Synovial inflammation in osteoarthritis progression

Molecular mechanisms of mechanical load-induced osteoarthritis

(2021) Tianshun Fang et al.   INTERNATIONAL ORTHOPAEDICS

Role of Metabolic Endotoxemia in Systemic Inflammation and Potential Interventions

(2021) Shireen Mohammad et al.   Frontiers in Immunology

The Damage-Associated Molecular Patterns (DAMPs) as Potential Targets to Treat Osteoarthritis: Perspectives From a Review of the Literature

(2021) Cécile Lambert et al.   Frontiers in Medicine

The histopathological synovitis score is influenced by biopsy location in patients with knee osteoarthritis

(2021) Haider Mussawy et al.   ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY

Osteoarthritis in 2020 and beyond – Authors' reply

(2021) David J Hunter et al.   LANCET

Elevation of Pro-Inflammatory Cytokine Levels Following Intra-Articular Fractures—A Systematic Review

(2021) That Minh Pham et al.   Cells

Detection of Osteoarthritis Inflammation by Single-Photon Emission Computed Tomography Based on an Inflammation-Targeting Peptide cFLFLF

(2021) Xinlin Yang et al.   MOLECULAR IMAGING AND BIOLOGY

Fundamentals of OA. An initiative of Osteoarthritis and Cartilage. Chapter 9: Obesity and metabolic factors in OA

(2021) Albert Batushansky et al.   OSTEOARTHRITIS AND CARTILAGE

Cell Interplay in Osteoarthritis

(2021) Zihao Li et al.   Frontiers in Cell and Developmental Biology

Synovial tissue from sites of joint pain in knee osteoarthritis patients exhibits a differential phenotype with distinct fibroblast subsets

(2021) Dominika E Nanus et al.   EBioMedicine

Imaging inflammation in atherosclerotic plaques, targeting SST2 with [111In]In-DOTA-JR11

(2020) Eric J. Meester et al.   JOURNAL OF NUCLEAR CARDIOLOGY

Early stage blockade of the alarmin HMGB1 reduces cartilage destruction in experimental OA

(2020) C. Aulin et al.   OSTEOARTHRITIS AND CARTILAGE

Prematurely aging mitochondrial DNA mutator mice display subchondral osteopenia and chondrocyte hypertrophy without further osteoarthritis features

(2020) Jeroen Geurts et al.   Scientific Reports

Identification of cartilage microbial DNA signatures and associations with knee and hip osteoarthritis

(2020) Christopher M. Dunn et al.   Arthritis & Rheumatology

Does cartilage loss cause pain in osteoarthritis and if so, how much?

(2020) Kathryn Bacon et al.   ANNALS OF THE RHEUMATIC DISEASES

Targeting Fibroblast Activation Protein: Radiosynthesis and Preclinical Evaluation of an 18F-labeled FAP Inhibitor

(2020) Johannes Toms et al.   JOURNAL OF NUCLEAR MEDICINE

High-fat feeding primes the mouse knee joint to develop osteoarthritis and pathologic infrapatellar fat pad changes after surgically induced injury

(2020) K. Warmink et al.   OSTEOARTHRITIS AND CARTILAGE

Single cell SOX9 dynamics reveals differential DNA binding in subpopulations of human chondrocytes

(2020) K. Govindaraj et al.   OSTEOARTHRITIS AND CARTILAGE

Expression of granulocyte macrophage-colony stimulating factor and its receptor in the synovium of osteoarthritis patients is negatively correlated with pain

(2020) Eefje M van Helvoort et al.   RHEUMATOLOGY

Transcriptional profiling of murine macrophages stimulated with cartilage fragments revealed a strategy for treatment of progressive osteoarthritis

(2020) Masanari Hamasaki et al.   Scientific Reports

Increase in Tryptase and Its Role in the Synovial Membrane of Overweight and Obese Patients with Osteoarthritis of the Knee

(2020) Ken Takata et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

Effects of Interleukin-1β Inhibition on Incident Hip and Knee Replacement

(2020) Matthias Schieker et al.   ANNALS OF INTERNAL MEDICINE

A Promising Treatment for Osteoarthritis?

(2020) Nancy Lane et al.   ANNALS OF INTERNAL MEDICINE

The impact of a significant weight loss on inflammation assessed on DCE-MRI and static MRI in knee osteoarthritis: a prospective cohort study

(2020) C.L. Daugaard et al.   OSTEOARTHRITIS AND CARTILAGE

Obese and overweight individuals have greater knee synovial inflammation and associated structural and cartilage compositional degeneration: data from the osteoarthritis initiative

(2020) Thanat Kanthawang et al.   SKELETAL RADIOLOGY

Synergistic roles of macrophages and neutrophils in osteoarthritis progression

(2020) Ming‐Feng Hsueh et al.   Arthritis & Rheumatology

T Helper Cell Infiltration in Osteoarthritis-Related Knee Pain and Disability

(2020) Timo Albert Nees et al.   Journal of Clinical Medicine

Effectiveness of Curcuma longa Extract for the Treatment of Symptoms and Effusion–Synovitis of Knee Osteoarthritis

(2020) Zhiqiang Wang et al.   ANNALS OF INTERNAL MEDICINE

Efficacy of tocilizumab in patients with hand osteoarthritis: double blind, randomised, placebo-controlled, multicentre trial

(2020) Pascal Richette et al.   ANNALS OF THE RHEUMATIC DISEASES

Infrapatellar fat pads participate in the development of knee osteoarthritis in obese patients via the activation of the NF‑κB signaling pathway

(2020) Lijun Duan et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Peripheral pain mechanisms in osteoarthritis

(2020) Tonia L. Vincent   PAIN

The evolution of nerve growth factor inhibition in clinical medicine

(2020) Barton L. Wise et al.   Nature Reviews Rheumatology

Mitochondria: Potential Targets for Osteoarthritis

(2020) Xingjia Mao et al.   Frontiers in Medicine

Metabolic osteoarthritis – relation of diabetes and cardiovascular disease with knee osteoarthritis

(2020) L. Kuusalo et al.   OSTEOARTHRITIS AND CARTILAGE

Time course analyses of structural changes in the infrapatellar fat pad and synovial membrane during inflammation-induced persistent pain development in rat knee joint

(2019) Kei Inomata et al.   BMC MUSCULOSKELETAL DISORDERS

Associations of symptomatic knee OA with histopathologic features in subchondral bone

(2019) Koji Aso et al.   Arthritis & Rheumatology

Effect of Vitamin D supplementation on synovial tissue volume and subchondral bone marrow lesion volume in symptomatic knee osteoarthritis

(2019) Thomas A. Perry et al.   BMC MUSCULOSKELETAL DISORDERS

Transforming growth factor-β stimulates nerve growth factor production in osteoarthritic synovium

(2019) Shotaro Takano et al.   BMC MUSCULOSKELETAL DISORDERS

Choline Uptake and Metabolism Modulate Macrophage IL-1β and IL-18 Production

(2019) Elsa Sanchez-Lopez et al.   Cell Metabolism

The role of macrophages in the resolution of inflammation

(2019) Satoshi Watanabe et al.   JOURNAL OF CLINICAL INVESTIGATION

Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry

(2019) Fan Zhang et al.   NATURE IMMUNOLOGY

SUCNR1 controls an anti-inflammatory program in macrophages to regulate the metabolic response to obesity

(2019) Noelia Keiran et al.   NATURE IMMUNOLOGY

Macrophage Polarization: Different Gene Signatures in M1(LPS+) vs. Classically and M2(LPS–) vs. Alternatively Activated Macrophages

(2019) Marco Orecchioni et al.   Frontiers in Immunology

The Metabolic Signature of Macrophage Responses

(2019) Antonella Viola et al.   Frontiers in Immunology

Dysregulated Inflammatory Response Related to Cartilage Degradation after ACL Injury

(2019) Cale A. Jacobs et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Mediating role of bone marrow lesion, synovitis, pain sensitization, and depressive symptoms on knee pain improvement following substantial weight loss

(2019) S. Reza Jafarzadeh et al.   Arthritis & Rheumatology

Are contrast-enhanced and non-contrast MRI findings reflecting synovial inflammation in knee osteoarthritis: a meta-analysis of observational studies

(2019) D. Shakoor et al.   OSTEOARTHRITIS AND CARTILAGE

Regulation of Gut Microbiota and Metabolic Endotoxemia with Dietary Factors

(2019) Nobuo Fuke et al.   Nutrients

Multiparameter Analysis Identifies Heterogeneity in Knee Osteoarthritis Synovial Responses

(2019) Hannah Labinsky et al.   Arthritis & Rheumatology

Dietary Patterns and Progression of Knee Osteoarthritis: Data from the Osteoarthritis Initiative

(2019) Chang Xu et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Interleukin 1 receptor antagonist (IL1RN) gene variants predict radiographic severity of knee osteoarthritis and risk of incident disease

(2019) Mukundan Attur et al.   ANNALS OF THE RHEUMATIC DISEASES

Association between Bone marrow lesions & synovitis and symptoms in symptomatic knee osteoarthritis

(2019) T.A. Perry et al.   OSTEOARTHRITIS AND CARTILAGE

Housekeeping gene validation for RT-qPCR studies on synovial fibroblasts derived from healthy and osteoarthritic patients with focus on mechanical loading

(2019) Ute Nazet et al.   PLoS One

Cartilage repair in degenerative osteoarthritis mediated by squid type II collagen via immunomodulating activation of M2 macrophages, inhibiting apoptosis and hypertrophy of chondrocytes

(2018) Meilu Dai et al.   BIOMATERIALS

Succinate induces synovial angiogenesis in rheumatoid arthritis through metabolic remodeling and HIF-1α/VEGF axis

(2018) Yi Li et al.   FREE RADICAL BIOLOGY AND MEDICINE

Omega-6 oxylipins generated by soluble epoxide hydrolase are associated with knee osteoarthritis

(2018) Ana M. Valdes et al.   JOURNAL OF LIPID RESEARCH

Role of TrkA signalling and mast cells in the initiation of osteoarthritis pain in the monoiodoacetate model

(2018) J. Sousa-Valente et al.   OSTEOARTHRITIS AND CARTILAGE

NLRP3 as a potentially novel biomarker for the management of osteoarthritis

(2018) M.J. McAllister et al.   OSTEOARTHRITIS AND CARTILAGE

Osteoarthritis induced by destabilization of the medial meniscus is reduced in germ-free mice

(2018) V. Ulici et al.   OSTEOARTHRITIS AND CARTILAGE

The importance of synovial inflammation in osteoarthritis: current evidence from imaging assessments and clinical trials

(2018) X. Wang et al.   OSTEOARTHRITIS AND CARTILAGE

Conventional and biologic disease-modifying anti-rheumatic drugs for osteoarthritis: a meta-analysis of randomized controlled trials

(2018) Monica S M Persson et al.   RHEUMATOLOGY

Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis

(2018) Fumitaka Mizoguchi et al.   Nature Communications

Circulating and Synovial Fluid Heat Shock Protein 70 Are Correlated with Severity in Knee Osteoarthritis

(2018) Srihatach Ngarmukos et al.   Cartilage

Pain-Associated Transcriptome Changes in Synovium of Knee Osteoarthritis Patients

(2018) Anna Bratus-Neuenschwander et al.   Genes

1H NMR metabolomics identifies underlying inflammatory pathology in osteoarthritis and rheumatoid arthritis synovial joints

(2018) James R. Anderson et al.   JOURNAL OF PROTEOME RESEARCH

New mitochondrial DNA synthesis enables NLRP3 inflammasome activation

(2018) Zhenyu Zhong et al.   NATURE

Modern-day environmental factors in the pathogenesis of osteoarthritis

(2018) Francis Berenbaum et al.   Nature Reviews Rheumatology

Associations between serum S100A8/S100A9 and knee symptoms, joint structures and cartilage enzymes in patients with knee osteoarthritis

(2018) G. Ruan et al.   OSTEOARTHRITIS AND CARTILAGE

Knee effusion volume assessed by magnetic resonance imaging and progression of knee osteoarthritis: data from the Osteoarthritis Initiative

(2018) Yuanyuan Wang et al.   RHEUMATOLOGY

OUP accepted manuscript

(2018)   RHEUMATOLOGY

Brief Report: Molecular and structural biomarkers of inflammation at 2 years after acute anterior cruciate ligament injury do not predict structural knee osteoarthritis at 5 years

(2018) Frank W. Roemer et al.   Arthritis & Rheumatology

Association of Changes in Effusion-Synovitis and Progression of Cartilage Damage Over 18 Months in Patients with Osteoarthritis and Meniscal Tear

(2018) Lindsey A. MacFarlane et al.   Arthritis & Rheumatology

Phase IIa, placebo-controlled, randomised study of lutikizumab, an anti-interleukin-1α and anti-interleukin-1β dual variable domain immunoglobulin, in patients with erosive hand osteoarthritis

(2018) Margreet Kloppenburg et al.   ANNALS OF THE RHEUMATIC DISEASES

Nature and nurture of tissue-specific macrophage phenotypes

(2018) Marten A. Hoeksema et al.   ATHEROSCLEROSIS

Mediterranean diet and knee osteoarthritis outcomes: A longitudinal cohort study

(2018) Nicola Veronese et al.   CLINICAL NUTRITION

Hand osteoarthritis: clinical phenotypes, molecular mechanisms and disease management

(2018) Michelle Marshall et al.   Nature Reviews Rheumatology

Molecular expression patterns in the synovium and their association with advanced symptomatic knee osteoarthritis

(2018) L.A. Wyatt et al.   OSTEOARTHRITIS AND CARTILAGE

Association of diabetes mellitus and biomarkers of abnormal glucose metabolism with incident radiographic knee osteoarthritis

(2018) Tara S. Rogers-Soeder et al.   ARTHRITIS CARE & RESEARCH

Genetic inactivation of ZCCHC6 suppresses IL-6 expression and reduces the severity of experimental osteoarthritis in mice

(2018) Mohammad Y. Ansari et al.   Arthritis & Rheumatology

The relationship between the dietary inflammatory index and prevalence of radiographic symptomatic osteoarthritis: data from the Osteoarthritis Initiative

(2017) Nicola Veronese et al.   EUROPEAN JOURNAL OF NUTRITION

Inflammatory Microenvironment Persists After Bone Healing in Intra-articular Ankle Fractures

(2017) Samuel B. Adams et al.   FOOT & ANKLE INTERNATIONAL

Epidemiology of Posttraumatic Osteoarthritis

(2017) Abbey C. Thomas et al.   JOURNAL OF ATHLETIC TRAINING

Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment

(2017) Ok Hee Jeon et al.   NATURE MEDICINE

The association between histological, macroscopic and magnetic resonance imaging assessed synovitis in end-stage knee osteoarthritis: a cross-sectional study

(2017) R.G.C. Riis et al.   OSTEOARTHRITIS AND CARTILAGE

Toward understanding the role of cartilage particulates in synovial inflammation

(2017) A.M. Silverstein et al.   OSTEOARTHRITIS AND CARTILAGE

Knee effusion-synovitis volume measurement and effects of vitamin D supplementation in patients with knee osteoarthritis

(2017) X. Wang et al.   OSTEOARTHRITIS AND CARTILAGE

Histopathological subgroups in knee osteoarthritis

(2017) L.A. Wyatt et al.   OSTEOARTHRITIS AND CARTILAGE

15 years of the histopathological synovitis score, further development and review: A diagnostic score for rheumatology and orthopaedics

(2017) V. Krenn et al.   PATHOLOGY RESEARCH AND PRACTICE

A single recent injury is a potent risk factor for the development of accelerated knee osteoarthritis: data from the osteoarthritis initiative

(2017) Julie E. Davis et al.   RHEUMATOLOGY INTERNATIONAL

Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death

(2017) Jianjin Shi et al.   TRENDS IN BIOCHEMICAL SCIENCES

Metabolic Syndrome, Its Components, and Knee Osteoarthritis: The Framingham Osteoarthritis Study

(2017) Jingbo Niu et al.   Arthritis & Rheumatology

Profibrotic Infrapatellar Fat Pad Remodeling Without M1 Macrophage Polarization Precedes Knee Osteoarthritis in Mice With Diet-Induced Obesity

(2017) Erika Barboza et al.   Arthritis & Rheumatology

Regional Differences Between Perisynovial and Infrapatellar Adipose Tissue Depots and Their Response to Class II and Class III Obesity in Patients With Osteoarthritis

(2017) Natalia S. Harasymowicz et al.   Arthritis & Rheumatology

Conditional Macrophage Depletion Increases Inflammation and Does Not Inhibit the Development of Osteoarthritis in Obese Macrophage Fas-Induced Apoptosis-Transgenic Mice

(2017) Chia-Lung Wu et al.   Arthritis & Rheumatology

Vascular Endothelial Growth Factor in Cartilage Development and Osteoarthritis

(2017) Masashi Nagao et al.   Scientific Reports

CCL2/CCR2, but not CCL5/CCR5, mediates monocyte recruitment, inflammation and cartilage destruction in osteoarthritis

(2016) Harini Raghu et al.   ANNALS OF THE RHEUMATIC DISEASES

Systemic inhibition of IL-6/Stat3 signalling protects against experimental osteoarthritis

(2016) Augustin Latourte et al.   ANNALS OF THE RHEUMATIC DISEASES

NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria

(2016) Zhenyu Zhong et al.   CELL

Moderate-intensity exercise alters markers of alternative activation in circulating monocytes in females: a putative role for PPARγ

(2016) J. S. Ruffino et al.   EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY

Synovitis assessed on static and dynamic contrast-enhanced magnetic resonance imaging and its association with pain in knee osteoarthritis: A cross-sectional study

(2016) Robert G.C. Riis et al.   EUROPEAN JOURNAL OF RADIOLOGY

Association between clinical and sonographic synovitis in patients with painful knee osteoarthritis

(2016) Bita Abbasi et al.   International Journal of Rheumatic Diseases

Inflammatory Cells in Patients with Endstage Knee Osteoarthritis: A Comparison between the Synovium and the Infrapatellar Fat Pad

(2016) I. R. Klein-Wieringa et al.   JOURNAL OF RHEUMATOLOGY

Ageing and the pathogenesis of osteoarthritis

(2016) Richard F. Loeser et al.   Nature Reviews Rheumatology

Characterization of synovial mast cells in knee osteoarthritis: association with clinical parameters

(2016) B.J.E. de Lange-Brokaar et al.   OSTEOARTHRITIS AND CARTILAGE

Synovitis and radiographic progression in non-erosive and erosive hand osteoarthritis: is erosive hand osteoarthritis a separate inflammatory phenotype?

(2016) I.K. Haugen et al.   OSTEOARTHRITIS AND CARTILAGE

Both systemic and local lipopolysaccharide (LPS) burden are associated with knee OA severity and inflammation

(2016) Z.Y. Huang et al.   OSTEOARTHRITIS AND CARTILAGE

Direct in vivo evidence of activated macrophages in human osteoarthritis

(2016) V.B. Kraus et al.   OSTEOARTHRITIS AND CARTILAGE

Synovitis and the risk of knee osteoarthritis: the MOST Study

(2016) D.T. Felson et al.   OSTEOARTHRITIS AND CARTILAGE

Number of Persons With Symptomatic Knee Osteoarthritis in the US: Impact of Race and Ethnicity, Age, Sex, and Obesity

(2016) Bhushan R. Deshpande et al.   ARTHRITIS CARE & RESEARCH

Mitochondrial Dysfunction Prevents Repolarization of Inflammatory Macrophages

(2016) Jan Van den Bossche et al.   Cell Reports

International consensus on the definition and classification of fibrosis of the knee joint

(2016) N. S. Kalson et al.   Bone & Joint Journal

Editorial: Insulin Resistance: Releasing the Brakes on Synovial Inflammation and Osteoarthritis?

(2016) Timothy M. Griffin et al.   Arthritis & Rheumatology

Suppressive Effects of Insulin on Tumor Necrosis Factor-Dependent Early Osteoarthritic Changes Associated With Obesity and Type 2 Diabetes Mellitus

(2016) Daisuke Hamada et al.   Arthritis & Rheumatology

Semiquantitative Imaging Biomarkers of Knee Osteoarthritis Progression: Data From the Foundation for the National Institutes of Health Osteoarthritis Biomarkers Consortium

(2016) Jamie E. Collins et al.   Arthritis & Rheumatology

Association Between Overweight and Obesity and Risk of Clinically Diagnosed Knee, Hip, and Hand Osteoarthritis: A Population-Based Cohort Study

(2016) Carlen Reyes et al.   Arthritis & Rheumatology

Interleukin-6 and chondrocyte mineralisation act in tandem to promote experimental osteoarthritis

(2015) Sonia Nasi et al.   ANNALS OF THE RHEUMATIC DISEASES

Links Between Osteoarthritis and Diabetes

(2015) Sara R. Piva et al.   CLINICS IN GERIATRIC MEDICINE

TGF-β is a potent inducer of Nerve Growth Factor in articular cartilage via the ALK5-Smad2/3 pathway. Potential role in OA related pain?

(2015) E.N. Blaney Davidson et al.   OSTEOARTHRITIS AND CARTILAGE

Inflammation in joint injury and post-traumatic osteoarthritis

(2015) J. Lieberthal et al.   OSTEOARTHRITIS AND CARTILAGE

Bone marrow lesions, subchondral bone cysts and subchondral bone attrition are associated with histological synovitis in patients with end-stage knee osteoarthritis: a cross-sectional study

(2015) A. Yusup et al.   OSTEOARTHRITIS AND CARTILAGE

The impact of early intra-articular administration of interleukin-1 receptor antagonist on lubricin metabolism and cartilage degeneration in an anterior cruciate ligament transection model

(2015) K.A. Elsaid et al.   OSTEOARTHRITIS AND CARTILAGE

Preliminary results of a phase II randomized study to determine the efficacy and safety of genetically engineered allogeneic human chondrocytes expressing TGF-β1 in patients with grade 3 chronic degenerative joint disease of the knee

(2015) J.J. Cherian et al.   OSTEOARTHRITIS AND CARTILAGE

Can Structural Joint Damage Measured with MR Imaging Be Used to Predict Knee Replacement in the Following Year?

(2015) Frank W. Roemer et al.   RADIOLOGY

Unravelling osteoarthritis-related synovial fibrosis: a step closer to solving joint stiffness

(2015) Dennis F. G. Remst et al.   RHEUMATOLOGY

Triamcinolone acetonide activates an anti-inflammatory and folate receptor–positive macrophage that prevents osteophytosis in vivo

(2015) Michiel Siebelt et al.   ARTHRITIS RESEARCH & THERAPY

The involvement of follistatin-like protein 1 in osteoarthritis by elevating NF-κB-mediated inflammatory cytokines and enhancing fibroblast like synoviocyte proliferation

(2015) Su Ni et al.   ARTHRITIS RESEARCH & THERAPY

What Comes First? Multitissue Involvement Leading to Radiographic Osteoarthritis: Magnetic Resonance Imaging-Based Trajectory Analysis Over Four Years in the Osteoarthritis Initiative

(2015) Frank W. Roemer et al.   Arthritis & Rheumatology

Soluble Macrophage Biomarkers Indicate Inflammatory Phenotypes in Patients With Knee Osteoarthritis

(2015) Hikmat N. Daghestani et al.   Arthritis & Rheumatology

Association of Pain in Knee Osteoarthritis With Distinct Patterns of Synovitis

(2015) B. J. E. de Lange-Brokaar et al.   Arthritis & Rheumatology

A Multicenter, Single-Blind, Phase IIa Clinical Trial to Evaluate the Efficacy and Safety of a Cell-Mediated Gene Therapy in Degenerative Knee Arthritis Patients

(2015) Chul-Won Ha et al.   Human Gene Therapy Clinical Development

MRI findings predict radiographic progression and development of erosions in hand osteoarthritis

(2014) Ida K Haugen et al.   ANNALS OF THE RHEUMATIC DISEASES

Adalimumab in patients with hand osteoarthritis refractory to analgesics and NSAIDs: a randomised, multicentre, double-blind, placebo-controlled trial

(2014) X Chevalier et al.   ANNALS OF THE RHEUMATIC DISEASES

Alarmins S100A8/S100A9 aggravate osteophyte formation in experimental osteoarthritis and predict osteophyte progression in early human symptomatic osteoarthritis

(2014) R F P Schelbergen et al.   ANNALS OF THE RHEUMATIC DISEASES

Synovitis in knee osteoarthritis: a precursor of disease?

(2014) I Atukorala et al.   ANNALS OF THE RHEUMATIC DISEASES

The relationship between synovial fluid VEGF and serum leptin with ultrasonographic findings in knee osteoarthritis

(2014) Hae-Rim Kim et al.   International Journal of Rheumatic Diseases

Prostaglandin E2 Exerts Catabolic Effects in Osteoarthritis Cartilage: Evidence for Signaling via the EP4 Receptor

(2014) M. Attur et al.   JOURNAL OF IMMUNOLOGY

The Role of Inflammatory and Anti-Inflammatory Cytokines in the Pathogenesis of Osteoarthritis

(2014) Piotr Wojdasiewicz et al.   MEDIATORS OF INFLAMMATION

Human osteoarthritic synovium impacts chondrogenic differentiation of mesenchymal stem cells via macrophage polarisation state

(2014) N. Fahy et al.   OSTEOARTHRITIS AND CARTILAGE

Structural changes in the knee during weight loss maintenance after a significant weight loss in obese patients with osteoarthritis: a report of secondary outcome analyses from a randomized controlled trial

(2014) M. Henriksen et al.   OSTEOARTHRITIS AND CARTILAGE

Knee pain and inflammation in the infrapatellar fat pad estimated by conventional and dynamic contrast-enhanced magnetic resonance imaging in obese patients with osteoarthritis: A cross-sectional study

(2014) C. Ballegaard et al.   OSTEOARTHRITIS AND CARTILAGE

Association of Knee Injuries With Accelerated Knee Osteoarthritis Progression: Data From the Osteoarthritis Initiative

(2014) Jeffrey B. Driban et al.   ARTHRITIS CARE & RESEARCH

Structural Associations of Symptomatic Knee Osteoarthritis

(2014) Laura A. Stoppiello et al.   Arthritis & Rheumatology

Incidence and risk factors for clinically diagnosed knee, hip and hand osteoarthritis: influences of age, gender and osteoarthritis affecting other joints

(2013) Daniel Prieto-Alhambra et al.   ANNALS OF THE RHEUMATIC DISEASES

Stimulation of Fibrotic Processes by the Infrapatellar Fat Pad in Cultured Synoviocytes From Patients With Osteoarthritis: A Possible Role for Prostaglandin F2α

(2013) Yvonne M. Bastiaansen-Jenniskens et al.   ARTHRITIS AND RHEUMATISM

Changes in bone marrow lesions in response to weight-loss in obese knee osteoarthritis patients: a prospective cohort study

(2013) Henrik Gudbergsen et al.   BMC MUSCULOSKELETAL DISORDERS

The ADAM12 is upregulated in synovitis and postinflammatory fibrosis of the synovial membrane in patients with early radiographic osteoarthritis

(2013) Irina Kerna et al.   JOINT BONE SPINE

M2-like macrophages are responsible for collagen degradation through a mannose receptor–mediated pathway

(2013) Daniel H. Madsen et al.   JOURNAL OF CELL BIOLOGY

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

Biologic agents in osteoarthritis: hopes and disappointments

(2013) Xavier Chevalier et al.   Nature Reviews Rheumatology

Degree of synovitis on MRI by comprehensive whole knee semi-quantitative scoring method correlates with histologic and macroscopic features of synovial tissue inflammation in knee osteoarthritis

(2013) B.J.E. de Lange-Brokaar et al.   OSTEOARTHRITIS AND CARTILAGE

Heat-shock proteins in stromal joint tissues: innocent bystanders or disease-initiating proteins?

(2013) S. Lambrecht et al.   RHEUMATOLOGY

Incidence of total knee and hip replacement for osteoarthritis in relation to the metabolic syndrome and its components: A prospective cohort study

(2013) Sultana Monira Hussain et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

Gene Expression Analysis of Murine and Human Osteoarthritis Synovium Reveals Elevation of Transforming Growth Factor β-Responsive Genes in Osteoarthritis-Related Fibrosis

(2013) D. F. G. Remst et al.   Arthritis & Rheumatology

Gene Expression Pattern of Cells From Inflamed and Normal Areas of Osteoarthritis Synovial Membrane

(2013) Cécile Lambert et al.   Arthritis & Rheumatology

A 2-year randomised, double-blind, placebo-controlled, multicentre study of oral selective iNOS inhibitor, cindunistat (SD-6010), in patients with symptomatic osteoarthritis of the knee

(2012) Marie-Pierre Hellio le Graverand et al.   ANNALS OF THE RHEUMATIC DISEASES

High glucose induces vascular endothelial growth factor production in human synovial fibroblasts through reactive oxygen species generation

(2012) Chun-Hao Tsai et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Diabetes Is an Independent Predictor for Severe Osteoarthritis: Results from a longitudinal cohort study

(2012) G. Schett et al.   DIABETES CARE

Interleukin-18-induced inflammatory responses in synoviocytes and chondrocytes from osteoarthritic patients

(2012) ZHAOZONG FU et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Accumulation of metabolic risk factors such as overweight, hypertension, dyslipidaemia, and impaired glucose tolerance raises the risk of occurrence and progression of knee osteoarthritis: a 3-year follow-up of the ROAD study

(2012) N. Yoshimura et al.   OSTEOARTHRITIS AND CARTILAGE

Cartilage and bone markers and inflammatory cytokines are increased in synovial fluid in the acute phase of knee injury (hemarthrosis) – a cross-sectional analysis

(2012) P. Swärd et al.   OSTEOARTHRITIS AND CARTILAGE

Lifetime Risk and Age at Diagnosis of Symptomatic Knee Osteoarthritis in the US

(2012) Elena Losina et al.   ARTHRITIS CARE & RESEARCH

Presence of MRI-detected joint effusion and synovitis increases the risk of cartilage loss in knees without osteoarthritis at 30-month follow-up: the MOST study

(2011) F. W. Roemer et al.   ANNALS OF THE RHEUMATIC DISEASES

Identification of a central role for complement in osteoarthritis

(2011) Qian Wang et al.   NATURE MEDICINE

NLRP3 inflammasome plays a critical role in the pathogenesis of hydroxyapatite-associated arthropathy

(2011) C. Jin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Uric acid is a danger signal of increasing risk for osteoarthritis through inflammasome activation

(2011) Anna E. Denoble et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A randomized, double-blind study of AMG 108 (a fully human monoclonal antibody to IL-1R1) in patients with osteoarthritis of the knee

(2011) Stanley B Cohen et al.   ARTHRITIS RESEARCH & THERAPY

Relation of synovitis to knee pain using contrast-enhanced MRIs

(2010) K. Baker et al.   ANNALS OF THE RHEUMATIC DISEASES

Assessment of synovitis with contrast-enhanced MRI using a whole-joint semiquantitative scoring system in people with, or at high risk of, knee osteoarthritis: the MOST study

(2010) A. Guermazi et al.   ANNALS OF THE RHEUMATIC DISEASES

Angiogenesis and blood vessel stability in inflammatory arthritis

(2010) Aisling Kennedy et al.   ARTHRITIS AND RHEUMATISM

The role of synovial macrophages and macrophage-produced mediators in driving inflammatory and destructive responses in osteoarthritis

(2010) Jan Bondeson et al.   ARTHRITIS AND RHEUMATISM

Synovial inflammation in patients undergoing arthroscopic meniscectomy: Molecular characterization and relationship to symptoms

(2010) Carla R. Scanzello et al.   ARTHRITIS AND RHEUMATISM

Fast18F Labeling of a Near-Infrared Fluorophore Enables Positron Emission Tomography and Optical Imaging of Sentinel Lymph Nodes

(2010) Richard Ting et al.   BIOCONJUGATE CHEMISTRY

Quantitative determination of the diagnostic accuracy of the synovitis score and its components

(2010) Elisabeth Slansky et al.   HISTOPATHOLOGY

Inflammatory Characteristics on Ultrasound Predict Poorer Longterm Response to Intraarticular Corticosteroid Injections in Knee Osteoarthritis

(2010) J. CHAO et al.   JOURNAL OF RHEUMATOLOGY

The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis

(2010) Jérémie Sellam et al.   Nature Reviews Rheumatology

Role of proinflammatory cytokines in the pathophysiology of osteoarthritis

(2010) Mohit Kapoor et al.   Nature Reviews Rheumatology

Anatomical distribution of synovitis in knee osteoarthritis and its association with joint effusion assessed on non-enhanced and contrast-enhanced MRI

(2010) F.W. Roemer et al.   OSTEOARTHRITIS AND CARTILAGE

One in four people may develop symptomatic hip osteoarthritis in his or her lifetime

(2010) L.B. Murphy et al.   OSTEOARTHRITIS AND CARTILAGE

Circulating levels of IL-6 and TNF-α are associated with knee radiographic osteoarthritis and knee cartilage loss in older adults

(2010) O. Stannus et al.   OSTEOARTHRITIS AND CARTILAGE

The NLRP3 Inflammasome: A Sensor for Metabolic Danger?

(2010) K. Schroder et al.   SCIENCE

Exercise increases interleukin-10 levels both intraarticularly and peri-synovially in patients with knee osteoarthritis: a randomized controlled trial

(2010) Ida C Helmark et al.   ARTHRITIS RESEARCH & THERAPY

Association between weight or body mass index and hand osteoarthritis: a systematic review

(2009) E. Yusuf et al.   ANNALS OF THE RHEUMATIC DISEASES

Intraarticular injection of anakinra in osteoarthritis of the knee: A multicenter, randomized, double-blind, placebo-controlled study

(2009) X. Chevalier et al.   ARTHRITIS AND RHEUMATISM

Interleukin-6 is a significant predictor of radiographic knee osteoarthritis: The Chingford study

(2009) Gregory Livshits et al.   ARTHRITIS AND RHEUMATISM

Evaluation of arthroscopy and macroscopic scoring

(2009) Erik af Klint et al.   ARTHRITIS RESEARCH & THERAPY

The synovitis of "non-inflammatory" orthopaedic arthropathies: a quantitative histological and immunohistochemical analysis

(2008) F Pessler et al.   ANNALS OF THE RHEUMATIC DISEASES

Osteoprotegerin inhibits cartilage degradation through an effect on trabecular bone in murine experimental osteoarthritis

(2008) A. Kadri et al.   ARTHRITIS AND RHEUMATISM

High levels of serum IL-18 promote cartilage loss through suppression of aggrecan synthesis

(2008) Hidetake Inoue et al.   BONE

The Interleukin 1β Pathway in the Pathogenesis of Osteoarthritis

(2008) Massoud Daheshia et al.   JOURNAL OF RHEUMATOLOGY

Nitric oxide in inflammation and pain associated with osteoarthritis

(2008) Steven B Abramson   ARTHRITIS RESEARCH & THERAPY