The role of macrophages in the resolution of inflammation

Tissue Resident CCR2− and CCR2+ Cardiac Macrophages Differentially Orchestrate Monocyte Recruitment and Fate Specification Following Myocardial Injury

(2019) Geetika Bajpai et al.   CIRCULATION RESEARCH

Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage

(2019) Dvir Aran et al.   NATURE IMMUNOLOGY

Two distinct interstitial macrophage populations coexist across tissues in specific subtissular niches

(2019) Svetoslav Chakarov et al.   SCIENCE

Deletion of c-FLIP from CD11bhi Macrophages Prevents Development of Bleomycin-induced Lung Fibrosis

(2018) Alexandra L. McCubbrey et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

CD47-signal regulatory protein α signaling system and its application to cancer immunotherapy

(2018) Yoji Murata et al.   CANCER SCIENCE

Resolvins in inflammation: emergence of the pro-resolving superfamily of mediators

(2018) Charles N. Serhan et al.   JOURNAL OF CLINICAL INVESTIGATION

Tissue-resident macrophages in the intestine are long lived and defined by Tim-4 and CD4 expression

(2018) Tovah N. Shaw et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inflammatory Monocytes Drive Influenza A Virus–Mediated Lung Injury in Juvenile Mice

(2018) Bria M. Coates et al.   JOURNAL OF IMMUNOLOGY

Macrophage Depletion Ameliorates Peripheral Neuropathy in Aging Mice

(2018) Xidi Yuan et al.   JOURNAL OF NEUROSCIENCE

Skeletal muscle regeneration is modulated by inflammation

(2018) Wenjun Yang et al.   Journal of Orthopaedic Translation

Self-Maintaining Gut Macrophages Are Essential for Intestinal Homeostasis

(2018) Sebastiaan De Schepper et al.   CELL

Induction of innate immune memory via microRNA targeting of chromatin remodelling factors

(2018) John J. Seeley et al.   NATURE

Alveolar Macrophages in the Resolution of Inflammation, Tissue Repair, and Tolerance to Infection

(2018) Benoit Allard et al.   Frontiers in Immunology

Induction of Autonomous Memory Alveolar Macrophages Requires T Cell Help and Is Critical to Trained Immunity

(2018) Yushi Yao et al.   CELL

Efferocytosis Fuels Requirements of Fatty Acid Oxidation and the Electron Transport Chain to Polarize Macrophages for Tissue Repair

(2018) Shuang Zhang et al.   Cell Metabolism

Developmental and Functional Heterogeneity of Monocytes

(2018) Martin Guilliams et al.   IMMUNITY

Efferocytosis induces a novel SLC program to promote glucose uptake and lactate release

(2018) Sho Morioka et al.   NATURE

Single-cell transcriptomics of 20 mouse organs creates a Tabula Muris

(2018) et al.   NATURE

Self-renewing resident cardiac macrophages limit adverse remodeling following myocardial infarction

(2018) Sarah A. Dick et al.   NATURE IMMUNOLOGY

DEL-1 promotes macrophage efferocytosis and clearance of inflammation

(2018) Ioannis Kourtzelis et al.   NATURE IMMUNOLOGY

Innate Immune Cell Suppression and the Link With Secondary Lung Bacterial Pneumonia

(2018) David J. Morgan et al.   Frontiers in Immunology

Origin, Differentiation, and Function of Intestinal Macrophages

(2018) Calum C. Bain et al.   Frontiers in Immunology

CCR2-dependent monocyte-derived macrophages resolve inflammation and restore gut motility in postoperative ileus

(2017) Giovanna Farro et al.   GUT

The Cytokine TGF-β Promotes the Development and Homeostasis of Alveolar Macrophages

(2017) Xueyang Yu et al.   IMMUNITY

Inflammatory Ly6Chi monocytes and their conversion to M2 macrophages drive atherosclerosis regression

(2017) Karishma Rahman et al.   JOURNAL OF CLINICAL INVESTIGATION

Microglia in Alzheimer’s disease

(2017) Heela Sarlus et al.   JOURNAL OF CLINICAL INVESTIGATION

Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span

(2017) Alexander V. Misharin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Phagocytosis imprints heterogeneity in tissue-resident macrophages

(2017) Noelia A-Gonzalez et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Intersection of Aging Biology and the Pathobiology of Lung Diseases: A Joint NHLBI/NIA Workshop

(2017) GR Scott Budinger et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Inflammasome-driven catecholamine catabolism in macrophages blunts lipolysis during ageing

(2017) Christina D. Camell et al.   NATURE

A new fate mapping system reveals context-dependent random or clonal expansion of microglia

(2017) Tuan Leng Tay et al.   NATURE NEUROSCIENCE

Mouse macrophages show different requirements for phosphatidylserine receptor Tim4 in efferocytosis

(2017) Yuichi Yanagihashi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mTOR regulates metabolic adaptation of APCs in the lung and controls the outcome of allergic inflammation

(2017) Charles Sinclair et al.   SCIENCE

Tumor-Associated Macrophages Derived from Circulating Inflammatory Monocytes Degrade Collagen through Cellular Uptake

(2017) Daniel Hargbøl Madsen et al.   Cell Reports

Macrophage Autophagy and Bacterial Infections

(2017) Aïcha Bah et al.   Frontiers in Immunology

miRNA in Macrophage Development and Function

(2016) Sashwati Roy   ANTIOXIDANTS & REDOX SIGNALING

Myeloid-Epithelial-Reproductive Receptor Tyrosine Kinase and Milk Fat Globule Epidermal Growth Factor 8 Coordinately Improve Remodeling After Myocardial Infarction via Local Delivery of Vascular Endothelial Growth FactorCLINICAL PERSPECTIVE

(2016) Kiave-Yune Howangyin et al.   CIRCULATION

Abandoning M1/M2 for a Network Model of Macrophage Function

(2016) Matthias Nahrendorf et al.   CIRCULATION RESEARCH

Yolk Sac Macrophages, Fetal Liver, and Adult Monocytes Can Colonize an Empty Niche and Develop into Functional Tissue-Resident Macrophages

(2016) Lianne van de Laar et al.   IMMUNITY

Tissue-Resident Macrophage Ontogeny and Homeostasis

(2016) Florent Ginhoux et al.   IMMUNITY

Macrophage Epithelial Reprogramming Underlies Mycobacterial Granuloma Formation and Promotes Infection

(2016) Mark R. Cronan et al.   IMMUNITY

Highly Dynamic Transcriptional Signature of Distinct Macrophage Subsets during Sterile Inflammation, Resolution, and Tissue Repair

(2016) Tamas Varga et al.   JOURNAL OF IMMUNOLOGY

Suppressor of Cytokine Signaling-2 (SOCS2) Regulates the Microglial Response and Improves Functional Outcome after Traumatic Brain Injury in Mice

(2016) Harleen S. Basrai et al.   PLoS One

Transcriptome analysis highlights the conserved difference between embryonic and postnatal-derived alveolar macrophages

(2015) S. L. Gibbings et al.   BLOOD

A Distinct Function of Regulatory T Cells in Tissue Protection

(2015) Nicholas Arpaia et al.   CELL

Pathogen Cell-to-Cell Variability Drives Heterogeneity in Host Immune Responses

(2015) Roi Avraham et al.   CELL

CSF1 Restores Innate Immunity After Liver Injury in Mice and Serum Levels Indicate Outcomes of Patients With Acute Liver Failure

(2015) Benjamin M. Stutchfield et al.   GASTROENTEROLOGY

Network Integration of Parallel Metabolic and Transcriptional Data Reveals Metabolic Modules that Regulate Macrophage Polarization

(2015) Abhishek K. Jha et al.   IMMUNITY

Distinct Contributions of Neutrophils and CCR2+Monocytes to Pulmonary Clearance of Different Klebsiella pneumoniae Strains

(2015) Huizhong Xiong et al.   INFECTION AND IMMUNITY

Transcellular delivery of vesicular SOCS proteins from macrophages to epithelial cells blunts inflammatory signaling

(2015) Emilie Bourdonnay et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A dynamic spectrum of monocytes arising from the in situ reprogramming of CCR2+monocytes at a site of sterile injury

(2015) Daniela Dal-Secco et al.   JOURNAL OF EXPERIMENTAL MEDICINE

MMP-10 Regulates Collagenolytic Activity of Alternatively Activated Resident Macrophages

(2015) Maryam G. Rohani et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Altered Macrophage Phenotype Transition Impairs Skeletal Muscle Regeneration

(2014) Hanzhou Wang et al.   AMERICAN JOURNAL OF PATHOLOGY

Cardiac macrophages and their role in ischaemic heart disease

(2014) Stefan Frantz et al.   CARDIOVASCULAR RESEARCH

Tissue-Resident Macrophage Enhancer Landscapes Are Shaped by the Local Microenvironment

(2014) Yonit Lavin et al.   CELL

Environment Drives Selection and Function of Enhancers Controlling Tissue-Specific Macrophage Identities

(2014) David Gosselin et al.   CELL

Embryonic and Adult-Derived Resident Cardiac Macrophages Are Maintained through Distinct Mechanisms at Steady State and during Inflammation

(2014) Slava Epelman et al.   IMMUNITY

Transcriptome-Based Network Analysis Reveals a Spectrum Model of Human Macrophage Activation

(2014) Jia Xue et al.   IMMUNITY

Macrophage heterogeneity in tissues: phenotypic diversity and functions

(2014) Siamon Gordon et al.   IMMUNOLOGICAL REVIEWS

Pulmonary macrophage transplantation therapy

(2014) Takuji Suzuki et al.   NATURE

Constant replenishment from circulating monocytes maintains the macrophage pool in the intestine of adult mice

(2014) Calum C Bain et al.   NATURE IMMUNOLOGY

Induction of the nuclear receptor PPAR-γ by the cytokine GM-CSF is critical for the differentiation of fetal monocytes into alveolar macrophages

(2014) Christoph Schneider et al.   NATURE IMMUNOLOGY

TWEAK/Fn14 Signaling Is Required for Liver Regeneration after Partial Hepatectomy in Mice

(2014) Gamze Karaca et al.   PLoS One

The Transcription Factor Gata6 Links Tissue Macrophage Phenotype and Proliferative Renewal

(2014) M. Rosas et al.   SCIENCE

Pulmonary transplantation of macrophage progenitors as effective and long-lasting therapy for hereditary pulmonary alveolar proteinosis

(2014) C. Happle et al.   Science Translational Medicine

M1 and M2 Macrophages: Oracles of Health and Disease

(2013) Charles Mills   CRITICAL REVIEWS IN IMMUNOLOGY

Monocyte/macrophage interactions with myogenic precursor cells during skeletal muscle regeneration

(2013) Marielle Saclier et al.   FEBS Journal

Minimal Differentiation of Classical Monocytes as They Survey Steady-State Tissues and Transport Antigen to Lymph Nodes

(2013) Claudia Jakubzick et al.   IMMUNITY

Tissue-Resident Macrophages Self-Maintain Locally throughout Adult Life with Minimal Contribution from Circulating Monocytes

(2013) Daigo Hashimoto et al.   IMMUNITY

M2-like macrophages are responsible for collagen degradation through a mannose receptor–mediated pathway

(2013) Daniel H. Madsen et al.   JOURNAL OF CELL BIOLOGY

Alveolar macrophages develop from fetal monocytes that differentiate into long-lived cells in the first week of life via GM-CSF

(2013) Martin Guilliams et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Macrophage biology in development, homeostasis and disease

(2013) Thomas A. Wynn et al.   NATURE

Inflammatory monocytes regulate pathologic responses to commensals during acute gastrointestinal infection

(2013) John R Grainger et al.   NATURE MEDICINE

Biology of the TAM Receptors

(2013) G. Lemke   Cold Spring Harbor Perspectives in Biology

Myeloid Krüppel-Like Factor 4 Deficiency Augments Atherogenesis in ApoE −/− Mice—Brief Report

(2012) Nikunj Sharma et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Source and characterization of hepatic macrophages in acetaminophen-induced acute liver failure in humans

(2012) Charalambos Gustav Antoniades et al.   HEPATOLOGY

Ly6Chi Monocytes in the Inflamed Colon Give Rise to Proinflammatory Effector Cells and Migratory Antigen-Presenting Cells

(2012) Ehud Zigmond et al.   IMMUNITY

Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis

(2012) Simon Yona et al.   IMMUNITY

CSF-1 signaling mediates recovery from acute kidney injury

(2012) Ming-Zhi Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

Resident and pro-inflammatory macrophages in the colon represent alternative context-dependent fates of the same Ly6Chi monocyte precursors

(2012) C C Bain et al.   Mucosal Immunology

The neuroimmune guidance cue netrin-1 promotes atherosclerosis by inhibiting the emigration of macrophages from plaques

(2012) Janine M van Gils et al.   NATURE IMMUNOLOGY

Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages

(2012) Emmanuel L Gautier et al.   NATURE IMMUNOLOGY

Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease

(2012) Luke Boulter et al.   NATURE MEDICINE

Oval Cell Response Is Attenuated by Depletion of Liver Resident Macrophages in the 2-AAF/Partial Hepatectomy Rat

(2012) Shuai Xiang et al.   PLoS One

Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis

(2012) P. Ramachandran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells

(2012) C. Schulz et al.   SCIENCE

Self-Limited versus Delayed Resolution of Acute Inflammation: Temporal Regulation of Pro-Resolving Mediators and MicroRNA

(2012) Gabrielle Fredman et al.   Scientific Reports

Non-Identical Twins – Microglia and Monocyte-Derived Macrophages in Acute Injury and Autoimmune Inflammation

(2012) Steffen Jung et al.   Frontiers in Immunology

Ly6ChiMonocytes Direct Alternatively Activated Profibrotic Macrophage Regulation of Lung Fibrosis

(2011) Michael A. Gibbons et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Fas Determines Differential Fates of Resident and Recruited Macrophages during Resolution of Acute Lung Injury

(2011) William J Janssen et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Macrophages and Tissue Injury: Agents of Defense or Destruction?

(2011) Debra L. Laskin et al.   Annual Review of Pharmacology and Toxicology

Regulation and function of the E-cadherin/catenin complex in cells of the monocyte-macrophage lineage and DCs

(2011) J. Van den Bossche et al.   BLOOD

Bone Marrow–Specific Deficiency of Nuclear Receptor Nur77 Enhances Atherosclerosis

(2011) Anouk A.J. Hamers et al.   CIRCULATION RESEARCH

NR4A1 (Nur77) Deletion Polarizes Macrophages Toward an Inflammatory Phenotype and Increases Atherosclerosis

(2011) Richard N. Hanna et al.   CIRCULATION RESEARCH

Specific depletion reveals a novel role for neutrophil-mediated protection in the liver during Listeria monocytogenes infection

(2011) Karen D. Carr et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

CX3CR1 defines functionally distinct intestinal mononuclear phagocyte subsets which maintain their respective functions during homeostatic and inflammatory conditions

(2011) Benjamin Weber et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Macrophage therapy for murine liver fibrosis recruits host effector cells improving fibrosis, regeneration, and function

(2011) James A. Thomas et al.   HEPATOLOGY

The Nod2 Sensor Promotes Intestinal Pathogen Eradication via the Chemokine CCL2-Dependent Recruitment of Inflammatory Monocytes

(2011) Yun-Gi Kim et al.   IMMUNITY

Beginnings of a Good Apoptotic Meal: The Find-Me and Eat-Me Signaling Pathways

(2011) Kodi S. Ravichandran   IMMUNITY

Krüppel-like factor 4 regulates macrophage polarization

(2011) Xudong Liao et al.   JOURNAL OF CLINICAL INVESTIGATION

Minimizing Oxidation and Stable Nanoscale Dispersion Improves the Biocompatibility of Graphene in the Lung

(2011) Matthew C. Duch et al.   NANO LETTERS

Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool

(2011) Bahareh Ajami et al.   NATURE NEUROSCIENCE

MicroRNAs in resolution of acute inflammation: identification of novel resolvin D1-miRNA circuits

(2010) Antonio Recchiuti et al.   FASEB JOURNAL

Impaired Infarct Healing in Atherosclerotic Mice With Ly-6ChiMonocytosis

(2010) Peter Panizzi et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Monocytes in atherosclerosis: subsets and functions

(2010) Kevin J. Woollard et al.   Nature Reviews Cardiology

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

Lung environment determines unique phenotype of alveolar macrophages

(2009) Amanda M. Guth et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

CCR2+Ly-6Chi monocytes are crucial for the effector phase of autoimmunity in the central nervous system

(2009) Alexander Mildner et al.   BRAIN

Stem Cells and Liver Regeneration

(2009) Andrew W. Duncan et al.   GASTROENTEROLOGY

MafB/c-Maf Deficiency Enables Self-Renewal of Differentiated Functional Macrophages

(2009) A. Aziz et al.   SCIENCE

Infiltrating Blood-Derived Macrophages Are Vital Cells Playing an Anti-inflammatory Role in Recovery from Spinal Cord Injury in Mice

(2009) Ravid Shechter et al.   PLOS MEDICINE

Bone marrow-derived cell regulation of skeletal muscle regeneration

(2008) Dongxu Sun et al.   FASEB JOURNAL

Gr1+ Inflammatory Monocytes Are Required for Mucosal Resistance to the Pathogen Toxoplasma gondii

(2008) Ildiko R. Dunay et al.   IMMUNITY