Mitochondrial fission links ECM mechanotransduction to metabolic redox homeostasis and metastatic chemotherapy resistance

Mechanical Stiffness Controls Dendritic Cell Metabolism and Function

(2021) Mainak Chakraborty et al.   Cell Reports

Actin cables and comet tails organize mitochondrial networks in mitosis

(2021) Andrew S. Moore et al.   NATURE

Function and regulation of the divisome for mitochondrial fission

(2021) Felix Kraus et al.   NATURE

Distinct fission signatures predict mitochondrial degradation or biogenesis

(2021) Tatjana Kleele et al.   NATURE

Adhesion-mediated mechanosignaling forces mitohormesis

(2021) Kevin M. Tharp et al.   Cell Metabolism

Fascin1 empowers YAP mechanotransduction and promotes cholangiocarcinoma development

(2021) Arianna Pocaterra et al.   Communications Biology

Applications and Approaches for 3D Precision-cut Lung Slices: Disease Modeling and Drug Discovery

(2020) Hani N Alsafadi et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

An epigenetic increase in mitochondrial fission by MiD49 and MiD51 regulates the cell cycle in cancer: Diagnostic and therapeutic implications

(2020) Asish Dasgupta et al.   FASEB JOURNAL

Crosstalk with lung epithelial cells regulates Sfrp2-mediated latency in breast cancer dissemination

(2020) Marco Montagner et al.   NATURE CELL BIOLOGY

The cell biology of mitochondrial membrane dynamics

(2020) Marta Giacomello et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanical Forces as Determinants of Disseminated Metastatic Cell Fate

(2020) Marco Montagner et al.   Cells

In vitro Models of Breast Cancer Metastatic Dormancy

(2020) Marco Montagner et al.   Frontiers in Cell and Developmental Biology

Lipid peroxidation and ferroptosis: The role of GSH and GPx4

(2020) Fulvio Ursini et al.   FREE RADICAL BIOLOGY AND MEDICINE

Reactive oxygen species (ROS) as pleiotropic physiological signalling agents

(2020) Helmut Sies et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The NRF2/KEAP1 Axis in the Regulation of Tumor Metabolism: Mechanisms and Therapeutic Perspectives

(2020) Emiliano Panieri et al.   Biomolecules

Intravital three-dimensional bioprinting

(2020) Anna Urciuolo et al.   Nature Biomedical Engineering

Mechanical Adaptability of Tumor Cells in Metastasis

(2020) Valentin Gensbittel et al.   DEVELOPMENTAL CELL

3D Culture Models with CRISPR Screens Reveal Hyperactive NRF2 as a Prerequisite for Spheroid Formation via Regulation of Proliferation and Ferroptosis

(2020) Nobuaki Takahashi et al.   MOLECULAR CELL

Heat stress activates YAP/TAZ to induce the heat shock transcriptome

(2020) Min Luo et al.   NATURE CELL BIOLOGY

An expanded palette of improved SPLICS reporters detects multiple organelle contacts in vitro and in vivo

(2020) Francesca Vallese et al.   Nature Communications

Translocating transcription factors in fluid shear stress-mediated vascular remodeling and disease

(2019) Elizabeth Min et al.   EXPERIMENTAL CELL RESEARCH

Extracellular matrix mechanical cues regulate lipid metabolism through Lipin-1 and SREBP

(2019) Patrizia Romani et al.   NATURE CELL BIOLOGY

F-actin dynamics regulates mammalian organ growth and cell fate maintenance

(2019) Arianna Pocaterra et al.   JOURNAL OF HEPATOLOGY

Identification of a mechanogenetic link between substrate stiffness and chemotherapeutic response in breast cancer

(2019) Scott H. Medina et al.   BIOMATERIALS

Materials Stiffness‐Dependent Redox Metabolic Reprogramming of Mesenchymal Stem Cells for Secretome‐Based Therapeutic Angiogenesis

(2019) Haibo Yang et al.   Advanced Healthcare Materials

Identification of novel dynamin‐related protein 1 (Drp1) GTPase inhibitors: Therapeutic potential of Drpitor1 and Drpitor1a in cancer and cardiac ischemia‐reperfusion injury

(2019) Danchen Wu et al.   FASEB JOURNAL

Extracellular matrix hydrogel derived from decellularized tissues enables endodermal organoid culture

(2019) Giovanni Giuseppe Giobbe et al.   Nature Communications

NRF2 and the Hallmarks of Cancer

(2018) Montserrat Rojo de la Vega et al.   CANCER CELL

Epigenetic Dysregulation of the Dynamin-Related Protein 1 Binding Partners MiD49 and MiD51 Increases Mitotic Mitochondrial Fission and Promotes Pulmonary Arterial Hypertension

(2018) Kuang-Hueih Chen et al.   CIRCULATION

A polydnavirus-encoded ANK protein has a negative impact on steroidogenesis and development

(2018) Marilena Ignesti et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Mechanosensing and fibrosis

(2018) Daniel J. Tschumperlin et al.   JOURNAL OF CLINICAL INVESTIGATION

Caveolin-1 Controls Hyperresponsiveness to Mechanical Stimuli and Fibrogenesis-Associated RUNX2 Activation in Keloid Fibroblasts

(2018) Chao-Kai Hsu et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

RIPK1-mediated induction of mitophagy compromises the viability of extracellular-matrix-detached cells

(2018) Mark A. Hawk et al.   NATURE CELL BIOLOGY

Mechanisms and impact of altered tumour mechanics

(2018) Hamid Mohammadi et al.   NATURE CELL BIOLOGY

Autophagy promotes the survival of dormant breast cancer cells and metastatic tumour recurrence

(2018) Laura Vera-Ramirez et al.   Nature Communications

Uncoupled mitochondria quickly shorten along their long axis to form indented spheroids, instead of rings, in a fission-independent manner

(2018) Yoshihiro Miyazono et al.   Scientific Reports

Tumor-Stroma Mechanics Coordinate Amino Acid Availability to Sustain Tumor Growth and Malignancy

(2018) Thomas Bertero et al.   Cell Metabolism

Dormant tumour cells, their niches and the influence of immunity

(2018) Erica T. Goddard et al.   NATURE CELL BIOLOGY

Metabolic shifts in residual breast cancer drive tumor recurrence

(2017) Kristina M. Havas et al.   JOURNAL OF CLINICAL INVESTIGATION

Multiscale force sensing in development

(2017) Nicoletta I. Petridou et al.   NATURE CELL BIOLOGY

Keap1 loss promotes Kras-driven lung cancer and results in dependence on glutaminolysis

(2017) Rodrigo Romero et al.   NATURE MEDICINE

Genetically encoded fluorescent sensors reveal dynamic regulation of NADPH metabolism

(2017) Rongkun Tao et al.   NATURE METHODS

Global treadmilling coordinates actin turnover and controls the size of actin networks

(2017) Marie-France Carlier et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanical forces direct stem cell behaviour in development and regeneration

(2017) Kyle H. Vining et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanical force induces mitochondrial fission

(2017) Sebastian Carsten Johannes Helle et al.   eLife

Mitochondrial Dynamics Impacts Stem Cell Identity and Fate Decisions by Regulating a Nuclear Transcriptional Program

(2016) Mireille Khacho et al.   Cell Stem Cell

The role of Drp1 adaptor proteins MiD49 and MiD51 in mitochondrial fission: implications for human disease

(2016) K. Atkins et al.   CLINICAL SCIENCE

Three-dimensional modelling identifies novel genetic dependencies associated with breast cancer progression in the isogenic MCF10 model

(2016) Sarah L Maguire et al.   JOURNAL OF PATHOLOGY

Early Evaluation of Relative Changes in Tumor Stiffness by Shear Wave Elastography Predicts the Response to Neoadjuvant Chemotherapy in Patients With Breast Cancer

(2016) Hui Jing et al.   JOURNAL OF ULTRASOUND IN MEDICINE

Actin filaments as dynamic reservoirs for Drp1 recruitment

(2016) Anna L. Hatch et al.   MOLECULAR BIOLOGY OF THE CELL

Reductive carboxylation supports redox homeostasis during anchorage-independent growth

(2016) Lei Jiang et al.   NATURE

Internetwork competition for monomers governs actin cytoskeleton organization

(2016) Cristian Suarez et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Dynamin controls extracellular level of Awd/Nme1 metastasis suppressor protein

(2016) Patrizia Romani et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Dynamic actin cycling through mitochondrial subpopulations locally regulates the fission–fusion balance within mitochondrial networks

(2016) Andrew S. Moore et al.   Nature Communications

Mitochondrial ROS Signaling in Organismal Homeostasis

(2015) Gerald S. Shadel et al.   CELL

Evolution of Mitochondria as Signaling Organelles

(2015) Navdeep S. Chandel   Cell Metabolism

Aerobic glycolysis tunes YAP/TAZ transcriptional activity

(2015) E. Enzo et al.   EMBO JOURNAL

Inhibition of the autocrine IL-6–JAK2–STAT3–calprotectin axis as targeted therapy for HR−/HER2+breast cancers

(2015) Ruth Rodriguez-Barrueco et al.   GENES & DEVELOPMENT

Competition for actin between two distinct F-actin networks defines a bistable switch for cell polarization

(2015) Alexis J. Lomakin et al.   NATURE CELL BIOLOGY

Down-regulation of oxidative phosphorylation in the liver by expression of the ATPase inhibitory factor 1 induces a tumor-promoter metabolic state

(2015) Fulvio Santacatterina et al.   Oncotarget

A mitochondria-anchored isoform of the actin-nucleating spire protein regulates mitochondrial division

(2015) Uri Manor et al.   eLife

Mitohormesis

(2014) Jeanho Yun et al.   Cell Metabolism

Transient assembly of F-actin on the outer mitochondrial membrane contributes to mitochondrial fission

(2014) Sunan Li et al.   JOURNAL OF CELL BIOLOGY

Mechanotransduction and extracellular matrix homeostasis

(2014) Jay D. Humphrey et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Appreciating force and shape — the rise of mechanotransduction in cell biology

(2014) Thomas Iskratsch et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Nrf2 regulatory network provides an interface between redox and intermediary metabolism

(2014) John D. Hayes et al.   TRENDS IN BIOCHEMICAL SCIENCES

Preservation of micro-architecture and angiogenic potential in a pulmonary acellular matrix obtained using intermittent intra-tracheal flow of detergent enzymatic treatment

(2013) Panagiotis Maghsoudlou et al.   BIOMATERIALS

An Integrin-Linked Machinery of Cytoskeletal Regulation that Enables Experimental Tumor Initiation and Metastatic Colonization

(2013) Tsukasa Shibue et al.   CANCER CELL

Interchangeable adaptors regulate mitochondrial dynamin assembly for membrane scission

(2013) S. Koirala et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Actin-Dependent Step in Mitochondrial Fission Mediated by the ER-Associated Formin INF2

(2013) F. Korobova et al.   SCIENCE

HSF1 Drives a Transcriptional Program Distinct from Heat Shock to Support Highly Malignant Human Cancers

(2012) Marc L. Mendillo et al.   CELL

Fibroproliferative Disorders and Their Mechanobiology

(2012) Chenyu Huang et al.   CONNECTIVE TISSUE RESEARCH

Inhibition of mitochondrial fission prevents cell cycle progression in lung cancer

(2012) Jalees Rehman et al.   FASEB JOURNAL

Arp2/3 complex–dependent actin networks constrain myosin II function in driving retrograde actin flow

(2012) Qing Yang et al.   JOURNAL OF CELL BIOLOGY

Transcriptomic and proteomic profiling of KEAP1 disrupted and sulforaphane-treated human breast epithelial cells reveals common expression profiles

(2011) Abena S. Agyeman et al.   BREAST CANCER RESEARCH AND TREATMENT

Altered fusion dynamics underlie unique morphological changes in mitochondria during hypoxia–reoxygenation stress

(2011) X Liu et al.   CELL DEATH AND DIFFERENTIATION

 1-Integrin: A Potential Therapeutic Target in the Battle against Cancer Recurrence

(2011) D. Barkan et al.   CLINICAL CANCER RESEARCH

MiD49 and MiD51, new components of the mitochondrial fission machinery

(2011) Catherine S Palmer et al.   EMBO REPORTS

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

Metastatic Growth from Dormant Cells Induced by a Col-I-Enriched Fibrotic Environment

(2010) D. Barkan et al.   CANCER RESEARCH

Feedback amplification of fibrosis through matrix stiffening and COX-2 suppression

(2010) Fei Liu et al.   JOURNAL OF CELL BIOLOGY

Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment

(2009) Zachary T. Schafer et al.   NATURE

Inhibition of Metastatic Outgrowth from Single Dormant Tumor Cells by Targeting the Cytoskeleton

(2008) D. Barkan et al.   CANCER RESEARCH

Chemical Inhibition of the Mitochondrial Division Dynamin Reveals Its Role in Bax/Bak-Dependent Mitochondrial Outer Membrane Permeabilization

(2008) Ann Cassidy-Stone et al.   DEVELOPMENTAL CELL

Real-time imaging of the intracellular glutathione redox potential

(2008) Marcus Gutscher et al.   NATURE METHODS