Development of a multistep reaction cascade for the synthesis of a sacubitril precursor in continuous flow

Multistep synthesis of a valsartan precursor in continuous flow

(2019) Katharina Hiebler et al.   Journal of Flow Chemistry

Suzuki-Miyaura coupling reactions using novel metal oxide supported ionic palladium catalysts

(2017) G.J. Lichtenegger et al.   JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL

Identification and Characterization ofD-Succinylase, and a Proposed Enzymatic Method forD-Amino Acid Synthesis

(2016) Yosuke Sumida et al.   ADVANCED SYNTHESIS & CATALYSIS

The Plug & Play Reactor: A Highly Flexible Device for Heterogeneous Reactions in Continuous Flow

(2016) Georg J. Lichtenegger et al.   CHEMIE INGENIEUR TECHNIK

Molecular Driving Forces behind the Tetrahydrofuran–Water Miscibility Gap

(2016) Micholas Dean Smith et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Multigram scale, chiron-based synthesis of sacubitril

(2016) Yun Wang et al.   TETRAHEDRON LETTERS

Spotlight on valsartan–sacubitril fixed-dose combination for heart failure: the evidence to date

(2016) José F. Vilela-Martin   Drug Design Development and Therapy

Continuous Suzuki—Miyaura reactions with novel Ce—Sn—Pd oxides and integrated crystallization as continuous downstream protocol

(2016) Georg J. Lichtenegger et al.   Journal of Flow Chemistry

Continuous-Flow Technology-A Tool for the Safe Manufacturing of Active Pharmaceutical Ingredients

(2015) Bernhard Gutmann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

LCZ696 (Valsartan/Sacubitril) - A Possible New Treatment for Hypertension and Heart Failure

(2015) Mathilde Borring Andersen et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Synthesis of a Precursor to Sacubitril Using Enabling Technologies

(2015) Shing-Hing Lau et al.   ORGANIC LETTERS

Flow Chemistry: Recent Developments in the Synthesis of Pharmaceutical Products

(2015) Riccardo Porta et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Continuous synthesis of artemisinin-derived medicines

(2014) Kerry Gilmore et al.   CHEMICAL COMMUNICATIONS

Asymmetric Synthesis of α,α-Disubstituted Amino Acids by Cycloaddition of (E)-Ketonitrones with Vinyl Ethers

(2014) Xiaofei Zhang et al.   ORGANIC LETTERS

Development of a Multi-Step Synthesis and Workup Sequence for an Integrated, Continuous Manufacturing Process of a Pharmaceutical

(2014) Patrick L. Heider et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

The role of flow in green chemistry and engineering

(2013) Stephen G. Newman et al.   GREEN CHEMISTRY

Continuous process technology: a tool for sustainable production

(2013) Charlotte Wiles et al.   GREEN CHEMISTRY

Trifluoroacetic acid: Uses and recent applications in organic synthesis

(2013) Simón E. López et al.   JOURNAL OF FLUORINE CHEMISTRY

On Being Green: Can Flow Chemistry Help?

(2012) Steven V. Ley   CHEMICAL RECORD

Large-Scale Applications of Transition Metal-Catalyzed Couplings for the Synthesis of Pharmaceuticals

(2011) Javier Magano et al.   CHEMICAL REVIEWS

Economic Analysis of Integrated Continuous and Batch Pharmaceutical Manufacturing: A Case Study

(2011) Spencer D. Schaber et al.   INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH

Cost Analysis for a Continuously Operated Fine Chemicals Production Plant at 10 Kg/Day Using a Combination of Microprocessing and Microwave Heating

(2011) F. Benaskar et al.   Journal of Flow Chemistry

From Noble Metal to Nobel Prize: Palladium-Catalyzed Coupling Reactions as Key Methods in Organic Synthesis

(2010) Xiao-Feng Wu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalysis by Palladium Pincer Complexes

(2010) Nicklas Selander et al.   CHEMICAL REVIEWS

A Continuous Flow Process Using a Sequence of Microreactors with In-line IR Analysis for the Preparation of N,N-Diethyl-4-(3-fluorophenylpiperidin-4-ylidenemethyl)benzamide as a Potent and Highly Selective δ-Opioid Receptor Agonist

(2010) Zizheng Qian et al.   CHEMISTRY-A EUROPEAN JOURNAL

Novel Process Windows - Gate to Maximizing Process Intensification via Flow Chemistry

(2009) V. Hessel   CHEMICAL ENGINEERING & TECHNOLOGY

Green Chemistry: Principles and Practice

(2009) Paul Anastas et al.   CHEMICAL SOCIETY REVIEWS

Cross Coupling

(2008) Stephen L. Buchwald   ACCOUNTS OF CHEMICAL RESEARCH

A simple and efficient synthesis of the valsartan

(2008) Chen Xi Zhang et al.   CHINESE CHEMICAL LETTERS

Adsorption of palladium(II) from chloride solutions on Amberlyst A 29 and Amberlyst A 21 resins

(2008) Z. Hubicki et al.   HYDROMETALLURGY

Microreactor Technology and Continuous Processes in the Fine Chemical and Pharmaceutical Industry: Is the Revolution Underway?

(2008) Dominique M. Roberge et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Green chemistry tools to influence a medicinal chemistry and research chemistry based organisation

(2007) Kim Alfonsi et al.   GREEN CHEMISTRY