Article
Endocrinology & Metabolism
J. Everts-Graber, S. Reichenbach, B. Gahl, H. R. Ziswiler, U. Studer, T. Lehmann
Summary: Patients who received zoledronate after denosumab discontinuation had fewer vertebral fractures, while all subsequent therapies were able to maintain bone mineral density to some extent. Factors such as age, BMI, treatment duration, prior therapy, and BMD gains during denosumab treatment influenced bone mineral density loss, while bone turnover markers correlated with total hip bone loss and treatment duration.
Article
Endocrinology & Metabolism
Rikke Viggers, Zheer Al-Mashhadi, Jakob Starup-Linde, Peter Vestergaard
Summary: This study aimed to investigate the risk of major osteoporotic fractures in diabetes patients initiated with alendronate and denosumab. Results showed that the risk of incident major osteoporotic fractures among subjects with diabetes was similar between those initially treated with alendronate and denosumab, suggesting both treatments are equally effective in preventing osteoporotic fractures in subjects with diabetes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Neil Binkley, Heenam Goel, Erin Shives, Diane Krueger, Kristyn Hare
Summary: This case report describes a probable atypical ulnar fracture associated with denosumab use in a male patient who was treated with teriparatide. The findings suggest that clinicians should be aware of the risk of atypical fractures with anti-resorptive therapy, particularly at non-femur sites.
Article
Health Care Sciences & Services
Sara Jane Cromer, Kristin M. D'Silva, Elaine W. Yu, Joan Landon, Rishi J. Desai, Seoyoung C. Kim
Summary: The study found that the use of denosumab has surpassed all other bone-directed therapies over the past decade, especially since its approval in 2010. The use of denosumab also showed increasing trends among patients with osteoporosis, malignancies, and recent fractures. However, it is noteworthy that the proportion of using any bone-directed therapy after fractures is low and has declined over time.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Peter Burckhardt, Mohamed Faouzi, Thierry Buclin, Olivier Lamy
Summary: The risk of vertebral fractures (VFs) after treatment with denosumab (Dmab) is associated with increase in bone resorption markers and bone mineral density during and after treatment. Bisphosphonates, especially after Dmab, have a protective effect against VFs. The risk of VFs is poorly predictable before Dmab prescription, but bone markers and BMD during and after treatment have predictive value.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Endocrinology & Metabolism
Karine Briot, Anne-Marie Schott, Jean-Philippe Sanchez, Jean-Vannak Chauny, Pascale Samama, Gaelle Desamericq
Summary: In a real-world clinical practice in France, postmenopausal women with osteoporosis showed high persistence with denosumab at 12 and 24 months, with a good tolerability profile.
Article
Endocrinology & Metabolism
Chi Chiu Mok, Ling Yin Ho, Stella Mei Tik Leung, Hoi Ning Cheung, Sammy Pak Lam Chen, Kwok Man Ma
Summary: In patients receiving long-term glucocorticoids, denosumab was superior to alendronate in increasing spine bone mineral density after 12 months, with both drugs being well-tolerated.
Review
Medicine, General & Internal
Athanasios D. Anastasilakis, Polyzois Makras, Maria P. Yavropoulou, Gaia Tabacco, Anda Mihaela Naciu, Andrea Palermo
Summary: Denosumab is a potent antiresorptive agent that can increase bone density and reduce fracture rates, but its effects reverse quickly upon discontinuation, leading to bone loss and increased bone turnover. Subsequent antiresorptive treatment is necessary to prevent fractures.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Maria-Jose Montoya-Garcia, Merce Giner, Rodrigo Marcos, David Garcia-Romero, Francisco-Jesus Olmo-Montes, Ma Jose Miranda, Blanca Hernandez-Cruz, Miguel-Angel Colmenero, Ma Angeles Vazquez-Gamez
Summary: Fragility fractures are a significant public health issue globally, with hip fractures being most prevalent in women aged 80 and above. Older age and recent fractures were identified as independent risk factors for further fracture events. There was a significant excess mortality rate in individuals aged 80 and above with a previous hip fracture.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Rheumatology
Simeon Monov, Rodina Nestorova, Margarita Velkova, Mihail Boyanov, Silvia Jeleva, Renata Petkova, Tzvetanka Petranova
Summary: This study found that elderly women at high fracture risk in Bulgaria demonstrated high persistence with denosumab treatment, despite some patients discontinuing treatment due to financial reasons or loss to follow-up.
RHEUMATOLOGY AND THERAPY
(2021)
Article
Transplantation
Rikako Hiramatsu, Yoshifumi Ubara, Naoki Sawa, Akinori Sakai
Summary: The study revealed that hemodialysis patients may experience acute hypocalcemia following denosumab injection. High bone turnover was identified as an independent risk factor for the calcium declines induced by denosumab. Denosumab significantly increased bone mineral density at the lumbar spine and femoral neck after 24 months.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Article
Endocrinology & Metabolism
Houchen Lyu, Sizheng Zhao, Jiatian Li, Xiaoxiao Li, Yilun Wang, Dongxing Xie, Chao Zeng, Guanghua Lei, Jie Wei, Hui Li
Summary: This study found that denosumab treatment does not significantly increase the susceptibility of community-acquired pneumonia compared to alendronate treatment.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Anna Wawrzyniak, Marzena Skrzypczak-Zielinska, Michal Michalak, Marta Kaczmarek-Rys, Alicja Ewa Ratajczak, Anna Maria Rychter, Kinga Skoracka, Michalina Marcinkowska, Ryszard Slomski, Agnieszka Dobrowolska, Iwona Krela-Kazmierczak
Summary: This study aimed to determine the influence of VDR gene variation on anti-osteoporotic one-year treatment with denosumab in Polish women with postmenopausal osteoporosis. The results showed that BB and Bb genotypes of the Bsml polymorphism of the VDR gene determine higher DXA parameter values both before and after one-year denosumab therapy in postmenopausal women with osteoporosis.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Alma B. Pedersen, Nickolaj Risbo, George Kafatos, David Neasham, James O'Kelly, Vera Ehrenstein
Summary: The study found that persistence with initial treatment was highest after 1 year and decreased afterwards. Denosumab had the highest persistence, followed by alendronate. Several factors associated with treatment persistence were identified, some of which were the same regardless of the specific medication, which could help target subgroups of patients in terms of social and healthcare support.
ARCHIVES OF OSTEOPOROSIS
(2023)
Article
Endocrinology & Metabolism
Sabashini K. Ramchand, Joy N. Tsai, Hang Lee, Grace Sassana-Khadka, Mackenzie Jordan, Savannah Ryan, Benjamin Z. Leder
Summary: Discontinuing denosumab results in accelerated bone remodeling, decreased bone mineral density, and increased risk of fractures. This study evaluated the comparative efficacy of alendronate and raloxifene in preventing post-denosumab high-turnover bone loss. The results showed that after one year of denosumab, one year of alendronate is more effective in maintaining bone remodeling inhibition and bone mineral density gains compared to raloxifene.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Dentistry, Oral Surgery & Medicine
Martina Ferrillo, Mario Migliario, Nicola Marotta, Francesco Fortunato, Marino Bindi, Federica Pezzotti, Antonio Ammendolia, Amerigo Giudice, Pier Luigi Foglio Bonda, Alessandro de Sire
Summary: This study evaluated the association between temporomandibular disorder (TMD) and neck pain in patients with primary headaches. The results showed that migraine patients reported higher TMD and neck pain. Machine learning analysis demonstrated that TMD was correlated to migraine, while neck pain was correlated to tension-type headache (TTH) or migraine.
ACTA ODONTOLOGICA SCANDINAVICA
(2023)
Article
Oncology
Mauro Nascimben, Lorenzo Lippi, Alessandro De Sire, Marco Invernizzi, Lia Rimondini
Summary: The current study employed a cohort of 294 patients to stratify the risk of breast cancer-related lymphedema (BCRL) and identify factors associated with high-risk patients. The findings of this study provide potential insight into precise risk assessment of BCRL patients, with implications in prevention strategies.
Review
Oncology
Lorenzo Lippi, Alessio Turco, Stefano Moalli, Marco Gallo, Claudio Curci, Antonio Maconi, Alessandro de Sire, Marco Invernizzi
Summary: This review provides a comprehensive overview of prehabilitation and rehabilitation strategies for thyroid cancer survivors, focusing on optimizing functional outcomes and enhancing quality of life. Physical exercise is highlighted as an important component of the rehabilitation process, improving cardiovascular fitness, muscle strength, body composition, and reducing fatigue. Scar management techniques and addressing dysphonia and dysphagia are also emphasized for functional recovery and cosmetic outcomes. Digital innovation and patient-centered approaches are suggested as effective strategies for implementing rehabilitative treatment. Valuable insights are provided for optimizing functional outcomes and enhancing quality of life for thyroid cancer survivors.
Article
Sport Sciences
Antonio Ammendolia, Alessandro de Sire, Lorenzo Lippi, Valerio Ammendolia, Riccardo Spano, Andrea Reggiani, Marco Invernizzi, Nicola Marotta
Summary: This study confirms the positive impact of cryo-ultrasound therapy combined with conventional physical therapy on the short-term recovery of elite football players with acute lateral ankle sprains, accelerating their rehabilitation and early return to sport. However, further research is needed to validate and optimize the long-term effects of this physical therapy modality.
Review
Chemistry, Multidisciplinary
Lorenzo Lippi, Alessio Turco, Stefano Moalli, Mauro Nascimben, Claudio Curci, Alessandro de Sire, Lia Rimondini, Marco Invernizzi
Summary: Upper-limb lymphedema is a chronic condition characterized by lymphatic fluid accumulation, leading to swelling and impairment in the arm or hand. Various methods for volumetric assessment of upper-limb lymphedema have been proposed, but each has specific strengths and limitations. Factors such as operator experience and equipment availability also impact the accuracy and practicality of volume assessment. Precise volumetric assessment is crucial for improving rehabilitation, patient education, and research outcomes.
APPLIED SCIENCES-BASEL
(2023)
Article
Geriatrics & Gerontology
Raffaello Pellegrino, Roberto Paganelli, Angelo Di Iorio, Stefania Bandinelli, Antimo Moretti, Giovanni Iolascon, Eleonora Sparvieri, Domiziano Tarantino, Luigi Ferrucci
Summary: The study finds that the collagen turnover marker P3NP is associated with changes in muscle density and physical performance. Participants with lower P3NP levels perform better in terms of muscle density and physical performance and have a lower risk of developing chronic degenerative age-related diseases. The interaction between P3NP and factors such as leptin, muscle density, and fat mass affects muscle density and physical performance.
Review
Rheumatology
Giuseppe Toro, Antonio Benedetto Cecere, Adriano Braile, Annalisa De Cicco, Sara Liguori, Umberto Tarantino, Giovanni Iolascon
Summary: High Energy Musculoskeletal Traumas (HEMTs) are a significant problem for healthcare systems due to high social costs, and the high morbidity and mortality. Complications such as bone infection, fracture malunion, and non-union contribute to poor outcomes associated with HEMT. Treatment of these complications can be challenging, with limb reconstruction often requiring multiple procedures. Amputation may theoretically offer better function and lower complications, but also comes with its own set of complications and long-term social costs. A comprehensive literature review was conducted to propose ways to optimize limb preservation surgeries for HEMT complications and improve their management.
THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE
(2023)
Review
Rheumatology
Alessandro de Sire, Lorenzo Lippi, Nicola Marotta, Martina Ferrillo, Arianna Folli, Alessio Turco, Antonio Ammendolia, Marco Invernizzi
Summary: Musculoskeletal disorders (MSD) have significant impacts on physical function, social, and economic costs, making them an important issue in current literature. Rehabilitation has shown positive effects in improving functional outcomes for individuals with MSD, but there are still questions about the underlying mechanisms. This review focuses on the biophysical dimensions of available treatments for MSD and highlights the potential of integrating a biophysical approach to enhance regenerative processes and improve pain management.
THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE
(2023)
Review
Geriatrics & Gerontology
Lorenzo Lippi, Alessio Turco, Arianna Folli, Francesco D'Abrosca, Claudio Curci, Kamal Mezian, Alessandro de Sire, Marco Invernizzi
Summary: Several technological advances have been proposed to improve Health-Related Quality of Life (HR-QoL) in older adults with COPD. This study aimed to assess the effects of tele-monitoring devices on HR-QoL in these patients. The findings show that tele-monitoring devices did not significantly improve HR-QoL, but showed positive effects on respiratory events and hospitalization.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2023)
Review
Rheumatology
Antimo Moretti, Sara Liguori, Marco Paoletta, Silvia Migliaccio, Giuseppe Toro, Francesca Gimigliano, Giovanni Iolascon
Summary: Bone fragility is associated with aging, comorbidities, disability, poor quality of life, and increased mortality. International guidelines recommend a nutritional approach for managing patients with bone fragility, focusing on optimal protein, calcium, and vitamin D intake. Patients with major fragility fractures often have poor dietary habits and lack intake of nutrients that affect bone health, which can be further worsened during the COVID-19 pandemic. This narrative review discusses the role of macro- and micronutrients in patients with bone fragility during this pandemic.
THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE
(2023)
Review
Rheumatology
Maria Chiara Massari, Viviana Maria Bimonte, Lavinia Falcioni, Antimo Moretti, Carlo Baldari, Giovanni Iolascon, Silvia Migliaccio
Summary: 'Frailty' is a state of increased vulnerability caused by impairment of homeostasis due to stress. Frail individuals are more likely to experience significant health decline and have a higher risk of adverse outcomes such as osteoporosis, falls, and disability. Frailty is becoming increasingly important due to global population aging. The pathophysiology of frailty involves cumulative molecular and cellular damage and is partially independent of aging but closely related. Uncorrected nutrition and sedentary behavior worsen frailty.
THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE
(2023)
Article
Rheumatology
Alberto Migliore, Liudmila Alekseeva, Sachin R. Avasthi, Raveendhara R. Bannuru, Xavier Chevalier, Thierry Conrozier, Sergio Crimaldi, Gustavo C. de Campos, Demirhan Diracoglu, Gianfranco Gigliucci, Gabriel Herrero-Beaumont, Giovanni Iolascon, Ruxandra Ionescu, Joerg Jerosch, Jorge Lains, Emmanuel Maheu, Souz Makri, Natalia Martusevich, Marco Matucci-Cerinic, Karen Pavelka, Robert J. Petrella, Raghu Raman, Umberto Tarantino
Summary: The lack of a validated definition of early osteoarthritis (EOA) hinders early diagnosis and effective therapeutic strategies. Therefore, the development of a specific questionnaire to evaluate and monitor the clinical progress of patients with early knee OA is essential.
THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE
(2023)
Review
Rheumatology
Giuseppe Toro, Adriano Braile, Sara Liguori, Antimo Moretti, Giovanni Landi, Antonio Benedetto Cecere, Gianluca Conza, Annalisa De Cicco, Umberto Tarantino, Giovanni Iolascon
Summary: Osteoporosis and fragility fractures are critical health problems that can lead to high morbidity, mortality, and healthcare costs. Fracture liaison service has shown to reduce fracture risk and improve patient adherence to treatment, but long-term and high adherence to medications may result in atypical fractures. A comprehensive and interdisciplinary approach involving a dedicated healthcare team can improve the standard of care.
THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE
(2023)
Review
Medicine, General & Internal
Lorenzo Lippi, Martina Ferrillo, Alessio Turco, Arianna Folli, Stefano Moalli, Fjorelo Refati, Luca Perrero, Antonio Ammendolia, Alessandro de Sire, Marco Invernizzi
Summary: The aim of this narrative review is to elucidate the multilevel benefits and synergies of integrating rehabilitation and hyaluronic acid injections in multidisciplinary osteoarthritis (OA) rehabilitation. Results show that HA injections can improve joint biomechanics, and rehabilitation can enhance muscle strength and overall function. Optimizing rehabilitation following HA injection may provide additional benefits in joint health. OA management requires a multidisciplinary approach integrating HA injections, rehabilitation, and personalized care.
MEDICINA-LITHUANIA
(2023)
Article
Medicine, General & Internal
Dalila Scaturro, Antimo Moretti, Fabio Vitagliani, Giuliana Guggino, Sofia Tomasello, Davide Lo Nardo, Lorenza Lauricella, Giovanni Iolascon, Giulia Letizia Mauro
Summary: Combined treatment with manual therapy and ultrasound therapy appears to be useful in the management of ischemic digital ulcers in patients with systemic sclerosis.
MEDICINA-LITHUANIA
(2023)