Differential effects of the dynein-regulatory factor Lissencephaly-1 on processive dynein-dynactin motility

DYNC1H1 mutations associated with neurological diseases compromise processivity of dynein–dynactin–cargo adaptor complexes

(2017) Ha Thi Hoang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lissencephaly-1 is a context-dependent regulator of the human dynein complex

(2017) Janina Baumbach et al.   eLife

How dynein and dynactin transport cargos: a structural perspective

(2016) Andrew P Carter et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Tyrosination of α‐tubulin controls the initiation of processive dynein–dynactin motility

(2016) Richard J McKenney et al.   EMBO JOURNAL

Hook Adaptors Induce Unidirectional Processive Motility by Enhancing the Dynein-Dynactin Interaction

(2016) Mara A. Olenick et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bicaudal D Family of Motor Adaptors: Linking Dynein Motility to Cargo Binding

(2016) Casper C. Hoogenraad et al.   TRENDS IN CELL BIOLOGY

Load-induced enhancement of Dynein force production by LIS1–NudE in vivo and in vitro

(2016) Babu J. N. Reddy et al.   Nature Communications

α-Tubulin Tyrosination and CLIP-170 Phosphorylation Regulate the Initiation of Dynein-Driven Transport in Neurons

(2016) Jeffrey J. Nirschl et al.   Cell Reports

Mechanism and Regulation of Cytoplasmic Dynein

(2015) Michael A. Cianfrocco et al.   Annual Review of Cell and Developmental Biology

The dynein cortical anchor Num1 activates dynein motility by relieving Pac1/LIS1-mediated inhibition

(2015) Lindsay G. Lammers et al.   JOURNAL OF CELL BIOLOGY

Structural organization of the dynein–dynactin complex bound to microtubules

(2015) Saikat Chowdhury et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cytoplasmic dynein regulates its attachment to microtubules via nucleotide state-switched mechanosensing at multiple AAA domains

(2015) Matthew P. Nicholas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The structure of the dynactin complex and its interaction with dynein

(2015) L. Urnavicius et al.   SCIENCE

Direct observation shows superposition and large scale flexibility within cytoplasmic dynein motors moving along microtubules

(2015) Hiroshi Imai et al.   Nature Communications

Structural organization of the dynein–dynactin complex bound to microtubules

(2015) Saikat Chowdhury et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mutations in cytoplasmic dynein and its regulators cause malformations of cortical development and neurodegenerative diseases

(2015) Joanna Lipka et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Allosteric Communication in the Dynein Motor Domain

(2014) Gira Bhabha et al.   CELL

In vitroreconstitution of a highly processive recombinant human dynein complex

(2014) Max A Schlager et al.   EMBO JOURNAL

Confidence limits, error bars and method comparison in molecular modeling. Part 1: The calculation of confidence intervals

(2014) A. Nicholls   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Structure of human cytoplasmic dynein-2 primed for its power stroke

(2014) Helgo Schmidt et al.   NATURE

Reconstitution of a hierarchical +TIP interaction network controlling microtubule end tracking of dynein

(2014) Christian Duellberg et al.   NATURE CELL BIOLOGY

The AAA3 domain of cytoplasmic dynein acts as a switch to facilitate microtubule release

(2014) Mark A DeWitt et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Activation of cytoplasmic dynein motility by dynactin-cargo adapter complexes

(2014) R. J. McKenney et al.   SCIENCE

Lis1 regulates dynein by sterically blocking its mechanochemical cycle

(2014) Katerina Toropova et al.   eLife

Lissencephaly-1 promotes the recruitment of dynein and dynactin to transported mRNAs

(2013) Carly I. Dix et al.   JOURNAL OF CELL BIOLOGY

Ordered Recruitment of Dynactin to the Microtubule Plus-End is Required for Efficient Initiation of Retrograde Axonal Transport

(2013) A. J. Moughamian et al.   JOURNAL OF NEUROSCIENCE

Nudel/NudE and Lis1 promote dynein and dynactin interaction in the context of spindle morphogenesis

(2013) Shusheng Wang et al.   MOLECULAR BIOLOGY OF THE CELL

Cytoplasmic dynein

(2012) Victoria J. Allan   BIOCHEMICAL SOCIETY TRANSACTIONS

Lis1 Acts as a “Clutch” between the ATPase and Microtubule-Binding Domains of the Dynein Motor

(2012) Julie Huang et al.   CELL

Intrinsic Disorder in Dynein Intermediate Chain Modulates Its Interactions with NudE and Dynactin

(2012) Afua Nyarko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lis1 is an initiation factor for dynein-driven organelle transport

(2012) Martin J. Egan et al.   JOURNAL OF CELL BIOLOGY

The 2.8 Å crystal structure of the dynein motor domain

(2012) Takahide Kon et al.   NATURE

Multiple modes of cytoplasmic dynein regulation

(2012) Richard B. Vallee et al.   NATURE CELL BIOLOGY

The p150Glued CAP-Gly Domain Regulates Initiation of Retrograde Transport at Synaptic Termini

(2012) Thomas E. Lloyd et al.   NEURON

Regulated Offloading of Cytoplasmic Dynein from Microtubule Plus Ends to the Cortex

(2011) Steven M. Markus et al.   DEVELOPMENTAL CELL

Mutually Exclusive Cytoplasmic Dynein Regulation by NudE-Lis1 and Dynactin

(2011) Richard J. McKenney et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The N-terminal coiled-coil of Ndel1 is a regulated scaffold that recruits LIS1 to dynein

(2011) Eliza Żyłkiewicz et al.   JOURNAL OF CELL BIOLOGY

High-resolution imaging reveals indirect coordination of opposite motors and a role for LIS1 in high-load axonal transport

(2011) Julie Y. Yi et al.   JOURNAL OF CELL BIOLOGY

A Cdk5-Dependent Switch Regulates Lis1/Ndel1/Dynein-Driven Organelle Transport in Adult Axons

(2011) J. P. Pandey et al.   JOURNAL OF NEUROSCIENCE

Crystal Structure of the Dynein Motor Domain

(2011) A. P. Carter et al.   SCIENCE

LIS1 and NudE Induce a Persistent Dynein Force-Producing State

(2010) Richard J. McKenney et al.   CELL

Functional Dissection of LIS1 and NDEL1 Towards Understanding the Molecular Mechanisms of Cytoplasmic Dynein Regulation

(2010) Takayuki Torisawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Retrograde axonal transport: pathways to cell death?

(2010) Eran Perlson et al.   TRENDS IN NEUROSCIENCES

Regulators of the cytoplasmic dynein motor

(2009) Julia R. Kardon et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Regulation of the processivity and intracellular localization of Saccharomyces cerevisiae dynein by dynactin

(2009) J. R. Kardon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Emerging roles for myosin II and cytoplasmic dynein in migrating neurons and growth cones

(2009) Richard B. Vallee et al.   TRENDS IN CELL BIOLOGY

LIS1 and NDEL1 coordinate the plus-end-directed transport of cytoplasmic dynein

(2008) Masami Yamada et al.   EMBO JOURNAL