Nanoscale synthesis and affinity ranking

Snap deconvolution: An informatics approach to high-throughput discovery of catalytic reactions

(2017) Konstantin Troshin et al.   SCIENCE

Integrated Platform for Expedited Synthesis–Purification–Testing of Small Molecule Libraries

(2017) Aleksandra Baranczak et al.   ACS Medicinal Chemistry Letters

Practical High-Throughput Experimentation for Chemists

(2017) Michael Shevlin   ACS Medicinal Chemistry Letters

Encoded Silicon-Chip-Based Platform for Combinatorial Synthesis and Screening

(2017) Julian Vastl et al.   ACS Combinatorial Science

hνSABR: Photochemical Dose–Response Bead Screening in Droplets

(2016) Alexander K. Price et al.   ANALYTICAL CHEMISTRY

De Novo Design at the Edge of Chaos

(2016) Petra Schneider et al.   JOURNAL OF MEDICINAL CHEMISTRY

Big Data from Pharmaceutical Patents: A Computational Analysis of Medicinal Chemists’ Bread and Butter

(2016) Nadine Schneider et al.   JOURNAL OF MEDICINAL CHEMISTRY

DNA-encoded chemistry: enabling the deeper sampling of chemical space

(2016) Robert A. Goodnow et al.   NATURE REVIEWS DRUG DISCOVERY

Chemistry informer libraries: a chemoinformatics enabled approach to evaluate and advance synthetic methods

(2016) Peter S. Kutchukian et al.   Chemical Science

The Chemical Space Project

(2015) Jean-Louis Reymond   ACCOUNTS OF CHEMICAL RESEARCH

Activity-Directed Synthesis with Intermolecular Reactions: Development of a Fragment into a Range of Androgen Receptor Agonists

(2015) George Karageorgis et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Analysis of Past and Present Synthetic Methodologies on Medicinal Chemistry: Where Have All the New Reactions Gone?

(2015) Dean G. Brown et al.   JOURNAL OF MEDICINAL CHEMISTRY

P2Et Phosphazene: A Mild, Functional Group Tolerant Base for Soluble, Room Temperature Pd-Catalyzed C–N, C–O, and C–C Cross-Coupling Reactions

(2015) Alexander Buitrago Santanilla et al.   ORGANIC LETTERS

Solution-Based Indirect Affinity Selection Mass Spectrometry—A General Tool For High-Throughput Screening Of Pharmaceutical Compound Libraries

(2014) Thomas N. O’Connell et al.   ANALYTICAL CHEMISTRY

Seamless Integration of Dose-Response Screening and Flow Chemistry: Efficient Generation of Structure-Activity Relationship Data of β-Secretase (BACE1) Inhibitors

(2014) Michael Werner et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Off-Rate Screening (ORS) By Surface Plasmon Resonance. An Efficient Method to Kinetically Sample Hit to Lead Chemical Space from Unpurified Reaction Products

(2014) James B. Murray et al.   JOURNAL OF MEDICINAL CHEMISTRY

Contemporary screening approaches to reaction discovery and development

(2014) Karl D. Collins et al.   Nature Chemistry

Nanomole-scale high-throughput chemistry for the synthesis of complex molecules

(2014) A. Buitrago Santanilla et al.   SCIENCE

Structure-based design and optimization of 2-aminothiazole-4-carboxamide as a new class of CHK1 inhibitors

(2013) Xiaohua Huang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Rapid Discovery of a Novel Series of Abl Kinase Inhibitors by Application of an Integrated Microfluidic Synthesis and Screening Platform

(2013) Bimbisar Desai et al.   JOURNAL OF MEDICINAL CHEMISTRY

Beyond the Numbers: Charting Chemical Reaction Space

(2012) Paul M. Murray et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Flow chemistry synthesis of zolpidem, alpidem and other GABAAagonists and their biological evaluation through the use of in-line frontal affinity chromatography

(2012) Lucie Guetzoyan et al.   Chemical Science

Design and preparation of new palladium precatalysts for C–C and C–N cross-coupling reactions

(2012) Nicholas C. Bruno et al.   Chemical Science