Cleavage of GSDME by caspase-3 determines lobaplatin-induced pyroptosis in colon cancer cells

GSDME mediates caspase-3-dependent pyroptosis in gastric cancer

(2018) Yubin Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mass Spectrometry-based Structural Analysis and Systems Immunoproteomics Strategies for Deciphering the Host Response to Endotoxin

(2018) Mohd M. Khan et al.   JOURNAL OF MOLECULAR BIOLOGY

A randomized and open-label phase II trial reports the efficacy of neoadjuvant lobaplatin in breast cancer

(2018) Xiujuan Wu et al.   Nature Communications

Tom20 senses iron-activated ROS signaling to promote melanoma cell pyroptosis 

(2018) Bo Zhou et al.   CELL RESEARCH

Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection

(2018) Joseph Sarhan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathogen blockade of TAK1 triggers caspase-8–dependent cleavage of gasdermin D and cell death

(2018) Pontus Orning et al.   SCIENCE

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

(2017) Yupeng Wang et al.   NATURE

Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death

(2017) Corey Rogers et al.   Nature Communications

DFNA5 promoter methylation a marker for breast tumorigenesis

(2017) Lieselot Croes et al.   Oncotarget

Lobaplatin induces BGC-823 human gastric carcinoma cell apoptosis via ROS- mitochondrial apoptotic pathway and impairs cell migration and invasion

(2016) Yali Li et al.   BIOMEDICINE & PHARMACOTHERAPY

Oxidation of ion channels in the aging nervous system

(2016) Rahul Patel et al.   BRAIN RESEARCH

Cancer statistics in China, 2015

(2016) Wanqing Chen et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Pore-forming activity and structural autoinhibition of the gasdermin family

(2016) Jingjin Ding et al.   NATURE

Programmed necrosis in inflammation: Toward identification of the effector molecules

(2016) D. Wallach et al.   SCIENCE

Lobaplatin arrests cell cycle progression, induces apoptosis and impairs migration and invasion in B16-F10 melanoma cell line in vitro

(2015) Fangfang Yang et al.   BIOMEDICINE & PHARMACOTHERAPY

Caspase-11 Requires the Pannexin-1 Channel and the Purinergic P2X7 Pore to Mediate Pyroptosis and Endotoxic Shock

(2015) Dahai Yang et al.   IMMUNITY

Pyroptotic cell death defends against intracellular pathogens

(2015) Ine Jorgensen et al.   IMMUNOLOGICAL REVIEWS

HCV upregulates Bim through the ROS/JNK signalling pathway, leading to Bax-mediated apoptosis

(2015) Lin Deng et al.   JOURNAL OF GENERAL VIROLOGY

NLRP1 inflammasome is activated in patients with medial temporal lobe epilepsy and contributes to neuronal pyroptosis in amygdala kindling-induced rat model

(2015) Chen-Chen Tan et al.   Journal of Neuroinflammation

Maintenance strategies after first-line oxaliplatin plus fluoropyrimidine plus bevacizumab for patients with metastatic colorectal cancer (AIO 0207): a randomised, non-inferiority, open-label, phase 3 trial

(2015) Susanna Hegewisch-Becker et al.   LANCET ONCOLOGY

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Celastrol induces apoptosis and autophagy via the ROS/JNK signaling pathway in human osteosarcoma cells: an in vitro and in vivo study

(2015) H-Y Li et al.   Cell Death & Disease

Death-Defining Immune Responses After Apoptosis

(2014) L. Campisi et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Adverse Immunoregulatory Effects of 5FU and CPT11 Chemotherapy on Myeloid-Derived Suppressor Cells and Colorectal Cancer Outcomes

(2014) J. Kanterman et al.   CANCER RESEARCH

Mechanisms and Functions of Inflammasomes

(2014) Mohamed Lamkanfi et al.   CELL

Inflammatory caspases are innate immune receptors for intracellular LPS

(2014) Jianjin Shi et al.   NATURE

Activation of p38/JNK Pathway Is Responsible for Embelin Induced Apoptosis in Lung Cancer Cells: Transitional Role of Reactive Oxygen Species

(2014) Deepa R. Avisetti et al.   PLoS One

Lobaplatin inhibits growth of gastric cancer cells by inducing apoptosis

(2014) Chu-Yang Yin   WORLD JOURNAL OF GASTROENTEROLOGY

Amyloid-β induces NLRP1-dependent neuronal pyroptosis in models of Alzheimer’s disease

(2014) M-S Tan et al.   Cell Death & Disease

Follow-up After Curative Resection of Colorectal Cancer

(2013) Bridget N. Fahy   ANNALS OF SURGICAL ONCOLOGY

The expression and regulation of DFNA5 in human hepatocellular carcinoma DFNA5 in hepatocellular carcinoma

(2013) Cong-Jun Wang et al.   MOLECULAR BIOLOGY REPORTS

Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection

(2013) Gilad Doitsh et al.   NATURE

Cytoplasmic LPS Activates Caspase-11: Implications in TLR4-Independent Endotoxic Shock

(2013) J. A. Hagar et al.   SCIENCE

Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4

(2013) N. Kayagaki et al.   SCIENCE

Effects of lobaplatin as a single agent and in combination with TRAIL on the growth of triple-negative p53-mutated breast cancers in vitro

(2012) Jörg B. Engel et al.   ANTI-CANCER DRUGS

Shedding Light on Apoptosis at Subcellular Membranes

(2012) Justin Kale et al.   CELL

NLRP1-Dependent Pyroptosis Leads to Acute Lung Injury and Morbidity in Mice

(2012) M. Kovarova et al.   JOURNAL OF IMMUNOLOGY

Genetic heterogeneity and cancer drug resistance

(2012) Nicholas C Turner et al.   LANCET ONCOLOGY

Non-canonical inflammasome activation targets caspase-11

(2011) Nobuhiko Kayagaki et al.   NATURE

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

Necroptosis, necrosis and secondary necrosis converge on similar cellular disintegration features

(2009) T Vanden Berghe et al.   CELL DEATH AND DIFFERENTIATION

Methylation of the DFNA5 increases risk of lymph node metastasis in human breast cancer

(2008) Myoung Sook Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Aberrant promoter methylation and tumor suppressive activity of the DFNA5 gene in colorectal carcinoma

(2008) M S Kim et al.   ONCOGENE