Role of Dietary Supplements and Probiotics in Modulating Microbiota and Bone Health: The Gut-Bone Axis

Do Only Calcium and Vitamin D Matter? Micronutrients in the Diet of Inflammatory Bowel Diseases Patients and the Risk of Osteoporosis

(2021) Alicja Ewa Ratajczak et al.   Nutrients

Osteoporosis guidelines from a rehabilitation perspective: systematic analysis and quality appraisal using AGREE II

(2021) Giovanni IOLASCON et al.   European Journal of Physical and Rehabilitation Medicine

The microbiota‐gut‐bone axis and bone health

(2021) Ye Tu et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Probiotics as a New Regulator for Bone Health: A Systematic Review and Meta-Analysis

(2021) Hanieh Malmir et al.   Evidence-based Complementary and Alternative Medicine

The Human Gut Microbiota: A Key Mediator of Osteoporosis and Osteogenesis

(2021) Kevin D. Seely et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Association of Gut Microbiota With Osteoporosis Is Mediated by Amino Acid Metabolism: Multiomics in a Large Cohort

(2021) Chu-wen Ling et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Bone Homeostasis and Gut Microbial-Dependent Signaling Pathways

(2021) Xiaohui Zhong et al.   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

Cell‐free culture supernatant of Lactobacillus curvatus Wikim38 inhibits RANKL‐induced osteoclast differentiation and ameliorates bone loss in ovariectomized mice

(2021) A.‐R. Jang et al.   LETTERS IN APPLIED MICROBIOLOGY

Alliances of the gut and bone axis

(2021) Morten Steen Hansen et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Nutritional intake and bone health

(2021) René Rizzoli et al.   Lancet Diabetes & Endocrinology

SCOPE 2021: a new scorecard for osteoporosis in Europe

(2021) John A. Kanis et al.   Archives of Osteoporosis

Inflammatory Bowel Diseases and Sarcopenia: The Role of Inflammation and Gut Microbiota in the Development of Muscle Failure

(2021) Olga Maria Nardone et al.   Frontiers in Immunology

Low-Dose Lactulose as a Prebiotic for Improved Gut Health and Enhanced Mineral Absorption

(2021) Tarkan Karakan et al.   Frontiers in Nutrition

An update on fecal microbiota transplantation for the treatment of gastrointestinal diseases

(2021) Karen M. J. Waller et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Fecal microbiota transplantation mitigates bone loss by improving gut microbiome composition and gut barrier function in aged rats

(2021) Sicong Ma et al.   PeerJ

Romosozumab or alendronate for fracture prevention in East Asian patients: a subanalysis of the phase III, randomized ARCH study

(2020) E. M. C. Lau et al.   OSTEOPOROSIS INTERNATIONAL

Gut–Joint Axis: The Role of Physical Exercise on Gut Microbiota Modulation in Older People with Osteoarthritis

(2020) Alessandro de Sire et al.   Nutrients

How Probiotics Affect the Microbiota

(2020) Grégoire Wieërs et al.   Frontiers in Cellular and Infection Microbiology

Bioregional Alterations in Gut Microbiome Contribute to the Plasma Metabolomic Changes in Pigs Fed with Inulin

(2020) Weida Wu et al.   Microorganisms

Dietary Approaches to Stop Hypertension, Mediterranean, and Alternative Healthy Eating indices are associated with bone health among Puerto Rican adults from the Boston Puerto Rican Osteoporosis Study

(2020) Sabrina E Noel et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Comparison between teriparatide and bisphosphonates for improving bone mineral density in postmenopausal osteoporosis patients

(2020) Guiyong Fan et al.   MEDICINE

Are Probiotics the New Calcium and Vitamin D for Bone Health?

(2020) René Rizzoli et al.   Current Osteoporosis Reports

Gut microbiota–dependent Trimethylamine N-Oxide are related with hip fracture in postmenopausal women: a matched case-control study

(2020) Yakun Liu et al.   Aging-US

MiR-1-3p regulates the differentiation of mesenchymal stem cells to prevent osteoporosis by targeting secreted frizzled-related protein 1

(2020) Huijie Gu et al.   BONE

The role of gut microbiota in bone homeostasis

(2020) Jyotirmaya Behera et al.   BONE

Gut microbiota modulation: a novel strategy for prevention and treatment of colorectal cancer

(2020) Winnie Fong et al.   ONCOGENE

A prebiotic, short-chain fructo-oligosaccharides promotes peak bone mass and maintains bone mass in ovariectomized rats by an osteogenic mechanism

(2020) Konica Porwal et al.   BIOMEDICINE & PHARMACOTHERAPY

Association between gut microbiota, bone metabolism, and fracture risk in postmenopausal Japanese women

(2020) D. Ozaki et al.   OSTEOPOROSIS INTERNATIONAL

Effect of Xylo-Oligosaccharides Supplementation by Drinking Water on the Bone Properties and Related Calcium Transporters in Growing Mice

(2020) Hang Gao et al.   Nutrients

A fructooligosaccharide from Achyranthes bidentata inhibits osteoporosis by stimulating bone formation

(2019) Chunyan Yan et al.   CARBOHYDRATE POLYMERS

Dietary Fructooligosaccharide and Glucomannan Alter Gut Microbiota and Improve Bone Metabolism in Senescence-Accelerated Mouse

(2019) Kenichi Tanabe et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Resistant Starch Attenuates Bone Loss in Ovariectomised Mice by Regulating the Intestinal Microbiota and Bone-Marrow Inflammation

(2019) Yuko Tousen et al.   Nutrients

The interplay among gut microbiota, hypertension and kidney diseases: The role of short-chain fatty acids

(2019) R.J.F. Felizardo et al.   PHARMACOLOGICAL RESEARCH

Osteoporosis

(2019) Juliet E Compston et al.   LANCET

Probiotic Lactobacillus reuteri Prevents Postantibiotic Bone Loss by Reducing Intestinal Dysbiosis and Preventing Barrier Disruption

(2019) Jonathan D Schepper et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Altered gut microbiota ameliorates bone pathology in the mandible of obese–insulin-resistant rats

(2019) Sathima Eaimworawuthikul et al.   EUROPEAN JOURNAL OF NUTRITION

Microbial osteoporosis: The interplay between the gut microbiota and bones via host metabolism and immunity

(2019) Lishan Li et al.   MicrobiologyOpen

The gut-bone axis: how bacterial metabolites bridge the distance

(2019) Mario M. Zaiss et al.   JOURNAL OF CLINICAL INVESTIGATION

The gut microbiota influences skeletal muscle mass and function in mice

(2019) Shawon Lahiri et al.   Science Translational Medicine

Selenium intake, status, and health: a complex relationship

(2019) Margaret P Rayman   Hormones-International Journal of Endocrinology and Metabolism

Postbiotics and Their Potential Applications in Early Life Nutrition and Beyond

(2019) Wegh et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Gut microbiota alterations associated with reduced bone mineral density in older adults

(2019) Mrinmoy Das et al.   RHEUMATOLOGY

Gut microbiota and osteoarthritis management: An expert consensus of the European society for clinical and economic aspects of osteoporosis, osteoarthritis and musculoskeletal diseases (ESCEO)

(2019) Emmanuel Biver et al.   AGEING RESEARCH REVIEWS

Duck Egg White–Derived Peptide VSEE (Val‐Ser‐Glu‐Glu) Regulates Bone and Lipid Metabolisms by Wnt/β‐Catenin Signaling Pathway and Intestinal Microbiota

(2019) Danjun Guo et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Adherence to the Mediterranean Diet and Bone Fracture Risk in Middle-Aged Women: A Case Control Study

(2019) Anna Palomeras-Vilches et al.   Nutrients

Characterization of Sarcopenia in an IBD Population Attending an Italian Gastroenterology Tertiary Center

(2019) Marco Pizzoferrato et al.   Nutrients

Modulation of Gut Microbiota for Health by Current and Next-Generation Probiotics

(2019) Reetta Satokari   Nutrients

Fermented Milk Products and Bone Health in Postmenopausal Women: A Systematic Review of Randomized Controlled Trials, Prospective Cohorts, and Case-Control Studies

(2019) Angel M Ong et al.   Advances in Nutrition

Association between dietary selenium intake and the prevalence of osteoporosis: a cross-sectional study

(2019) Yuqing Wang et al.   BMC MUSCULOSKELETAL DISORDERS

Involvement of the Gut Microbiota and Barrier Function in Glucocorticoid‐Induced Osteoporosis

(2019) Jonathan D Schepper et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Hematopoiesis and the bacterial microbiome

(2018) Hannah Yan et al.   BLOOD

Microbiota and Bone Health: The Gut-Musculoskeletal Axis

(2018) René Rizzoli   CALCIFIED TISSUE INTERNATIONAL

Volumetric Bone Mineral Density and Failure Load of Distal Limbs Predict Incident Clinical Fracture Independent HR-pQCT BMD and Failure Load Predicts Incident Clinical Fracture of FRAX and Clinical Risk Factors Among Older Men

(2018) Lisa Langsetmo et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Lactobacillus reuteri reduces bone loss in older women with low bone mineral density - a randomized, placebo-controlled, double-blind, clinical trial

(2018) Anna G. Nilsson et al.   JOURNAL OF INTERNAL MEDICINE

Oral administration of liquid iron preparation containing excess iron induces intestine and liver injury, impairs intestinal barrier function and alters the gut microbiota in rats

(2018) Shenglin Fang et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Fermented dairy products consumption is associated with attenuated cortical bone loss independently of total calcium, protein, and energy intakes in healthy postmenopausal women

(2018) E. Biver et al.   OSTEOPOROSIS INTERNATIONAL

Bioactive peptide isolated from casein phosphopeptides promotes calcium uptake in vitro and in vivo

(2018) Guo Liu et al.   Food & Function

Metronidazole Causes Skeletal Muscle Atrophy and Modulates Muscle Chronometabolism

(2018) Ravikumar Manickam et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A dual-specific macrophage colony-stimulating factor antagonist of c-FMS and αvβ3 integrin for osteoporosis therapy

(2018) Yuval Zur et al.   PLOS BIOLOGY

Effectiveness of denosumab on back pain-related disability and quality-of-life in patients with vertebral fragility fractures

(2018) Antimo Moretti et al.   CURRENT MEDICAL RESEARCH AND OPINION

Biological Activities of Lactose-Based Prebiotics and Symbiosis with Probiotics on Controlling Osteoporosis, Blood-Lipid and Glucose Levels

(2018) Arijit Nath et al.   Medicina-Lithuania

Associations between radius low-frequency axial ultrasound velocity and bone fragility in elderly men and women

(2018) E. Biver et al.   OSTEOPOROSIS INTERNATIONAL

The gut microbiota at the intersection of diet and human health

(2018) Christopher L. Gentile et al.   SCIENCE

Inhibition of osteoporosis by the αvβ3 integrin antagonist of rhodostomin variants

(2017) Tzu-Hung Lin et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Association Between Gut Microbiota and Bone Health: Potential Mechanisms and Prospective

(2017) Yuan-Cheng Chen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The Relationship between Habitual Dietary Intake and Gut Microbiota in Young Japanese Women

(2017) Takahiro SEURA et al.   JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY

Effects of a Multispecies Probiotic Supplement on Bone Health in Osteopenic Postmenopausal Women: A Randomized, Double-blind, Controlled Trial

(2017) Sadegh Jafarnejad et al.   JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION

Greater yogurt consumption is associated with increased bone mineral density and physical function in older adults

(2017) E. Laird et al.   OSTEOPOROSIS INTERNATIONAL

Impact of short-chain galactooligosaccharides on the gut microbiome of lactose-intolerant individuals

(2017) M. Andrea Azcarate-Peril et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impact of Dietary Resistant Starch on the Human Gut Microbiome, Metaproteome, and Metabolome

(2017) Tanja V. Maier et al.   mBio

Succinate and its G-protein-coupled receptor stimulates osteoclastogenesis

(2017) Yuqi Guo et al.   Nature Communications

Effects of Probiotics, Prebiotics, and Synbiotics on Human Health

(2017) et al.   Nutrients

Aging Gut Microbiota at the Cross-Road between Nutrition, Physical Frailty, and Sarcopenia: Is There a Gut–Muscle Axis?

(2017) Andrea Ticinesi et al.   Nutrients

Persistence with denosumab therapy in women affected by osteoporosis with fragility fractures: a multicenter observational real practice study in Italy

(2017) S. Migliaccio et al.   JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION

10 years of denosumab treatment in postmenopausal women with osteoporosis: results from the phase 3 randomised FREEDOM trial and open-label extension

(2017) Henry G Bone et al.   Lancet Diabetes & Endocrinology

Commensal Gut Microbiota Immunomodulatory Actions in Bone Marrow and Liver have Catabolic Effects on Skeletal Homeostasis in Health

(2017) Chad M. Novince et al.   Scientific Reports

Serum fibroblast growth factor 23, serum iron and bone mineral density in premenopausal women

(2016) Erik A. Imel et al.   BONE

The combined effects of soya isoflavones and resistant starch on equol production and trabecular bone loss in ovariectomised mice

(2016) Yuko Tousen et al.   BRITISH JOURNAL OF NUTRITION

Antibiotics as deep modulators of gut microbiota: between good and evil

(2016) Gianluca Ianiro et al.   GUT

Epigenetic Mechanisms in Bone Biology and Osteoporosis: Can They Drive Therapeutic Choices?

(2016) Francesca Marini et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A clinical update on the significance of the gut microbiota in systemic autoimmunity

(2016) Elizabeth C. Rosser et al.   JOURNAL OF AUTOIMMUNITY

Mediterranean Diet and Hip Fracture in Swedish Men and Women

(2016) Liisa Byberg et al.   JOURNAL OF BONE AND MINERAL RESEARCH

The human gut microbiota and its interactive connections to diet

(2016) C. Milani et al.   JOURNAL OF HUMAN NUTRITION AND DIETETICS

Gut microbiota induce IGF-1 and promote bone formation and growth

(2016) Jing Yan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microbial Metabolism Shifts Towards an Adverse Profile with Supplementary Iron in the TIM-2 In vitro Model of the Human Colon

(2016) Guus A. M. Kortman et al.   Frontiers in Microbiology

Interactions between host genetics and gut microbiome in diabetes and metabolic syndrome

(2016) Siegfried Ussar et al.   Molecular Metabolism

Selenium Status Is Positively Associated with Bone Mineral Density in Healthy Aging European Men

(2016) Carolien M. Beukhof et al.   PLoS One

Immune homeostasis, dysbiosis and therapeutic modulation of the gut microbiota

(2015) C. T. Peterson et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Influence of high-fat diet on gut microbiota

(2015) E. Angela Murphy et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Loss of Bone and Wnt10b Expression in Male Type 1 Diabetic Mice Is Blocked by the ProbioticLactobacillus reuteri

(2015) Jing Zhang et al.   ENDOCRINOLOGY

High-level adherence to a Mediterranean diet beneficially impacts the gut microbiota and associated metabolome

(2015) Francesca De Filippis et al.   GUT

Recent Advances in Characterizing the Gastrointestinal Microbiome in Crohnʼs Disease

(2015) Emily K. Wright et al.   INFLAMMATORY BOWEL DISEASES

In vitrostudy of the prebiotic xylooligosaccharide (XOS) on the growth ofBifidobacteriumspp andLactobacillusspp

(2015) Zhaoping Li et al.   INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION

Amino Acid Intakes Are Associated With Bone Mineral Density and Prevalence of Low Bone Mass in Women: Evidence From Discordant Monozygotic Twins

(2015) Amy Jennings et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Gut microbiota and liver diseases

(2015) Masami Minemura   WORLD JOURNAL OF GASTROENTEROLOGY

Chronic Zinc Deficiency Alters Chick Gut Microbiota Composition and Function

(2015) Spenser Reed et al.   Nutrients

Prebiotic and Probiotic Regulation of Bone Health: Role of the Intestine and its Microbiome

(2015) Laura McCabe et al.   Current Osteoporosis Reports

Magnesium intake, bone mineral density, and fractures: results from the Women’s Health Initiative Observational Study

(2014) Tonya S Orchard et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Conducting a Microbiome Study

(2014) Julia K. Goodrich et al.   CELL

Altering the Intestinal Microbiota during a Critical Developmental Window Has Lasting Metabolic Consequences

(2014) Laura M. Cox et al.   CELL

Therapeutic Modulation of Gut Microbiota: Current Clinical Applications and Future Perspectives

(2014) Gianluca Ianiro et al.   CURRENT DRUG TARGETS

Gut microbiota modulation: probiotics, antibiotics or fecal microbiota transplantation?

(2014) Giovanni Cammarota et al.   Internal and Emergency Medicine

ProbioticL. reuteriTreatment Prevents Bone Loss in a Menopausal Ovariectomized Mouse Model

(2014) Robert A. Britton et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Supplementation with Calcium and Short-Chain Fructo-Oligosaccharides Affects Markers of Bone Turnover but Not Bone Mineral Density in Postmenopausal Women

(2014) Mary M. Slevin et al.   JOURNAL OF NUTRITION

Artificial sweeteners induce glucose intolerance by altering the gut microbiota

(2014) Jotham Suez et al.   NATURE

The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic

(2014) Colin Hill et al.   Nature Reviews Gastroenterology & Hepatology

Kefir improves bone mass and microarchitecture in an ovariectomized rat model of postmenopausal osteoporosis

(2014) H.-L. Chen et al.   OSTEOPOROSIS INTERNATIONAL

Correction: Through Ageing, and Beyond: Gut Microbiota and Inflammatory Status in Seniors and Centenarians

(2014) Elena Biagi et al.   PLoS One

Probiotics Protect Mice from Ovariectomy-Induced Cortical Bone Loss

(2014) Claes Ohlsson et al.   PLoS One

Comparison of bone tissue trace-element concentrations and mineral density in osteoporotic femoral neck fractures and osteoarthritis

(2014) Fatih Karaaslan et al.   Clinical Interventions in Aging

Galacto-oligosaccharides increase calcium absorption and gut bifidobacteria in young girls: a double-blind cross-over trial

(2013) Corrie M. Whisner et al.   BRITISH JOURNAL OF NUTRITION

The impact of high dietary zinc oxide on the development of the intestinal microbiota in weaned piglets

(2013) Ingo C. Starke et al.   FEMS MICROBIOLOGY ECOLOGY

The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism

(2013) Gijs den Besten et al.   JOURNAL OF LIPID RESEARCH

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

(2013) Yukihiro Furusawa et al.   NATURE

Adamts1 is highly induced in rachitic bones of FGF23 transgenic mice and participates in degradation of non-mineralized bone matrix collagen

(2012) Lijuan Hu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Insight into the prebiotic concept: lessons from an exploratory, double blind intervention study with inulin-type fructans in obese women

(2012) Evelyne M Dewulf et al.   GUT

Gut microbiota composition correlates with diet and health in the elderly

(2012) Marcus J. Claesson et al.   NATURE

Antibiotics in early life alter the murine colonic microbiome and adiposity

(2012) Ilseung Cho et al.   NATURE

Murine Gut Microbiota Is Defined by Host Genetics and Modulates Variation of Metabolic Traits

(2012) Autumn M. McKnite et al.   PLoS One

Regulation of Bone Mass by Serotonin: Molecular Biology and Therapeutic Implications

(2011) Gerard Karsenty et al.   Annual Review of Medicine

Dietary selenium affects host selenoproteome expression by influencing the gut microbiota

(2011) Marina V. Kasaikina et al.   FASEB JOURNAL

Galactooligosaccharides Improve Mineral Absorption and Bone Properties in Growing Rats through Gut Fermentation

(2011) Connie M. Weaver et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Antiosteoporotic Effects ofLactobacillus-Fermented Soy Skim Milk on Bone Mineral Density and the Microstructure of Femoral Bone in Ovariectomized Mice

(2011) Shen-Shih Chiang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Resistant starch promotes equol production and inhibits tibial bone loss in ovariectomized mice treated with daidzein

(2011) Yuko Tousen et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

A human gut microbial gene catalogue established by metagenomic sequencing

(2010) Junjie Qin et al.   NATURE

The NIH Human Microbiome Project

(2009) et al.   GENOME RESEARCH

Impaired gastric acidification negatively affects calcium homeostasis and bone mass

(2009) Thorsten Schinke et al.   NATURE MEDICINE