (2020) Zarith Nameyrra Md Nesran et al. Evidence-based Complementary and Alternative Medicine
- Iron overload contributes to general anaesthesia-induced neurotoxicity and cognitive deficits
- (2020) Jing Wu et al. Journal of Neuroinflammation
- Amentoflavone suppresses cell proliferation and induces cell death through triggering autophagy-dependent ferroptosis in human glioma
- (2020) Yan Chen et al. LIFE SCIENCES
- Targeting ferroptosis alleviates methionine‐choline deficient (MCD)‐diet induced NASH by suppressing liver lipotoxicity
- (2020) Xiaoya Li et al. LIVER INTERNATIONAL
- Ferroptosis inhibitory constituents from the fruits of Cullen corylifolium
- (2020) Aftab Yaseen et al. NATURAL PRODUCT RESEARCH
- Guidelines and definitions for research on epithelial–mesenchymal transition
- (2020) Jing Yang et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- β-Phenethyl Isothiocyanate Induces Cell Death in Human Osteosarcoma through Altering Iron Metabolism, Disturbing the Redox Balance, and Activating the MAPK Signaling Pathway
- (2020) Huanhuan Lv et al. Oxidative Medicine and Cellular Longevity
- Dietary lipids fuel GPX4-restricted enteritis resembling Crohn’s disease
- (2020) Lisa Mayr et al. Nature Communications
- The Value of Herbarium Collections to the Discovery of Novel Treatments for Alzheimer’s Disease, a Case Made With the Genus Eriodictyon
- (2020) Pamela Maher et al. Frontiers in Pharmacology
- Actinidia chinensis Planch prevents proliferation and migration of gastric cancer associated with apoptosis, ferroptosis activation and mesenchymal phenotype suppression
- (2020) Zhuowei Gao et al. BIOMEDICINE & PHARMACOTHERAPY
- Identification of two novel prenylated flavonoids in mulberry leaf and their bioactivities
- (2020) Lingrong Wen et al. FOOD CHEMISTRY
- Artemisinin and its derivatives: a promising cancer therapy
- (2020) Bushra Hafeez Kiani et al. MOLECULAR BIOLOGY REPORTS
- New Probucol Analogues Inhibit Ferroptosis, Improve Mitochondrial Parameters, and Induce Glutathione Peroxidase in HT22 Cells
- (2020) Diones Caeran Bueno et al. MOLECULAR NEUROBIOLOGY
- CD44 regulates epigenetic plasticity by mediating iron endocytosis
- (2020) Sebastian Müller et al. Nature Chemistry
- Inhibition of ferroptosis attenuates busulfan-induced oligospermia in mice
- (2020) Xi Zhao et al. TOXICOLOGY
- Evaluation of the efficacy and safety of deferiprone compared with deferasirox in paediatric patients with transfusion-dependent haemoglobinopathies (DEEP-2): a multicentre, randomised, open-label, non-inferiority, phase 3 trial
- (2020) Aurelio Maggio et al. Lancet Haematology
- Extract of Naotaifang, a compound Chinese herbal medicine, protects neuron ferroptosis induced by acute cerebral ischemia in rats
- (2020) Bin Lan et al. Journal of Integrative Medicine-JIM
- Solasonine promotes ferroptosis of hepatoma carcinoma cells via glutathione peroxidase 4-induced destruction of the glutathione redox system
- (2020) Mingming Jin et al. BIOMEDICINE & PHARMACOTHERAPY
- Inhibition of ACSL4 attenuates ferroptotic damage after pulmonary ischemia‐reperfusion
- (2020) Yixin Xu et al. FASEB JOURNAL
- Proanthocyanidin promotes functional recovery of spinal cord injury via inhibiting ferroptosis
- (2020) Huangao Zhou et al. JOURNAL OF CHEMICAL NEUROANATOMY
- N-acetylglycoside of oleanolic acid (aridanin) displays promising cytotoxicity towards human and animal cancer cells, inducing apoptotic, ferroptotic and necroptotic cell death
- (2020) Armelle T. Mbaveng et al. PHYTOMEDICINE
- Quercetin Alleviates Ferroptosis of Pancreatic β Cells in Type 2 Diabetes
- (2020) Dan Li et al. Nutrients
- NRF2 regulates the sensitivity of human NSCLC cells to cystine deprivation-induced ferroptosis via FOCAD-FAK signaling pathway
- (2020) Pengfei Liu et al. Redox Biology
- Ferroptosis involves in renal tubular cell death in diabetic nephropathy
- (2020) Yue Wang et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Thioredoxin and Glutaredoxin Systems as Potential Targets for the Development of New Treatments in Friedreich’s Ataxia
- (2020) Marta Seco-Cervera et al. Antioxidants
- Ferroptosis as a novel therapeutic target for Friedreich's ataxia
- (2019) M. Grazia Cotticelli et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Cytotoxicity of ungeremine towards multi-factorial drug resistant cancer cells and induction of apoptosis, ferroptosis, necroptosis and autophagy
- (2019) Armelle T. Mbaveng et al. PHYTOMEDICINE
- Ferroptosis as a target for protection against cardiomyopathy
- (2019) Xuexian Fang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- FDA-approved ferumoxytol displays anti-leukaemia efficacy against cells with low ferroportin levels
- (2019) Vicenta Trujillo-Alonso et al. Nature Nanotechnology
- Herb-Drug Interactions and Hepatotoxicity
- (2019) Mohammad K. Parvez et al. CURRENT DRUG METABOLISM
- Ischemia-induced ACSL4 activation contributes to ferroptosis-mediated tissue injury in intestinal ischemia/reperfusion
- (2019) Yang Li et al. CELL DEATH AND DIFFERENTIATION
- Targeting Ferroptosis to Iron Out Cancer
- (2019) Behrouz Hassannia et al. CANCER CELL
- Artemisinin compounds sensitize cancer cells to ferroptosis by regulating iron homeostasis
- (2019) Guo-Qing Chen et al. CELL DEATH AND DIFFERENTIATION
- Curcumin reduces renal damage associated with rhabdomyolysis by decreasing ferroptosis-mediated cell death
- (2019) Melania Guerrero-Hue et al. FASEB JOURNAL
- Ferroptotic cell death and TLR4/Trif signaling initiate neutrophil recruitment after heart transplantation
- (2019) Wenjun Li et al. JOURNAL OF CLINICAL INVESTIGATION
- CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy
- (2019) Weimin Wang et al. NATURE
- ALOX12 is required for p53-mediated tumour suppression through a distinct ferroptosis pathway
- (2019) Bo Chu et al. NATURE CELL BIOLOGY
- Diverse compounds from pleuromutilin lead to a thioredoxin inhibitor and inducer of ferroptosis
- (2019) Evijola Llabani et al. Nature Chemistry
- Cystine/glutamate antiporter xCT (SLC7A11) facilitates oncogenic RAS transformation by preserving intracellular redox balance
- (2019) Jonathan K. M. Lim et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Genetic Ablation of the Cystine Transporter xCT in PDAC Cells Inhibits mTORC1, Growth, Survival, and Tumor Formation via Nutrient and Oxidative Stresses
- (2019) Boutaina Daher et al. CANCER RESEARCH
- Moxibustion Exerts a Neuroprotective Effect through Antiferroptosis in Parkinson’s Disease
- (2019) Juan Lu et al. Evidence-based Complementary and Alternative Medicine
- Betula etnensis Raf. (Betulaceae) Extract Induced HO-1 Expression and Ferroptosis Cell Death in Human Colon Cancer Cells
- (2019) Giuseppe Antonio Malfa et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Safety and efficacy of deferiprone for pantothenate kinase-associated neurodegeneration: a randomised, double-blind, controlled trial and an open-label extension study
- (2019) Thomas Klopstock et al. LANCET NEUROLOGY
- Intercellular interaction dictates cancer cell ferroptosis via NF2–YAP signalling
- (2019) Jiao Wu et al. NATURE
- Sulfasalazine‑induced ferroptosis in breast cancer cells is reduced by the inhibitory effect of estrogen receptor on the transferrin receptor
- (2019) Haochen Yu et al. ONCOLOGY REPORTS
- Cytotoxic Effects of Artemisia annua L. and Pure Artemisinin on the D-17 Canine Osteosarcoma Cell Line
- (2019) Gloria Isani et al. Oxidative Medicine and Cellular Longevity
- Hepatic ferroptosis plays an important role as the trigger for initiating inflammation in nonalcoholic steatohepatitis
- (2019) Shinya Tsurusaki et al. Cell Death & Disease
- Involvement of cigarette smoke-induced epithelial cell ferroptosis in COPD pathogenesis
- (2019) Masahiro Yoshida et al. Nature Communications
- Role of GRP78 inhibiting artesunate-induced ferroptosis in KRAS mutant pancreatic cancer cells
- (2019) Kang Wang et al. Drug Design Development and Therapy
- Cell recovery by reversal of ferroptosis
- (2019) Ho Man Tang et al. Biology Open
- Baicalein Exerts Neuroprotective Effects in FeCl3-Induced Posttraumatic Epileptic Seizures via Suppressing Ferroptosis
- (2019) Qin Li et al. Frontiers in Pharmacology
- Ferroptosis is governed by differential regulation of transcription in liver cancer
- (2019) Xiao Zhang et al. Redox Biology
- Typhaneoside prevents acute myeloid leukemia (AML) through suppressing proliferation and inducing ferroptosis associated with autophagy
- (2019) Hai-Yan Zhu et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Sigma‐1 receptor protects against ferroptosis in hepatocellular carcinoma cells
- (2019) Tao Bai et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Dihydroartemisinin-induced unfolded protein response feedback attenuates ferroptosis via PERK/ATF4/HSPA5 pathway in glioma cells
- (2019) Yibing Chen et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Mechanism of glycyrrhizin on ferroptosis during acute liver failure by inhibiting oxidative stress
- (2019) Yao Wang et al. Molecular Medicine Reports
- Radiotherapy and immunotherapy promote tumoral lipid oxidation and ferroptosis via synergistic repression of SLC7A11
- (2019) Xueting Lang et al. Cancer Discovery
- The Hippo Pathway Effector TAZ Regulates Ferroptosis in Renal Cell Carcinoma
- (2019) Wen-Hsuan Yang et al. Cell Reports
- Gallic Acid Triggers Iron-Dependent Cell Death with Apoptotic, Ferroptotic, and Necroptotic Features
- (2019) Ho Man Tang et al. Toxins
- Recent Progress in Ferroptosis Inducers for Cancer Therapy
- (2019) Chen Liang et al. ADVANCED MATERIALS
- Artesunate activates the ATF4-CHOP-CHAC1 pathway and affects ferroptosis in Burkitt's Lymphoma
- (2019) Ning Wang et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Cu II (atsm) inhibits ferroptosis: implications for treatment of neurodegenerative disease
- (2019) Authors Adam Southon et al. BRITISH JOURNAL OF PHARMACOLOGY
- Neuroprotective effects of Brazilian green propolis on oxytosis/ferroptosis in mouse hippocampal HT22 cells
- (2019) Madoka Takashima et al. FOOD AND CHEMICAL TOXICOLOGY
- Physcion 8-O-β-glucopyranoside induced ferroptosis via regulating miR-103a-3p/GLS2 axis in gastric cancer
- (2019) Ying Niu et al. LIFE SCIENCES
- A TAZ–ANGPTL4–NOX2 Axis Regulates Ferroptotic Cell Death and Chemoresistance in Epithelial Ovarian Cancer
- (2019) Wen-Hsuan Yang et al. MOLECULAR CANCER RESEARCH
- FSP1 is a glutathione-independent ferroptosis suppressor
- (2019) Sebastian Doll et al. NATURE
- The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis
- (2019) Kirill Bersuker et al. NATURE
- The chemical basis of ferroptosis
- (2019) Marcus Conrad et al. Nature Chemical Biology
- Mitochondria as multifaceted regulators of cell death
- (2019) Florian J. Bock et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Exquisite sensitivity of adrenocortical carcinomas to induction of ferroptosis
- (2019) Alexia Belavgeni et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine
- (2019) Hua Luo et al. Chinese Medicine
- Danshen Improves Survival of Patients With Breast Cancer and Dihydroisotanshinone I Induces Ferroptosis and Apoptosis of Breast Cancer Cells
- (2019) Yu-Shih Lin et al. Frontiers in Pharmacology
- 7-O-Esters of taxifolin with pronounced and overadditive effects in neuroprotection, anti-neuroinflammation, and amelioration of short-term memory impairment in vivo
- (2019) Sandra Gunesch et al. Redox Biology
- Ruscogenin induces ferroptosis in pancreatic cancer cells
- (2019) Zhiwang Song et al. ONCOLOGY REPORTS
- Determination of the Subcellular Localization and Mechanism of Action of Ferrostatins in Suppressing Ferroptosis
- (2018) Michael M. Gaschler et al. ACS Chemical Biology
- Protective effects of the mechanistic target of rapamycin against excess iron and ferroptosis in cardiomyocytes
- (2018) Yuichi Baba et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Puerarin protects against heart failure induced by pressure overload through mitigation of ferroptosis
- (2018) Bei Liu et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Effects of intracellular iron overload on cell death and identification of potent cell death inhibitors
- (2018) Shenglin Fang et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Ferroptosis is a lysosomal cell death process
- (2018) Huan Gao et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Magnesium isoglycyrrhizinate ameliorates liver fibrosis and hepatic stellate cell activation by regulating ferroptosis signaling pathway
- (2018) Miao Sui et al. BIOMEDICINE & PHARMACOTHERAPY
- Increased erythrophagocytosis induces ferroptosis in red pulp macrophages in a mouse model of transfusion
- (2018) Lyla A. Youssef et al. BLOOD
- Multi-stage Differentiation Defines Melanoma Subtypes with Differential Vulnerability to Drug-Induced Iron-Dependent Oxidative Stress
- (2018) Jennifer Tsoi et al. CANCER CELL
- NRF2 and the Hallmarks of Cancer
- (2018) Montserrat Rojo de la Vega et al. CANCER CELL
- Pseudolaric acid B triggers ferroptosis in glioma cells via activation of Nox4 and inhibition of xCT
- (2018) Zongqi Wang et al. CANCER LETTERS
- CISD2 inhibition overcomes resistance to sulfasalazine-induced ferroptotic cell death in head and neck cancer
- (2018) Eun Hye Kim et al. CANCER LETTERS
- miR-137 regulates ferroptosis by targeting glutamine transporter SLC1A5 in melanoma
- (2018) Meiying Luo et al. CELL DEATH AND DIFFERENTIATION
- A Review of Chinese Herbal Medicine for the Treatment of Chronic Heart Failure
- (2018) Yong Wang et al. CURRENT PHARMACEUTICAL DESIGN
- Piperlongumine rapidly induces the death of human pancreatic cancer cells mainly through the induction of ferroptosis
- (2018) Yuki Yamaguchi et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma
- (2018) Behrouz Hassannia et al. JOURNAL OF CLINICAL INVESTIGATION
- Isothiocyanates: Translating the Power of Plants to People
- (2018) Dushani L. Palliyaguru et al. MOLECULAR NUTRITION & FOOD RESEARCH
- FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation
- (2018) Michael M. Gaschler et al. Nature Chemical Biology
- Epithelial–mesenchymal-transition-inducing transcription factors: new targets for tackling chemoresistance in cancer?
- (2018) Jente van Staalduinen et al. ONCOGENE
- A naturally occuring triterpene saponin ardisiacrispin B displayed cytotoxic effects in multi-factorial drug resistant cancer cells via ferroptotic and apoptotic cell death
- (2018) Armelle T. Mbaveng et al. PHYTOMEDICINE
- Glutathione depletion induces ferroptosis, autophagy, and premature cell senescence in retinal pigment epithelial cells
- (2018) Yun Sun et al. Cell Death & Disease
- Ferroptosis: A Novel Anti-tumor Action for Cisplatin
- (2018) Jipeng Guo et al. Cancer Research and Treatment
- α-Lipoic acid improves abnormal behavior by mitigation of oxidative stress, inflammation, ferroptosis, and tauopathy in P301S Tau transgenic mice
- (2018) Yan-Hui Zhang et al. Redox Biology
- Bromelain effectively suppresses Kras-mutant colorectal cancer by stimulating ferroptosis
- (2018) Sujeong Park et al. Animal Cells and Systems
- The ferroptosis inducer erastin promotes proliferation and differentiation in human peripheral blood mononuclear cells
- (2018) Ding Wang et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Glutathione peroxidase 4 participates in secondary brain injury through mediating ferroptosis in a rat model of intracerebral hemorrhage
- (2018) Zhuwei Zhang et al. BRAIN RESEARCH
- Emerging cellular functions of the lipid metabolizing enzyme 15-Lipoxygenase-1
- (2018) Melis Çolakoğlu et al. CELL PROLIFERATION
- Novel antitumor compound optimized from natural saponin Albiziabioside A induced caspase-dependent apoptosis and ferroptosis as a p53 activator through the mitochondrial pathway
- (2018) Gaofei Wei et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- BAP1 links metabolic regulation of ferroptosis to tumour suppression
- (2018) Yilei Zhang et al. NATURE CELL BIOLOGY
- Fenton-Reaction-Acceleratable Magnetic Nanoparticles for Ferroptosis Therapy of Orthotopic Brain Tumors
- (2018) Zheyu Shen et al. ACS Nano
- N-acetylcysteine targets 5 lipoxygenase-derived, toxic lipids and can synergize with prostaglandin E2 to inhibit ferroptosis and improve outcomes following hemorrhagic stroke in mice
- (2018) Saravanan S. Karuppagounder et al. ANNALS OF NEUROLOGY
- Artesunate alleviates liver fibrosis by regulating ferroptosis signaling pathway
- (2018) Zhaoyan Kong et al. BIOMEDICINE & PHARMACOTHERAPY
- Ferroptosis Contributes to Neuronal Death and Functional Outcome After Traumatic Brain Injury
- (2018) Elizabeth M. Kenny et al. CRITICAL CARE MEDICINE
- Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancer
- (2018) Daiha Shin et al. FREE RADICAL BIOLOGY AND MEDICINE
- P53-dependent induction of ferroptosis is required for artemether to alleviate carbon tetrachloride-induced liver fibrosis and hepatic stellate cell activation
- (2018) Ling Wang et al. IUBMB LIFE
- Reduced expression of the ferroptosis inhibitor glutathione peroxidase-4 in multiple sclerosis and experimental autoimmune encephalomyelitis
- (2018) Che-Lin Hu et al. JOURNAL OF NEUROCHEMISTRY
- Role of Mitochondria in Ferroptosis
- (2018) Minghui Gao et al. MOLECULAR CELL
- Old age-associated phenotypic screening for Alzheimer's disease drug candidates identifies sterubin as a potent neuroprotective compound from Yerba santa
- (2018) Wolfgang Fischer et al. Redox Biology
- DHA inhibits proliferation and induces ferroptosis of leukemia cells through autophagy dependent degradation of ferritin
- (2018) Jing Du et al. FREE RADICAL BIOLOGY AND MEDICINE
- Characterization of ferroptosis in murine models of hemochromatosis
- (2017) Hao Wang et al. HEPATOLOGY
- Iron and ferroptosis: A still ill-defined liaison
- (2017) Sebastian Doll et al. IUBMB LIFE
- NRF2 Is a Major Target of ARF in p53-Independent Tumor Suppression
- (2017) Delin Chen et al. MOLECULAR CELL
- Tau-mediated iron export prevents ferroptotic damage after ischemic stroke
- (2017) Q-z Tuo et al. MOLECULAR PSYCHIATRY
- NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis
- (2017) Samantha W. Alvarez et al. NATURE
- Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition
- (2017) Matthew J. Hangauer et al. NATURE
- Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway
- (2017) Vasanthi S. Viswanathan et al. NATURE
- Salinomycin kills cancer stem cells by sequestering iron in lysosomes
- (2017) Trang Thi Mai et al. Nature Chemistry
- Targeting iron metabolism in drug discovery and delivery
- (2017) Bart J. Crielaard et al. NATURE REVIEWS DRUG DISCOVERY
- Cytotoxicity of epunctanone and four other phytochemicals isolated from the medicinal plants Garcinia epunctata and Ptycholobium contortum towards multi-factorial drug resistant cancer
- (2017) Armelle T. Mbaveng et al. PHYTOMEDICINE
- Ferroptosis and autophagy induced cell death occur independently after siramesine and lapatinib treatment in breast cancer cells
- (2017) Shumei Ma et al. PLoS One
- In vitro polyphenol effects on apoptosis: An update of literature data
- (2017) Valeria Curti et al. SEMINARS IN CANCER BIOLOGY
- Mitochondrial complex I inhibition triggers a mitophagy-dependent ROS increase leading to necroptosis and ferroptosis in melanoma cells
- (2017) Farhan Basit et al. Cell Death & Disease
- The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity
- (2017) Yangchun Xie et al. Cell Reports
- Nrf2-Keap1 pathway promotes cell proliferation and diminishes ferroptosis
- (2017) Z Fan et al. Oncogenesis
- Cysteine Dioxygenase 1 Mediates Erastin-Induced Ferroptosis in Human Gastric Cancer Cells
- (2017) Shihui Hao et al. NEOPLASIA
- Nrf2 inhibition reverses the resistance of cisplatin-resistant head and neck cancer cells to artesunate-induced ferroptosis
- (2017) Jong-Lyel Roh et al. Redox Biology
- Ablation of ferroptosis regulator glutathione peroxidase 4 in forebrain neurons promotes cognitive impairment and neurodegeneration
- (2017) William Sealy Hambright et al. Redox Biology
- Brain iron chelation by deferiprone in a phase 2 randomised double-blinded placebo controlled clinical trial in Parkinson’s disease
- (2017) Antonio Martin-Bastida et al. Scientific Reports
- Autophagy promotes ferroptosis by degradation of ferritin
- (2016) Wen Hou et al. Autophagy
- Identification of baicalein as a ferroptosis inhibitor by natural product library screening
- (2016) Yangchun Xie et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Identification of ACSL4 as a biomarker and contributor of ferroptosis
- (2016) Hua Yuan et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Antiferroptotic activity of non-oxidative dopamine
- (2016) Ding Wang et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Induction of ferroptotic cell death for overcoming cisplatin resistance of head and neck cancer
- (2016) Jong-Lyel Roh et al. CANCER LETTERS
- Dihydroartemisinin (DHA) induces ferroptosis and causes cell cycle arrest in head and neck carcinoma cells
- (2016) Renyu Lin et al. CANCER LETTERS
- Ferroptosis: process and function
- (2016) Y Xie et al. CELL DEATH AND DIFFERENTIATION
- Ferroptosis is an autophagic cell death process
- (2016) Minghui Gao et al. CELL RESEARCH
- Deferoxamine-mediated up-regulation of HIF-1α prevents dopaminergic neuronal death via the activation of MAPK family proteins in MPTP-treated mice
- (2016) Chuang Guo et al. EXPERIMENTAL NEUROLOGY
- An African-specific polymorphism in theTP53gene impairs p53 tumor suppressor function in a mouse model
- (2016) Matthew Jennis et al. GENES & DEVELOPMENT
- Metallothionein-1G facilitates sorafenib resistance through inhibition of ferroptosis
- (2016) Xiaofang Sun et al. HEPATOLOGY
- Ferrous Iron Induces Nrf2 Expression in Mouse Brain Astrocytes to Prevent Neurotoxicity
- (2016) Zhenwen Cui et al. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
- Iron neurochemistry in Alzheimer's disease and Parkinson's disease: targets for therapeutics
- (2016) Abdel A. Belaidi et al. JOURNAL OF NEUROCHEMISTRY
- Metallothionein-1 as a biomarker of altered redox metabolism in hepatocellular carcinoma cells exposed to sorafenib
- (2016) Aline Houessinon et al. Molecular Cancer
- Contribution of reactive oxygen species to ovarian cancer cell growth arrest and killing by the anti-malarial drug artesunate
- (2016) Anna L. Greenshields et al. MOLECULAR CARCINOGENESIS
- Switching Apoptosis to Ferroptosis: Metal–Organic Network for High-Efficiency Anticancer Therapy
- (2016) Di-Wei Zheng et al. NANO LETTERS
- Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis
- (2016) Valerian E Kagan et al. Nature Chemical Biology
- ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition
- (2016) Sebastian Doll et al. Nature Chemical Biology
- Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis
- (2016) Kenichi Shimada et al. Nature Chemical Biology
- Ferroptosis, a newly characterized form of cell death in Parkinson's disease that is regulated by PKC
- (2016) Bruce Do Van et al. NEUROBIOLOGY OF DISEASE
- A combination of an iron chelator with an antioxidant effectively diminishes the dendritic loss, tau-hyperphosphorylation, amyloids-β accumulation and brain mitochondrial dynamic disruption in rats with chronic iron-overload
- (2016) Jirapas Sripetchwandee et al. NEUROSCIENCE
- Combined treatment with cotylenin A and phenethyl isothiocyanate induces strong antitumor activity mainly through the induction of ferroptotic cell death in human pancreatic cancer cells
- (2016) Takashi Kasukabe et al. ONCOLOGY REPORTS
- Cisplatin resistance and opportunities for precision medicine
- (2016) Lauren Amable PHARMACOLOGICAL RESEARCH
- Activation ofSAT1engages polyamine metabolism with p53-mediated ferroptotic responses
- (2016) Yang Ou et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis
- (2016) Wan Seok Yang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Ferroptosis: Death by Lipid Peroxidation
- (2016) Wan Seok Yang et al. TRENDS IN CELL BIOLOGY
- Acetylation Is Crucial for p53-Mediated Ferroptosis and Tumor Suppression
- (2016) Shang-Jui Wang et al. Cell Reports
- An essential cell-autonomous role for hepcidin in cardiac iron homeostasis
- (2016) Samira Lakhal-Littleton et al. eLife
- Systematic Analysis of Gene Expression Alterations and Clinical Outcomes for Long-Chain Acyl-Coenzyme A Synthetase Family in Cancer
- (2016) Wei-Ching Chen et al. PLoS One
- The 5-Lipoxygenase Inhibitor Zileuton Confers Neuroprotection against Glutamate Oxidative Damage by Inhibiting Ferroptosis
- (2015) Yang Liu et al. BIOLOGICAL & PHARMACEUTICAL BULLETIN
- Effects of deferasirox-deferoxamine on myocardial and liver iron in patients with severe transfusional iron overload
- (2015) Yesim Aydinok et al. BLOOD
- Glutathione peroxidase 4 prevents necroptosis in mouse erythroid precursors
- (2015) O. Canli et al. BLOOD
- Ceruloplasmin activity and iron chelation treatment of patients with Parkinson’s disease
- (2015) Guillaume Grolez et al. BMC Neurology
- Immunotargeting of Antigen xCT Attenuates Stem-like Cell Behavior and Metastatic Progression in Breast Cancer
- (2015) S. Lanzardo et al. CANCER RESEARCH
- Elucidating Compound Mechanism of Action by Network Perturbation Analysis
- (2015) Jung Hoon Woo et al. CELL
- Loss of cysteinyl-tRNA synthetase (CARS) induces the transsulfuration pathway and inhibits ferroptosis induced by cystine deprivation
- (2015) M Hayano et al. CELL DEATH AND DIFFERENTIATION
- Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells
- (2015) Xiaofang Sun et al. HEPATOLOGY
- T cell lipid peroxidation induces ferroptosis and prevents immunity to infection
- (2015) Mai Matsushita et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Glutaminolysis and Transferrin Regulate Ferroptosis
- (2015) Minghui Gao et al. MOLECULAR CELL
- High nigral iron deposition in LRRK2 and Parkin mutation carriers using R2* relaxometry
- (2015) Nadya Pyatigorskaya et al. MOVEMENT DISORDERS
- Network pharmacology applications to map the unexplored target space and therapeutic potential of natural products
- (2015) Milla Kibble et al. NATURAL PRODUCT REPORTS
- Ferroptosis as a p53-mediated activity during tumour suppression
- (2015) Le Jiang et al. NATURE
- Erastin sensitizes glioblastoma cells to temozolomide by restraining xCT and cystathionine-γ-lyase function
- (2015) LIANGYU CHEN et al. ONCOLOGY REPORTS
- Cardiac ferroportin regulates cellular iron homeostasis and is important for cardiac function
- (2015) Samira Lakhal-Littleton et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Ferritin levels in the cerebrospinal fluid predict Alzheimer’s disease outcomes and are regulated by APOE
- (2015) Scott Ayton et al. Nature Communications
- Nitric oxide induces hypoxia ischemic injury in the neonatal brain via the disruption of neuronal iron metabolism
- (2015) Qing Lu et al. Redox Biology
- Regulation of Ferroptotic Cancer Cell Death by GPX4
- (2014) Wan Seok Yang et al. CELL
- Essential versus accessory aspects of cell death: recommendations of the NCCD 2015
- (2014) L Galluzzi et al. CELL DEATH AND DIFFERENTIATION
- Role of duodenal iron transporters and hepcidin in patients with alcoholic liver disease
- (2014) Marketa Dostalikova-Cimburova et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Ferrostatins Inhibit Oxidative Lipid Damage and Cell Death in Diverse Disease Models
- (2014) Rachid Skouta et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy
- (2014) Joseph D. Mancias et al. NATURE
- Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice
- (2014) Jose Pedro Friedmann Angeli et al. NATURE CELL BIOLOGY
- Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis
- (2014) Scott J Dixon et al. eLife
- Targeting Chelatable Iron as a Therapeutic Modality in Parkinson's Disease
- (2013) David Devos et al. ANTIOXIDANTS & REDOX SIGNALING
- Iron and Cancer Risk--A Systematic Review and Meta-analysis of the Epidemiological Evidence
- (2013) A. Fonseca-Nunes et al. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
- Caspase-Independent Cell Death Is Involved in the Negative Effect of EGF Receptor Inhibitors on Cisplatin in Non-Small Cell Lung Cancer Cells
- (2013) H. Yamaguchi et al. CLINICAL CANCER RESEARCH
- The role of iron and reactive oxygen species in cell death
- (2013) Scott J Dixon et al. Nature Chemical Biology
- Iron Accumulates in Huntington’s Disease Neurons: Protection by Deferoxamine
- (2013) Jianfang Chen et al. PLoS One
- Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
- (2012) Scott J. Dixon et al. CELL
- Ironing Out Cell Death Mechanisms
- (2012) John C. Reed et al. CELL
- Systematic review of β-Elemene injection as adjunctive treatment for lung cancer
- (2012) Bin Wang et al. Chinese Journal of Integrative Medicine
- Trigonelline: A Plant Alkaloid with Therapeutic Potential for Diabetes and Central Nervous System Disease
- (2012) J. Zhou et al. CURRENT MEDICINAL CHEMISTRY
- Cystine/glutamic acid transporter is a novel marker for predicting poor survival in patients with hepatocellular carcinoma
- (2012) HIROKI KINOSHITA et al. ONCOLOGY REPORTS
- The transsulfuration pathway: a source of cysteine for glutathione in astrocytes
- (2011) Gethin J. McBean AMINO ACIDS
- Long-term safety and efficacy of deferasirox (Exjade®) for up to 5 years in transfusional iron-overloaded patients with sickle cell disease
- (2011) Elliott Vichinsky et al. BRITISH JOURNAL OF HAEMATOLOGY
- Programmed Cell Death in Animal Development and Disease
- (2011) Yaron Fuchs et al. CELL
- Selective killing of K-ras mutant cancer cells by small molecule inducers of oxidative stress
- (2011) A. T. Shaw et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Modulation of lipid peroxidation and mitochondrial function improves neuropathology in Huntington’s disease mice
- (2010) Junghee Lee et al. ACTA NEUROPATHOLOGICA
- Blood-derived iron mediates free radical production and neuronal death in the hippocampal CA1 area following transient forebrain ischemia in rat
- (2010) Ui Jin Park et al. ACTA NEUROPATHOLOGICA
- Transferrin receptor (CD71) is a marker of poor prognosis in breast cancer and can predict response to tamoxifen
- (2009) Hany Onsy Habashy et al. BREAST CANCER RESEARCH AND TREATMENT
- Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
- (2009) Dunyaporn Trachootham et al. NATURE REVIEWS DRUG DISCOVERY
- Synthetic Lethal Screening Identifies Compounds Activating Iron-Dependent, Nonapoptotic Cell Death in Oncogenic-RAS-Harboring Cancer Cells
- (2008) Wan Seok Yang et al. CHEMISTRY & BIOLOGY
- Iron-binding and anti-Fenton properties of baicalein and baicalin
- (2008) Carlos A. Perez et al. JOURNAL OF INORGANIC BIOCHEMISTRY
- Suppression of atherogenesis by overexpression of glutathione peroxidase-4 in apolipoprotein E-deficient mice
- (2007) ZhongMao Guo et al. FREE RADICAL BIOLOGY AND MEDICINE
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started