Programming inflammatory cell death for therapy

Protective effect of necrosulfonamide on rat pulmonary ischemia-reperfusion injury via inhibition of necroptosis

(2021) Satoshi Ueda et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

Cryo-EM structural analysis of FADD:Caspase-8 complexes defines the catalytic dimer architecture for co-ordinated control of cell fate

(2021) Joanna L. Fox et al.   Nature Communications

DPP9 sequesters the C terminus of NLRP1 to repress inflammasome activation

(2021) L. Robert Hollingsworth et al.   NATURE

Structural and biochemical mechanisms of NLRP1 inhibition by DPP9

(2021) Menghang Huang et al.   NATURE

Gasdermin E permits interleukin-1 beta release in distinct sublytic and pyroptotic phases

(2021) Bowen Zhou et al.   Cell Reports

AIM2 forms a complex with pyrin and ZBP1 to drive PANoptosis and host defence

(2021) SangJoon Lee et al.   NATURE

The ‘cytokine storm’: molecular mechanisms and therapeutic prospects

(2021) Rajendra Karki et al.   TRENDS IN IMMUNOLOGY

Hierarchical Cell Death Program Disrupts the Intracellular Niche Required for Burkholderia thailandensis Pathogenesis

(2021) David E. Place et al.   mBio

Caspases in Cell Death, Inflammation, and Gasdermin-Induced Pyroptosis

(2020) Sannula Kesavardhana et al.   Annual Review of Immunology

Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense

(2020) Min Zheng et al.   CELL

Toward targeting inflammasomes: insights into their regulation and activation

(2020) Shelbi Christgen et al.   CELL RESEARCH

The Zα2 domain of ZBP1 is a molecular switch regulating influenza-induced PANoptosis and perinatal lethality during development

(2020) Sannula Kesavardhana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation

(2020) Jun Jacob Hu et al.   NATURE IMMUNOLOGY

Identification of the PANoptosome: A Molecular Platform Triggering Pyroptosis, Apoptosis, and Necroptosis (PANoptosis)

(2020) Shelbi Christgen et al.   Frontiers in Cellular and Infection Microbiology

Evaluation of IL-1 Blockade as an Adjunct to Linezolid Therapy for Tuberculosis in Mice and Macaques

(2020) Caylin G. Winchell et al.   Frontiers in Immunology

Impaired NLRP3 inflammasome activation/pyroptosis leads to robust inflammatory cell death via caspase-8/RIPK3 during coronavirus infection

(2020) Min Zheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Apoptotic Caspase Network Safeguards Cell Death Induction in Pyroptotic Macrophages

(2020) Nathalia Moraes de Vasconcelos et al.   Cell Reports

Interferon regulatory factor 1 regulates PANoptosis to prevent colorectal cancer

(2020) Rajendra Karki et al.   JCI Insight

Succination inactivates gasdermin D and blocks pyroptosis

(2020) Fiachra Humphries et al.   SCIENCE

ZBP1 promotes fungi-induced inflammasome activation and pyroptosis, apoptosis, and necroptosis (PANoptosis)

(2020) Balaji Banoth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PANoptosis in microbial infection

(2020) David E Place et al.   CURRENT OPINION IN MICROBIOLOGY

Cleavage of GSDME by caspase-3 determines lobaplatin-induced pyroptosis in colon cancer cells

(2019) Junhui Yu et al.   Cell Death & Disease

Chemotherapeutic paclitaxel and cisplatin differentially induce pyroptosis in A549 lung cancer cells via caspase-3/GSDME activation

(2019) Cheng-cheng Zhang et al.   APOPTOSIS

Ubiquitin Ligases cIAP1 and cIAP2 Limit Cell Death to Prevent Inflammation

(2019) Jieqiong Zhang et al.   Cell Reports

Caspases in Cell Death, Inflammation, and Disease

(2019) Nina Van Opdenbosch et al.   IMMUNITY

Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome

(2019) Humayun Sharif et al.   NATURE

Caspase-1 initiates apoptosis in the absence of gasdermin D

(2019) Kohsuke Tsuchiya et al.   Nature Communications

Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis

(2019) Kim Newton et al.   NATURE

DDX3X acts as a live-or-die checkpoint in stressed cells by regulating NLRP3 inflammasome

(2019) Parimal Samir et al.   NATURE

Inflammasomes and the fine line between defense and disease

(2019) Shelbi Christgen et al.   CURRENT OPINION IN IMMUNOLOGY

Innate immune priming in the absence of TAK1 drives RIPK1 kinase activity–independent pyroptosis, apoptosis, necroptosis, and inflammatory disease

(2019) R.K. Subbarao Malireddi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

GSDME mediates caspase-3-dependent pyroptosis in gastric cancer

(2018) Yubin Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

TAK1 restricts spontaneous NLRP3 activation and cell death to control myeloid proliferation

(2018) R.K. Subbarao Malireddi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IRF1 Is a Transcriptional Regulator of ZBP1 Promoting NLRP3 Inflammasome Activation and Cell Death during Influenza Virus Infection

(2018) Teneema Kuriakose et al.   JOURNAL OF IMMUNOLOGY

Venetoclax–Rituximab in Relapsed or Refractory Chronic Lymphocytic Leukemia

(2018) John F. Seymour et al.   NEW ENGLAND JOURNAL OF MEDICINE

Regulation of a distinct activated RIPK1 intermediate bridging complex I and complex II in TNFα-mediated apoptosis

(2018) Palak Amin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity

(2018) Hongbin He et al.   Nature Communications

Necrosulfonamide Attenuates Spinal Cord Injury via Necroptosis Inhibition

(2018) Yongxiang Wang et al.   World Neurosurgery

ASC- and caspase-8-dependent apoptotic pathway diverges from the NLRC4 inflammasome in macrophages

(2018) Bettina L. Lee et al.   Scientific Reports

Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection

(2018) Joseph Sarhan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathogen blockade of TAK1 triggers caspase-8–dependent cleavage of gasdermin D and cell death

(2018) Pontus Orning et al.   SCIENCE

ZBP1/DAI ubiquitination and sensing of influenza vRNPs activate programmed cell death

(2017) Sannula Kesavardhana et al.   JOURNAL OF EXPERIMENTAL MEDICINE

MLKL Activation Triggers NLRP3-Mediated Processing and Release of IL-1β Independently of Gasdermin-D

(2017) Kimberley D. Gutierrez et al.   JOURNAL OF IMMUNOLOGY

Development of an Acrylate Derivative Targeting the NLRP3 Inflammasome for the Treatment of Inflammatory Bowel Disease

(2017) Mattia Cocco et al.   JOURNAL OF MEDICINAL CHEMISTRY

Effect of interleukin-1β inhibition with canakinumab on incident lung cancer in patients with atherosclerosis: exploratory results from a randomised, double-blind, placebo-controlled trial

(2017) Paul M Ridker et al.   LANCET

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

(2017) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner

(2017) Stephanie A. Conos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death

(2017) Jianjin Shi et al.   TRENDS IN BIOCHEMICAL SCIENCES

Complex Pathologic Roles of RIPK1 and RIPK3: Moving Beyond Necroptosis

(2017) Kelby W. Wegner et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Regulation of RIPK1 activation by TAK1-mediated phosphorylation dictates apoptosis and necroptosis

(2017) Jiefei Geng et al.   Nature Communications

Caspase-1 Engagement and TLR-Induced c-FLIP Expression Suppress ASC/Caspase-8-Dependent Apoptosis by Inflammasome Sensors NLRP1b and NLRC4

(2017) Nina Van Opdenbosch et al.   Cell Reports

Inhibition of caspase-1 or gasdermin-D enable caspase-8 activation in the Naip5/NLRC4/ASC inflammasome

(2017) Danielle P. A. Mascarenhas et al.   PLoS Pathogens

GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death

(2016) Lorenzo Sborgi et al.   EMBO JOURNAL

Cryo-EM Structure of Caspase-8 Tandem DED Filament Reveals Assembly and Regulation Mechanisms of the Death-Inducing Signaling Complex

(2016) Tian-Min Fu et al.   MOLECULAR CELL

RIPK1 inhibits ZBP1-driven necroptosis during development

(2016) Kim Newton et al.   NATURE

RIPK1 counteracts ZBP1-mediated necroptosis to inhibit inflammation

(2016) Juan Lin et al.   NATURE

NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux

(2016) Yuan He et al.   NATURE

NLRP3 inflammasome plays a redundant role with caspase 8 to promote IL-1β–mediated osteomyelitis

(2016) Prajwal Gurung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes

(2016) Robin A. Aglietti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Holding RIPK1 on the Ubiquitin Leash in TNFR1 Signaling

(2016) Nieves Peltzer et al.   TRENDS IN CELL BIOLOGY

Molecular architecture of the DED chains at the DISC: regulation of procaspase-8 activation by short DED proteins c-FLIP and procaspase-8 prodomain

(2015) K Schleich et al.   CELL DEATH AND DIFFERENTIATION

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

(2015) Wan-ting He et al.   CELL RESEARCH

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component

(2015) Hexin Shi et al.   NATURE IMMUNOLOGY

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

(2015) Rebecca C Coll et al.   NATURE MEDICINE

RIPK1 Blocks Early Postnatal Lethality Mediated by Caspase-8 and RIPK3

(2014) Christopher P. Dillon et al.   CELL

FADD and Caspase-8 Mediate Priming and Activation of the Canonical and Noncanonical Nlrp3 Inflammasomes

(2014) P. Gurung et al.   JOURNAL OF IMMUNOLOGY

Mixed Lineage Kinase Domain-like Protein MLKL Causes Necrotic Membrane Disruption upon Phosphorylation by RIP3

(2014) Huayi Wang et al.   MOLECULAR CELL

Dietary modulation of the microbiome affects autoinflammatory disease

(2014) John R. Lukens et al.   NATURE

Mutation of NLRC4 causes a syndrome of enterocolitis and autoinflammation

(2014) Neil Romberg et al.   NATURE GENETICS

An activating NLRC4 inflammasome mutation causes autoinflammation with recurrent macrophage activation syndrome

(2014) Scott W Canna et al.   NATURE GENETICS

Critical role for inflammasome-independent IL-1  production in osteomyelitis

(2014) J. R. Lukens et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RIP1 suppresses innate immune necrotic as well as apoptotic cell death during mammalian parturition

(2014) W. J. Kaiser et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular mechanisms of regulated necrosis

(2014) Lorenzo Galluzzi et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Chronic Inflammation and Cytokines in the Tumor Microenvironment

(2014) Glauben Landskron et al.   Journal of Immunology Research

RIPK3 contributes to TNFR1-mediated RIPK1 kinase-dependent apoptosis in conditions of cIAP1/2 depletion or TAK1 kinase inhibition

(2013) Y Dondelinger et al.   CELL DEATH AND DIFFERENTIATION

AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC

(2013) V Sagulenko et al.   CELL DEATH AND DIFFERENTIATION

Toll-like Receptor 3-mediated Necrosis via TRIF, RIP3, and MLKL

(2013) William J. Kaiser et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RIP1-driven autoinflammation targets IL-1α independently of inflammasomes and RIP3

(2013) John R. Lukens et al.   NATURE

Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis

(2013) Zhenyu Cai et al.   NATURE CELL BIOLOGY

Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

(2012) Liming Sun et al.   CELL

AIM2/ASC triggers caspase-8-dependent apoptosis in Francisella-infected caspase-1-deficient macrophages

(2012) R Pierini et al.   CELL DEATH AND DIFFERENTIATION

Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis

(2012) J. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interleukin-1β inhibition and the prevention of recurrent cardiovascular events: Rationale and Design of the Canakinumab Anti-inflammatory Thrombosis Outcomes Study (CANTOS)

(2011) Paul M Ridker et al.   AMERICAN HEART JOURNAL

Programmed Cell Death in Animal Development and Disease

(2011) Yaron Fuchs et al.   CELL

Caspase-1 Protein Induces Apoptosis-associated Speck-like Protein Containing a Caspase Recruitment Domain (ASC)-mediated Necrosis Independently of Its Catalytic Activity

(2011) Kou Motani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Ripoptosome, a Signaling Platform that Assembles in Response to Genotoxic Stress and Loss of IAPs

(2011) Tencho Tenev et al.   MOLECULAR CELL

Catalytic activity of the caspase-8–FLIPL complex inhibits RIPK3-dependent necrosis

(2011) Andrew Oberst et al.   NATURE

Cutting Edge: Proteolytic Inactivation of Poly(ADP-Ribose) Polymerase 1 by the Nlrp3 and Nlrc4 Inflammasomes

(2010) R. K. S. Malireddi et al.   JOURNAL OF IMMUNOLOGY

Nek7 kinase targeting leads to early mortality, cytokinesis disturbance and polyploidy

(2010) H Salem et al.   ONCOGENE

Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation

(2009) YoungSik Cho et al.   CELL

Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α

(2009) Sudan He et al.   CELL

Glyburide inhibits the Cryopyrin/Nalp3 inflammasome

(2009) Mohamed Lamkanfi et al.   JOURNAL OF CELL BIOLOGY

Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

(2009) F. G. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

RIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis

(2009) D.-W. Zhang et al.   SCIENCE

Neuronal cell death in neurodegenerative diseases: recurring themes around protein handling

(2008) Adrienne M. Gorman   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Targeted Peptidecentric Proteomics Reveals Caspase-7 as a Substrate of the Caspase-1 Inflammasomes

(2008) Mohamed Lamkanfi et al.   MOLECULAR & CELLULAR PROTEOMICS

Identification of RIP1 kinase as a specific cellular target of necrostatins

(2008) Alexei Degterev et al.   Nature Chemical Biology