Intensified Continuous Flow Synthesis and Workup of 1,5-Disubstituted Tetrazoles Enhanced by Real-Time Process Analytics

Advanced Real‐Time Process Analytics for Multistep Synthesis in Continuous Flow

(2021) Peter Sagmeister et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Current and future requirements to industrial analytical infrastructure—part 1: process analytical laboratories

(2020) Kristina Eisen et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Current and future requirements to industrial analytical infrastructure—part 2: smart sensors

(2020) Tobias Eifert et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Synthesis of 5-Substituted 1H-Tetrazoles from Nitriles by Continuous Flow: Application to the Synthesis of Valsartan

(2020) Florian Carpentier et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

An Expeditious Approach to Tetrazoles from Amides Utilizing Phosphorazidates

(2020) Kotaro Ishihara et al.   ORGANIC LETTERS

A Vilsmeier Chloroformylation by Continuous Flow Chemistry

(2020) Manuel Carrera et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Design and Commercialization of an End-to-End Continuous Pharmaceutical Production Process: A Pilot Plant Case Study

(2020) Christopher J. Testa et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Tetrazoles via Multicomponent Reactions

(2019) Constantinos G. Neochoritis et al.   CHEMICAL REVIEWS

Flexible automation with compact NMR spectroscopy for continuous production of pharmaceuticals

(2019) Simon Kern et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Online low-field NMR spectroscopy for process control of an industrial lithiation reaction—automated data analysis

(2018) Simon Kern et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Selective synthesis of ureas and tetrazoles from amides controlled by experimental conditions using conventional and microwave irradiation

(2018) Rajendran Sribalan et al.   Journal of Saudi Chemical Society

Flow reactors integrated with in-line monitoring using benchtop NMR spectroscopy

(2018) Patrick Giraudeau et al.   Reaction Chemistry & Engineering

Development and Demonstration of a Safer Protocol for the Synthesis of 5-Aryltetrazoles from Aryl Nitriles

(2017) Daniel S. Treitler et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Process analytical tools for flow analysis: A perspective

(2017) Gregory A. Price et al.   Journal of Flow Chemistry

Forbidden chemistries — paths to a sustainable future engaging continuous processing

(2017) Bernhard Gutmann et al.   Journal of Flow Chemistry

Taming hazardous chemistry by continuous flow technology

(2016) M. Movsisyan et al.   CHEMICAL SOCIETY REVIEWS

Convergent Three-Component Tetrazole Synthesis

(2016) Ajay L. Chandgude et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Updating and further expanding GSK's solvent sustainability guide

(2016) Catherine M. Alder et al.   GREEN CHEMISTRY

Continuous-Flow Technology-A Tool for the Safe Manufacturing of Active Pharmaceutical Ingredients

(2015) Bernhard Gutmann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Novel Triazolopyrimidine-Derived Cannabinoid Receptor 2 Agonists as Potential Treatment for Inflammatory Kidney Diseases

(2015) Matthias Nettekoven et al.   ChemMedChem

Synthesis of Vildagliptin Utilizing Continuous Flow and Batch Technologies

(2015) Laurent Pellegatti et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Assessment of Recent Process Analytical Technology (PAT) Trends: A Multiauthor Review

(2015) Levente L. Simon et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Integration of enabling methods for the automated flow preparation of piperazine-2-carboxamide

(2014) Richard J Ingham et al.   Beilstein Journal of Organic Chemistry

A review of syntheses of 1,5-disubstituted tetrazole derivatives

(2014) Afshin Sarvary et al.   MOLECULAR DIVERSITY

“Batch” Kinetics in Flow: Online IR Analysis and Continuous Control

(2013) Jason S. Moore et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Continuous Flow Production of Thermally Unstable Intermediates in a Microreactor with Inline IR-Analysis: Controlled Vilsmeier–Haack Formylation of Electron-Rich Arenes

(2012) Sebastiaan (Bas) A. M. W. van den Broek et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Continuous-Flow Preparation and Use of β-Chloro Enals Using the Vilsmeier Reagent

(2012) Laurent Pellegatti et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Safe Generation and Synthetic Utilization of Hydrazoic Acid in a Continuous Flow Reactor

(2012) Bernhard Gutmann et al.   Journal of Flow Chemistry

Process Analytical Chemistry

(2011) Jerome Workman et al.   ANALYTICAL CHEMISTRY

Safe and Efficient Tetrazole Synthesis in a Continuous-Flow Microreactor

(2011) Prakash B. Palde et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis and evaluation of 1,5-diaryl-substituted tetrazoles as novel selective cyclooxygenase-2 (COX-2) inhibitors

(2011) Baker Jawabrah Al-Hourani et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Mechanistic Insights on Azide−Nitrile Cycloadditions: On the Dialkyltin Oxide−Trimethylsilyl Azide Route and a New Vilsmeier−Haack-Type Organocatalyst

(2011) David Cantillo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of 5-Substituted 1H-Tetrazoles from Nitriles and Hydrazoic Acid by Using a Safe and Scalable High-Temperature Microreactor Approach

(2010) Bernhard Gutmann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Hydrolysis of Phosphoryl Trichloride (POCl3): Characterization, in Situ Detection, and Safe Quenching of Energetic Metastable Intermediates

(2010) Michał M. Achmatowicz et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

ReactIR Flow Cell: A New Analytical Tool for Continuous Flow Chemical Processing

(2010) Catherine F. Carter et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

A mild and general one-pot preparation of cyanoethyl-protected tetrazoles

(2010) Lawrence J. Kennedy   TETRAHEDRON LETTERS

Cadmium Chloride as an Efficient Catalyst for Neat Synthesis of 5-Substituted 1H-Tetrazoles

(2009) G. Venkateshwarlu et al.   SYNTHETIC COMMUNICATIONS

FeCl3–SiO2 as a reusable heterogeneous catalyst for the synthesis of 5-substituted 1H-tetrazoles via [2+3] cycloaddition of nitriles and sodium azide

(2009) Mahmoud Nasrollahzadeh et al.   TETRAHEDRON LETTERS