Article
Nutrition & Dietetics
Julie A. Pasco, Kara B. Anderson, Natalie K. Hyde, Lana J. Williams, Pamela Rufus-Membere, Kara L. Holloway-Kew
Summary: The study aimed to determine the impact of high alcohol intake on fracture risk. Results showed a correlation between high alcohol intake and increased risk of hip fractures, and reducing alcohol consumption among drinkers may lower the risk of fractures.
Article
Endocrinology & Metabolism
Gregory A. Kline, Suzanne N. Morin, Lisa M. Lix, Eugene McCloskey, Helena Johansson, Nicholas C. Harvey, John A. Kanis, William D. Leslie
Summary: This study found that medical comorbidity is associated with fracture risk and can increase the risk of fractures independently of FRAX. By using complex and simple measures of medical comorbidity, FRAX-based risk estimates can be modified to capture the increased fracture risk associated with multiple comorbid conditions in older patients.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Francesca Vigevano, Giulia Gregori, Georgia Colleluori, Rui Chen, Vimlin Autemrongsawat, Nicola Napoli, Clifford Qualls, Dennis T. Villareal, Reina Armamento-Villareal
Summary: In men, the combination of obesity and T2D is associated with reduced bone turnover and poorer trabecular bone microarchitecture and bone strength compared to those who are obese but without T2D, suggesting worse bone disease.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Danielle Elizabeth Whittier, Sarah L. Manske, Emma Billington, Richard E. A. Walker, Prism S. Schneider, Lauren A. Burt, David Arthur Hanley, Steven Kyle Boyd
Summary: This study used HR-pQCT scanning technology to investigate the bone microarchitecture characteristics of hip fracture patients and found that these patients had significantly reduced bone density, more pronounced osteoporosis, and larger void defects. Bone phenotyping analysis revealed a significant association between hip fractures and low density phenotype, but there were differences in bone phenotype continuum between male and female patients.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Tanchanok Chattaris, Laiji Yang, Helena Johansson, Shivani Sahni, Elizabeth J. Samelson, Douglas P. Kiel, Sarah D. Berry
Summary: This study compared the performance of FRAX in identifying fracture risk in individuals with and without frailty. It found that FRAX had lower discrimination ability in individuals with frailty, but this improved when bone mineral density (BMD) was included. The study suggests that BMD is an important factor for fracture prediction in frail individuals.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Endocrinology & Metabolism
Danielle E. Whittier, Elizabeth J. Samelson, Marian T. Hannan, Lauren A. Burt, David A. Hanley, Emmanuel Biver, Pawel Szulc, Elisabeth Sornay-Rendu, Blandine Merle, Roland Chapurlat, Eric Lespessailles, Andy Kin On Wong, David Goltzman, Sundeep Khosla, Serge Ferrari, Mary L. Bouxsein, Douglas P. Kiel, Steven K. Boyd
Summary: The prevalence of osteoporosis in older adults is high, but current clinical methods fail to detect most fragility fracture cases. High-resolution peripheral quantitative computed tomography (HR-pQCT) provides additional information about bone density and structure, but interpretation is challenging. In this study, the authors identified common bone phenotypes associated with fracture risk using HR-pQCT data from a multinational cohort. They found that different phenotypes had significantly different fracture risks and identified imaging biomarkers for fractures within each phenotype.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Lan Yang, Mary Dempsey, Attracta Brennan, Bryan Whelan, E. Erjiang, Tingyan Wang, Rebecca Egan, Kelly Gorham, Fiona Heaney, Catherine Armstrong, Guadalupe Morote Ibarrola, Amina Gsel, Ming J. Yu, John Carey
Summary: The appropriate use of FRAX can reduce the need for DXA scans and identify individuals at the highest risk. Comparing FRAX results with and without inclusion of BMD suggests that clinicians should carefully consider the importance of including BMD in fracture risk estimation for individual patients.
ARCHIVES OF OSTEOPOROSIS
(2023)
Article
Medicine, General & Internal
Yui Ogiso, Tatsunori Hanai, Kayoko Nishimura, Takao Miwa, Toshihide Maeda, Kenji Imai, Atsushi Suetsugu, Koji Takai, Masahito Shimizu
Summary: This cross-sectional study aimed to determine whether TBS can identify patients with liver cirrhosis that are at risk of vertebral fractures. The results showed a significant correlation between TBS and vertebral fractures, indicating that TBS can help identify patients at risk of vertebral fractures in liver cirrhosis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Rayne de Almeida Marques Bernabe, Mariana de Souza Vieira, Vanusa Felicio de Souza, Luana Gomes Fontana, Ben-Hur Albergaria, Jose Luiz Marques-Rocha, Valdete Regina Guandalini
Summary: This study investigated the association between sarcopenia phenotypes and fracture risk in women with breast cancer, and found that low muscle strength was associated with fracture risk.
Article
Endocrinology & Metabolism
Carrie Ye, Suzanne N. Morin, Lisa M. Lix, Eugene V. McCloskey, Helena Johansson, Nicholas C. Harvey, John A. Kanis, William D. Leslie
Summary: The study assessed the performance of the Fracture Risk Assessment Tool (FRAX) in predicting incident fractures in men with prostate cancer. The results showed that FRAX reliably predicts fractures in this population.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Philippe Paul Wagner, Danielle E. Whittier, Dominique Foesser, Steven K. Boyd, Roland Chapurlat, Pawel Szulc
Summary: In men, those with low lower-limb relative appendicular lean mass (RALM-LL) and poor physical performance showed faster decline in bone microarchitecture and estimated bone strength, leading to higher risk of falls and fractures.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Geriatrics & Gerontology
Kyoung Min Kim, Li-Yung Lui, Steven R. Cummings
Summary: This study aimed to investigate the association between falls occurring within four months and the risk of fractures in the following year. The results showed that falls within four months indicated a high risk of non-spine and hip fractures in both men and women, regardless of previous fracture occurrence. Falls increased the risk of fractures, and urgent evaluation and consideration of treatment are necessary to reduce the imminent risk of fractures in older individuals.
Article
Endocrinology & Metabolism
Pawel Szulc, Dominique Foesser, Roland Chapurlat
Summary: In older men, higher areal bone mineral density, preserved cortical bone status, and higher estimated bone strength are associated with a lower risk of major adverse coronary events (MACE) after adjustment for relevant confounders.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Orthopedics
Constantin Schmidt, Christoph Riedel, Julian Stuerznickel, Herbert Mushumba, Maximilian M. Delsmann, Christian Ries, Sebastian Kleiss, Peter Bannas, Frank Timo Beil, Michael Amling, Klaus Pueschel, Tim Rolvien, Jan Hubert
Summary: This study investigates the association between demographic characteristics and microarchitectural parameters in distal femur fractures. The findings suggest that female sex, advanced age, and low bone mineral density (BMD) are major risk factors for impaired microarchitecture and fracture in this skeletal site.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2022)
Article
Urology & Nephrology
Betul Cetin, Emin Ahmet Cetin, Hakki Arikan, Arzu Velioglu, Fatma Alibaz-Oner, Haner Direskeneli, Serhan Tuglular, Ebru Asicioglu
Summary: The study found that patients with ANCA-associated vasculitis (AAV) have a higher risk of osteoporosis and fractures, as indicated by FRAX scores showing higher risks of major fractures and hip fractures compared to healthy controls.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2021)
Article
Oncology
Juhua Luo, John T. Schousboe, Kristine E. Ensrud, Michael Hendryx
Summary: Our study aimed to examine long-term cognitive impairment among older breast cancer survivors. We found that breast cancer survivors had accelerated cognitive impairment after cancer diagnosis, especially among women diagnosed at older age or at advanced stage.
JOURNAL OF CANCER SURVIVORSHIP
(2023)
Article
Geriatrics & Gerontology
Mary E. Winger, Paolo Caserotti, Jane A. Cauley, Robert M. Boudreau, Sara R. Piva, Peggy M. Cawthon, Eric S. Orwoll, Kristine E. Ensrud, Deborah M. Kado, Elsa S. Strotmeyer
Summary: This study investigated the application of lower-extremity power and upper-extremity strength in fall injuries and found that lower leg power and grip strength predicted future fall injury risk in older men, independent of physical performance.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Geriatrics & Gerontology
Lisa Langsetmo, John T. Schousboe, Brent C. Taylor, Jane A. Cauley, Howard A. Fink, Peggy M. Cawthon, Marcia L. Stefanick, Deborah M. Kado, Allyson M. Kats, Kristine E. Ensrud
Summary: This study evaluated the risks of clinical fracture, hip fracture, and mortality prior to fracture among men aged at least 80 years. The results showed that fall history, hip bone mineral density, and recent fracture were strong predictors of clinical fracture and hip fracture. Age and multimorbidity were strong predictors of mortality before fracture. The study results have important implications for guiding osteoporosis drug treatment decisions.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Critical Care Medicine
Sobhan Salari Shahrbabaki, Dominik Linz, Susan Redline, Katie Stone, Kristine Ensrud, Mathias Baumert
Summary: Arousal during sleep triggers ventricular repolarization lability, which may increase the risk of long-term cardiovascular mortality. The QT variability index during arousal is independently associated with all-cause and cardiovascular mortality, indicating maladaptation of ventricular repolarization to the arousal stimulus. Further study is needed to determine if arousal suppression can reduce ventricular repolarization lability and subsequent mortality, and if arousal-related QT variability index can be used for more accurate risk stratification.
Article
Geriatrics & Gerontology
Alexandra Cours, Mei-Hua Huang, Howard Fink, Kristine E. Ensrud, John T. Schousboe, Wendy Katzman, Diane Schneider, Nancy E. Lane, Peggy Cawthon, Deborah M. Kado
Summary: This study found that increasing blocks-measured kyphosis is associated with a higher risk of mortality in older men, indicating that hyperkyphosis should be considered as a clinically significant problem.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Article
Geriatrics & Gerontology
Terri L. Blackwell, Mariana G. Figueiro, Gregory J. Tranah, Jamie M. Zeitzer, Kristine Yaffe, Sonia Ancoli-Israel, Deborah M. Kado, Kristine E. Ensrud, Nancy E. Lane, Yue Leng, Katie L. Stone
Summary: This study found that older men with worse alignment of activity and light had lower levels of cognition and increased rates of cognitive decline. However, there was no association between phasor angle and cognition. Interventions that improve the alignment of light and activity may help slow cognitive decline in older adults.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Review
Geriatrics & Gerontology
Mehrbod Estaki, Lisa Langsetmo, Michelle Shardell, Anna Mischel, Lingjing Jiang, Yuan Zhong, Christopher Kaufmann, Rob Knight, Katie Stone, Deborah Kado
Summary: Growing evidence suggests bidirectional links between gut microbiota and sleep quality as shared contributors to health. However, little is known about the relationship between microbiota and sleep among older persons. This study analyzed stool microbiota and sleep quality among older men, and found that men with poor sleep tended to have lower microbiota diversity and that sleep regularity was significantly associated with microbiota composition.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Medicine, General & Internal
Dana A. Bliuc, Thach Tran, Weiwen Chen, Dunia E. Alarkawi, Dima D. Alajlouni, Fiona R. Blyth, Lyn March, Kristine Ensrud, Robert Blank, Jacqueline Center
Summary: This study investigated the association between multimorbidity and osteoporosis investigation and treatment in fracture patients, and found that multimorbidity significantly impacted the treatment of osteoporosis. This suggests that fracture risk may be underestimated or underprioritized in the presence of other chronic conditions, highlighting the need for improved fracture care in these patients.
Article
Geriatrics & Gerontology
Megan Hetherington-Rauth, Eileen Johnson, Eugenia Migliavacca, Neeta Parimi, Lisa Langsetmo, Russell T. Hepple, Yohan Grzywinski, John Corthesy, Terence E. Ryan, Luigi Ferrucci, Jerome N. Feige, Eric S. Orwoll, Peggy M. Cawthon
Summary: This study investigates the associations between amino acids, B vitamins, and their metabolites with D3Cr muscle mass in older men. The results suggest that tryptophan and alpha-hydroxy-5-methyl-tetrahydrofolate (hm-THF) have significant correlations with D3Cr muscle mass, walking speed, and grip strength.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Letter
Medicine, General & Internal
Carolyn J. Crandall, Kristine E. Ensrud
JAMA INTERNAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Paul C. Okoro, Eric S. Orwoll, Curtis Huttenhower, Xochitl Morgan, Thomas M. Kuntz, Lauren J. Mciver, Alyssa B. Dufour, Mary L. Bouxsein, Lisa Langsetmo, Samaneh Farsijani, Deborah M. Kado, Roberto Pacifici, Shivani Sahni, Douglas P. Kiel
Summary: The study found an association between the human gut microbiome and skeletal health, with the abundance of gut microbiota being related to bone measures.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Lisa T. Langsetmo, John C. Schousboe, Brent A. Taylor, Jane A. Cauley, Howard M. Fink, Peggy M. Cawthon, Deborah E. Kado, Kristine Ensrud
Summary: Targeted fracture prevention strategies among late-life adults should consider both fracture risk and competing mortality risk. A machine learning method was used to evaluate risk factors and create models for hip fractures and competing mortality among adults aged 80 years and older. Random forest models were compared to Fine-Gray models with six variables. Top variables for predicting hip fractures were bone mineral density, while frailty was associated with competing mortality. Random forest models performed slightly better than Fine-Gray models for predicting mortality, but similarly for predicting hip fractures.
Article
Geriatrics & Gerontology
S. R. Bauer, C. E. McCulloch, P. M. Cawthon, K. E. Ensrud, A. M. Suskind, J. C. Newman, S. L. Harrison, A. Senders, K. Covinsky, L. M. Marshall
Summary: Change in phenotypic frailty is associated with non-linear increases in lower urinary tract symptoms (LUTS) severity among older men, independent of age and comorbidities.
JOURNAL OF FRAILTY & AGING
(2023)