Fascin1 empowers YAP mechanotransduction and promotes cholangiocarcinoma development

YAP/TAZ functions and their regulation at a glance

(2020) Arianna Pocaterra et al.   JOURNAL OF CELL SCIENCE

Anti-Metastasis Fascin Inhibitors Decrease the Growth of Specific Subtypes of Cancers

(2020) Yufeng Wang et al.   Cancers

Filopodome Mapping Identifies p130Cas as a Mechanosensitive Regulator of Filopodia Stability

(2019) Guillaume Jacquemet et al.   CURRENT BIOLOGY

F-actin dynamics regulates mammalian organ growth and cell fate maintenance

(2019) Arianna Pocaterra et al.   JOURNAL OF HEPATOLOGY

Structure-based design, synthesis and biological evaluation of a novel series of isoquinolone and pyrazolo[4,3-c]pyridine inhibitors of fascin 1 as potential anti-metastatic agents

(2019) Stuart Francis et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Integrins as biomechanical sensors of the microenvironment

(2019) Jenny Z. Kechagia et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Nuclear envelope deformation controls cell cycle progression in response to mechanical force

(2019) Julien Aureille et al.   EMBO REPORTS

Capping Protein Insulates Arp2/3-Assembled Actin Patches from Formins

(2019) Ingrid Billault-Chaumartin et al.   CURRENT BIOLOGY

Peritumoral activation of the Hippo pathway effectors YAP and TAZ suppresses liver cancer in mice

(2019) Iván M. Moya et al.   SCIENCE

Genetic Mouse Models as In Vivo Tools for Cholangiocarcinoma Research

(2019) Oihane Erice et al.   Cancers

Filopodia and their links with membrane traffic and cell adhesion

(2019) J.L. Gallop   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Hippo Cascade Controls Lineage Commitment of Liver Tumors in Mice and Humans

(2018) Shanshan Zhang et al.   AMERICAN JOURNAL OF PATHOLOGY

Rho Kinase Inhibition by AT13148 Blocks Pancreatic Ductal Adenocarinoma Invasion and Tumor Growth

(2018) Nicola Rath et al.   CANCER RESEARCH

Fascin induces melanoma tumorigenesis and stemness through regulating the Hippo pathway

(2018) Jiaxin Kang et al.   Cell Communication and Signaling

dNTP metabolism links mechanical cues and YAP/TAZ to cell growth and oncogene‐induced senescence

(2018) Giulia Santinon et al.   EMBO JOURNAL

A polydnavirus-encoded ANK protein has a negative impact on steroidogenesis and development

(2018) Marilena Ignesti et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Mechanisms and impact of altered tumour mechanics

(2018) Hamid Mohammadi et al.   NATURE CELL BIOLOGY

Notch2 controls hepatocyte-derived cholangiocarcinoma formation in mice

(2018) Jingxiao Wang et al.   ONCOGENE

RAP2 mediates mechanoresponses of the Hippo pathway

(2018) Zhipeng Meng et al.   NATURE

Contact inhibition controls cell survival and proliferation via YAP/TAZ-autophagy axis

(2018) Mariana Pavel et al.   Nature Communications

The SWI/SNF complex is a mechanoregulated inhibitor of YAP and TAZ

(2018) Lei Chang et al.   NATURE

Hippo–YAP/TAZ signalling in organ regeneration and regenerative medicine

(2018) Iván M. Moya et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Hippo Signaling in the Liver Regulates Organ Size, Cell Fate, and Carcinogenesis

(2017) Sachin H. Patel et al.   GASTROENTEROLOGY

Adhesion forces and cortical tension couple cell proliferation and differentiation to drive epidermal stratification

(2017) Yekaterina A. Miroshnikova et al.   NATURE CELL BIOLOGY

Mechanical forces direct stem cell behaviour in development and regeneration

(2017) Kyle H. Vining et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Filament rigidity and connectivity tune the deformation modes of active biopolymer networks

(2017) Samantha Stam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evidence for a novel function of Awd in maintenance of genomic stability

(2017) Patrizia Romani et al.   Scientific Reports

YAP/TAZ at the Roots of Cancer

(2016) Francesca Zanconato et al.   CANCER CELL

Fascin Regulates Nuclear Movement and Deformation in Migrating Cells

(2016) Asier Jayo et al.   DEVELOPMENTAL CELL

Role of YAP/TAZ in cell-matrix adhesion-mediated signalling and mechanotransduction

(2016) Sirio Dupont   EXPERIMENTAL CELL RESEARCH

Physiological ranges of matrix rigidity modulate primary mouse hepatocyte function in part through hepatocyte nuclear factor 4 alpha

(2016) Seema S. Desai et al.   HEPATOLOGY

Improving fascin inhibitors to block tumor cell migration and metastasis

(2016) Shaoqin Han et al.   Molecular Oncology

Mechanical regulation of a molecular clutch defines force transmission and transduction in response to matrix rigidity

(2016) Alberto Elosegui-Artola et al.   NATURE CELL BIOLOGY

Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression

(2016) Hanane Laklai et al.   NATURE MEDICINE

Internetwork competition for monomers governs actin cytoskeleton organization

(2016) Cristian Suarez et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Fascin 1 promoted the growth and migration of non-small cell lung cancer cells by activating YAP/TEAD signaling

(2016) Zhigang Liang et al.   TUMOR BIOLOGY

Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis

(2015) Fei Liu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Profilin Regulates F-Actin Network Homeostasis by Favoring Formin over Arp2/3 Complex

(2015) Cristian Suarez et al.   DEVELOPMENTAL CELL

Aerobic glycolysis tunes YAP/TAZ transcriptional activity

(2015) E. Enzo et al.   EMBO JOURNAL

The Hippo pathway effector YAP controls mouse hepatic stellate cell activation

(2015) Inge Mannaerts et al.   JOURNAL OF HEPATOLOGY

Competition for actin between two distinct F-actin networks defines a bistable switch for cell polarization

(2015) Alexis J. Lomakin et al.   NATURE CELL BIOLOGY

Targeted inhibition of fascin function blocks tumour invasion and metastatic colonization

(2015) Fang-Ke Huang et al.   Nature Communications

Co-activation of PIK3CA and Yap promotes development of hepatocellular and cholangiocellular tumors in mouse and human liver

(2015) Xiaolei Li et al.   Oncotarget

Hydrodynamic Transfection for Generation of Novel Mouse Models for Liver Cancer Research

(2014) Xin Chen et al.   AMERICAN JOURNAL OF PATHOLOGY

Differential mapping of the free barbed and pointed ends of actin filaments in cells

(2014) Noa Ofer et al.   Cytoskeleton

Fascin Is Regulated by Slug, Promotes Progression of Pancreatic Cancer in Mice, and Is Associated With Patient Outcomes

(2014) Ang Li et al.   GASTROENTEROLOGY

Metabolic control of YAP and TAZ by the mevalonate pathway

(2014) Giovanni Sorrentino et al.   NATURE CELL BIOLOGY

Appreciating force and shape — the rise of mechanotransduction in cell biology

(2014) Thomas Iskratsch et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Capping protein regulators fine-tune actin assembly dynamics

(2014) Marc Edwards et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Fibroblasts probe substrate rigidity with filopodia extensions before occupying an area

(2014) Stephanie Wong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Mechanical Checkpoint Controls Multicellular Growth through YAP/TAZ Regulation by Actin-Processing Factors

(2013) Mariaceleste Aragona et al.   CELL

Small Molecules CK-666 and CK-869 Inhibit Actin-Related Protein 2/3 Complex by Blocking an Activating Conformational Change

(2013) Byron Hetrick et al.   CHEMISTRY & BIOLOGY

MT1-MMP-Dependent Control of Skeletal Stem Cell Commitment via a β1-Integrin/YAP/TAZ Signaling Axis

(2013) Yi Tang et al.   DEVELOPMENTAL CELL

Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts

(2013) Fernando Calvo et al.   NATURE CELL BIOLOGY

Fascin 1 is dispensable for developmental and tumour angiogenesis

(2013) Y. Ma et al.   Biology Open

Arp2/3 complex–dependent actin networks constrain myosin II function in driving retrograde actin flow

(2012) Qing Yang et al.   JOURNAL OF CELL BIOLOGY

Cholangiocarcinomas can originate from hepatocytes in mice

(2012) Biao Fan et al.   JOURNAL OF CLINICAL INVESTIGATION

Actomyosin-Mediated Cellular Tension Drives Increased Tissue Stiffness and β-Catenin Activation to Induce Epidermal Hyperplasia and Tumor Growth

(2011) Michael S. Samuel et al.   CANCER CELL

The Hippo Transducer TAZ Confers Cancer Stem Cell-Related Traits on Breast Cancer Cells

(2011) Michelangelo Cordenonsi et al.   CELL

Actin-Capping Protein and the Hippo pathway regulate F-actin and tissue growth in Drosophila

(2011) B. G. Fernandez et al.   DEVELOPMENT

Hippo pathway regulation by cell morphology and stress fibers

(2011) K.-I. Wada et al.   DEVELOPMENT

A Hitchhiker's Guide to Mechanobiology

(2011) Jeroen Eyckmans et al.   DEVELOPMENTAL CELL

Modulating F-actin organization induces organ growth by affecting the Hippo pathway

(2011) Leticia Sansores-Garcia et al.   EMBO JOURNAL

AKT (v-akt murine thymoma viral oncogene homolog 1) and N-Ras (neuroblastoma ras viral oncogene homolog) coactivation in the mouse liver promotes rapid carcinogenesis by way of mTOR (mammalian target of rapamycin complex 1), FOXM1 (forkhead box M1)/SKP2,

(2011) Coral Ho et al.   HEPATOLOGY

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

E-cadherin mediates contact inhibition of proliferation through Hippo signaling-pathway components

(2011) N.-G. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Actin-Bundling Protein Fascin Stabilizes Actin in Invadopodia and Potentiates Protrusive Invasion

(2010) Ang Li et al.   CURRENT BIOLOGY

Nf2/Merlin controls progenitor homeostasis and tumorigenesis in the liver

(2010) S. Benhamouche et al.   GENES & DEVELOPMENT

A Pathogenic Relationship Between a Regulator of the Actin Cytoskeleton and Serum Response Factor

(2010) Angela M. Verdoni et al.   GENETICS

Fascin: A key regulator of cytoskeletal dynamics

(2010) Asier Jayo et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Integrins and Extracellular Matrix in Mechanotransduction

(2010) M. A. Schwartz   Cold Spring Harbor Perspectives in Biology

Fascin1 is dispensable for mouse development but is favorable for neonatal survival

(2009) Yoshihiko Yamakita et al.   CELL MOTILITY AND THE CYTOSKELETON

Capping Protein Increases the Rate of Actin-Based Motility by Promoting Filament Nucleation by the Arp2/3 Complex

(2008) Orkun Akin et al.   CELL

WASP family members and formin proteins coordinate regulation of cell protrusions in carcinoma cells

(2008) Corina Sarmiento et al.   JOURNAL OF CELL BIOLOGY

WAVE and Arp2/3 jointly inhibit filopodium formation by entering into a complex with mDia2

(2008) Petra Beli et al.   NATURE CELL BIOLOGY