Flash Chemistry Approach to Organometallic C-Glycosylation for the Synthesis of Remdesivir

Development of a Large-Scale Cyanation Process Using Continuous Flow Chemistry en Route to the Synthesis of Remdesivir

(2020) Tiago Vieira et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Organolithium Bases in Flow Chemistry: A Review

(2020) Mark Power et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Research and Development on Therapeutic Agents and Vaccines for COVID-19 and Related Human Coronavirus Diseases

(2020) Cynthia Liu et al.   ACS Central Science

Quest for a COVID-19 Cure by Repurposing Small-Molecule Drugs: Mechanism of Action, Clinical Development, Synthesis at Scale, and Outlook for Supply

(2020) Chris De Savi et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Improvement of the C-glycosylation Step for the Synthesis of Remdesivir

(2020) Fei Xue et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Oscillatory flow reactors for synthetic chemistry applications

(2020) Pauline Bianchi et al.   Journal of Flow Chemistry

Treating a Global Health Crisis with a Dose of Synthetic Chemistry

(2020) Melissa A. Hardy et al.   ACS Central Science

Organomagnesium Based Flash Chemistry: Continuous Flow Generation and Utilization of Halomethylmagnesium Intermediates

(2020) Timo von Keutz et al.   ORGANIC LETTERS

Expanding Access to Remdesivir via an Improved Pyrrolotriazine Synthesis: Supply Centered Synthesis

(2020) Dinesh J. Paymode et al.   ORGANIC LETTERS

Continuous Flow C-Glycosylation via Metal–Halogen Exchange: Process Understanding and Improvements toward Efficient Manufacturing of Remdesivir

(2020) Timo von Keutz et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Optimization and Scale-Up of the Continuous Flow Acetylation and Nitration of 4-Fluoro-2-methoxyaniline to Prepare a Key Building Block of Osimertinib

(2020) Manuel Köckinger et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Experimental Methods in Chemical Engineering: Micro‐Reactors

(2019) Arturo Macchi et al.   CANADIAN JOURNAL OF CHEMICAL ENGINEERING

Flow Technology for Genesis and Use of (Highly) Reactive Organometallic Reagents

(2019) Marco Colella et al.   CHEMISTRY-A EUROPEAN JOURNAL

Recent topics of functionalized organolithiums using flow microreactor chemistry

(2019) Aiichiro Nagaki   TETRAHEDRON LETTERS

A Continuous Stirred-Tank Reactor (CSTR) Cascade for Handling Solid-Containing Photochemical Reactions

(2019) Alexander Pomberger et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Continuous Flow Synthesis of Terminal Epoxides from Ketones Using in Situ Generated Bromomethyl Lithium

(2019) Timo von Keutz et al.   ORGANIC LETTERS

The Evolving State of Continuous Processing in Pharmaceutical API Manufacturing: A Survey of Pharmaceutical Companies and Contract Manufacturing Organizations

(2018) J. Christopher McWilliams et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses

(2017) Dustin Siegel et al.   JOURNAL OF MEDICINAL CHEMISTRY

Dichloromethyllithium: Synthesis and Application in Continuous Flow Mode

(2017) Andreas Hafner et al.   ORGANIC LETTERS

Mixing Performance Evaluation for Commercially Available Micromixers Using Villermaux–Dushman Reaction Scheme with the Interaction by Exchange with the Mean Model

(2017) Joseph M. Reckamp et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Liquid–liquid flow regimes and mass transfer in various micro-reactors

(2016) Patrick Plouffe et al.   CHEMICAL ENGINEERING JOURNAL

Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys

(2016) Travis K. Warren et al.   NATURE

A Simple Scale-up Strategy for Organolithium Chemistry in Flow Mode: From Feasibility to Kilogram Quantities

(2016) Andreas Hafner et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Continuous-Flow Technology-A Tool for the Safe Manufacturing of Active Pharmaceutical Ingredients

(2015) Bernhard Gutmann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The synthesis of active pharmaceutical ingredients (APIs) using continuous flow chemistry

(2015) Marcus Baumann et al.   Beilstein Journal of Organic Chemistry

Flow Chemistry: Recent Developments in the Synthesis of Pharmaceutical Products

(2015) Riccardo Porta et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Modernizing Pharmaceutical Manufacturing: from Batch to Continuous Production

(2015) Sau L. Lee et al.   Journal of Pharmaceutical Innovation

From Batch to Continuous Chemical Synthesis—A Toolbox Approach

(2014) Patrick Plouffe et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Flash chemistry: flow chemistry that cannot be done in batch

(2013) Jun-ichi Yoshida et al.   CHEMICAL COMMUNICATIONS

Continuous Flow-Processing of Organometallic Reagents Using an Advanced Peristaltic Pumping System and the Telescoped Flow Synthesis of (E/Z)-Tamoxifen

(2013) Philip R. D. Murray et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Scale-up concept for modular microstructured reactors based on mixing, heat transfer, and reactor safety

(2011) Norbert Kockmann et al.   CHEMICAL ENGINEERING AND PROCESSING

Continuous Flow Processing of Slurries: Evaluation of an Agitated Cell Reactor

(2011) Duncan L. Browne et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Flash Chemistry: Fast Chemical Synthesis by Using Microreactors

(2008) Jun-ichi Yoshida et al.   CHEMISTRY-A EUROPEAN JOURNAL