Appreciating force and shape — the rise of mechanotransduction in cell biology

Integrin-Generated Forces Lead to Streptavidin-Biotin Unbinding in Cellular Adhesions

(2014) Carol Jurchenko et al.   BIOPHYSICAL JOURNAL

FHOD1 regulates stress fiber organization by controlling the dynamics of transverse arcs and dorsal fibers

(2014) N. Schulze et al.   JOURNAL OF CELL SCIENCE

Decoupling Cell and Matrix Mechanics in Engineered Microtissues Using Magnetically Actuated Microcantilevers

(2013) Ruogang Zhao et al.   ADVANCED MATERIALS

Hydrogel Micropillars with Integrin Selective Peptidomimetic Functionalized Nanopatterned Tops: A New Tool for the Measurement of Cell Traction Forces Transmitted through αvβ3- or α5β1-Integrins

(2013) Sabri Rahmouni et al.   ADVANCED MATERIALS

A Mechanical Checkpoint Controls Multicellular Growth through YAP/TAZ Regulation by Actin-Processing Factors

(2013) Mariaceleste Aragona et al.   CELL

Vinculin Regulates the Recruitment and Release of Core Focal Adhesion Proteins in a Force-Dependent Manner

(2013) Alex Carisey et al.   CURRENT BIOLOGY

FHOD1 Is Needed for Directed Forces and Adhesion Maturation during Cell Spreading and Migration

(2013) Thomas Iskratsch et al.   DEVELOPMENTAL CELL

Tension Sensing Nanoparticles for Mechano-Imaging at the Living/Nonliving Interface

(2013) Yang Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cell Adhesion and Shape Regulate TGF-Beta1-Induced Epithelial-Myofibroblast Transition via MRTF-A Signaling

(2013) Joseph W. O’Connor et al.   PLoS One

Tension modulates actin filament polymerization mediated by formin and profilin

(2013) N. Courtemanche et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integrin-dependent force transmission to the extracellular matrix by  -actinin triggers adhesion maturation

(2013) P. Roca-Cusachs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear Actin Network Assembly by Formins Regulates the SRF Coactivator MAL

(2013) C. Baarlink et al.   SCIENCE

Formin mDia1 senses and generates mechanical forces on actin filaments

(2013) Antoine Jégou et al.   Nature Communications

Force Fluctuations within Focal Adhesions Mediate ECM-Rigidity Sensing to Guide Directed Cell Migration

(2012) Sergey V. Plotnikov et al.   CELL

Finding the weakest link – exploring integrin-mediated mechanical molecular pathways

(2012) Pere Roca-Cusachs et al.   JOURNAL OF CELL SCIENCE

Physical and chemical microenvironmental cues orthogonally control the degree and duration of fibrosis-associated epithelial-to-mesenchymal transitions

(2012) Ashley C Brown et al.   JOURNAL OF PATHOLOGY

Endoplasmic spreading requires coalescence of vimentin intermediate filaments at force-bearing adhesions

(2012) Christopher D. Lynch et al.   MOLECULAR BIOLOGY OF THE CELL

Cells test substrate rigidity by local contractions on submicrometer pillars

(2012) S. Ghassemi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamic force sensing of filamin revealed in single-molecule experiments

(2012) L. Rognoni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evidence for Multisite Ligand Binding and Stretching of Filamin by Integrin and Migfilin

(2011) Sujay Subbayya Ithychanda et al.   BIOCHEMISTRY

Quantitative proteomics of the integrin adhesome show a myosin II-dependent recruitment of LIM domain proteins

(2011) Herbert B Schiller et al.   EMBO REPORTS

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

Fibroblast polarization is a matrix-rigidity-dependent process controlled by focal adhesion mechanosensing

(2011) Masha Prager-Khoutorsky et al.   NATURE CELL BIOLOGY

Visualizing mechanical tension across membrane receptors with a fluorescent sensor

(2011) Daniel R Stabley et al.   NATURE METHODS

Early integrin binding to Arg-Gly-Asp peptide activates actin polymerization and contractile movement that stimulates outward translocation

(2011) C.-h. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Temporary increase in plasma membrane tension coordinates the activation of exocytosis and contraction during cell spreading

(2011) N. C. Gauthier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanotransduction In Vivo by Repeated Talin Stretch-Relaxation Events Depends upon Vinculin

(2011) Felix Margadant et al.   PLOS BIOLOGY

Transient Frictional Slip between Integrin and the ECM in Focal Adhesions under Myosin II Tension

(2010) Yvonne Aratyn-Schaus et al.   CURRENT BIOLOGY

Cytoskeletal coherence requires myosin-IIA contractility

(2010) Y. Cai et al.   JOURNAL OF CELL SCIENCE

The switchable integrin adhesome

(2010) R. Zaidel-Bar et al.   JOURNAL OF CELL SCIENCE

The NPIY motif in the integrin  1 tail dictates the requirement for talin-1 in outside-in signaling

(2010) B. Nieves et al.   JOURNAL OF CELL SCIENCE

Filamin A regulates focal adhesion disassembly and suppresses breast cancer cell migration and invasion

(2010) Yingjie Xu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mechanobiology

(2010) C. T. Lim et al.   Journal of the Royal Society Interface

Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics

(2010) Carsten Grashoff et al.   NATURE

A nucleator arms race: cellular control of actin assembly

(2010) Kenneth G. Campellone et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The mechanical integrin cycle

(2009) E. Puklin-Faucher et al.   JOURNAL OF CELL SCIENCE

Force-induced cell polarisation is linked to RhoA-driven microtubule-independent focal-adhesion sliding

(2009) A. M. Goldyn et al.   JOURNAL OF CELL SCIENCE

Stretching Single Talin Rod Molecules Activates Vinculin Binding

(2009) A. del Rio et al.   SCIENCE

Two Characteristic Regimes in Frequency-Dependent Dynamic Reorientation of Fibroblasts on Cyclically Stretched Substrates

(2008) Simon Jungbauer et al.   BIOPHYSICAL JOURNAL

A fluorescence energy transfer-based mechanical stress sensor for specific proteins in situ

(2008) Fanjie Meng et al.   FEBS Journal

Quantification of Cell Edge Velocities and Traction Forces Reveals Distinct Motility Modules during Cell Spreading

(2008) Benjamin J. Dubin-Thaler et al.   PLoS One

Mechanoenzymatics of titin kinase

(2008) E. M. Puchner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Traction Dynamics of Filopodia on Compliant Substrates

(2008) C. E. Chan et al.   SCIENCE