Towards 4th industrial revolution efficient and sustainable continuous flow manufacturing of active pharmaceutical ingredients
出版年份 2021 全文链接
标题
Towards 4th industrial revolution efficient and sustainable continuous flow manufacturing of active pharmaceutical ingredients
作者
关键词
-
出版物
Reaction Chemistry & Engineering
Volume 7, Issue 2, Pages 214-244
出版商
Royal Society of Chemistry (RSC)
发表日期
2021-12-30
DOI
10.1039/d1re00483b
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- High-Throughput Synthesis of (S)-α-Phellandrene through Three-Step Sequential Continuous-Flow Reactions
- (2021) Samuel J. Miller et al. ORGANIC PROCESS RESEARCH & DEVELOPMENT
- A Comment on Continuous Flow Technologies within the Agrochemical Industry
- (2021) Steven V. Ley et al. ORGANIC PROCESS RESEARCH & DEVELOPMENT
- Flash Chemistry Approach to Organometallic C-Glycosylation for the Synthesis of Remdesivir
- (2021) Timo von Keutz et al. ORGANIC PROCESS RESEARCH & DEVELOPMENT
- Integrated Continuous Pharmaceutical Technologies—A Review
- (2021) András Domokos et al. ORGANIC PROCESS RESEARCH & DEVELOPMENT
- Automated synthesis of prexasertib and derivatives enabled by continuous-flow solid-phase synthesis
- (2021) Chenguang Liu et al. Nature Chemistry
- API Continuous Cooling and Antisolvent Crystallization for Kinetic Impurity Rejection in cGMP Manufacturing
- (2021) Martin D. Johnson et al. ORGANIC PROCESS RESEARCH & DEVELOPMENT
- Intensified Continuous Flow Synthesis and Workup of 1,5-Disubstituted Tetrazoles Enhanced by Real-Time Process Analytics
- (2021) Peter Sagmeister et al. ORGANIC PROCESS RESEARCH & DEVELOPMENT
- Expanding the Tool Kit of Automated Flow Synthesis: Development of In-line Flash Chromatography Purification
- (2021) Christopher G. Thomson et al. JOURNAL OF ORGANIC CHEMISTRY
- Multistep Continuous Flow Synthesis of Stavudine
- (2021) Cloudius R. Sagandira et al. JOURNAL OF ORGANIC CHEMISTRY
- On-Demand Continuous Manufacturing of Ciprofloxacin in Portable Plug-and-Play Factories: Implementation and In Situ Control of Downstream Production
- (2021) Gerard Capellades et al. ORGANIC PROCESS RESEARCH & DEVELOPMENT
- Minimal manual input
- (2020) David M. Heard et al. Nature Chemistry
- Current and Future Roles of Artificial Intelligence in Medicinal Chemistry Synthesis
- (2020) Thomas J. Struble et al. JOURNAL OF MEDICINAL CHEMISTRY
- Flow Chemistry in Contemporary Chemical Sciences: A Real Variety of Its Applications
- (2020) Marek Trojanowicz MOLECULES
- A mobile robotic chemist
- (2020) Benjamin Burger et al. NATURE
- Fully Automated Chemical Synthesis: Toward the Universal Synthesizer
- (2020) Nathan Collins et al. ORGANIC PROCESS RESEARCH & DEVELOPMENT
- Recent Advances in Multi‐Step Continuous‐Flow Organic Synthesis
- (2020) Jiao Jiao et al. CHEMISTRY-A EUROPEAN JOURNAL
- Telescoped Continuous Flow Synthesis of Optically Active γ-Nitrobutyric Acids as Key Intermediates of Baclofen, Phenibut, and Fluorophenibut
- (2020) Sándor B. Ötvös et al. ORGANIC LETTERS
- Optimization and Scale-Up of the Continuous Flow Acetylation and Nitration of 4-Fluoro-2-methoxyaniline to Prepare a Key Building Block of Osimertinib
- (2020) Manuel Köckinger et al. ORGANIC PROCESS RESEARCH & DEVELOPMENT
- A universal system for digitization and automatic execution of the chemical synthesis literature
- (2020) S. Hessam M. Mehr et al. SCIENCE
- 3D printing and continuous flow chemistry technology to advance pharmaceutical manufacturing in developing countries
- (2020) Cloudius R. Sagandira et al. Arabian Journal of Chemistry
- Living with our machines: Towards a more sustainable future
- (2020) Steven V. Ley et al. Current Opinion in Green and Sustainable Chemistry
- Wound healing activity of terpinolene and α-phellandrene by attenuating inflammation and oxidative stress in vitro
- (2019) Marcella Malavazi de Christo Scherer et al. Journal of Tissue Viability
- Emerging Trends in Flow Chemistry and Applications to the Pharmaceutical Industry
- (2019) Andrew R. Bogdan et al. JOURNAL OF MEDICINAL CHEMISTRY
- Multistep synthesis of a valsartan precursor in continuous flow
- (2019) Katharina Hiebler et al. Journal of Flow Chemistry
- A robotic platform for flow synthesis of organic compounds informed by AI planning
- (2019) Connor W. Coley et al. SCIENCE
- Artificial-Intelligence-Driven Organic Synthesis-En Route towards Autonomous Synthesis?
- (2019) Claire Empel et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- A New World for Chemical Synthesis?
- (2019) Steven V. Ley et al. CHIMIA
- In-Line Purification: A Key Component to Facilitate Drug Synthesis and Process Development in Medicinal Chemistry
- (2019) Nopphon Weeranoppanant et al. ACS Medicinal Chemistry Letters
- Development of a multistep reaction cascade for the synthesis of a sacubitril precursor in continuous flow
- (2019) Katharina Hiebler et al. Journal of Flow Chemistry
- Machine Learning in Computer-Aided Synthesis Planning
- (2018) Connor W. Coley et al. ACCOUNTS OF CHEMICAL RESEARCH
- Impact of continuous flow chemistry in the synthesis of natural products and active pharmaceutical ingredients
- (2018) JULIANA M. DE SOUZA et al. ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS
- Applications of Flow Chemistry in Drug Development: Highlights of Recent Patent Literature
- (2018) David L. Hughes ORGANIC PROCESS RESEARCH & DEVELOPMENT
- Controlling an organic synthesis robot with machine learning to search for new reactivity
- (2018) Jarosław M. Granda et al. NATURE
- Nanoscale synthesis and affinity ranking
- (2018) Nathan J. Gesmundo et al. NATURE
- Networking chemical robots for reaction multitasking
- (2018) Dario Caramelli et al. Nature Communications
- In-line separation of multicomponent reaction mixtures using a new semi-continuous supercritical fluid chromatography system
- (2018) Daniel E. Fitzpatrick et al. Reaction Chemistry & Engineering
- Across-the-World Automated Optimization and Continuous-Flow Synthesis of Pharmaceutical Agents Operating Through a Cloud-Based Server
- (2018) Daniel E. Fitzpatrick et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Organic synthesis in a modular robotic system driven by a chemical programming language
- (2018) Sebastian Steiner et al. SCIENCE
- Kilogram-scale prexasertib monolactate monohydrate synthesis under continuous-flow CGMP conditions
- (2017) Kevin P. Cole et al. SCIENCE
- Process analytical tools for flow analysis: A perspective
- (2017) Gregory A. Price et al. Journal of Flow Chemistry
- Feedback in Flow for Accelerated Reaction Development
- (2016) Brandon J. Reizman et al. ACCOUNTS OF CHEMICAL RESEARCH
- Using PAT to accelerate the transition to continuous API manufacturing
- (2016) Francisca F. Gouveia et al. ANALYTICAL AND BIOANALYTICAL CHEMISTRY
- Computer-Assisted Synthetic Planning: The End of the Beginning
- (2016) Sara Szymkuć et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Taming hazardous chemistry by continuous flow technology
- (2016) M. Movsisyan et al. CHEMICAL SOCIETY REVIEWS
- Machine-learning-assisted materials discovery using failed experiments
- (2016) Paul Raccuglia et al. NATURE
- On-demand continuous-flow production of pharmaceuticals in a compact, reconfigurable system
- (2016) A. Adamo et al. SCIENCE
- Enabling Technologies for the Future of Chemical Synthesis
- (2016) Daniel E. Fitzpatrick et al. ACS Central Science
- Organic Synthesis: March of the Machines
- (2015) Steven V. Ley et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Machine-Assisted Organic Synthesis
- (2015) Steven V. Ley et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Continuous-Flow Technology-A Tool for the Safe Manufacturing of Active Pharmaceutical Ingredients
- (2015) Bernhard Gutmann et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- The synthesis of active pharmaceutical ingredients (APIs) using continuous flow chemistry
- (2015) Marcus Baumann et al. Beilstein Journal of Organic Chemistry
- Rapid Vortex Fluidics: Continuous Flow Synthesis of Amides and Local Anesthetic Lidocaine
- (2015) Joshua Britton et al. CHEMISTRY-A EUROPEAN JOURNAL
- Deep learning
- (2015) Yann LeCun et al. NATURE
- One-Pot Synthesis of (S)-Baclofen via Aldol Condensation of Acetaldehyde with Diphenylprolinol Silyl Ether Mediated Asymmetric Michael Reaction as a Key Step
- (2015) Yujiro Hayashi et al. ORGANIC LETTERS
- Industry Perspectives on Process Analytical Technology: Tools and Applications in API Manufacturing
- (2015) Shailendra Bordawekar et al. ORGANIC PROCESS RESEARCH & DEVELOPMENT
- Flow Chemistry: Recent Developments in the Synthesis of Pharmaceutical Products
- (2015) Riccardo Porta et al. ORGANIC PROCESS RESEARCH & DEVELOPMENT
- Machine learning: Trends, perspectives, and prospects
- (2015) M. I. Jordan et al. SCIENCE
- Advances in steady-state continuous-flow purification by small-scale free-flow electrophoresis
- (2015) Fletcher J. Agostino et al. TRAC-TRENDS IN ANALYTICAL CHEMISTRY
- A self optimizing synthetic organic reactor system using real-time in-line NMR spectroscopy
- (2015) Victor Sans et al. Chemical Science
- A Systems Approach towards an Intelligent and Self-Controlling Platform for Integrated Continuous Reaction Sequences
- (2014) Richard J. Ingham et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- A Short Review of Chemical Reaction Database Systems, Computer-Aided Synthesis Design, Reaction Prediction and Synthetic Feasibility
- (2014) Wendy A. Warr Molecular Informatics
- Contemporary screening approaches to reaction discovery and development
- (2014) Karl D. Collins et al. Nature Chemistry
- End-to-End Continuous Manufacturing of Pharmaceuticals: Integrated Synthesis, Purification, and Final Dosage Formation
- (2013) Salvatore Mascia et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Flash chemistry: flow chemistry that cannot be done in batch
- (2013) Jun-ichi Yoshida et al. CHEMICAL COMMUNICATIONS
- Continuous Synthesis and Purification by Direct Coupling of a Flow Reactor with Simulated Moving-Bed Chromatography
- (2012) Alexander G. O'Brien et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Quality by design for biopharmaceuticals
- (2009) Anurag S Rathore et al. NATURE BIOTECHNOLOGY
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started