Biologic agents in osteoarthritis: hopes and disappointments

A 2-year randomised, double-blind, placebo-controlled, multicentre study of oral selective iNOS inhibitor, cindunistat (SD-6010), in patients with symptomatic osteoarthritis of the knee

(2012) Marie-Pierre Hellio le Graverand et al.   ANNALS OF THE RHEUMATIC DISEASES

Stress-induced cartilage degradation does not depend on the NLRP3 inflammasome in human osteoarthritis and mouse models

(2012) Carole Bougault et al.   ARTHRITIS AND RHEUMATISM

The role of synovitis in osteoarthritis pathogenesis

(2012) Carla R. Scanzello et al.   BONE

Efficacy of Infliximab in a Rabbit Model of Osteoarthritis

(2012) Qiankun Zhang et al.   CONNECTIVE TISSUE RESEARCH

Acute and late changes in intraarticular cytokine levels following anterior cruciate ligament injury

(2012) Marco Bigoni et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Tanezumab Reduces Osteoarthritic Knee Pain: Results of a Randomized, Double-Blind, Placebo-Controlled Phase III Trial

(2012) Mark T. Brown et al.   JOURNAL OF PAIN

Mechanisms and targets of angiogenesis and nerve growth in osteoarthritis

(2012) Paul I. Mapp et al.   Nature Reviews Rheumatology

In vivo reduction or blockade of interleukin-1β in primary osteoarthritis influences expression of mediators implicated in pathogenesis

(2012) K.S. Santangelo et al.   OSTEOARTHRITIS AND CARTILAGE

Effects of intraarticular IL1-Ra for acute anterior cruciate ligament knee injury: a randomized controlled pilot trial (NCT00332254)

(2012) V.B. Kraus et al.   OSTEOARTHRITIS AND CARTILAGE

American College of Rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee

(2012) Marc C. Hochberg et al.   ARTHRITIS CARE & RESEARCH

Targeting tumour necrosis factor alleviates signs and symptoms of inflammatory osteoarthritis of the knee

(2012) Walter P Maksymowych et al.   ARTHRITIS RESEARCH & THERAPY

Control of Arthritis Pain with Anti–Nerve-Growth Factor: Risk and Benefit

(2012) Matthias F. Seidel et al.   Current Rheumatology Reports

NGF – the TrkA to successful pain treatment

(2012) Vinayak Kumar et al.   Journal of Pain Research

Tumour necrosis factor blockade for the treatment of erosive osteoarthritis of the interphalangeal finger joints: a double blind, randomised trial on structure modification

(2011) Gust Verbruggen et al.   ANNALS OF THE RHEUMATIC DISEASES

Assessing health-related quality of life in hand osteoarthritis: a literature review

(2011) M. Michon et al.   ANNALS OF THE RHEUMATIC DISEASES

Nerve growth factor: A key local regulator in the pathogenesis of inflammatory arthritis

(2011) Siba P. Raychaudhuri et al.   ARTHRITIS AND RHEUMATISM

Efficacy and safety of oral strontium ranelate for the treatment of knee osteoarthritis: rationale and design of randomised, double-blind, placebo-controlled trial

(2011) Cyrus Cooper et al.   CURRENT MEDICAL RESEARCH AND OPINION

Patients' perceptions of the treatment and management of hand osteoarthritis: a focus group enquiry

(2011) Susan Hill et al.   DISABILITY AND REHABILITATION

Are we moving in the right direction with osteoarthritis drug discovery?

(2011) Jan Bondeson   EXPERT OPINION ON THERAPEUTIC TARGETS

Osteoarthritis: an update with relevance for clinical practice

(2011) Johannes WJ Bijlsma et al.   LANCET

Best evidence for best therapies in hand osteoarthritis

(2011) Krysia S. Dziedzic   Nature Reviews Rheumatology

65 A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, MULTICENTER STUDY OF RHFGF18 ADMINISTERED INTRAARTICULARLY USING SINGLE OR MULTIPLE ASCENDING DOSES IN PATIENTS WFTH PRIMARY KNEE OSTEOARTHRITIS (OA), NOT EXPECTED TO REQUIRE KNEE SURGERY WITHIN 1 YEAR

(2011) R. McPherson et al.   OSTEOARTHRITIS AND CARTILAGE

Preliminary assessment of the safety and efficacy of tanezumab in Japanese patients with moderate to severe osteoarthritis of the knee: a randomized, double-blind, dose-escalation, placebo-controlled study

(2011) H. Nagashima et al.   OSTEOARTHRITIS AND CARTILAGE

Long-term open-label study of tanezumab for moderate to severe osteoarthritic knee pain

(2011) T.J. Schnitzer et al.   OSTEOARTHRITIS AND CARTILAGE

The diagnostic performance of MRI in osteoarthritis: a systematic review and meta-analysis

(2011) L. Menashe et al.   OSTEOARTHRITIS AND CARTILAGE

Efficacy and safety of tanezumab in the treatment of chronic low back pain

(2011) Nathaniel Katz et al.   PAIN

Nerve growth factor concentrations in the synovial fluid from healthy dogs and dogs with secondary osteoarthritis

(2011) M. Isola et al.   VETERINARY AND COMPARATIVE ORTHOPAEDICS AND TRAUMATOLOGY

Measures of social function and participation in musculoskeletal populations: Impact on Participation and Autonomy (IPA), Keele Assessment of Participation (KAP), Participation Measure for Post-Acute Care (PM-PAC), Participation Objective, Participation S

(2011) Ross Wilkie et al.   ARTHRITIS CARE & RESEARCH

Desperately looking for the right target in osteoarthritis: the anti-IL-1 strategy

(2011) Xavier Chevalier et al.   ARTHRITIS RESEARCH & THERAPY

A randomized, double-blind study of AMG 108 (a fully human monoclonal antibody to IL-1R1) in patients with osteoarthritis of the knee

(2011) Stanley B Cohen et al.   ARTHRITIS RESEARCH & THERAPY

Clinical Benefits of Intra-articular Anakinra for Persistent Knee Effusion

(2011) Christopher Brown et al.   Journal of Knee Surgery

The role of synovial macrophages and macrophage-produced mediators in driving inflammatory and destructive responses in osteoarthritis

(2010) Jan Bondeson et al.   ARTHRITIS AND RHEUMATISM

Synovial inflammation in patients undergoing arthroscopic meniscectomy: Molecular characterization and relationship to symptoms

(2010) Carla R. Scanzello et al.   ARTHRITIS AND RHEUMATISM

Phase 1 safety and tolerability study of BMP-7 in symptomatic knee osteoarthritis

(2010) David J Hunter et al.   BMC MUSCULOSKELETAL DISORDERS

Activated Synovial Macrophages as Targets for Osteoarthritis Drug Therapy

(2010) Jan Bondeson   CURRENT DRUG TARGETS

To Seek Shelter from the Wnt in Osteoarthritis? Wnt-Signaling as a Target for Osteoarthritis Therapy

(2010) Arjen B. Blom et al.   CURRENT DRUG TARGETS

Intraarticular Treatments for Osteoarthritis: New Perspectives

(2010) Xavier Chevalier   CURRENT DRUG TARGETS

Osteochondral plate angiogenesis: A new treatment target in osteoarthritis

(2010) Laurence Pesesse et al.   JOINT BONE SPINE

The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis

(2010) Jérémie Sellam et al.   Nature Reviews Rheumatology

Pharmacologic therapy for osteoarthritis—the era of disease modification

(2010) David J. Hunter   Nature Reviews Rheumatology

Nerve Growth Factor and Pain

(2010) John N. Wood   NEW ENGLAND JOURNAL OF MEDICINE

Tanezumab for the Treatment of Pain from Osteoarthritis of the Knee

(2010) Nancy E. Lane et al.   NEW ENGLAND JOURNAL OF MEDICINE

Treatment with TNF-α inhibitor infliximab might reduce hand osteoarthritis in patients with rheumatoid arthritis

(2010) M. Güler-Yüksel et al.   OSTEOARTHRITIS AND CARTILAGE

Circulating levels of IL-6 and TNF-α are associated with knee radiographic osteoarthritis and knee cartilage loss in older adults

(2010) O. Stannus et al.   OSTEOARTHRITIS AND CARTILAGE

Erosive osteoarthritis of the hand: clinical experience with anakinra

(2009) L Bacconnier et al.   ANNALS OF THE RHEUMATIC DISEASES

Intraarticular injection of anakinra in osteoarthritis of the knee: A multicenter, randomized, double-blind, placebo-controlled study

(2009) X. Chevalier et al.   ARTHRITIS AND RHEUMATISM

Recent advances in BMP receptor signaling

(2009) Christina Sieber et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Treatment of erosive osteoarthritis of the hands by intra-articular infliximab injections: a pilot study

(2009) Antonella Fioravanti et al.   RHEUMATOLOGY INTERNATIONAL

Nerve growth factor and receptor expression in rheumatoid arthritis and spondyloarthritis

(2009) Christian Barthel et al.   ARTHRITIS RESEARCH & THERAPY

OARSI recommendations for the management of hip and knee osteoarthritis, Part II: OARSI evidence-based, expert consensus guidelines

(2008) W. Zhang et al.   OSTEOARTHRITIS AND CARTILAGE

Intra-articular injection of tumor necrosis factor-α in the rat: an acute and reversible in vivo model of cartilage proteoglycan degradation

(2008) A.M. Malfait et al.   OSTEOARTHRITIS AND CARTILAGE

High sensitivity C-reactive protein is associated with lower tibial cartilage volume but not lower patella cartilage volume in healthy women at mid-life

(2008) Fahad M Hanna et al.   ARTHRITIS RESEARCH & THERAPY