Role of Metabolic Endotoxemia in Systemic Inflammation and Potential Interventions

Metabolic Endotoxemia, Feeding Studies and the Use of the Limulus Amebocyte (LAL) Assay; Is It Fit for Purpose?

(2020) Karma Pearce et al.   Diagnostics

Effects of the Human Gut Microbiota on Cognitive Performance, Brain Structure and Function: A Narrative Review

(2020) Katie Louise Tooley   Nutrients

Tight Junction Proteins and Signaling Pathways in Cancer and Inflammation: A Functional Crosstalk

(2019) Ajaz A. Bhat et al.   Frontiers in Physiology

Cathelicidin-related antimicrobial peptide protects against myocardial ischemia/reperfusion injury

(2019) Yihua Bei et al.   BMC Medicine

Sterilized bifidobacteria suppressed fat accumulation and blood glucose level

(2018) Keita Kikuchi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Intestinal dysbiosis and permeability: the yin and yang in alcohol dependence and alcoholic liver disease

(2018) Peter Stärkel et al.   CLINICAL SCIENCE

Bacterial Periplasmic Oxidoreductases Control the Activity of Oxidized Human Antimicrobial β-Defensin 1

(2018) J. Wendler et al.   INFECTION AND IMMUNITY

Microbiome-Mediated Effects of the Mediterranean Diet on Inflammation

(2018) Melisa A Bailey et al.   Advances in Nutrition

Antimicrobial Peptides and Their Therapeutic Potential for Bacterial Skin Infections and Wounds

(2018) Anja Pfalzgraff et al.   Frontiers in Pharmacology

Toll-Like Receptors, Associated Biological Roles, and Signaling Networks in Non-Mammals

(2018) Li Nie et al.   Frontiers in Immunology

Energy intake is associated with endotoxemia in apparently healthy men

(2018) Jacques Amar et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Zinc Deficiency Induces Membrane Barrier Damage and Increases Neutrophil Transmigration in Caco-2 Cells

(2018) Alberto Finamore et al.   JOURNAL OF NUTRITION

A Dynamic Overview of Antimicrobial Peptides and Their Complexes

(2018) Viviane Silva de Paula et al.   MOLECULES

Diet induced obesity is independent of metabolic endotoxemia and TLR4 signalling, but markedly increases hypothalamic expression of the acute phase protein, SerpinA3N

(2018) Matthew J. Dalby et al.   Scientific Reports

Inhibition of Lipopolysaccharide- and Lipoprotein-Induced Inflammation by Antitoxin Peptide Pep19-2.5

(2018) Lena Heinbockel et al.   Frontiers in Immunology

Effect of dietary additives on intestinal permeability in both Drosophila and a human cell co-culture

(2018) Matthew T. Pereira et al.   Disease Models & Mechanisms

DYSBIOSIS AND METABOLIC ENDOTOXEMIA INDUCED BY HIGH-FAT DIET

(2018) Thalita Lin Netto Candido et al.   Nutricion Hospitalaria

Saving the horseshoe crab: A synthetic alternative to horseshoe crab blood for endotoxin detection

(2018) Tom Maloney et al.   PLOS BIOLOGY

Tight Junction in the Intestinal Epithelium: Its Association with Diseases and Regulation by Phytochemicals

(2018) Bonggi Lee et al.   Journal of Immunology Research

Inflammation and cancer

(2018) Mariko Murata   Environmental Health and Preventive Medicine

Interplay between tight junctions & adherens junctions

(2017) Hannah K. Campbell et al.   EXPERIMENTAL CELL RESEARCH

Sleeve Gastrectomy Alters Intestinal Permeability in Diet-Induced Obese Mice

(2017) Claire Blanchard et al.   OBESITY SURGERY

Orexin activation counteracts decreases in nonexercise activity thermogenesis (NEAT) caused by high-fat diet

(2017) P.E. Bunney et al.   PHYSIOLOGY & BEHAVIOR

The effects of micronutrient deficiencies on bacterial species from the human gut microbiota

(2017) Matthew C. Hibberd et al.   Science Translational Medicine

Cell–Cell Junctions Organize Structural and Signaling Networks

(2017) Miguel A. Garcia et al.   Cold Spring Harbor Perspectives in Biology

Antimicrobial peptides with selective antitumor mechanisms: prospect for anticancer applications

(2017) Berthony Deslouches et al.   Oncotarget

Gut microbiota as a potential target of metabolic syndrome: the role of probiotics and prebiotics

(2017) Mingqian He et al.   Cell and Bioscience

Guardians of the Gut: Enteric Defensins

(2017) Sumathi Sankaran-Walters et al.   Frontiers in Microbiology

Gut microbiota and antimicrobial peptides

(2017) Katia Sivieri et al.   Current Opinion in Food Science

Quantity of alcohol drinking positively correlates with serum levels of endotoxin and markers of monocyte activation

(2017) Suthat Liangpunsakul et al.   Scientific Reports

Metabolic endotoxemia with obesity: Is it real and is it relevant?

(2016) Nabil E. Boutagy et al.   BIOCHIMIE

Bilayer Properties of Lipid A from Various Gram-Negative Bacteria

(2016) Seonghoon Kim et al.   BIOPHYSICAL JOURNAL

Chasing a ghost? – Issues with the determination of circulating levels of endotoxin in human blood

(2016) Anne Gnauck et al.   CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES

Antimicrobial peptides

(2016) Ling-juan Zhang et al.   CURRENT BIOLOGY

Mechanisms and consequences of bacterial resistance to antimicrobial peptides

(2016) D.I. Andersson et al.   DRUG RESISTANCE UPDATES

From inflammation to cancer

(2016) A. Korniluk et al.   IRISH JOURNAL OF MEDICAL SCIENCE

Bacterial strategies of resistance to antimicrobial peptides

(2016) Hwang-Soo Joo et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Is Endotoxemia in Stable Hemodialysis Patients an Artefact? Limitations of the Limulus Amebocyte Lysate Assay and Role of (1→3)-β-D Glucan

(2016) Jonathan Wong et al.   PLoS One

The emerging role of Toll-like receptor 4 in myocardial inflammation

(2016) Y Yang et al.   Cell Death & Disease

Revised Estimates for the Number of Human and Bacteria Cells in the Body

(2016) Ron Sender et al.   PLOS BIOLOGY

Will 10 Million People Die a Year due to Antimicrobial Resistance by 2050?

(2016) Marlieke E. A. de Kraker et al.   PLOS MEDICINE

Antimicrobial Peptides: An Emerging Category of Therapeutic Agents

(2016) Margit Mahlapuu et al.   Frontiers in Cellular and Infection Microbiology

Gut microbiota and metabolic syndrome

(2016) Davide Festi et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Synthetic antimicrobial and LPS-neutralising peptides suppress inflammatory and immune responses in skin cells and promote keratinocyte migration

(2016) Anja Pfalzgraff et al.   Scientific Reports

The synthetic antimicrobial peptide 19-2.5 attenuates septic cardiomyopathy and prevents down-regulation of SERCA2 in polymicrobial sepsis

(2016) Lukas Martin et al.   Scientific Reports

Low-grade inflammation, diet composition and health: current research evidence and its translation

(2015) Anne M. Minihane et al.   BRITISH JOURNAL OF NUTRITION

Inulin-type fructans modulate intestinal Bifidobacterium species populations and decrease fecal short-chain fatty acids in obese women

(2015) Nuria Salazar et al.   CLINICAL NUTRITION

An Overview of Pathogen Recognition Receptors for Innate Immunity in Dental Pulp

(2015) Ji-Hyun Jang et al.   MEDIATORS OF INFLAMMATION

Inflammation and cancer: Till death tears them apart

(2015) T.P. Raposo et al.   VETERINARY JOURNAL

Antimicrobial Peptides in Human Sepsis

(2015) Lukas Martin et al.   Frontiers in Immunology

Probiotics as Complementary Treatment for Metabolic Disorders

(2015) Mélanie Le Barz et al.   Diabetes & Metabolism Journal

Endotoxemia, nutrition, and cardiometabolic disorders

(2014) K. A. Elisa Kallio et al.   ACTA DIABETOLOGICA

Hepatocyte Toll-like receptor 4 regulates obesity-induced inflammation and insulin resistance

(2014) Lin Jia et al.   Nature Communications

MicroencapsulatedBifidobacterium longumsubsp.infantisATCC 15697 Favorably Modulates Gut Microbiota and Reduces Circulating Endotoxins in F344 Rats

(2014) Laetitia Rodes et al.   Biomed Research International

Toll-Like Receptor Signaling Pathways

(2014) Takumi Kawasaki et al.   Frontiers in Immunology

Little Peptide, Big Effects: The Role of LL-37 in Inflammation and Autoimmune Disease

(2013) J. M. Kahlenberg et al.   JOURNAL OF IMMUNOLOGY

Pro-inflammatory effects of matrix metalloproteinase 7 in acute inflammation

(2013) R E Vandenbroucke et al.   Mucosal Immunology

Dietary oil composition differentially modulates intestinal endotoxin transport and postprandial endotoxemia

(2013) Venkatesh Mani et al.   Nutrition & Metabolism

Anti-endotoxin vaccines

(2013) Alan S Cross   Virulence

The Human Cathelicidin Antimicrobial Peptide LL-37 as a Potential Treatment for Polymicrobial Infected Wounds

(2013) Allen J. Duplantier et al.   Frontiers in Immunology

Lipopolysaccharide Causes an Increase in Intestinal Tight Junction Permeability in Vitro and in Vivo by Inducing Enterocyte Membrane Expression and Localization of TLR-4 and CD14

(2012) Shuhong Guo et al.   AMERICAN JOURNAL OF PATHOLOGY

Toll-Like Receptor 4 Deficiency Decreases Atherosclerosis But Does Not Protect Against Inflammation in Obese Low-Density Lipoprotein Receptor–Deficient Mice

(2012) Yilei Ding et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

A High-Fat Diet Is Associated With Endotoxemia That Originates From the Gut

(2012) Swaroop Pendyala et al.   GASTROENTEROLOGY

Structural resilience of the gut microbiota in adult mice under high-fat dietary perturbations

(2012) Chenhong Zhang et al.   ISME Journal

Antimicrobial peptides: Clinical relevance and therapeutic implications

(2012) Fabiano Pinheiro da Silva et al.   PEPTIDES

High Fat Diet-Induced Gut Microbiota Exacerbates Inflammation and Obesity in Mice via the TLR4 Signaling Pathway

(2012) Kyung-Ah Kim et al.   PLoS One

Protein kinase Cζ phosphorylates occludin and promotes assembly of epithelial tight junctions

(2011) Suneet Jain et al.   BIOCHEMICAL JOURNAL

Biophysical Mechanisms of Endotoxin Neutralization by Cationic Amphiphilic Peptides

(2011) Yani Kaconis et al.   BIOPHYSICAL JOURNAL

Regulation of Tight Junction Permeability by Intestinal Bacteria and Dietary Components

(2011) Dulantha Ulluwishewa et al.   JOURNAL OF NUTRITION

Interferon-γ-induced increases in intestinal epithelial macromolecular permeability requires the Src kinase Fyn

(2011) David Smyth et al.   LABORATORY INVESTIGATION

Synthetic surfactant food additives can cause intestinal barrier dysfunction

(2011) Katalin F. Csáki   MEDICAL HYPOTHESES

Linking Long-Term Dietary Patterns with Gut Microbial Enterotypes

(2011) G. D. Wu et al.   SCIENCE

Upregulation of Monocyte Tissue Factor Activity Is Significantly Associated With Low-Grade Chronic Inflammation and Insulin Resistance in Patients With Metabolic Syndrome

(2010) Akihiro Nakagomi et al.   CIRCULATION JOURNAL

Evidence for Endotoxin Contamination in Plastic Na+-Heparin Blood Collection Tube Lots

(2010) K. J. Newhall et al.   CLINICAL CHEMISTRY

A Marker of Endotoxemia Is Associated With Obesity and Related Metabolic Disorders in Apparently Healthy Chinese

(2010) L. Sun et al.   DIABETES CARE

Endotoxin and Plasminogen Activator Inhibitor-1 Serum Levels Associated With Nonalcoholic Steatohepatitis in Children

(2010) Anna Alisi et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Dietary fat and bile juice, but not obesity, are responsible for the increase in small intestinal permeability induced through the suppression of tight junction protein expression in LETO and OLETF rats

(2010) Takuya Suzuki et al.   Nutrition & Metabolism

Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa

(2010) C. De Filippo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Current Views of Toll-Like Receptor Signaling Pathways

(2010) Masahiro Yamamoto et al.   Gastroenterology Research and Practice

Changes in endotoxin levels in T2DM subjects on anti-diabetic therapies

(2009) Omar S Al-Attas et al.   Cardiovascular Diabetology

Pathogen Recognition and Inflammatory Signaling in Innate Immune Defenses

(2009) T. H. Mogensen   CLINICAL MICROBIOLOGY REVIEWS

Increase in Plasma Endotoxin Concentrations and the Expression of Toll-Like Receptors and Suppressor of Cytokine Signaling-3 in Mononuclear Cells After a High-Fat, High-Carbohydrate Meal: Implications for insulin resistance

(2009) H. Ghanim et al.   DIABETES CARE

The roles of TLRs, RLRs and NLRs in pathogen recognition

(2009) T. Kawai et al.   INTERNATIONAL IMMUNOLOGY

Current views on type 2 diabetes

(2009) Yi Lin et al.   JOURNAL OF ENDOCRINOLOGY

Enteric defensins are essential regulators of intestinal microbial ecology

(2009) Nita H Salzman et al.   NATURE IMMUNOLOGY

Ethnic and sex differences in circulating endotoxin levels: A novel marker of atherosclerotic and cardiovascular risk in a British multi-ethnic population

(2008) Michelle A. Miller et al.   ATHEROSCLEROSIS

LPS/TLR4 signal transduction pathway

(2008) Yong-Chen Lu et al.   CYTOKINE

Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet-Induced Obesity and Diabetes in Mice

(2008) P. D. Cani et al.   DIABETES

The critical role of toll-like receptor (TLR) 4 in alcoholic liver disease is independent of the common TLR adapter MyD88

(2008) Istvan Hritz et al.   HEPATOLOGY

Novel role of the vitamin D receptor in maintaining the integrity of the intestinal mucosal barrier

(2007) Juan Kong et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Desmosome structure, composition and function

(2007) David Garrod et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Adherens and tight junctions: Structure, function and connections to the actin cytoskeleton

(2007) Andrea Hartsock et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES