End-to-End Continuous Manufacturing of Pharmaceuticals: Integrated Synthesis, Purification, and Final Dosage Formation

In-line monitoring of the drug content of powder mixtures and tablets by near-infrared spectroscopy during the continuous direct compression tableting process

(2013) Kristiina Järvinen et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Multi-scale flowsheet simulation of an integrated continuous purification–downstream pharmaceutical manufacturing process

(2013) Maitraye Sen et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Flow Chemistry - A Key Enabling Technology for (Multistep) Organic Synthesis

(2012) Jens Wegner et al.   ADVANCED SYNTHESIS & CATALYSIS

Impact of process parameters on critical performance attributes of a continuous blender-A DEM-based study

(2012) Atul Dubey et al.   AICHE JOURNAL

An integrated approach for dynamic flowsheet modeling and sensitivity analysis of a continuous tablet manufacturing process

(2012) Fani Boukouvala et al.   COMPUTERS & CHEMICAL ENGINEERING

Continuous Crystallization of Aliskiren Hemifumarate

(2012) Justin L. Quon et al.   CRYSTAL GROWTH & DESIGN

Development of Continuous Crystallization Processes Using a Single-Stage Mixed-Suspension, Mixed-Product Removal Crystallizer with Recycle

(2012) Shin Yee Wong et al.   CRYSTAL GROWTH & DESIGN

Active pharmaceutical ingredient (API) production involving continuous processes – A process system engineering (PSE)-assisted design framework

(2012) Albert E. Cervera-Padrell et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

A Plant-Wide Dynamic Model of a Continuous Pharmaceutical Process

(2012) Brahim Benyahia et al.   INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH

An engineering study on the enhanced control and operation of continuous manufacturing of pharmaceutical tablets via roller compaction

(2012) Ravendra Singh et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Continuous Flow Synthesis. A Pharma Perspective

(2012) Laia Malet-Sanz et al.   JOURNAL OF MEDICINAL CHEMISTRY

A prototype continuous-flow liquid–liquid extraction system using open-source technology

(2012) Matthew O'Brien et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Development of Continuous Anti-Solvent/Cooling Crystallization Process using Cascaded Mixed Suspension, Mixed Product Removal Crystallizers

(2012) Haitao Zhang et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Continuous Hydrolysis and Liquid–Liquid Phase Separation of an Active Pharmaceutical Ingredient Intermediate Using a Miniscale Hydrophobic Membrane Separator

(2012) Albert E. Cervera-Padrell et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Development and Scale-Up of a Continuous, High-Pressure, Asymmetric Hydrogenation Reaction, Workup, and Isolation

(2012) Martin D. Johnson et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Continuous Processing in the Manufacture of Active Pharmaceutical Ingredients and Finished Dosage Forms: An Industry Perspective

(2012) Peter Poechlauer et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Electrospun Formulations Containing Crystalline Active Pharmaceutical Ingredients

(2012) Blair Kathryn Brettmann et al.   PHARMACEUTICAL RESEARCH

Deciding Whether To Go with the Flow: Evaluating the Merits of Flow Reactors for Synthesis

(2011) Ryan L. Hartman et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ten key issues in modern flow chemistry

(2011) Jens Wegner et al.   CHEMICAL COMMUNICATIONS

Design and operation of a filter reactor for continuous production of a selected pharmaceutical intermediate

(2011) Kim Müller Christensen et al.   CHEMICAL ENGINEERING SCIENCE

Pharmaceutical Crystallization

(2011) Jie Chen et al.   CRYSTAL GROWTH & DESIGN

Seed loading effects on the mean crystal size of acetylsalicylic acid in a continuous-flow crystallization device

(2011) R. J. P. Eder et al.   CRYSTAL RESEARCH AND TECHNOLOGY

Economic Analysis of Integrated Continuous and Batch Pharmaceutical Manufacturing: A Case Study

(2011) Spencer D. Schaber et al.   INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH

Production and Characterization of Carbamazepine Nanocrystals by Electrospraying for Continuous Pharmaceutical Manufacturing

(2011) Mao Wang et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Key Green Engineering Research Areas for Sustainable Manufacturing: A Perspective from Pharmaceutical and Fine Chemicals Manufacturers

(2011) Concepción Jiménez-González et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Cost Analysis for a Continuously Operated Fine Chemicals Production Plant at 10 Kg/Day Using a Combination of Microprocessing and Microwave Heating

(2011) F. Benaskar et al.   Journal of Flow Chemistry

Reducing the mean size of API crystals by continuous manufacturing with product classification and recycle

(2010) Derek W. Griffin et al.   CHEMICAL ENGINEERING SCIENCE

Total Synthesis of “Aliskiren”: The First Renin Inhibitor in Clinical Practice for Hypertension

(2010) Stephen Hanessian et al.   ORGANIC LETTERS

Amide Bond Formation via Reversible, Carboxylic Acid-Promoted Lactone Aminolysis

(2010) Megan A. Foley et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Continuous flow multi-step organic synthesis

(2010) Damien Webb et al.   Chemical Science

The Continuous-Flow Synthesis of Ibuprofen

(2009) Andrew R. Bogdan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Production of (S)-1-Benzyl-3-diazo-2-oxopropylcarbamic Acidtert-Butyl Ester, a Diazoketone Pharmaceutical Intermediate, Employing a Small Scale Continuous Reactor

(2009) Pamela Pollet et al.   INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH

Continuous Crystallization of Pharmaceuticals Using a Continuous Oscillatory Baffled Crystallizer

(2009) Simon Lawton et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Quality by Design: Concepts for ANDAs

(2008) Robert A. Lionberger et al.   AAPS Journal

Comparison of two twin-screw extruders for continuous granulation

(2008) D DJURIC et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

A modular flow reactor for performing Curtius rearrangements as a continuous flow process

(2008) Marcus Baumann et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Microreactor Technology and Continuous Processes in the Fine Chemical and Pharmaceutical Industry: Is the Revolution Underway?

(2008) Dominique M. Roberge et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Improving Pharmaceutical Product Development and Manufacturing: Impact on Cost of Drug Development and Cost of Goods Sold of Pharmaceuticals

(2008) Pradeep Suresh et al.   Journal of Pharmaceutical Innovation

Process design applied to optimise a directly compressible powder produced via a continuous manufacturing process

(2007) Y GONNISSEN   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Characterization of continuous convective powder mixing processes

(2007) Patricia M. Portillo et al.   POWDER TECHNOLOGY