Journal
BLOOD
Volume 132, Issue 6, Pages 559-564Publisher
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2018-02-832519
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Funding
- National Institutes of Health, National Heart, Lung, and Blood Institute [R01HL136333, R01HL134880]
- Aplastic Anemia and MDS International Foundation Liviya Anderson Award
- March of Dimes Basil O'Connor Starter Scholar Award
- Global Probiotics Council's Young Investigator Grant for Probiotics Research
- National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases [T32 DK060445]
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Recent studies have revealed that the intestinal bacterial microbiome plays an important role in the regulation of hematopoiesis. A correlation between adverse hematologic effects and imbalance of the intestinal microbiome, or dysbiosis, is evident in several human conditions, such as inflammatory bowel disease, obesity, and, critically, in the setting of antibiotic exposure. Here we review the effects of gut dysbiosis on the hematological compartment and our current understanding of the mechanisms through which changes in the bacterial microbiome affect hematopoiesis.
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