Impact of continuous flow chemistry in the synthesis of natural products and active pharmaceutical ingredients

Development of a concise, scalable synthesis of a CCR1 antagonist utilizing a continuous flow Curtius rearrangement

(2017) Maurice A. Marsini et al.   GREEN CHEMISTRY

Synthetic Approaches to the New Drugs Approved During 2015

(2017) Andrew C. Flick et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of Fused Pyrimidinone and Quinolone Derivatives in an Automated High-Temperature and High-Pressure Flow Reactor

(2017) Jennifer Tsoung et al.   JOURNAL OF ORGANIC CHEMISTRY

Total Synthesis of Neomarchantin A: Key Bond Constructions Performed Using Continuous Flow Methods

(2017) Émilie Morin et al.   ORGANIC LETTERS

Kilogram-scale prexasertib monolactate monohydrate synthesis under continuous-flow CGMP conditions

(2017) Kevin P. Cole et al.   SCIENCE

What is medicinal chemistry? – Demystifying a rapidly evolving discipline!

(2017) Selina Y. L. Holbrook et al.   MedChemComm

Integrated Platform for Expedited Synthesis–Purification–Testing of Small Molecule Libraries

(2017) Aleksandra Baranczak et al.   ACS Medicinal Chemistry Letters

A sensitivity analysis of a numbered-up photomicroreactor system

(2017) Koen P. L. Kuijpers et al.   Reaction Chemistry & Engineering

Combining batch and continuous flow setups in the end-to-end synthesis of naturally occurring curcuminoids

(2017) Christian C. Carmona-Vargas et al.   Reaction Chemistry & Engineering

On the design of complex drug candidate syntheses in the pharmaceutical industry

(2017) Martin D. Eastgate et al.   Nature Reviews Chemistry

Feedback in Flow for Accelerated Reaction Development

(2016) Brandon J. Reizman et al.   ACCOUNTS OF CHEMICAL RESEARCH

Applications of Continuous-Flow Photochemistry in Organic Synthesis, Material Science, and Water Treatment

(2016) Dario Cambié et al.   CHEMICAL REVIEWS

Taming hazardous chemistry by continuous flow technology

(2016) M. Movsisyan et al.   CHEMICAL SOCIETY REVIEWS

A Sustainable, Semi-Continuous Flow Synthesis of Hydantoins

(2016) Stella Vukelić et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synthesis of Natural and Unnatural Cyclooligomeric Depsipeptides Enabled by Flow Chemistry

(2016) Daniel Lücke et al.   CHEMISTRY-A EUROPEAN JOURNAL

Batch and Flow Synthesis of Disulfides by Visible-Light-Induced TiO2Photocatalysis

(2016) Cecilia Bottecchia et al.   ChemSusChem

The Generation of a Library of ­Bromodomain-Containing Protein Modulators Expedited by Continuous Flow Synthesis

(2016) Paolo Filipponi et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

The Evolution and Impact of Total Synthesis on Chemistry, Biology and Medicine

(2016) Kyriacos C. Nicolaou et al.   ISRAEL JOURNAL OF CHEMISTRY

Underexplored Opportunities for Natural Products in Drug Discovery

(2016) Bart L. DeCorte   JOURNAL OF MEDICINAL CHEMISTRY

Natural Products as Sources of New Drugs from 1981 to 2014

(2016) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

Porphyrins as Catalysts in Scalable Organic Reactions

(2016) Juan Barona-Castaño et al.   MOLECULES

Flow Chemistry on Multigram Scale: Continuous Synthesis of Boronic Acids within 1 s

(2016) Andreas Hafner et al.   ORGANIC LETTERS

Development and Manufacturing GMP Scale-Up of a Continuous Ir-Catalyzed Homogeneous Reductive Amination Reaction

(2016) Scott A. May et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

A Small-Footprint, High-Capacity Flow Reactor for UV Photochemical Synthesis on the Kilogram Scale

(2016) Luke D. Elliott et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

On-demand continuous-flow production of pharmaceuticals in a compact, reconfigurable system

(2016) A. Adamo et al.   SCIENCE

Discovery and mechanistic study of a photocatalytic indoline dehydrogenation for the synthesis of elbasvir

(2016) Hatice G. Yayla et al.   Chemical Science

Enabling Technologies for the Future of Chemical Synthesis

(2016) Daniel E. Fitzpatrick et al.   ACS Central Science

Continuous photochemistry: the flow synthesis of ibuprofen via a photo-Favorskii rearrangement

(2016) M. Baumann et al.   Reaction Chemistry & Engineering

A multistep continuous flow synthesis machine for the preparation of pyrazoles via a metal-free amine-redox process

(2016) Jian-Siang Poh et al.   Reaction Chemistry & Engineering

A convenient numbering-up strategy for the scale-up of gas–liquid photoredox catalysis in flow

(2016) Yuanhai Su et al.   Reaction Chemistry & Engineering

Metal-Free Photocatalytic Aerobic Oxidation of Thiols to Disulfides in Batch and Continuous-Flow

(2015) Ali Talla et al.   ADVANCED SYNTHESIS & CATALYSIS

Machine-Assisted Organic Synthesis

(2015) Steven V. Ley et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Continuous-Flow Technology-A Tool for the Safe Manufacturing of Active Pharmaceutical Ingredients

(2015) Bernhard Gutmann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Facilitating Biomimetic Syntheses of Borrerine Derived Alkaloids by Means of Flow-Chemical Methods

(2015) Sonja B. Kamptmann et al.   AUSTRALIAN JOURNAL OF CHEMISTRY

Flow “Fine” Synthesis: High Yielding and Selective Organic Synthesis by Flow Methods

(2015) Shū Kobayashi   Chemistry-An Asian Journal

The New Directions of Organic Synthesis

(2015) Timothy Brocksom et al.   CURRENT ORGANIC SYNTHESIS

Batch and Flow Synthesis of Pyrrolo[1,2-a]-quinolines via an Allene-Based Reaction Cascade

(2015) Marcus Baumann et al.   JOURNAL OF ORGANIC CHEMISTRY

Streamlining drug synthesis

(2015) Joel M. Hawkins   NATURE

A practical deca-gram scale ring expansion of (R)-(−)-carvone to (R)-(+)-3-methyl-6-isopropenyl-cyclohept-3-enone-1

(2015) Leandro de C. Alves et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Flow synthesis of ethyl isocyanoacetate enabling the telescoped synthesis of 1,2,4-triazoles and pyrrolo-[1,2-c]pyrimidines

(2015) Marcus Baumann et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

The rapid synthesis of oxazolines and their heterogeneous oxidation to oxazoles under flow conditions

(2015) Steffen Glöckner et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Development of a Direct Photocatalytic C–H Fluorination for the Preparative Synthesis of Odanacatib

(2015) Shira D. Halperin et al.   ORGANIC LETTERS

Flow Chemistry: Recent Developments in the Synthesis of Pharmaceutical Products

(2015) Riccardo Porta et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Continuous-Flow Synthesis of 2H-Azirines and Their Diastereoselective Transformation to Aziridines

(2015) Marcus Baumann et al.   SYNLETT

Modernizing Pharmaceutical Manufacturing: from Batch to Continuous Production

(2015) Sau L. Lee et al.   Journal of Pharmaceutical Innovation

A continuous-flow synthesis of 1,4-benzodiazepin-5-ones, privileged scaffolds for drug discovery

(2015) Monica Viviano et al.   RSC Advances

A high-throughput synthesis of 1,2,4-oxadiazole and 1,2,4-triazole libraries in a continuous flow reactor

(2015) Andrew R. Bogdan et al.   RSC Advances

Exploiting novel process windows for the synthesis of meso-substituted porphyrins under continuous flow conditions

(2015) Patrícia B. Momo et al.   RSC Advances

Control of Hazardous Processes in Flow: Synthesis of 2-Nitroethanol

(2015) Dominique Roberge et al.   Journal of Flow Chemistry

Exploring New Parameter Spaces for the Oxidative Homocoupling of Aniline Derivatives: Sustainable Synthesis of Azobenzenes in a Flow System

(2015) Ádám Georgiádes et al.   ACS Sustainable Chemistry & Engineering

Process Intensified Flow Synthesis of 1H-4-Substituted Imidazoles: Toward the Continuous Production of Daclatasvir

(2015) Paula F. Carneiro et al.   ACS Sustainable Chemistry & Engineering

A Three-Minute Synthesis and Purification of Ibuprofen: Pushing the Limits of Continuous-Flow Processing

(2014) David R. Snead et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Accelerating Spirocyclic Polyketide Synthesis using Flow Chemistry

(2014) Sean Newton et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Multistep Flow Synthesis of 5-Amino-2-aryl-2H-[1,2,3]-triazole-4-carbonitriles

(2014) Jérôme Jacq et al.   CHEMISTRY-A EUROPEAN JOURNAL

Photochemical Transformations Accelerated in Continuous-Flow Reactors: Basic Concepts and Applications

(2014) Yuanhai Su et al.   CHEMISTRY-A EUROPEAN JOURNAL

Flow approaches towards sustainability

(2014) Luigi Vaccaro et al.   GREEN CHEMISTRY

Recreational drug discovery: natural products as lead structures for the synthesis of smart drugs

(2014) Giovanni Appendino et al.   NATURAL PRODUCT REPORTS

Expedient Preparation of Nazlinine and a Small Library of Indole Alkaloids Using Flow Electrochemistry as an Enabling Technology

(2014) Mikhail A. Kabeshov et al.   ORGANIC LETTERS

Microwave Heated Flow Synthesis of Spiro-oxindole Dihydroquinazolinone Based IRAP Inhibitors

(2014) Karin Engen et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Silver-Mediated Cycloaddition of Alkynes with CF3CHN2: Highly Regioselective Synthesis of 3-Trifluoromethylpyrazoles

(2013) Feng Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A View Through Novel Process Windows

(2013) Stefan C. Stouten et al.   AUSTRALIAN JOURNAL OF CHEMISTRY

Investigating the continuous synthesis of a nicotinonitrile precursor to nevirapine

(2013) Ashley R Longstreet et al.   Beilstein Journal of Organic Chemistry

Packed-Bed Microreactor for Continuous-Flow Adipic Acid Synthesis from Cyclohexene and Hydrogen Peroxide

(2013) M. Shang et al.   CHEMICAL ENGINEERING & TECHNOLOGY

Flow chemistry syntheses of natural products

(2013) Julio C. Pastre et al.   CHEMICAL SOCIETY REVIEWS

Solvent- and Catalyst-Free Huisgen Cycloaddition to Rufinamide in Flow with a Greener, Less Expensive Dipolarophile

(2013) Svetlana Borukhova et al.   ChemSusChem

Novel Process Windows for Enabling, Accelerating, and Uplifting Flow Chemistry

(2013) Volker Hessel et al.   ChemSusChem

En route to full implementation: driving the green chemistry agenda in the pharmaceutical industry

(2013) Hans-Jürgen Federsel   GREEN CHEMISTRY

Continuous process technology: a tool for sustainable production

(2013) Charlotte Wiles et al.   GREEN CHEMISTRY

Natural products as starting points for the synthesis of complex and diverse compounds

(2013) Karen C. Morrison et al.   NATURAL PRODUCT REPORTS

The past, present and potential for microfluidic reactor technology in chemical synthesis

(2013) Katherine S. Elvira et al.   Nature Chemistry

Scaling Up of Continuous Flow Processes with Gases Using a Tube-in-Tube Reactor: Inline Titrations and Fanetizole Synthesis with Ammonia

(2013) Julio C. Pastre et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Continuous Flow-Processing of Organometallic Reagents Using an Advanced Peristaltic Pumping System and the Telescoped Flow Synthesis of (E/Z)-Tamoxifen

(2013) Philip R. D. Murray et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Lead-Oriented Synthesis: A New Opportunity for Synthetic Chemistry

(2012) Alan Nadin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of Aryl(di)azinyl Ketones through Copper- and Iron-catalyzed Oxidation of the Methylene Group of Aryl(di)azinylmethanes

(2012) Johan De Houwer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Continuous-Flow Synthesis of the Anti-Malaria Drug Artemisinin

(2012) François Lévesque et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Photooxygenations in a bubble column reactor

(2012) Alexander Yavorskyy et al.   GREEN CHEMISTRY

Direct aerobic oxidation of 2-benzylpyridines in a gas–liquid continuous-flow regime using propylene carbonate as a solvent

(2012) Bartholomäus Pieber et al.   GREEN CHEMISTRY

Continuous Flow Synthesis. A Pharma Perspective

(2012) Laia Malet-Sanz et al.   JOURNAL OF MEDICINAL CHEMISTRY

Ceria nanoparticles as an efficient catalyst for oxidation of benzylic CH bonds

(2012) Batool Akhlaghinia et al.   JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL

Parallel Microflow Photochemistry: Process Optimization, Scale-up, and Library Synthesis

(2012) Alexander Yavorskyy et al.   ORGANIC LETTERS

Rapid Development and Scale-Up of a 1H-4-Substituted Imidazole Intermediate Enabled by Chemistry in Continuous Plug Flow Reactors

(2012) Scott A. May et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Convergent, Kilogram Scale Synthesis of an Akt Kinase Inhibitor

(2012) Pintipa Grongsaard et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Application of Flow Photochemical Bromination in the Synthesis of a 5-Bromomethylpyrimidine Precursor of Rosuvastatin: Improvement of Productivity and Product Purity

(2012) Damjan Šterk et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Flow chemistry synthesis of zolpidem, alpidem and other GABAAagonists and their biological evaluation through the use of in-line frontal affinity chromatography

(2012) Lucie Guetzoyan et al.   Chemical Science

Rapid Access to Compound Libraries through Flow Technology: Fully Automated Synthesis of a 3-Aminoindolizine Library via Orthogonal Diversification

(2012) Paul P. Lange et al.   ACS Combinatorial Science

Deciding Whether To Go with the Flow: Evaluating the Merits of Flow Reactors for Synthesis

(2011) Ryan L. Hartman et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

An overview of the key routes to the best selling 5-membered ring heterocyclic pharmaceuticals

(2011) Marcus Baumann et al.   Beilstein Journal of Organic Chemistry

Recent Advances in Microflow Photochemistry

(2011) Michael Oelgemöller et al.   MOLECULES

A Scalable Two-Step Continuous Flow Synthesis of Nabumetone and Related 4-Aryl-2-butanones

(2011) Monica Viviano et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Synthesis of a Drug-Like Focused Library of Trisubstituted Pyrrolidines Using Integrated Flow Chemistry and Batch Methods

(2011) Marcus Baumann et al.   ACS Combinatorial Science

Flow chemistry using milli- and microstructured reactors—From conventional to novel process windows

(2010) Tobias Illg et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Continuous-flow synthesis of vitamin D3

(2010) Shinichiro Fuse et al.   CHEMICAL COMMUNICATIONS

Novel process windows – Concept, proposition and evaluation methodology, and intensified superheated processing

(2010) Volker Hessel et al.   CHEMICAL ENGINEERING SCIENCE

One-Step Continuous Flow Synthesis of Highly Substituted Pyrrole-3-carboxylic Acid Derivatives via in Situ Hydrolysis oftert-Butyl Esters

(2010) Ananda Herath et al.   ORGANIC LETTERS

Flow Ozonolysis Using a Semipermeable Teflon AF-2400 Membrane To Effect Gas−Liquid Contact

(2010) Matthew O’Brien et al.   ORGANIC LETTERS

Aminolysis of Epoxides in a Microreactor System: A Continuous Flow Approach to β-Amino Alcohols

(2010) Matthew W. Bedore et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

An efficient synthesis of rufinamide, an antiepileptic drug

(2010) Whitney H. Mudd et al.   TETRAHEDRON LETTERS

Chemical Process Research and Development in the 21st Century: Challenges, Strategies, and Solutions from a Pharmaceutical Industry Perspective

(2009) Hans-Jürgen Federsel   ACCOUNTS OF CHEMICAL RESEARCH

The Continuous-Flow Synthesis of Ibuprofen

(2009) Andrew R. Bogdan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Novel Process Windows - Gate to Maximizing Process Intensification via Flow Chemistry

(2009) V. Hessel   CHEMICAL ENGINEERING & TECHNOLOGY

A metal-free catalytic system for the oxidation of benzylic methylenes and primary amines under solvent-free conditions

(2009) Jintang Zhang et al.   GREEN CHEMISTRY

Sustainability through green processing – novel process windows intensify micro and milli process technologies

(2008) Volker Hessel et al.   Energy & Environmental Science