Towards 4th industrial revolution efficient and sustainable continuous flow manufacturing of active pharmaceutical ingredients

High-Throughput Synthesis of (S)-α-Phellandrene through Three-Step Sequential Continuous-Flow Reactions

(2021) Samuel J. Miller et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

A Comment on Continuous Flow Technologies within the Agrochemical Industry

(2021) Steven V. Ley et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Flash Chemistry Approach to Organometallic C-Glycosylation for the Synthesis of Remdesivir

(2021) Timo von Keutz et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Integrated Continuous Pharmaceutical Technologies—A Review

(2021) András Domokos et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Automated synthesis of prexasertib and derivatives enabled by continuous-flow solid-phase synthesis

(2021) Chenguang Liu et al.   Nature Chemistry

API Continuous Cooling and Antisolvent Crystallization for Kinetic Impurity Rejection in cGMP Manufacturing

(2021) Martin D. Johnson et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Intensified Continuous Flow Synthesis and Workup of 1,5-Disubstituted Tetrazoles Enhanced by Real-Time Process Analytics

(2021) Peter Sagmeister et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Expanding the Tool Kit of Automated Flow Synthesis: Development of In-line Flash Chromatography Purification

(2021) Christopher G. Thomson et al.   JOURNAL OF ORGANIC CHEMISTRY

Multistep Continuous Flow Synthesis of Stavudine

(2021) Cloudius R. Sagandira et al.   JOURNAL OF ORGANIC CHEMISTRY

On-Demand Continuous Manufacturing of Ciprofloxacin in Portable Plug-and-Play Factories: Implementation and In Situ Control of Downstream Production

(2021) Gerard Capellades et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Minimal manual input

(2020) David M. Heard et al.   Nature Chemistry

Current and Future Roles of Artificial Intelligence in Medicinal Chemistry Synthesis

(2020) Thomas J. Struble et al.   JOURNAL OF MEDICINAL CHEMISTRY

Flow Chemistry in Contemporary Chemical Sciences: A Real Variety of Its Applications

(2020) Marek Trojanowicz   MOLECULES

A mobile robotic chemist

(2020) Benjamin Burger et al.   NATURE

Fully Automated Chemical Synthesis: Toward the Universal Synthesizer

(2020) Nathan Collins et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Recent Advances in Multi‐Step Continuous‐Flow Organic Synthesis

(2020) Jiao Jiao et al.   CHEMISTRY-A EUROPEAN JOURNAL

Telescoped Continuous Flow Synthesis of Optically Active γ-Nitrobutyric Acids as Key Intermediates of Baclofen, Phenibut, and Fluorophenibut

(2020) Sándor B. Ötvös et al.   ORGANIC LETTERS

Optimization and Scale-Up of the Continuous Flow Acetylation and Nitration of 4-Fluoro-2-methoxyaniline to Prepare a Key Building Block of Osimertinib

(2020) Manuel Köckinger et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

A universal system for digitization and automatic execution of the chemical synthesis literature

(2020) S. Hessam M. Mehr et al.   SCIENCE

3D printing and continuous flow chemistry technology to advance pharmaceutical manufacturing in developing countries

(2020) Cloudius R. Sagandira et al.   Arabian Journal of Chemistry

Living with our machines: Towards a more sustainable future

(2020) Steven V. Ley et al.   Current Opinion in Green and Sustainable Chemistry

Wound healing activity of terpinolene and α-phellandrene by attenuating inflammation and oxidative stress in vitro

(2019) Marcella Malavazi de Christo Scherer et al.   Journal of Tissue Viability

Emerging Trends in Flow Chemistry and Applications to the Pharmaceutical Industry

(2019) Andrew R. Bogdan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Multistep synthesis of a valsartan precursor in continuous flow

(2019) Katharina Hiebler et al.   Journal of Flow Chemistry

A robotic platform for flow synthesis of organic compounds informed by AI planning

(2019) Connor W. Coley et al.   SCIENCE

Artificial-Intelligence-Driven Organic Synthesis-En Route towards Autonomous Synthesis?

(2019) Claire Empel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A New World for Chemical Synthesis?

(2019) Steven V. Ley et al.   CHIMIA

In-Line Purification: A Key Component to Facilitate Drug Synthesis and Process Development in Medicinal Chemistry

(2019) Nopphon Weeranoppanant et al.   ACS Medicinal Chemistry Letters

Development of a multistep reaction cascade for the synthesis of a sacubitril precursor in continuous flow

(2019) Katharina Hiebler et al.   Journal of Flow Chemistry

Machine Learning in Computer-Aided Synthesis Planning

(2018) Connor W. Coley et al.   ACCOUNTS OF CHEMICAL RESEARCH

Impact of continuous flow chemistry in the synthesis of natural products and active pharmaceutical ingredients

(2018) JULIANA M. DE SOUZA et al.   ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS

Applications of Flow Chemistry in Drug Development: Highlights of Recent Patent Literature

(2018) David L. Hughes   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Controlling an organic synthesis robot with machine learning to search for new reactivity

(2018) Jarosław M. Granda et al.   NATURE

Nanoscale synthesis and affinity ranking

(2018) Nathan J. Gesmundo et al.   NATURE

Networking chemical robots for reaction multitasking

(2018) Dario Caramelli et al.   Nature Communications

In-line separation of multicomponent reaction mixtures using a new semi-continuous supercritical fluid chromatography system

(2018) Daniel E. Fitzpatrick et al.   Reaction Chemistry & Engineering

Across-the-World Automated Optimization and Continuous-Flow Synthesis of Pharmaceutical Agents Operating Through a Cloud-Based Server

(2018) Daniel E. Fitzpatrick et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Organic synthesis in a modular robotic system driven by a chemical programming language

(2018) Sebastian Steiner et al.   SCIENCE

Kilogram-scale prexasertib monolactate monohydrate synthesis under continuous-flow CGMP conditions

(2017) Kevin P. Cole et al.   SCIENCE

Process analytical tools for flow analysis: A perspective

(2017) Gregory A. Price et al.   Journal of Flow Chemistry

Feedback in Flow for Accelerated Reaction Development

(2016) Brandon J. Reizman et al.   ACCOUNTS OF CHEMICAL RESEARCH

Using PAT to accelerate the transition to continuous API manufacturing

(2016) Francisca F. Gouveia et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Computer-Assisted Synthetic Planning: The End of the Beginning

(2016) Sara Szymkuć et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Taming hazardous chemistry by continuous flow technology

(2016) M. Movsisyan et al.   CHEMICAL SOCIETY REVIEWS

Machine-learning-assisted materials discovery using failed experiments

(2016) Paul Raccuglia et al.   NATURE

On-demand continuous-flow production of pharmaceuticals in a compact, reconfigurable system

(2016) A. Adamo et al.   SCIENCE

Enabling Technologies for the Future of Chemical Synthesis

(2016) Daniel E. Fitzpatrick et al.   ACS Central Science

Organic Synthesis: March of the Machines

(2015) Steven V. Ley et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Machine-Assisted Organic Synthesis

(2015) Steven V. Ley et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Continuous-Flow Technology-A Tool for the Safe Manufacturing of Active Pharmaceutical Ingredients

(2015) Bernhard Gutmann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The synthesis of active pharmaceutical ingredients (APIs) using continuous flow chemistry

(2015) Marcus Baumann et al.   Beilstein Journal of Organic Chemistry

Rapid Vortex Fluidics: Continuous Flow Synthesis of Amides and Local Anesthetic Lidocaine

(2015) Joshua Britton et al.   CHEMISTRY-A EUROPEAN JOURNAL

Deep learning

(2015) Yann LeCun et al.   NATURE

One-Pot Synthesis of (S)-Baclofen via Aldol Condensation of Acetaldehyde with Diphenylprolinol Silyl Ether Mediated Asymmetric Michael Reaction as a Key Step

(2015) Yujiro Hayashi et al.   ORGANIC LETTERS

Industry Perspectives on Process Analytical Technology: Tools and Applications in API Manufacturing

(2015) Shailendra Bordawekar et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Flow Chemistry: Recent Developments in the Synthesis of Pharmaceutical Products

(2015) Riccardo Porta et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Machine learning: Trends, perspectives, and prospects

(2015) M. I. Jordan et al.   SCIENCE

Advances in steady-state continuous-flow purification by small-scale free-flow electrophoresis

(2015) Fletcher J. Agostino et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

A self optimizing synthetic organic reactor system using real-time in-line NMR spectroscopy

(2015) Victor Sans et al.   Chemical Science

A Systems Approach towards an Intelligent and Self-Controlling Platform for Integrated Continuous Reaction Sequences

(2014) Richard J. Ingham et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Short Review of Chemical Reaction Database Systems, Computer-Aided Synthesis Design, Reaction Prediction and Synthetic Feasibility

(2014) Wendy A. Warr   Molecular Informatics

Contemporary screening approaches to reaction discovery and development

(2014) Karl D. Collins et al.   Nature Chemistry

End-to-End Continuous Manufacturing of Pharmaceuticals: Integrated Synthesis, Purification, and Final Dosage Formation

(2013) Salvatore Mascia et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Flash chemistry: flow chemistry that cannot be done in batch

(2013) Jun-ichi Yoshida et al.   CHEMICAL COMMUNICATIONS

Continuous Synthesis and Purification by Direct Coupling of a Flow Reactor with Simulated Moving-Bed Chromatography

(2012) Alexander G. O'Brien et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Quality by design for biopharmaceuticals

(2009) Anurag S Rathore et al.   NATURE BIOTECHNOLOGY