Efficacy of tocilizumab in patients with hand osteoarthritis: double blind, randomised, placebo-controlled, multicentre trial

2019 American College of Rheumatology/Arthritis Foundation Guideline for the Management of Osteoarthritis of the Hand, Hip, and Knee

(2020) Sharon L. Kolasinski et al.   Arthritis & Rheumatology

Peripheral and Central Sensitization of Pain in Individuals with Hand Osteoarthritis and Associations with Self-Reported Pain Severity

(2019) Pernille Steen Pettersen et al.   Arthritis & Rheumatology

Therapeutic options for targeting inflammatory osteoarthritis pain

(2019) Philip G. Conaghan et al.   Nature Reviews Rheumatology

In finger osteoarthritis, change in synovitis is associated with change in pain on a joint-level; a longitudinal magnetic resonance imaging study

(2019) S. van Beest et al.   OSTEOARTHRITIS AND CARTILAGE

Results of a 6-week treatment with 10 mg prednisolone in patients with hand osteoarthritis (HOPE): a double-blind, randomised, placebo-controlled trial

(2019) Féline P B Kroon et al.   LANCET

Multiparameter Analysis Identifies Heterogeneity in Knee Osteoarthritis Synovial Responses

(2019) Hannah Labinsky et al.   Arthritis & Rheumatology

The innate immune response as a mediator of osteoarthritis pain

(2019) R.J. Miller et al.   OSTEOARTHRITIS AND CARTILAGE

Hydroxychloroquine Effectiveness in Reducing Symptoms of Hand Osteoarthritis

(2018) Sarah R. Kingsbury et al.   ANNALS OF INTERNAL MEDICINE

A randomised double-blind placebo-controlled crossover trial of HUMira (adalimumab) for erosive hand OsteoaRthritis – the HUMOR trial

(2018) D. Aitken et al.   OSTEOARTHRITIS AND CARTILAGE

2018 update of the EULAR recommendations for the management of hand osteoarthritis

(2018) Margreet Kloppenburg et al.   ANNALS OF THE RHEUMATIC DISEASES

Etanercept in patients with inflammatory hand osteoarthritis (EHOA): a multicentre, randomised, double-blind, placebo-controlled trial

(2018) Margreet Kloppenburg et al.   ANNALS OF THE RHEUMATIC DISEASES

Phase IIa, placebo-controlled, randomised study of lutikizumab, an anti-interleukin-1α and anti-interleukin-1β dual variable domain immunoglobulin, in patients with erosive hand osteoarthritis

(2018) Margreet Kloppenburg et al.   ANNALS OF THE RHEUMATIC DISEASES

Hand osteoarthritis: clinical phenotypes, molecular mechanisms and disease management

(2018) Michelle Marshall et al.   Nature Reviews Rheumatology

Genetic inactivation of ZCCHC6 suppresses IL-6 expression and reduces the severity of experimental osteoarthritis in mice

(2018) Mohammad Y. Ansari et al.   Arthritis & Rheumatology

Inhibition of interleukin-6 function attenuates the central sensitization and pain behavior induced by osteoarthritis

(2017) Yuangui Lin et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Neurotrophic factors and their inhibitors in chronic pain treatment

(2017) Jayne H. Kelleher et al.   NEUROBIOLOGY OF DISEASE

Synovial fluid pro-inflammatory profile differs according to the characteristics of knee pain

(2017) Y.Y. Leung et al.   OSTEOARTHRITIS AND CARTILAGE

Bone marrow lesions on magnetic resonance imaging in hand osteoarthritis are associated with pain and interact with synovitis

(2017) R. Liu et al.   OSTEOARTHRITIS AND CARTILAGE

Osteoarthritis: the genesis of pain

(2017) Kai Fu et al.   RHEUMATOLOGY

Mechanisms of Osteoarthritic Pain. Studies in Humans and Experimental Models

(2017) Annett Eitner et al.   Frontiers in Molecular Neuroscience

Systemic inhibition of IL-6/Stat3 signalling protects against experimental osteoarthritis

(2016) Augustin Latourte et al.   ANNALS OF THE RHEUMATIC DISEASES

Bone marrow lesions and synovitis on MRI associate with radiographic progression after 2 years in hand osteoarthritis

(2016) W Damman et al.   ANNALS OF THE RHEUMATIC DISEASES

Interleukin-6 and chondrocyte mineralisation act in tandem to promote experimental osteoarthritis

(2015) Sonia Nasi et al.   ANNALS OF THE RHEUMATIC DISEASES

Increasing synovitis and bone marrow lesions are associated with incident joint tenderness in hand osteoarthritis

(2015) Ida K Haugen et al.   ANNALS OF THE RHEUMATIC DISEASES

Interleukin-6 and tumor necrosis factor alpha in synovial fluid are associated with progression of radiographic knee osteoarthritis in subjects with previous meniscectomy

(2015) S. Larsson et al.   OSTEOARTHRITIS AND CARTILAGE

Adalimumab in patients with hand osteoarthritis refractory to analgesics and NSAIDs: a randomised, multicentre, double-blind, placebo-controlled trial

(2014) X Chevalier et al.   ANNALS OF THE RHEUMATIC DISEASES

Nerve Growth Factor Downregulates Inflammatory Response in Human Monocytes through TrkA

(2014) G. Prencipe et al.   JOURNAL OF IMMUNOLOGY

Cytokine profiles in the joint depend on pathology, but are different between synovial fluid, cartilage tissue and cultured chondrocytes

(2014) Anika I Tsuchida et al.   ARTHRITIS RESEARCH & THERAPY

Induction of an Inflammatory and Prodegradative Phenotype in Autologous Fibroblast-like Synoviocytes by the Infrapatellar Fat Pad From Patients With Knee Osteoarthritis

(2014) Florent Eymard et al.   Arthritis & Rheumatology

Sensitivity and sensitisation in relation to pain severity in knee osteoarthritis: trait or state?

(2013) Tuhina Neogi et al.   ANNALS OF THE RHEUMATIC DISEASES

Associations between serum levels of inflammatory markers and change in knee pain over 5 years in older adults: a prospective cohort study

(2012) Oliver P Stannus et al.   ANNALS OF THE RHEUMATIC DISEASES

CCR2 chemokine receptor signaling mediates pain in experimental osteoarthritis

(2012) R. E. Miller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A randomized, double-blind, placebo-controlled trial of low-dose oral prednisolone for treating painful hand osteoarthritis

(2012) C. Y. J. Wenham et al.   RHEUMATOLOGY

Erosive hand osteoarthritis: its prevalence and clinical impact in the general population and symptomatic hand osteoarthritis

(2011) W. Y. Kwok et al.   ANNALS OF THE RHEUMATIC DISEASES

Efficacy of tocilizumab in patients with moderate to severe active rheumatoid arthritis and a previous inadequate response to disease-modifying antirheumatic drugs: the ROSE study

(2011) Yusuf Yazici et al.   ANNALS OF THE RHEUMATIC DISEASES

Tumour necrosis factor blockade for the treatment of erosive osteoarthritis of the interphalangeal finger joints: a double blind, randomised trial on structure modification

(2011) Gust Verbruggen et al.   ANNALS OF THE RHEUMATIC DISEASES

Associations between MRI-defined synovitis, bone marrow lesions and structural features and measures of pain and physical function in hand osteoarthritis

(2011) Ida Kristin Haugen et al.   ANNALS OF THE RHEUMATIC DISEASES

Prevalence, incidence and progression of hand osteoarthritis in the general population: the Framingham Osteoarthritis Study

(2011) I. K. Haugen et al.   ANNALS OF THE RHEUMATIC DISEASES

Interleukin-6 plays an essential role in hypoxia-inducible factor 2α-induced experimental osteoarthritic cartilage destruction in mice

(2011) Je-Hwang Ryu et al.   ARTHRITIS AND RHEUMATISM

Clinical pharmacology of tocilizumab for the treatment of patients with rheumatoid arthritis

(2011) Xiaoping Zhang et al.   Expert Review of Clinical Pharmacology

Pain in hand osteoarthritis is associated with inflammation: the value of ultrasound

(2010) M. C. Kortekaas et al.   ANNALS OF THE RHEUMATIC DISEASES

Low innate production of interleukin-1β and interleukin-6 is associated with the absence of osteoarthritis in old age

(2010) R.J. Goekoop et al.   OSTEOARTHRITIS AND CARTILAGE

Circulating levels of IL-6 and TNF-α are associated with knee radiographic osteoarthritis and knee cartilage loss in older adults

(2010) O. Stannus et al.   OSTEOARTHRITIS AND CARTILAGE

Interleukin-6 is a significant predictor of radiographic knee osteoarthritis: The Chingford study

(2009) Gregory Livshits et al.   ARTHRITIS AND RHEUMATISM

Nerve Growth Factor in Rheumatic Diseases

(2009) Matthias F. Seidel et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

IL-6 receptor inhibition with tocilizumab improves treatment outcomes in patients with rheumatoid arthritis refractory to anti-tumour necrosis factor biologicals: results from a 24-week multicentre randomised placebo-controlled trial

(2008) P. Emery et al.   ANNALS OF THE RHEUMATIC DISEASES

Mechanisms and pathologic significances in increase in serum interleukin-6 (IL-6) and soluble IL-6 receptor after administration of an anti-IL-6 receptor antibody, tocilizumab, in patients with rheumatoid arthritis and Castleman disease

(2008) N. Nishimoto et al.   BLOOD

Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): a double-blind, placebo-controlled, randomised trial

(2008) Josef S Smolen et al.   LANCET

Mechanical loading highly increases IL-6 production and decreases OPG expression by osteoblasts

(2008) C. Sanchez et al.   OSTEOARTHRITIS AND CARTILAGE