Contemporary screening approaches to reaction discovery and development

Three-Component Asymmetric Catalytic Ugi Reaction-Concinnity from Diversity by Substrate-Mediated Catalyst Assembly

(2014) Wenjun Zhao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Late-Stage Functionalization of Biologically Active Heterocycles Through Photoredox Catalysis

(2014) Daniel A. DiRocco et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Tailor-made N-heterocyclic carbenes for nanoparticle stabilization

(2014) Christian Richter et al.   CHEMICAL COMMUNICATIONS

Multidimensional Reaction Screening for Photochemical Transformations as a Tool for Discovering New Chemotypes

(2014) Véronique I. Martin et al.   JOURNAL OF ORGANIC CHEMISTRY

Application of a robustness screen for the evaluation of synthetic organic methodology

(2014) Karl D Collins et al.   Nature Protocols

Organocatalytic Asymmetric Conjugate Addition of Aldehydes to Nitroolefins: Identification of Catalytic Intermediates and the Stereoselectivity-Determining Step by ESI-MS

(2013) Florian Bächle et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Discovery of Chemoselective and Biocompatible Reactions Using a High-Throughput Immunoassay Screening

(2013) Sergii Kolodych et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Visible Light Photoredox Catalysis with Transition Metal Complexes: Applications in Organic Synthesis

(2013) Christopher K. Prier et al.   CHEMICAL REVIEWS

The past, present and potential for microfluidic reactor technology in chemical synthesis

(2013) Katherine S. Elvira et al.   Nature Chemistry

Label-assisted mass spectrometry for the acceleration of reaction discovery and optimization

(2013) Jaime R. Cabrera-Pardo et al.   Nature Chemistry

A robustness screen for the rapid assessment of chemical reactions

(2013) Karl D. Collins et al.   Nature Chemistry

Cobalt Precursors for High-Throughput Discovery of Base Metal Asymmetric Alkene Hydrogenation Catalysts

(2013) M. R. Friedfeld et al.   SCIENCE

Employing a robustness screen: rapid assessment of rhodium(III)-catalysed C–H activation reactions

(2013) Karl D. Collins et al.   TETRAHEDRON

Reaction Discovery by Using a Sandwich Immunoassay

(2012) Julia Quinton et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A simple, fast, and easy assay for transition metal-catalyzed coupling reactions using a paper-based colorimetric iodide sensor

(2012) Sudeok Kim et al.   CHEMICAL COMMUNICATIONS

Combinatorial evolution of site- and enantioselective catalysts for polyene epoxidation

(2012) Phillip A. Lichtor et al.   Nature Chemistry

Halocarbocyclization Entry into the Oxabicyclo[4.3.1]decyl Exomethylene-δ-Lactone Cores of Linearifolin and Zaluzanin A: Exploiting Combinatorial Catalysis

(2012) Sandeep K. Ginotra et al.   ORGANIC LETTERS

Selection of Chiral Zinc Catalysts for the Kinetic Resolution of Esters via Dynamic Templating

(2012) R. Kannappan et al.   ACS Combinatorial Science

Combinatorial Catalysis Employing a Visible Enzymatic Beacon in Real Time: Synthetically Versatile (Pseudo)Halometalation/Carbocyclizations

(2011) Jacob A. Friest et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Colorimetric High-Throughput Screening Method for Palladium-Catalyzed Coupling Reactions of Aryl Iodides Using a Gold Nanoparticle-Based Iodide-Selective Probe

(2011) Eunhye Jung et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Rapid determination of enantiomeric excess: a focus on optical approaches

(2011) Diana Leung et al.   CHEMICAL SOCIETY REVIEWS

Determining the Enantioselectivity of Chiral Catalysts by Mass Spectrometric Screening of Their Racemic Forms

(2011) Christian Ebner et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Three-component reaction discovery enabled by mass spectrometry of self-assembled monolayers

(2011) Timothy J. Montavon et al.   Nature Chemistry

A biomolecule-compatible visible-light-induced azide reduction from a DNA-encoded reaction-discovery system

(2011) Yiyun Chen et al.   Nature Chemistry

ESIPT-Mediated Photocycloadditions of 3-Hydroxyquinolinones: Development of a Fluorescence Quenching Assay for Reaction Screening

(2011) Bing Xia et al.   ORGANIC LETTERS

Discovery of an  -Amino C-H Arylation Reaction Using the Strategy of Accelerated Serendipity

(2011) A. McNally et al.   SCIENCE

A Simple, Multidimensional Approach to High-Throughput Discovery of Catalytic Reactions

(2011) D. W. Robbins et al.   SCIENCE

Toward the Limits of Sandwich Immunoassay of Very Low Molecular Weight Molecules

(2010) Julia Quinton et al.   ANALYTICAL CHEMISTRY

Evolution of Metal Complex-Catalysts by Dynamic Templating with Transition State Analogs

(2010) Masaomi Matsumoto et al.   EUROPEAN JOURNAL OF INORGANIC CHEMISTRY

Reaction Discovery Using Microfluidic-Based Multidimensional Screening of Polycyclic Iminium Ethers

(2010) Jennifer L. Treece et al.   JOURNAL OF ORGANIC CHEMISTRY

Tandem Processes Identified from Reaction Screening: Nucleophilic Addition to ArylN-Phosphinylimines Employing La(III)-TFAA Activation

(2010) Hidenori Kinoshita et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Palladium-Catalyzed, Direct Boronic Acid Synthesis from Aryl Chlorides: A Simplified Route to Diverse Boronate Ester Derivatives

(2010) Gary A. Molander et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Catalyst selection based on intermediate stability measured by mass spectrometry

(2010) Jeroen Wassenaar et al.   Nature Chemistry

Strategies for Innovation in Multicomponent Reaction Design

(2009) Bruce Ganem   ACCOUNTS OF CHEMICAL RESEARCH

Nonlinear Effects in Asymmetric Catalysis

(2009) Tummanapalli Satyanarayana et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective Michael Addition to α,β-Unsaturated Aldehydes: Combinatorial Catalyst Preparation and Screening, Reaction Optimization, and Mechanistic Studies

(2009) Ivana Fleischer et al.   CHEMISTRY-A EUROPEAN JOURNAL

Development of an Automated Microfluidic Reaction Platform for Multidimensional Screening: Reaction Discovery Employing Bicyclo[3.2.1]octanoid Scaffolds

(2009) John R. Goodell et al.   JOURNAL OF ORGANIC CHEMISTRY

Reactivity-Dependent PCR: Direct, Solution-Phasein VitroSelection for Bond Formation

(2009) David J. Gorin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A general protocol for creating high-throughput screening assays for reaction yield and enantiomeric excess applied to hydrobenzoin

(2009) S. H. Shabbir et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mass Spectrometric Screening of Chiral Catalysts by Monitoring the Back Reaction of Quasienantiomeric Products: Palladium-Catalyzed Allylic Substitution

(2008) Constanze A. Müller et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mass Spectrometric Screening of Enantioselective Diels–Alder Reactions

(2008) Antje Teichert et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Exploiting Neighboring-Group Interactions for the Self-Selection of a Catalytic Unit

(2008) Giulio Gasparini et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Insights into Sonogashira Cross-Coupling by High-Throughput Kinetics and Descriptor Modeling

(2008) Markus R. an der Heiden et al.   CHEMISTRY-A EUROPEAN JOURNAL

Combinatorial Ligand Development Based on Mass Spectrometric Screening and a Double Mass-Labeling Strategy

(2008) Christian Markert et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Fluorogenic Transformations Based on Formation of CC Bonds Catalyzed by Palladium: An Efficient Approach for High Throughput Optimizations and Kinetic Studies

(2007) Roman V. Rozhkov et al.   ADVANCED SYNTHESIS & CATALYSIS