Microbial osteoporosis: The interplay between the gut microbiota and bones via host metabolism and immunity

Dietary mung bean protein reduces high-fat diet-induced weight gain by modulating host bile acid metabolism in a gut microbiota-dependent manner

(2018) Akiho Nakatani et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inflammatory osteolysis: a conspiracy against bone

(2017) Gabriel Mbalaviele et al.   JOURNAL OF CLINICAL INVESTIGATION

New Frontiers in Fibers: Innovative and Emerging Research on the Gut Microbiome and Bone Health

(2017) Taylor C. Wallace et al.   JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION

Role of NOD2 and RIP2 in host–microbe interactions with Gram-negative bacteria: insights from the periodontal disease model

(2016) Joao AC Souza et al.   Innate Immunity

Sex steroid deficiency–associated bone loss is microbiota dependent and prevented by probiotics

(2016) Jau-Yi Li et al.   JOURNAL OF CLINICAL INVESTIGATION

The National Osteoporosis Foundation’s position statement on peak bone mass development and lifestyle factors: a systematic review and implementation recommendations

(2016) C. M. Weaver et al.   OSTEOPOROSIS INTERNATIONAL

Gut microbiota induce IGF-1 and promote bone formation and growth

(2016) Jing Yan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lactobacillus plantarum strain maintains growth of infant mice during chronic undernutrition

(2016) M. Schwarzer et al.   SCIENCE

Bone Loss in Surgically Ovariectomized Premenopausal Women Is Associated With T Lymphocyte Activation and Thymic Hypertrophy

(2016) Saira Adeel et al.   JOURNAL OF INVESTIGATIVE MEDICINE

Indigenous Bacteria from the Gut Microbiota Regulate Host Serotonin Biosynthesis

(2015) Jessica M. Yano et al.   CELL

The intestinal microbiome and skeletal fitness: Connecting bugs and bones

(2015) Julia F. Charles et al.   CLINICAL IMMUNOLOGY

Loss of Bone and Wnt10b Expression in Male Type 1 Diabetic Mice Is Blocked by the ProbioticLactobacillus reuteri

(2015) Jing Zhang et al.   ENDOCRINOLOGY

Gut microbes promote colonic serotonin production through an effect of short-chain fatty acids on enterochromaffin cells

(2015) Christopher S. Reigstad et al.   FASEB JOURNAL

Physiology of Proglucagon Peptides: Role of Glucagon and GLP-1 in Health and Disease

(2015) Darleen A. Sandoval et al.   PHYSIOLOGICAL REVIEWS

Effects of the gut microbiota on bone mass

(2015) Claes Ohlsson et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Prebiotic and Probiotic Regulation of Bone Health: Role of the Intestine and its Microbiome

(2015) Laura McCabe et al.   Current Osteoporosis Reports

Diet, Gut Microbiome, and Bone Health

(2015) Connie M. Weaver   Current Osteoporosis Reports

The Cytosolic Bacterial Peptidoglycan Sensor Nod2 Affords Stem Cell Protection and Links Microbes to Gut Epithelial Regeneration

(2014) Giulia Nigro et al.   Cell Host & Microbe

Bile acids and the gut microbiome

(2014) Jason M. Ridlon et al.   CURRENT OPINION IN GASTROENTEROLOGY

Role of the Microbiome in Energy Regulation and Metabolism

(2014) Max Nieuwdorp et al.   GASTROENTEROLOGY

Changes of serum cytokines-related Th1/Th2/Th17 concentration in patients with postmenopausal osteoporosis

(2014) Jing Zhang et al.   GYNECOLOGICAL ENDOCRINOLOGY

Segmented Filamentous Bacteria Antigens Presented by Intestinal Dendritic Cells Drive Mucosal Th17 Cell Differentiation

(2014) Yoshiyuki Goto et al.   IMMUNITY

Enhanced Immunoprotective Effects by Anti-IL-17 Antibody Translates to Improved Skeletal Parameters Under Estrogen Deficiency Compared With Anti-RANKL and Anti-TNF-α Antibodies

(2014) Abdul M Tyagi et al.   JOURNAL OF BONE AND MINERAL RESEARCH

ProbioticL. reuteriTreatment Prevents Bone Loss in a Menopausal Ovariectomized Mouse Model

(2014) Robert A. Britton et al.   JOURNAL OF CELLULAR PHYSIOLOGY

NOD2 Contributes to Porphyromonas gingivalis–induced Bone Resorption

(2014) T.P. Prates et al.   JOURNAL OF DENTAL RESEARCH

Agave Fructans: Their Effect on Mineral Absorption and Bone Mineral Content

(2014) María Isabel García-Vieyra et al.   JOURNAL OF MEDICINAL FOOD

Minireview: Gut Microbiota: The Neglected Endocrine Organ

(2014) Gerard Clarke et al.   MOLECULAR ENDOCRINOLOGY

Dynamics and associations of microbial community types across the human body

(2014) Tao Ding et al.   NATURE

Bacterial Bile Metabolising Gene Abundance in Crohn's, Ulcerative Colitis and Type 2 Diabetes Metagenomes

(2014) Alain Labbé et al.   PLoS One

Commensal bacteria protect against food allergen sensitization

(2014) A. T. Stefka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effect of Probiotics Supplementation on Bone Mineral Content and Bone Mass Density

(2014) Kolsoom Parvaneh et al.   TheScientificWorldJOURNAL

Colon Macrophages Polarized by Commensal Bacteria Cause Colitis and Cancer through the Bystander Effect

(2014) Yonghong Yang et al.   Translational Oncology

Gut microbiome of the Hadza hunter-gatherers

(2014) Stephanie L. Schnorr et al.   Nature Communications

Microbial Modulation of Energy Availability in the Colon Regulates Intestinal Transit

(2013) Anita Wichmann et al.   Cell Host & Microbe

Fusobacterium nucleatum Promotes Colorectal Carcinogenesis by Modulating E-Cadherin/β-Catenin Signaling via its FadA Adhesin

(2013) Mara Roxana Rubinstein et al.   Cell Host & Microbe

Increased intestinal permeability to oral chromium (51Cr)-EDTA in human Type 2 diabetes

(2013) F. Horton et al.   DIABETIC MEDICINE

Probiotic use decreases intestinal inflammation and increases bone density in healthy male but not female mice

(2013) Laura R. McCabe et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Impact of oral vancomycin on gut microbiota, bile acid metabolism, and insulin sensitivity

(2013) Anne Vrieze et al.   JOURNAL OF HEPATOLOGY

Clostridium scindens: a human gut microbe with a high potential to convert glucocorticoids into androgens

(2013) Jason M. Ridlon et al.   JOURNAL OF LIPID RESEARCH

The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism

(2013) Gijs den Besten et al.   JOURNAL OF LIPID RESEARCH

High prevalence of increased interleukin-17A serum levels in postmenopausal estrogen deficiency

(2013) Ildikó Molnár et al.   MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY

Increased circulatory levels of lipopolysaccharide (LPS) and zonulin signify novel biomarkers of proinflammation in patients with type 2 diabetes

(2013) B. Jayashree et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

(2013) Yukihiro Furusawa et al.   NATURE

Diet rapidly and reproducibly alters the human gut microbiome

(2013) Lawrence A. David et al.   NATURE

Gut metagenome in European women with normal, impaired and diabetic glucose control

(2013) Fredrik H. Karlsson et al.   NATURE

Serotonin signalling in the gut—functions, dysfunctions and therapeutic targets

(2013) Gary M. Mawe et al.   Nature Reviews Gastroenterology & Hepatology

IL-17A-mediated sRANK ligand elevation involved in postmenopausal osteoporosis

(2013) I. Molnár et al.   OSTEOPOROSIS INTERNATIONAL

Gut Microbiota Composition in Male Rat Models under Different Nutritional Status and Physical Activity and Its Association with Serum Leptin and Ghrelin Levels

(2013) María Isabel Queipo-Ortuño et al.   PLoS One

The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis

(2013) P. M. Smith et al.   SCIENCE

A serotonin-induced N-glycan switch regulates platelet aggregation

(2013) Charles P. Mercado et al.   Scientific Reports

A Dialogue between the Immune System and Brain, Spoken in the Language of Serotonin

(2012) Nicole L. Baganz et al.   ACS Chemical Neuroscience

Critical role of gut microbiota in the production of biologically active, free catecholamines in the gut lumen of mice

(2012) Yasunari Asano et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

TNF-  Mediates Macrophage-Induced Bystander Effects through Netrin-1

(2012) Y. Yang et al.   CANCER RESEARCH

Defining a Healthy Human Gut Microbiome: Current Concepts, Future Directions, and Clinical Applications

(2012) Fredrik Bäckhed et al.   Cell Host & Microbe

Intestinal microbiota determine severity of myocardial infarction in rats

(2012) Vy Lam et al.   FASEB JOURNAL

Activation of Colonic Mucosal 5-HT4 Receptors Accelerates Propulsive Motility and Inhibits Visceral Hypersensitivity

(2012) Jill M. Hoffman et al.   GASTROENTEROLOGY

The gut microbiota regulates bone mass in mice

(2012) Klara Sjögren et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Loss of wnt/β-catenin signaling causes cell fate shift of preosteoblasts from osteoblasts to adipocytes

(2012) Lige Song et al.   JOURNAL OF BONE AND MINERAL RESEARCH

IL-17 mediates estrogen-deficient osteoporosis in an Act1-dependent manner

(2012) Carl J. DeSelm et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

A framework for human microbiome research

(2012)   NATURE

A metagenome-wide association study of gut microbiota in type 2 diabetes

(2012) Junjie Qin et al.   NATURE

Antibiotics in early life alter the murine colonic microbiome and adiposity

(2012) Ilseung Cho et al.   NATURE

Inflammatory bone loss: pathogenesis and therapeutic intervention

(2012) Kurt Redlich et al.   NATURE REVIEWS DRUG DISCOVERY

Decreased osteoclastogenesis in serotonin-deficient mice

(2012) Y. Chabbi-Achengli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interactions Between the Microbiota and the Immune System

(2012) L. V. Hooper et al.   SCIENCE

Inhibition of Th17 differentiation by anti-TNF-alpha therapy in uveitis patients with Behçet's disease

(2012) Sunao Sugita et al.   ARTHRITIS RESEARCH & THERAPY

Lactobacillus plantarum Promotes Drosophila Systemic Growth by Modulating Hormonal Signals through TOR-Dependent Nutrient Sensing

(2011) Gilles Storelli et al.   Cell Metabolism

Estrogen enhances the functions of CD4+CD25+Foxp3+ regulatory T cells that suppress osteoclast differentiation and bone resorption in vitro

(2011) CY Luo et al.   Cellular & Molecular Immunology

Lactobacillus plantarum strain No. 14 reduces adipocyte size in mice fed high-fat diet

(2011) Naoki Takemura et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

IGF-1R signaling in chondrocytes modulates growth plate development by interacting with the PTHrP/Ihh pathway

(2011) Yongmei Wang et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination

(2011) Kerstin Berer et al.   NATURE

Enterotypes of the human gut microbiome

(2011) Manimozhiyan Arumugam et al.   NATURE

Utilization of amino acids by bacteria from the pig small intestine

(2010) Zhao-Lai Dai et al.   AMINO ACIDS

The nuclear receptor superfamily of steroid hormones and vitamin D gene regulation

(2010) Ronald N. Margolis et al.   Annals of the New York Academy of Sciences

Increased bone density and resistance to ovariectomy-induced bone loss in FoxP3-transgenic mice based on impaired osteoclast differentiation

(2010) Mario M. Zaiss et al.   ARTHRITIS AND RHEUMATISM

Regulatory T cells as a potent target for controlling bone loss

(2010) Feng-Lai Yuan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A Marker of Endotoxemia Is Associated With Obesity and Related Metabolic Disorders in Apparently Healthy Chinese

(2010) L. Sun et al.   DIABETES CARE

Gut Microbiota, Lipopolysaccharides, and Innate Immunity in the Pathogenesis of Obesity and Cardiovascular Risk

(2010) Melania Manco et al.   ENDOCRINE REVIEWS

The two faces of serotonin in bone biology

(2010) Patricia Ducy et al.   JOURNAL OF CELL BIOLOGY

Osteocyte Wnt/ -Catenin Signaling Is Required for Normal Bone Homeostasis

(2010) I. Kramer et al.   MOLECULAR AND CELLULAR BIOLOGY

Recognition of peptidoglycan from the microbiota by Nod1 enhances systemic innate immunity

(2010) Thomas B Clarke et al.   NATURE MEDICINE

Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis

(2010) Y. K. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species

(2010) K. Atarashi et al.   SCIENCE

IL-17 and Th17 Cells

(2009) Thomas Korn et al.   Annual Review of Immunology

Transport by SLC5A8 with subsequent inhibition of histone deacetylase 1 (HDAC1) and HDAC3 underlies the antitumor activity of 3-bromopyruvate

(2009) Muthusamy Thangaraju et al.   CANCER

A Serotonin-Dependent Mechanism Explains the Leptin Regulation of Bone Mass, Appetite, and Energy Expenditure

(2009) Vijay K. Yadav et al.   CELL

Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria

(2009) Ivaylo I. Ivanov et al.   CELL

Lithocholic acid downregulates vitamin D effects in human osteoblasts

(2009) S. Ruiz-Gaspà et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Leptin targets in the mouse brain

(2009) Michael M. Scott et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Activated CD4+CD25+ regulatory T cells inhibit osteoclastogenesis and collagen-induced arthritis

(2008) H Kelchtermans et al.   ANNALS OF THE RHEUMATIC DISEASES

Lrp5 Controls Bone Formation by Inhibiting Serotonin Synthesis in the Duodenum

(2008) Vijay K. Yadav et al.   CELL

Activated macrophages promote Wnt signalling through tumour necrosis factor-α in gastric tumour cells

(2008) Keisuke Oguma et al.   EMBO JOURNAL

Modulation of mouse RANKL gene expression by Runx2 and vitamin D3

(2008) Riko Kitazawa et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Chylomicrons promote intestinal absorption of lipopolysaccharides

(2008) Sarbani Ghoshal et al.   JOURNAL OF LIPID RESEARCH

The serotonin 5-HT2B receptor controls bone mass via osteoblast recruitment and proliferation

(2007) C. Collet et al.   FASEB JOURNAL