Unravelling osteoarthritis-related synovial fibrosis: a step closer to solving joint stiffness

Lysophosphatidic acid mediates fibrosis in injured joints by regulating collagen type I biosynthesis

(2015) L. Wu et al.   OSTEOARTHRITIS AND CARTILAGE

The epidemiology of osteoarthritis

(2014) Victoria L. Johnson et al.   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

Urotensin II (U-II), a novel cyclic peptide, possibly associated with the pathophysiology of osteoarthritis

(2014) Bülent Gögebakan et al.   PEPTIDES

Stimulation of Fibrotic Processes by the Infrapatellar Fat Pad in Cultured Synoviocytes From Patients With Osteoarthritis: A Possible Role for Prostaglandin F2α

(2013) Yvonne M. Bastiaansen-Jenniskens et al.   ARTHRITIS AND RHEUMATISM

TGF-ß induces Lysyl hydroxylase 2b in human synovial osteoarthritic fibroblasts through ALK5 signaling

(2013) Dennis F. G. Remst et al.   CELL AND TISSUE RESEARCH

ALK1-Smad1/5 signaling pathway in fibrosis development: Friend or foe?

(2013) José M. Muñoz-Félix et al.   CYTOKINE & GROWTH FACTOR REVIEWS

The ADAM12 is upregulated in synovitis and postinflammatory fibrosis of the synovial membrane in patients with early radiographic osteoarthritis

(2013) Irina Kerna et al.   JOINT BONE SPINE

siRNA Knockdown of Tissue Inhibitor of Metalloproteinase-1 in Keloid Fibroblasts Leads to Degradation of Collagen Type I

(2013) Masayo Aoki et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Heterozygous disruption of activin receptor–like kinase 1 is associated with increased renal fibrosis in a mouse model of obstructive nephropathy

(2013) José M. Muñoz-Félix et al.   KIDNEY INTERNATIONAL

Clinical Relevance of Plasma Prostaglandin F2α Metabolite Concentrations in Patients with Idiopathic Pulmonary Fibrosis

(2013) Kensaku Aihara et al.   PLoS One

CCN Family Member 2/Connective Tissue Growth Factor (CCN2/CTGF) Has Anti-Aging Effects That Protect Articular Cartilage from Age-Related Degenerative Changes

(2013) Shinsuke Itoh et al.   PLoS One

Urotensin II-induced collagen synthesis in cultured smooth muscle cells from rat aortic media and a possible involvement of transforming growth factor-β1/Smad2/3 signaling pathway

(2013) Jing Zhao et al.   REGULATORY PEPTIDES

Effects of intraarticular treatment with stanozolol on synovial membrane and cartilage in an ovine model of osteoarthritis

(2013) A. Spadari et al.   RESEARCH IN VETERINARY SCIENCE

Connective tissue growth factor (CCN2) in blood vessels

(2013) Markella Ponticos   VASCULAR PHARMACOLOGY

Gene Expression Analysis of Murine and Human Osteoarthritis Synovium Reveals Elevation of Transforming Growth Factor β-Responsive Genes in Osteoarthritis-Related Fibrosis

(2013) D. F. G. Remst et al.   Arthritis & Rheumatology

Organ fibrosis inhibited by blocking transforming growth factor-β signaling via peroxisome proliferator-activated receptor γ agonists

(2012) Yi-Lei Deng et al.   Hepatobiliary & Pancreatic Diseases International

Serum levels of ADAM12-S: possible association with the initiation and progression of dermal fibrosis and interstitial lung disease in patients with systemic sclerosis

(2012) T. Taniguchi et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Effects of PTH [1-34] on synoviopathy in an experimental model of osteoarthritis preceded by osteoporosis

(2012) L. Lugo et al.   OSTEOARTHRITIS AND CARTILAGE

Osteoarthritis-related fibrosis is associated with both elevated pyridinoline cross-link formation and lysyl hydroxylase 2b expression

(2012) D.F.G. Remst et al.   OSTEOARTHRITIS AND CARTILAGE

Proteomic Identification of ADAM12 as a Regulator for TGF-β1-Induced Differentiation of Human Mesenchymal Stem Cells to Smooth Muscle Cells

(2012) Young Mi Kim et al.   PLoS One

TGF-β Signaling via TAK1 Pathway: Role in Kidney Fibrosis

(2012) Mary E. Choi et al.   SEMINARS IN NEPHROLOGY

Hyaluronan injection in murine osteoarthritis prevents TGFbeta 1-induced synovial neovascularization and fibrosis and maintains articular cartilage integrity by a CD44-dependent mechanism

(2012) Jun Li et al.   ARTHRITIS RESEARCH & THERAPY

TGF-β signaling in fibrosis

(2011) Anna Biernacka et al.   GROWTH FACTORS

The Efficiency of a Urotensin II Antagonist in an Experimental Lung Fibrosis Model

(2011) Ahmet Mesut Onat et al.   INFLAMMATION

Endoglin promotes TGF-β/Smad1 signaling in scleroderma fibroblasts

(2011) Erin Morris et al.   JOURNAL OF CELLULAR PHYSIOLOGY

ADAM12 Produced by Tumor Cells Rather than Stromal Cells Accelerates Breast Tumor Progression

(2011) C. Frohlich et al.   MOLECULAR CANCER RESEARCH

The relationship between fibrogenic TGFβ1 signaling in the joint and cartilage degradation in post-injury osteoarthritis

(2011) A. Plaas et al.   OSTEOARTHRITIS AND CARTILAGE

CCN2 Is Required for the TGF-β Induced Activation of Smad1 - Erk1/2 Signaling Network

(2011) Sashidhar S. Nakerakanti et al.   PLoS One

ALK1 heterozygosity delays development of late normal tissue damage in the irradiated mouse kidney

(2011) Marion Scharpfenecker et al.   RADIOTHERAPY AND ONCOLOGY

Intraarticular injection of hyaluronan prevents cartilage erosion, periarticular fibrosis and mechanical allodynia and normalizes stance time in murine knee osteoarthritis

(2011) Anna Plaas et al.   ARTHRITIS RESEARCH & THERAPY

Urotensin-2 promotes collagen synthesis via ERK1/2-dependent and ERK1/2-independent TGF-β1 in neonatal cardiac fibroblasts

(2010) Hong‑Yan Dai et al.   CELL BIOLOGY INTERNATIONAL

Management of arthrofibrosis in haemophilic arthropathy

(2010) L. SOLIMENO et al.   HAEMOPHILIA

The Role of SnoN in Transforming Growth Factor β1-induced Expression of Metalloprotease-Disintegrin ADAM12

(2010) Emilia Solomon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Knockout of ADAMTS5 does not eliminate cartilage aggrecanase activity but abrogates joint fibrosis and promotes cartilage aggrecan deposition in murine osteoarthritis models

(2010) Jun Li et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Gene delivery of TGF-β1 induces arthrofibrosis and chondrometaplasia of synovium in vivo

(2010) Rachael S Watson et al.   LABORATORY INVESTIGATION

Modulation of TGFβ1-Dependent Myofibroblast Differentiation by Hyaluronan

(2009) Jason Webber et al.   AMERICAN JOURNAL OF PATHOLOGY

Urotensin II modulates hepatic fibrosis and portal hemodynamic alterations in rats

(2009) William Kemp et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Evaluation of polysulfated glycosaminoglycan or sodium hyaluronan administered intra-articularly for treatment of horses with experimentally induced osteoarthritis

(2009) David D. Frisbie et al.   AMERICAN JOURNAL OF VETERINARY RESEARCH

Increase in ALK1/ALK5 Ratio as a Cause for Elevated MMP-13 Expression in Osteoarthritis in Humans and Mice

(2009) E. N. Blaney Davidson et al.   JOURNAL OF IMMUNOLOGY

Prostaglandin F2α receptor signaling facilitates bleomycin-induced pulmonary fibrosis independently of transforming growth factor-β

(2009) Toru Oga et al.   NATURE MEDICINE

ADAM-12 (meltrin α) is involved in chondrocyte proliferation via cleavage of insulin-like growth factor binding protein 5 in osteoarthritic cartilage

(2008) Aiko Okada et al.   ARTHRITIS AND RHEUMATISM

Endocytic regulation of TGF-β signaling

(2008) Ye-Guang Chen   CELL RESEARCH

Regulation and function of connective tissue growth factor/CCN2 in tissue repair, scarring and fibrosis

(2008) Xu Shi-Wen et al.   CYTOKINE & GROWTH FACTOR REVIEWS

ALK1 Opposes ALK5/Smad3 Signaling and Expression of Extracellular Matrix Components in Human Chondrocytes

(2008) Kenneth W Finnson et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Significant synovial pathology in a meniscectomy model of osteoarthritis: modification by intra-articular hyaluronan therapy

(2008) M. M. Smith et al.   RHEUMATOLOGY