标题
Programming inflammatory cell death for therapy
作者
关键词
Pyroptosis, Apoptosis, Necroptosis, PANoptosis, PANoptosome, Inflammation, RIPK1, RIPK3, MLKL, NLRP3, Caspase-1, ASC, Caspase-8, Caspase-3, caspase-7, ZBP1, TNFα, IFNγ, IL-1, Inflammasome
出版物
PHARMACOLOGY & THERAPEUTICS
Volume -, Issue -, Pages 108010
出版商
Elsevier BV
发表日期
2021-10-05
DOI
10.1016/j.pharmthera.2021.108010
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Protective effect of necrosulfonamide on rat pulmonary ischemia-reperfusion injury via inhibition of necroptosis
- (2021) Satoshi Ueda et al. JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
- Cryo-EM structural analysis of FADD:Caspase-8 complexes defines the catalytic dimer architecture for co-ordinated control of cell fate
- (2021) Joanna L. Fox et al. Nature Communications
- DPP9 sequesters the C terminus of NLRP1 to repress inflammasome activation
- (2021) L. Robert Hollingsworth et al. NATURE
- Structural and biochemical mechanisms of NLRP1 inhibition by DPP9
- (2021) Menghang Huang et al. NATURE
- Gasdermin E permits interleukin-1 beta release in distinct sublytic and pyroptotic phases
- (2021) Bowen Zhou et al. Cell Reports
- AIM2 forms a complex with pyrin and ZBP1 to drive PANoptosis and host defence
- (2021) SangJoon Lee et al. NATURE
- The ‘cytokine storm’: molecular mechanisms and therapeutic prospects
- (2021) Rajendra Karki et al. TRENDS IN IMMUNOLOGY
- Hierarchical Cell Death Program Disrupts the Intracellular Niche Required for Burkholderia thailandensis Pathogenesis
- (2021) David E. Place et al. mBio
- Caspases in Cell Death, Inflammation, and Gasdermin-Induced Pyroptosis
- (2020) Sannula Kesavardhana et al. Annual Review of Immunology
- Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense
- (2020) Min Zheng et al. CELL
- Toward targeting inflammasomes: insights into their regulation and activation
- (2020) Shelbi Christgen et al. CELL RESEARCH
- The Zα2 domain of ZBP1 is a molecular switch regulating influenza-induced PANoptosis and perinatal lethality during development
- (2020) Sannula Kesavardhana et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation
- (2020) Jun Jacob Hu et al. NATURE IMMUNOLOGY
- Identification of the PANoptosome: A Molecular Platform Triggering Pyroptosis, Apoptosis, and Necroptosis (PANoptosis)
- (2020) Shelbi Christgen et al. Frontiers in Cellular and Infection Microbiology
- Evaluation of IL-1 Blockade as an Adjunct to Linezolid Therapy for Tuberculosis in Mice and Macaques
- (2020) Caylin G. Winchell et al. Frontiers in Immunology
- Impaired NLRP3 inflammasome activation/pyroptosis leads to robust inflammatory cell death via caspase-8/RIPK3 during coronavirus infection
- (2020) Min Zheng et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- An Apoptotic Caspase Network Safeguards Cell Death Induction in Pyroptotic Macrophages
- (2020) Nathalia Moraes de Vasconcelos et al. Cell Reports
- Interferon regulatory factor 1 regulates PANoptosis to prevent colorectal cancer
- (2020) Rajendra Karki et al. JCI Insight
- Succination inactivates gasdermin D and blocks pyroptosis
- (2020) Fiachra Humphries et al. SCIENCE
- ZBP1 promotes fungi-induced inflammasome activation and pyroptosis, apoptosis, and necroptosis (PANoptosis)
- (2020) Balaji Banoth et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- PANoptosis in microbial infection
- (2020) David E Place et al. CURRENT OPINION IN MICROBIOLOGY
- Cleavage of GSDME by caspase-3 determines lobaplatin-induced pyroptosis in colon cancer cells
- (2019) Junhui Yu et al. Cell Death & Disease
- Chemotherapeutic paclitaxel and cisplatin differentially induce pyroptosis in A549 lung cancer cells via caspase-3/GSDME activation
- (2019) Cheng-cheng Zhang et al. APOPTOSIS
- Ubiquitin Ligases cIAP1 and cIAP2 Limit Cell Death to Prevent Inflammation
- (2019) Jieqiong Zhang et al. Cell Reports
- Caspases in Cell Death, Inflammation, and Disease
- (2019) Nina Van Opdenbosch et al. IMMUNITY
- Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome
- (2019) Humayun Sharif et al. NATURE
- Caspase-1 initiates apoptosis in the absence of gasdermin D
- (2019) Kohsuke Tsuchiya et al. Nature Communications
- Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis
- (2019) Kim Newton et al. NATURE
- DDX3X acts as a live-or-die checkpoint in stressed cells by regulating NLRP3 inflammasome
- (2019) Parimal Samir et al. NATURE
- Inflammasomes and the fine line between defense and disease
- (2019) Shelbi Christgen et al. CURRENT OPINION IN IMMUNOLOGY
- Innate immune priming in the absence of TAK1 drives RIPK1 kinase activity–independent pyroptosis, apoptosis, necroptosis, and inflammatory disease
- (2019) R.K. Subbarao Malireddi et al. JOURNAL OF EXPERIMENTAL MEDICINE
- GSDME mediates caspase-3-dependent pyroptosis in gastric cancer
- (2018) Yubin Wang et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- TAK1 restricts spontaneous NLRP3 activation and cell death to control myeloid proliferation
- (2018) R.K. Subbarao Malireddi et al. JOURNAL OF EXPERIMENTAL MEDICINE
- IRF1 Is a Transcriptional Regulator of ZBP1 Promoting NLRP3 Inflammasome Activation and Cell Death during Influenza Virus Infection
- (2018) Teneema Kuriakose et al. JOURNAL OF IMMUNOLOGY
- Venetoclax–Rituximab in Relapsed or Refractory Chronic Lymphocytic Leukemia
- (2018) John F. Seymour et al. NEW ENGLAND JOURNAL OF MEDICINE
- Regulation of a distinct activated RIPK1 intermediate bridging complex I and complex II in TNFα-mediated apoptosis
- (2018) Palak Amin et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity
- (2018) Hongbin He et al. Nature Communications
- Necrosulfonamide Attenuates Spinal Cord Injury via Necroptosis Inhibition
- (2018) Yongxiang Wang et al. World Neurosurgery
- ASC- and caspase-8-dependent apoptotic pathway diverges from the NLRC4 inflammasome in macrophages
- (2018) Bettina L. Lee et al. Scientific Reports
- Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection
- (2018) Joseph Sarhan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Pathogen blockade of TAK1 triggers caspase-8–dependent cleavage of gasdermin D and cell death
- (2018) Pontus Orning et al. SCIENCE
- ZBP1/DAI ubiquitination and sensing of influenza vRNPs activate programmed cell death
- (2017) Sannula Kesavardhana et al. JOURNAL OF EXPERIMENTAL MEDICINE
- MLKL Activation Triggers NLRP3-Mediated Processing and Release of IL-1β Independently of Gasdermin-D
- (2017) Kimberley D. Gutierrez et al. JOURNAL OF IMMUNOLOGY
- Development of an Acrylate Derivative Targeting the NLRP3 Inflammasome for the Treatment of Inflammatory Bowel Disease
- (2017) Mattia Cocco et al. JOURNAL OF MEDICINAL CHEMISTRY
- Effect of interleukin-1β inhibition with canakinumab on incident lung cancer in patients with atherosclerosis: exploratory results from a randomised, double-blind, placebo-controlled trial
- (2017) Paul M Ridker et al. LANCET
- Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease
- (2017) Paul M Ridker et al. NEW ENGLAND JOURNAL OF MEDICINE
- Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner
- (2017) Stephanie A. Conos et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death
- (2017) Jianjin Shi et al. TRENDS IN BIOCHEMICAL SCIENCES
- Complex Pathologic Roles of RIPK1 and RIPK3: Moving Beyond Necroptosis
- (2017) Kelby W. Wegner et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Regulation of RIPK1 activation by TAK1-mediated phosphorylation dictates apoptosis and necroptosis
- (2017) Jiefei Geng et al. Nature Communications
- Caspase-1 Engagement and TLR-Induced c-FLIP Expression Suppress ASC/Caspase-8-Dependent Apoptosis by Inflammasome Sensors NLRP1b and NLRC4
- (2017) Nina Van Opdenbosch et al. Cell Reports
- Inhibition of caspase-1 or gasdermin-D enable caspase-8 activation in the Naip5/NLRC4/ASC inflammasome
- (2017) Danielle P. A. Mascarenhas et al. PLoS Pathogens
- GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death
- (2016) Lorenzo Sborgi et al. EMBO JOURNAL
- Cryo-EM Structure of Caspase-8 Tandem DED Filament Reveals Assembly and Regulation Mechanisms of the Death-Inducing Signaling Complex
- (2016) Tian-Min Fu et al. MOLECULAR CELL
- RIPK1 inhibits ZBP1-driven necroptosis during development
- (2016) Kim Newton et al. NATURE
- RIPK1 counteracts ZBP1-mediated necroptosis to inhibit inflammation
- (2016) Juan Lin et al. NATURE
- NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux
- (2016) Yuan He et al. NATURE
- NLRP3 inflammasome plays a redundant role with caspase 8 to promote IL-1β–mediated osteomyelitis
- (2016) Prajwal Gurung et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes
- (2016) Robin A. Aglietti et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Holding RIPK1 on the Ubiquitin Leash in TNFR1 Signaling
- (2016) Nieves Peltzer et al. TRENDS IN CELL BIOLOGY
- Molecular architecture of the DED chains at the DISC: regulation of procaspase-8 activation by short DED proteins c-FLIP and procaspase-8 prodomain
- (2015) K Schleich et al. CELL DEATH AND DIFFERENTIATION
- Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion
- (2015) Wan-ting He et al. CELL RESEARCH
- Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling
- (2015) Nobuhiko Kayagaki et al. NATURE
- Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
- (2015) Jianjin Shi et al. NATURE
- NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component
- (2015) Hexin Shi et al. NATURE IMMUNOLOGY
- A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases
- (2015) Rebecca C Coll et al. NATURE MEDICINE
- RIPK1 Blocks Early Postnatal Lethality Mediated by Caspase-8 and RIPK3
- (2014) Christopher P. Dillon et al. CELL
- FADD and Caspase-8 Mediate Priming and Activation of the Canonical and Noncanonical Nlrp3 Inflammasomes
- (2014) P. Gurung et al. JOURNAL OF IMMUNOLOGY
- Mixed Lineage Kinase Domain-like Protein MLKL Causes Necrotic Membrane Disruption upon Phosphorylation by RIP3
- (2014) Huayi Wang et al. MOLECULAR CELL
- Dietary modulation of the microbiome affects autoinflammatory disease
- (2014) John R. Lukens et al. NATURE
- Mutation of NLRC4 causes a syndrome of enterocolitis and autoinflammation
- (2014) Neil Romberg et al. NATURE GENETICS
- An activating NLRC4 inflammasome mutation causes autoinflammation with recurrent macrophage activation syndrome
- (2014) Scott W Canna et al. NATURE GENETICS
- Critical role for inflammasome-independent IL-1 production in osteomyelitis
- (2014) J. R. Lukens et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- RIP1 suppresses innate immune necrotic as well as apoptotic cell death during mammalian parturition
- (2014) W. J. Kaiser et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Molecular mechanisms of regulated necrosis
- (2014) Lorenzo Galluzzi et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Chronic Inflammation and Cytokines in the Tumor Microenvironment
- (2014) Glauben Landskron et al. Journal of Immunology Research
- RIPK3 contributes to TNFR1-mediated RIPK1 kinase-dependent apoptosis in conditions of cIAP1/2 depletion or TAK1 kinase inhibition
- (2013) Y Dondelinger et al. CELL DEATH AND DIFFERENTIATION
- AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC
- (2013) V Sagulenko et al. CELL DEATH AND DIFFERENTIATION
- Toll-like Receptor 3-mediated Necrosis via TRIF, RIP3, and MLKL
- (2013) William J. Kaiser et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- RIP1-driven autoinflammation targets IL-1α independently of inflammasomes and RIP3
- (2013) John R. Lukens et al. NATURE
- Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis
- (2013) Zhenyu Cai et al. NATURE CELL BIOLOGY
- Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase
- (2012) Liming Sun et al. CELL
- AIM2/ASC triggers caspase-8-dependent apoptosis in Francisella-infected caspase-1-deficient macrophages
- (2012) R Pierini et al. CELL DEATH AND DIFFERENTIATION
- Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis
- (2012) J. Zhao et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Interleukin-1β inhibition and the prevention of recurrent cardiovascular events: Rationale and Design of the Canakinumab Anti-inflammatory Thrombosis Outcomes Study (CANTOS)
- (2011) Paul M Ridker et al. AMERICAN HEART JOURNAL
- Programmed Cell Death in Animal Development and Disease
- (2011) Yaron Fuchs et al. CELL
- Caspase-1 Protein Induces Apoptosis-associated Speck-like Protein Containing a Caspase Recruitment Domain (ASC)-mediated Necrosis Independently of Its Catalytic Activity
- (2011) Kou Motani et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Ripoptosome, a Signaling Platform that Assembles in Response to Genotoxic Stress and Loss of IAPs
- (2011) Tencho Tenev et al. MOLECULAR CELL
- Catalytic activity of the caspase-8–FLIPL complex inhibits RIPK3-dependent necrosis
- (2011) Andrew Oberst et al. NATURE
- Cutting Edge: Proteolytic Inactivation of Poly(ADP-Ribose) Polymerase 1 by the Nlrp3 and Nlrc4 Inflammasomes
- (2010) R. K. S. Malireddi et al. JOURNAL OF IMMUNOLOGY
- Nek7 kinase targeting leads to early mortality, cytokinesis disturbance and polyploidy
- (2010) H Salem et al. ONCOGENE
- Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation
- (2009) YoungSik Cho et al. CELL
- Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α
- (2009) Sudan He et al. CELL
- Glyburide inhibits the Cryopyrin/Nalp3 inflammasome
- (2009) Mohamed Lamkanfi et al. JOURNAL OF CELL BIOLOGY
- Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression
- (2009) F. G. Bauernfeind et al. JOURNAL OF IMMUNOLOGY
- RIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis
- (2009) D.-W. Zhang et al. SCIENCE
- Neuronal cell death in neurodegenerative diseases: recurring themes around protein handling
- (2008) Adrienne M. Gorman JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Targeted Peptidecentric Proteomics Reveals Caspase-7 as a Substrate of the Caspase-1 Inflammasomes
- (2008) Mohamed Lamkanfi et al. MOLECULAR & CELLULAR PROTEOMICS
- Identification of RIP1 kinase as a specific cellular target of necrostatins
- (2008) Alexei Degterev et al. Nature Chemical Biology
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationPublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More