DPP9 sequesters the C terminus of NLRP1 to repress inflammasome activation

Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes

(2021) L. Robert Hollingsworth et al.   Nature Communications

Structural and biochemical mechanisms of NLRP1 inhibition by DPP9

(2021) Menghang Huang et al.   NATURE

Estimation of high-order aberrations and anisotropic magnification from cryo-EM data sets in RELION-3.1

(2020) Jasenko Zivanov et al.   IUCrJ

The NLRP1 and CARD8 inflammasomes

(2020) Cornelius Y. Taabazuing et al.   IMMUNOLOGICAL REVIEWS

GemSpot: A Pipeline for Robust Modeling of Ligands into Cryo-EM Maps

(2020) Michael J. Robertson et al.   STRUCTURE

Activation of the CARD8 Inflammasome Requires a Disordered Region

(2020) Ashley J. Chui et al.   Cell Reports

N-terminal degradation activates the NLRP1B inflammasome

(2019) Ashley J. Chui et al.   SCIENCE

Functional degradation: A mechanism of NLRP1 inflammasome activation by diverse pathogen enzymes

(2019) Andrew Sandstrom et al.   SCIENCE

DPP9’s Enzymatic Activity and Not Its Binding to CARD8 Inhibits Inflammasome Activation

(2019) Andrew R. Griswold et al.   ACS Chemical Biology

Deriving and refining atomic models in crystallography and cryo-EM: the latest Phenix tools to facilitate structure analysis

(2019) Bruno P. Klaholz   Acta Crystallographica Section D-Structural Biology

The NLRP1 inflammasome: new mechanistic insights and unresolved mysteries

(2019) Patrick S Mitchell et al.   CURRENT OPINION IN IMMUNOLOGY

Structural and mechanistic elucidation of inflammasome signaling by cryo-EM

(2019) Chen Shen et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

High-density chemical cross-linking for modeling protein interactions

(2019) Julian Mintseris et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The dTAG system for immediate and target-specific protein degradation

(2018) Behnam Nabet et al.   Nature Chemical Biology

DPP8/DPP9 inhibitor-induced pyroptosis for treatment of acute myeloid leukemia

(2018) Darren C. Johnson et al.   NATURE MEDICINE

Structures and mechanism of dipeptidyl peptidases 8 and 9, important players in cellular homeostasis and cancer

(2018) Breyan Ross et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structures of a bacterial dipeptidyl peptidase IV reveal a novel substrate recognition mechanism distinct from that of mammalian orthologues

(2018) Saori Roppongi et al.   Scientific Reports

Human DPP9 represses NLRP1 inflammasome and protects against autoinflammatory diseases via both peptidase activity and FIIND domain binding

(2018) Franklin L. Zhong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

goCTF: Geometrically optimized CTF determination for single-particle cryo-EM

(2018) Min Su   JOURNAL OF STRUCTURAL BIOLOGY

New tools for automated high-resolution cryo-EM structure determination in RELION-3

(2018) Jasenko Zivanov et al.   eLife

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

UCSF ChimeraX: Meeting modern challenges in visualization and analysis

(2017) Thomas D. Goddard et al.   PROTEIN SCIENCE

Measuring the effects of particle orientation to improve the efficiency of electron cryomicroscopy

(2017) Katerina Naydenova et al.   Nature Communications

A new autoinflammatory and autoimmune syndrome associated with NLRP1 mutations: NAIAD ( NLRP1- associated autoinflammation with arthritis and dyskeratosis)

(2016) Sylvie Grandemange et al.   ANNALS OF THE RHEUMATIC DISEASES

Germline NLRP1 Mutations Cause Skin Inflammatory and Cancer Susceptibility Syndromes via Inflammasome Activation

(2016) Franklin L. Zhong et al.   CELL

DPP8 and DPP9 inhibition induces pro-caspase-1-dependent monocyte and macrophage pyroptosis

(2016) Marian C Okondo et al.   Nature Chemical Biology

CTFFIND4: Fast and accurate defocus estimation from electron micrographs

(2015) Alexis Rohou et al.   JOURNAL OF STRUCTURAL BIOLOGY

XSEDE: Accelerating Scientific Discovery

(2014) John Towns et al.   COMPUTING IN SCIENCE & ENGINEERING

Whole exome sequencing identifies a mutation for a novel form of corneal intraepithelial dyskeratosis

(2013) Vincent José Soler et al.   JOURNAL OF MEDICAL GENETICS

Quantifying the local resolution of cryo-EM density maps

(2013) Alp Kucukelbir et al.   NATURE METHODS

Collaboration gets the most out of software

(2013) Andrew Morin et al.   eLife

Autolytic Proteolysis within the Function to Find Domain (FIIND) Is Required for NLRP1 Inflammasome Activity

(2012) Joshua N. Finger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of the ZU5-ZU5-UPA-DD tandem of ankyrin-B reveals interaction surfaces necessary for ankyrin function

(2012) C. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteolytic Processing of Nlrp1b Is Required for Inflammasome Activity

(2012) Bradley C. Frew et al.   PLoS Pathogens

CARD8 and NLRP1 Undergo Autoproteolytic Processing through a ZU5-Like Domain

(2011) Andrea D'Osualdo et al.   PLoS One

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The Cytoplasmic Peptidase DPP9 Is Rate-limiting for Degradation of Proline-containing Peptides

(2009) Ruth Geiss-Friedlander et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autoinhibition of UNC5b Revealed by the Cytoplasmic Domain Structure of the Receptor

(2009) Rui Wang et al.   MOLECULAR CELL