Dynein activation in vivo is regulated by the nucleotide states of its AAA3 domain

The spindle pole-body localization of activated cytoplasmic dynein is cell cycle-dependent in Aspergillus nidulans

(2021) Baronger Dowell Bieger et al.   FUNGAL GENETICS AND BIOLOGY

LIS1 promotes the formation of activated cytoplasmic dynein-1 complexes

(2020) Zaw Min Htet et al.   NATURE CELL BIOLOGY

Lis1 activates dynein motility by modulating its pairing with dynactin

(2020) Mohamed M. Elshenawy et al.   NATURE CELL BIOLOGY

Pac1/LIS1 stabilizes an uninhibited conformation of dynein to coordinate its localization and activity

(2020) Matthew G. Marzo et al.   NATURE CELL BIOLOGY

New insights into the mechanism of dynein motor regulation by lissencephaly-1

(2020) Steven M Markus et al.   eLife

Cargo-Mediated Activation of Cytoplasmic Dynein in vivo

(2020) Xin Xiang et al.   Frontiers in Cell and Developmental Biology

The regulatory function of the AAA4 ATPase domain of cytoplasmic dynein

(2020) Xinglei Liu et al.   Nature Communications

Dynein activators and adaptors at a glance

(2019) Mara A. Olenick et al.   JOURNAL OF CELL SCIENCE

Molecular mechanism of cytoplasmic dynein tension sensing

(2019) Lu Rao et al.   Nature Communications

LIS1 regulates cargo-adapter–mediated activation of dynein by overcoming its autoinhibition in vivo

(2019) Rongde Qiu et al.   JOURNAL OF CELL BIOLOGY

The cytoplasmic dynein transport machinery and its many cargoes

(2018) Samara L. Reck-Peterson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cryo-electron tomography reveals that dynactin recruits a team of dyneins for processive motility

(2018) Danielle A. Grotjahn et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cryo-electron tomography reveals that dynactin recruits a team of dyneins for processive motility

(2018) Danielle A. Grotjahn et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

p25 of the dynactin complex plays a dual role in cargo binding and dynactin regulation

(2018) Rongde Qiu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cryo-EM shows how dynactin recruits two dyneins for faster movement

(2018) Linas Urnavicius et al.   NATURE

Differential effects of the dynein-regulatory factor Lissencephaly-1 on processive dynein-dynactin motility

(2017) Pedro A. Gutierrez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microtubule-organizing centers of Aspergillus nidulans are anchored at septa by a disordered protein

(2017) Ying Zhang et al.   MOLECULAR MICROBIOLOGY

Nuclear movement in fungi

(2017) Xin Xiang   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Lissencephaly-1 is a context-dependent regulator of the human dynein complex

(2017) Janina Baumbach et al.   eLife

Review: Structure and mechanism of the dynein motor ATPase

(2016) Helgo Schmidt et al.   BIOPOLYMERS

Hook Adaptors Induce Unidirectional Processive Motility by Enhancing the Dynein-Dynactin Interaction

(2016) Mara A. Olenick et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The mammalian dynein–dynactin complex is a strong opponent to kinesin in a tug-of-war competition

(2016) Vladislav Belyy et al.   NATURE CELL BIOLOGY

How Dynein Moves Along Microtubules

(2016) Gira Bhabha et al.   TRENDS IN BIOCHEMICAL SCIENCES

The dynein cortical anchor Num1 activates dynein motility by relieving Pac1/LIS1-mediated inhibition

(2015) Lindsay G. Lammers et al.   JOURNAL OF CELL BIOLOGY

Structural organization of the dynein–dynactin complex bound to microtubules

(2015) Saikat Chowdhury et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cytoplasmic dynein regulates its attachment to microtubules via nucleotide state-switched mechanosensing at multiple AAA domains

(2015) Matthew P. Nicholas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The structure of the dynactin complex and its interaction with dynein

(2015) L. Urnavicius et al.   SCIENCE

Structural organization of the dynein–dynactin complex bound to microtubules

(2015) Saikat Chowdhury et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Allosteric Communication in the Dynein Motor Domain

(2014) Gira Bhabha et al.   CELL

In vitroreconstitution of a highly processive recombinant human dynein complex

(2014) Max A Schlager et al.   EMBO JOURNAL

HookA is a novel dynein–early endosome linker critical for cargo movement in vivo

(2014) Jun Zhang et al.   JOURNAL OF CELL BIOLOGY

Hook is an adapter that coordinates kinesin-3 and dynein cargo attachment on early endosomes

(2014) Ewa Bielska et al.   JOURNAL OF CELL BIOLOGY

A microscopy-based screen employing multiplex genome sequencing identifies cargo-specific requirements for dynein velocity

(2014) Kaeling Tan et al.   MOLECULAR BIOLOGY OF THE CELL

Structure of human cytoplasmic dynein-2 primed for its power stroke

(2014) Helgo Schmidt et al.   NATURE

Autoregulatory mechanism for dynactin control of processive and diffusive dynein transport

(2014) Suvranta K. Tripathy et al.   NATURE CELL BIOLOGY

The AAA3 domain of cytoplasmic dynein acts as a switch to facilitate microtubule release

(2014) Mark A DeWitt et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Activation of cytoplasmic dynein motility by dynactin-cargo adapter complexes

(2014) R. J. McKenney et al.   SCIENCE

Lis1 regulates dynein by sterically blocking its mechanochemical cycle

(2014) Katerina Toropova et al.   eLife

Dynein Motion Switches from Diffusive to Directed upon Cortical Anchoring

(2013) Vaishnavi Ananthanarayanan et al.   CELL

Regulation of mitosis by the NIMA kinase involves TINA and its newly discovered partner, An-WDR8, at spindle pole bodies

(2013) Kuo-Fang Shen et al.   MOLECULAR BIOLOGY OF THE CELL

Lis1 Acts as a “Clutch” between the ATPase and Microtubule-Binding Domains of the Dynein Motor

(2012) Julie Huang et al.   CELL

Analyses of Dynein Heavy Chain Mutations Reveal Complex Interactions Between Dynein Motor Domains and Cellular Dynein Functions

(2012) S. Sivagurunathan et al.   GENETICS

Identification of a Novel Site in the Tail of Dynein Heavy Chain Important for Dynein Functionin Vivo

(2012) Rongde Qiu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lis1 is an initiation factor for dynein-driven organelle transport

(2012) Martin J. Egan et al.   JOURNAL OF CELL BIOLOGY

Dynactin's pointed-end complex is a cargo-targeting module

(2012) Ting-Yu Yeh et al.   MOLECULAR BIOLOGY OF THE CELL

BICD2, dynactin, and LIS1 cooperate in regulating dynein recruitment to cellular structures

(2012) Daniël Splinter et al.   MOLECULAR BIOLOGY OF THE CELL

Insights into dynein motor domain function from a 3.3-Å crystal structure

(2012) Helgo Schmidt et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Regulated Offloading of Cytoplasmic Dynein from Microtubule Plus Ends to the Cortex

(2011) Steven M. Markus et al.   DEVELOPMENTAL CELL

The p25 subunit of the dynactin complex is required for dynein–early endosome interaction

(2011) Jun Zhang et al.   JOURNAL OF CELL BIOLOGY

In Vivo Roles of the Basic Domain of Dynactin p150 in Microtubule Plus-End Tracking and Dynein Function

(2011) Xuanli Yao et al.   TRAFFIC

LIS1 and NudE Induce a Persistent Dynein Force-Producing State

(2010) Richard J. McKenney et al.   CELL

The microtubule plus-end localization of Aspergillus dynein is important for dynein-early-endosome interaction but not for dynein ATPase activation

(2010) J. Zhang et al.   JOURNAL OF CELL SCIENCE

Aspergillus RabBRab5 Integrates Acquisition of Degradative Identity with the Long Distance Movement of Early Endosomes

(2010) Juan F. Abenza et al.   MOLECULAR BIOLOGY OF THE CELL

Motor- and Tail-Dependent Targeting of Dynein to Microtubule Plus Ends and the Cell Cortex

(2009) Steven M. Markus et al.   CURRENT BIOLOGY

Regulation of the processivity and intracellular localization of Saccharomyces cerevisiae dynein by dynactin

(2009) J. R. Kardon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulatory ATPase Sites of Cytoplasmic Dynein Affect Processivity and Force Generation

(2008) Carol Cho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynactin Function in Mitotic Spindle Positioning

(2008) Jeffrey K. Moore et al.   TRAFFIC

Long-Distance Movement of Aspergillus nidulans Early Endosomes on Microtubule Tracks

(2008) Juan F. Abenza et al.   TRAFFIC

Arp11 Affects Dynein–Dynactin Interaction and is Essential for Dynein Function in Aspergillus nidulans

(2008) Jun Zhang et al.   TRAFFIC