Adhesion-mediated mechanosignaling forces mitohormesis

Mitochondrial DNA alterations underlie an irreversible shift to aerobic glycolysis in fumarate hydratase–deficient renal cancer

(2021) Daniel R. Crooks et al.   Science Signaling

Mechanical regulation of glycolysis via cytoskeleton architecture

(2020) Jin Suk Park et al.   NATURE

Metabolic reprogramming and cancer progression

(2020) Brandon Faubert et al.   SCIENCE

HSF1 is required for induction of mitochondrial chaperones during the mitochondrial unfolded protein response

(2020) Arpit Katiyar et al.   FEBS Open Bio

Glucose metabolism links astroglial mitochondria to cannabinoid effects

(2020) Daniel Jimenez-Blasco et al.   NATURE

Na+ controls hypoxic signalling by the mitochondrial respiratory chain

(2020) Pablo Hernansanz-Agustín et al.   NATURE

Tumour-associated macrophages drive stromal cell-dependent collagen crosslinking and stiffening to promote breast cancer aggression

(2020) Ori Maller et al.   NATURE MATERIALS

Mitochondrial protein-induced stress triggers a global adaptive transcriptional programme

(2019) Felix Boos et al.   NATURE CELL BIOLOGY

Deconvoluting Stress-Responsive Proteostasis Signaling Pathways for Pharmacologic Activation Using Targeted RNA Sequencing

(2019) Julia M. D. Grandjean et al.   ACS Chemical Biology

The Extracellular Matrix Modulates the Metastatic Journey

(2019) FuiBoon Kai et al.   DEVELOPMENTAL CELL

Metascape provides a biologist-oriented resource for the analysis of systems-level datasets

(2019) Yingyao Zhou et al.   Nature Communications

The Good and the Bad of Mitochondrial Breakups

(2019) Hans-Georg Sprenger et al.   TRENDS IN CELL BIOLOGY

Neuronal TORC1 modulates longevity via AMPK and cell nonautonomous regulation of mitochondrial dynamics in C. elegans

(2019) Yue Zhang et al.   eLife

Lipid signalling drives proteolytic rewiring of mitochondria by YME1L

(2019) Thomas MacVicar et al.   NATURE

The Rise of Physiologic Media

(2019) Jason R. Cantor   TRENDS IN CELL BIOLOGY

Activation of Oxidative Stress Response in Cancer Generates a Druggable Dependency on Exogenous Non-essential Amino Acids

(2019) Sarah E. LeBoeuf et al.   Cell Metabolism

Metabolomics and Isotope Tracing

(2018) Cholsoon Jang et al.   CELL

Actomyosin-Mediated Tension Orchestrates Uncoupled Respiration in Adipose Tissues

(2018) Kevin M. Tharp et al.   Cell Metabolism

A Futile Battle? Protein Quality Control and the Stress of Aging

(2018) Ryo Higuchi-Sanabria et al.   DEVELOPMENTAL CELL

Versatile Histochemical Approach to Detection of Hydrogen Peroxide in Cells and Tissues Based on Puromycin Staining

(2018) Clive Yik-Sham Chung et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Maintaining a Healthy Proteome during Oxidative Stress

(2018) Dana Reichmann et al.   MOLECULAR CELL

Cancer metabolism gets physical

(2018) Peter DelNero et al.   Science Translational Medicine

Uncoupled mitochondria quickly shorten along their long axis to form indented spheroids, instead of rings, in a fission-independent manner

(2018) Yoshihiro Miyazono et al.   Scientific Reports

Modeling Tissue Polarity in Context

(2018) Kevin M. Tharp et al.   JOURNAL OF MOLECULAR BIOLOGY

The machineries, regulation and cellular functions of mitochondrial calcium

(2018) Carlotta Giorgi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

NRF2 transcriptionally activates the heat shock factor 1 promoter under oxidative stress and affects survival and migration potential of MCF7 cells

(2018) Soumyadip Paul et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Online Parallel Accumulation–Serial Fragmentation (PASEF) with a Novel Trapped Ion Mobility Mass Spectrometer

(2018) Florian Meier et al.   MOLECULAR & CELLULAR PROTEOMICS

Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals

(2017) Pedro M. Quirós et al.   JOURNAL OF CELL BIOLOGY

Heat Shock Protein 70 (Hsp70) Suppresses RIP1-Dependent Apoptotic and Necroptotic Cascades

(2017) Sharan R. Srinivasan et al.   MOLECULAR CANCER RESEARCH

Force loading explains spatial sensing of ligands by cells

(2017) Roger Oria et al.   NATURE

A CRISPR screen identifies a pathway required for paraquat-induced cell death

(2017) Colleen R Reczek et al.   Nature Chemical Biology

sCMOS noise-correction algorithm for microscopy images

(2017) Sheng Liu et al.   NATURE METHODS

Cell volume change through water efflux impacts cell stiffness and stem cell fate

(2017) Ming Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

“High-Throughput Characterization of Region-Specific Mitochondrial Function and Morphology”

(2017) Joseph R. Daniele et al.   Scientific Reports

Mitochondrial Stress Restores the Heat Shock Response and Prevents Proteostasis Collapse during Aging

(2017) Johnathan Labbadia et al.   Cell Reports

Human Organ Chip Models Recapitulate Orthotopic Lung Cancer Growth, Therapeutic Responses, and Tumor Dormancy In Vitro

(2017) Bryan A. Hassell et al.   Cell Reports

Mechanical force induces mitochondrial fission

(2017) Sebastian Carsten Johannes Helle et al.   eLife

Consequences of a tight squeeze: Nuclear envelope rupture and repair

(2017) Philipp Isermann et al.   Nucleus

Consequences of a tight squeeze: Nuclear envelope rupture and repair

(2017) Philipp Isermann et al.   Nucleus

Mitochondria and Cancer

(2016) Sejal Vyas et al.   CELL

Mitochondrial ROS Produced via Reverse Electron Transport Extend Animal Lifespan

(2016) Filippo Scialò et al.   Cell Metabolism

The Transcription Factor ATF5 Mediates a Mammalian Mitochondrial UPR

(2016) Christopher J. Fiorese et al.   CURRENT BIOLOGY

Metformin Suppresses Diabetes-Accelerated Atherosclerosis via the Inhibition of Drp1-Mediated Mitochondrial Fission

(2016) Qilong Wang et al.   DIABETES

Nuclear constriction segregates mobile nuclear proteins away from chromatin

(2016) Jerome Irianto et al.   MOLECULAR BIOLOGY OF THE CELL

Metabolism and the UPR mt

(2016) Yi-Fan Lin et al.   MOLECULAR CELL

The Mitochondrial Basis of Aging

(2016) Nuo Sun et al.   MOLECULAR CELL

Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition

(2016) Marco Sciacovelli et al.   NATURE

Tissue mechanics promote IDH1-dependent HIF1α–tenascin C feedback to regulate glioblastoma aggression

(2016) Yekaterina A. Miroshnikova et al.   NATURE CELL BIOLOGY

A practical guide to hydrogels for cell culture

(2016) Steven R Caliari et al.   NATURE METHODS

3,4-Dihydroxy-L-Phenylalanine as a Novel Covalent Linker of Extracellular Matrix Proteins to Polyacrylamide Hydrogels with a Tunable Stiffness

(2016) Olaf Y. Wouters et al.   TISSUE ENGINEERING PART C-METHODS

HSF1: Guardian of Proteostasis in Cancer

(2016) Chengkai Dai et al.   TRENDS IN CELL BIOLOGY

Dynamic actin cycling through mitochondrial subpopulations locally regulates the fission–fusion balance within mitochondrial networks

(2016) Andrew S. Moore et al.   Nature Communications

Unique fractal evaluation and therapeutic implications of mitochondrial morphology in malignant mesothelioma

(2016) Frances E. Lennon et al.   Scientific Reports

Celastrol Protects against Obesity and Metabolic Dysfunction through Activation of a HSF1-PGC1α Transcriptional Axis

(2015) Xinran Ma et al.   Cell Metabolism

Human breast cancer invasion and aggression correlates with ECM stiffening and immune cell infiltration

(2015) I. Acerbi et al.   Integrative Biology

ClearVolume: open-source live 3D visualization for light-sheet microscopy

(2015) Loic A Royer et al.   NATURE METHODS

MitoCarta2.0: an updated inventory of mammalian mitochondrial proteins

(2015) Sarah E. Calvo et al.   NUCLEIC ACIDS RESEARCH

A mitochondria-anchored isoform of the actin-nucleating spire protein regulates mitochondrial division

(2015) Uri Manor et al.   eLife

MSstats: an R package for statistical analysis of quantitative mass spectrometry-based proteomic experiments

(2014) Meena Choi et al.   BIOINFORMATICS

The Reprogramming of Tumor Stroma by HSF1 Is a Potent Enabler of Malignancy

(2014) Ruth Scherz-Shouval et al.   CELL

Mitohormesis

(2014) Jeanho Yun et al.   Cell Metabolism

Unraveling the Truth About Antioxidants: Mitohormesis explains ROS-induced health benefits

(2014) Michael Ristow   NATURE MEDICINE

Tissue mechanics modulate microRNA-dependent PTEN expression to regulate malignant progression

(2014) Janna K Mouw et al.   NATURE MEDICINE

HSF-1-mediated cytoskeletal integrity determines thermotolerance and life span

(2014) N. A. Baird et al.   SCIENCE

Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution

(2014) Bi-Chang Chen et al.   SCIENCE

Role of Nrf2 in Oxidative Stress and Toxicity

(2013) Qiang Ma   Annual Review of Pharmacology and Toxicology

Activation of beta 1 but not beta 3 integrin increases cell traction forces

(2013) Grace L. Lin et al.   FEBS LETTERS

pH sensing by FAK-His58 regulates focal adhesion remodeling

(2013) Chang-Hoon Choi et al.   JOURNAL OF CELL BIOLOGY

Analysis of GSH and GSSG after derivatization with N-ethylmaleimide

(2013) Daniela Giustarini et al.   Nature Protocols

Analogues of the Allosteric Heat Shock Protein 70 (Hsp70) Inhibitor, MKT-077, As Anti-Cancer Agents

(2013) Xiaokai Li et al.   ACS Medicinal Chemistry Letters

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

HSF1 Drives a Transcriptional Program Distinct from Heat Shock to Support Highly Malignant Human Cancers

(2012) Marc L. Mendillo et al.   CELL

A highly integrated and complex PPARGC1A transcription factor binding network in HepG2 cells

(2012) A. E. Charos et al.   GENOME RESEARCH

The Protein-Folding Problem, 50 Years On

(2012) K. A. Dill et al.   SCIENCE

Mitochondrial Import Efficiency of ATFS-1 Regulates Mitochondrial UPR Activation

(2012) A. M. Nargund et al.   SCIENCE

Mitochondrial Fission, Fusion, and Stress

(2012) R. J. Youle et al.   SCIENCE

Mitochondrial membrane potential probes and the proton gradient: a practical usage guide

(2011) Seth W. Perry et al.   BIOTECHNIQUES

Actomyosin-Mediated Cellular Tension Drives Increased Tissue Stiffness and β-Catenin Activation to Induce Epidermal Hyperplasia and Tumor Growth

(2011) Michael S. Samuel et al.   CANCER CELL

Altered fusion dynamics underlie unique morphological changes in mitochondria during hypoxia–reoxygenation stress

(2011) X Liu et al.   CELL DEATH AND DIFFERENTIATION

Extending life span by increasing oxidative stress

(2011) Michael Ristow et al.   FREE RADICAL BIOLOGY AND MEDICINE

High levels of nuclear heat-shock factor 1 (HSF1) are associated with poor prognosis in breast cancer

(2011) S. Santagata et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Mitochondrial view of aging, reactive oxygen species and metastatic cancer

(2010) Warren Ladiges et al.   AGING CELL

The Interplay Between Mitochondrial Dynamics and Mitophagy

(2010) Gilad Twig et al.   ANTIOXIDANTS & REDOX SIGNALING

A global network of transcription factors, involving E2A, EBF1 and Foxo1, that orchestrates B cell fate

(2010) Yin C Lin et al.   NATURE IMMUNOLOGY

Mitochondrial protein import: from proteomics to functional mechanisms

(2010) Oliver Schmidt et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mammary Gland ECM Remodeling, Stiffness, and Mechanosignaling in Normal Development and Tumor Progression

(2010) P. Schedin et al.   Cold Spring Harbor Perspectives in Biology

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment

(2009) Zachary T. Schafer et al.   NATURE

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY

Hormesis defined

(2007) Mark P. Mattson   AGEING RESEARCH REVIEWS