Mechanical Forces as Determinants of Disseminated Metastatic Cell Fate

Targeting the perivascular niche sensitizes disseminated tumour cells to chemotherapy

(2019) Patrick Carlson et al.   NATURE CELL BIOLOGY

Caveolin-1 Modulates Mechanotransduction Responses to Substrate Stiffness through Actin-Dependent Control of YAP

(2019) Roberto Moreno-Vicente et al.   Cell Reports

Sterol regulatory element binding protein 1 couples mechanical cues and lipid metabolism

(2019) Rebecca Bertolio et al.   Nature Communications

Extracellular matrix mechanical cues regulate lipid metabolism through Lipin-1 and SREBP

(2019) Patrizia Romani et al.   NATURE CELL BIOLOGY

F-actin dynamics regulates mammalian organ growth and cell fate maintenance

(2019) Arianna Pocaterra et al.   JOURNAL OF HEPATOLOGY

Inhibition of fascin in cancer and stromal cells blocks ovarian cancer metastasis

(2019) Sean McGuire et al.   GYNECOLOGIC ONCOLOGY

Structure-based design, synthesis and biological evaluation of a novel series of isoquinolone and pyrazolo[4,3-c]pyridine inhibitors of fascin 1 as potential anti-metastatic agents

(2019) Stuart Francis et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The Extracellular Matrix Modulates the Metastatic Journey

(2019) FuiBoon Kai et al.   DEVELOPMENTAL CELL

Mechanosensing by the Lamina Protects against Nuclear Rupture, DNA Damage, and Cell-Cycle Arrest

(2019) Sangkyun Cho et al.   DEVELOPMENTAL CELL

EMT and Cancer: More Than Meets the Eye

(2019) Rik Derynck et al.   DEVELOPMENTAL CELL

Integrins as biomechanical sensors of the microenvironment

(2019) Jenny Z. Kechagia et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Nuclear envelope deformation controls cell cycle progression in response to mechanical force

(2019) Julien Aureille et al.   EMBO REPORTS

Forced Unfolding of Proteins Directs Biochemical Cascades

(2019) Karanvir Saini et al.   BIOCHEMISTRY

Osteoblast-Secreted Factors Mediate Dormancy of Metastatic Prostate Cancer in the Bone via Activation of the TGFβRIII–p38MAPK–pS249/T252RB Pathway

(2018) Li-Yuan Yu-Lee et al.   CANCER RESEARCH

Tensile Forces and Mechanotransduction at Cell–Cell Junctions

(2018) Guillaume Charras et al.   CURRENT BIOLOGY

dNTP metabolism links mechanical cues and YAP/TAZ to cell growth and oncogene‐induced senescence

(2018) Giulia Santinon et al.   EMBO JOURNAL

How cells sense their own shape – mechanisms to probe cell geometry and their implications in cellular organization and function

(2018) Armin Haupt et al.   JOURNAL OF CELL SCIENCE

Pericyte-like spreading by disseminated cancer cells activates YAP and MRTF for metastatic colonization

(2018) Ekrem Emrah Er et al.   NATURE CELL BIOLOGY

Emerging views of the nucleus as a cellular mechanosensor

(2018) Tyler J. Kirby et al.   NATURE CELL BIOLOGY

Crosstalk between YAP/TAZ and Notch Signaling

(2018) Antonio Totaro et al.   TRENDS IN CELL BIOLOGY

Periostin: A Matricellular Protein With Multiple Functions in Cancer Development and Progression

(2018) Laura González-González et al.   Frontiers in Oncology

RAP2 mediates mechanoresponses of the Hippo pathway

(2018) Zhipeng Meng et al.   NATURE

EMT and Stemness in Tumor Dormancy and Outgrowth: Are They Intertwined Processes?

(2018) Keren Weidenfeld et al.   Frontiers in Oncology

The SWI/SNF complex is a mechanoregulated inhibitor of YAP and TAZ

(2018) Lei Chang et al.   NATURE

A Feedforward Mechanism Mediated by Mechanosensitive Ion Channel PIEZO1 and Tissue Mechanics Promotes Glioma Aggression

(2018) Xin Chen et al.   NEURON

Mutual dependence of the MRTF–SRF and YAP–TEAD pathways in cancer-associated fibroblasts is indirect and mediated by cytoskeletal dynamics

(2017) Charles T. Foster et al.   GENES & DEVELOPMENT

Multiscale force sensing in development

(2017) Nicoletta I. Petridou et al.   NATURE CELL BIOLOGY

Mechanoreciprocity in cell migration

(2017) Sjoerd van Helvert et al.   NATURE CELL BIOLOGY

Regulation of genome organization and gene expression by nuclear mechanotransduction

(2017) Caroline Uhler et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Piezos thrive under pressure: mechanically activated ion channels in health and disease

(2017) Swetha E. Murthy et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanical forces direct stem cell behaviour in development and regeneration

(2017) Kyle H. Vining et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Tissue Force Programs Cell Fate and Tumor Aggression

(2017) Jason J. Northey et al.   Cancer Discovery

Thrombospondin-1 is a multifaceted player in tumor progression

(2017) Tingting Huang et al.   Oncotarget

A bulky glycocalyx fosters metastasis formation by promoting G1 cell cycle progression

(2017) Elliot C Woods et al.   eLife

YAP/TAZ at the Roots of Cancer

(2016) Francesca Zanconato et al.   CANCER CELL

Inflammation Triggers Zeb1-Dependent Escape from Tumor Latency

(2016) Jasmine M. De Cock et al.   CANCER RESEARCH

Multi-organ Site Metastatic Reactivation Mediated by Non-canonical Discoidin Domain Receptor 1 Signaling

(2016) Hua Gao et al.   CELL

Role of YAP/TAZ in cell-matrix adhesion-mediated signalling and mechanotransduction

(2016) Sirio Dupont   EXPERIMENTAL CELL RESEARCH

Tenascin-C at a glance

(2016) Kim S. Midwood et al.   JOURNAL OF CELL SCIENCE

Improving fascin inhibitors to block tumor cell migration and metastasis

(2016) Shaoqin Han et al.   Molecular Oncology

Integrin-YAP/TAZ-JNK cascade mediates atheroprotective effect of unidirectional shear flow

(2016) Li Wang et al.   NATURE

Designer matrices for intestinal stem cell and organoid culture

(2016) Nikolce Gjorevski et al.   NATURE

Mechanism of early dissemination and metastasis in Her2+ mammary cancer

(2016) Kathryn L. Harper et al.   NATURE

Induction of LIFR confers a dormancy phenotype in breast cancer cells disseminated to the bone marrow

(2016) Rachelle W. Johnson et al.   NATURE CELL BIOLOGY

Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression

(2016) Hanane Laklai et al.   NATURE MEDICINE

Flow-dependent YAP/TAZ activities regulate endothelial phenotypes and atherosclerosis

(2016) Kuei-Chun Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ESCRT III repairs nuclear envelope ruptures during cell migration to limit DNA damage and cell death

(2016) M. Raab et al.   SCIENCE

The marrow niche controls the cancer stem cell phenotype of disseminated prostate cancer

(2016) Yusuke Shiozawa et al.   Oncotarget

Axl is required for TGF-β2-induced dormancy of prostate cancer cells in the bone marrow

(2016) Kenji Yumoto et al.   Scientific Reports

Nuclear F-actin Formation and Reorganization upon Cell Spreading

(2015) Matthias Plessner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genome-wide association between YAP/TAZ/TEAD and AP-1 at enhancers drives oncogenic growth

(2015) Francesca Zanconato et al.   NATURE CELL BIOLOGY

Matrix stiffness drives epithelial–mesenchymal transition and tumour metastasis through a TWIST1–G3BP2 mechanotransduction pathway

(2015) Spencer C. Wei et al.   NATURE CELL BIOLOGY

Mechanical Forces and Growth in Animal Tissues

(2015) Loïc LeGoff et al.   Cold Spring Harbor Perspectives in Biology

NR2F1 controls tumour cell dormancy via SOX9- and RARβ-driven quiescence programmes

(2015) Maria Soledad Sosa et al.   Nature Communications

Tenascin C in metastasis: A view from the invasive front

(2015) Camille M Lowy et al.   Cell Adhesion & Migration

Distinct mechanisms regulating mechanical force-induced Ca2+ signals at the plasma membrane and the ER in human MSCs

(2015) Tae-Jin Kim et al.   eLife

Transient SNAIL1 Expression Is Necessary for Metastatic Competence in Breast Cancer

(2014) H. D. Tran et al.   CANCER RESEARCH

Matrix Elasticity Regulates Lamin-A,C Phosphorylation and Turnover with Feedback to Actomyosin

(2014) Amnon Buxboim et al.   CURRENT BIOLOGY

Mechanical Role of Actin Dynamics in the Rheology of the Golgi Complex and in Golgi-Associated Trafficking Events

(2014) David Guet et al.   CURRENT BIOLOGY

The cancer glycocalyx mechanically primes integrin-mediated growth and survival

(2014) Matthew J. Paszek et al.   NATURE

Appreciating force and shape — the rise of mechanotransduction in cell biology

(2014) Thomas Iskratsch et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Stretch-activated ion channel Piezo1 directs lineage choice in human neural stem cells

(2014) Medha M. Pathak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Mechanical Checkpoint Controls Multicellular Growth through YAP/TAZ Regulation by Actin-Processing Factors

(2013) Mariaceleste Aragona et al.   CELL

Dimensions in cell migration

(2013) Andrew D Doyle et al.   CURRENT OPINION IN CELL BIOLOGY

MT1-MMP-Dependent Control of Skeletal Stem Cell Commitment via a β1-Integrin/YAP/TAZ Signaling Axis

(2013) Yi Tang et al.   DEVELOPMENTAL CELL

TGF-β2 dictates disseminated tumour cell fate in target organs through TGF-β-RIII and p38α/β signalling

(2013) Paloma Bragado et al.   NATURE CELL BIOLOGY

The perivascular niche regulates breast tumour dormancy

(2013) Cyrus M. Ghajar et al.   NATURE CELL BIOLOGY

Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation

(2013) J. Swift et al.   SCIENCE

Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition

(2013) M. Yu et al.   SCIENCE

Spatiotemporal Regulation of Epithelial-Mesenchymal Transition Is Essential for Squamous Cell Carcinoma Metastasis

(2012) Jeff H. Tsai et al.   CANCER CELL

The BMP Inhibitor Coco Reactivates Breast Cancer Cells at Lung Metastatic Sites

(2012) Hua Gao et al.   CELL

Matrix rigidity regulates a switch between TGF-β1–induced apoptosis and epithelial–mesenchymal transition

(2012) Jennifer L. Leight et al.   MOLECULAR BIOLOGY OF THE CELL

TGF-β stimulates Pyk2 expression as part of an epithelial-mesenchymal transition program required for metastatic outgrowth of breast cancer

(2012) M K Wendt et al.   ONCOGENE

The Outgrowth of Micrometastases Is Enabled by the Formation of Filopodium-like Protrusions

(2012) Tsukasa Shibue et al.   Cancer Discovery

Detection of circulating tumour cells with a hybrid (epithelial/mesenchymal) phenotype in patients with metastatic non-small cell lung cancer

(2011) A Lecharpentier et al.   BRITISH JOURNAL OF CANCER

VCAM-1 Promotes Osteolytic Expansion of Indolent Bone Micrometastasis of Breast Cancer by Engaging α4β1-Positive Osteoclast Progenitors

(2011) Xin Lu et al.   CANCER CELL

Actomyosin-Mediated Cellular Tension Drives Increased Tissue Stiffness and β-Catenin Activation to Induce Epidermal Hyperplasia and Tumor Growth

(2011) Michael S. Samuel et al.   CANCER CELL

Cells Respond to Mechanical Stress by Rapid Disassembly of Caveolae

(2011) Bidisha Sinha et al.   CELL

Biomechanical Remodeling of the Microenvironment by Stromal Caveolin-1 Favors Tumor Invasion and Metastasis

(2011) Jacky G. Goetz et al.   CELL

A Hitchhiker's Guide to Mechanobiology

(2011) Jeroen Eyckmans et al.   DEVELOPMENTAL CELL

Nuclear transport of the serum response factor coactivator MRTF-A is downregulated at tensional homeostasis

(2011) Karen M McGee et al.   EMBO REPORTS

Matrix stiffening sensitizes epithelial cells to EGF and enables the loss of contact inhibition of proliferation

(2011) J.-H. Kim et al.   JOURNAL OF CELL SCIENCE

Bone morphogenetic protein 7 in dormancy and metastasis of prostate cancer stem-like cells in bone

(2011) Aya Kobayashi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Temporal and Spatial Cooperation of Snail1 and Twist1 during Epithelial-Mesenchymal Transition Predicts for Human Breast Cancer Recurrence

(2011) D. D. Tran et al.   MOLECULAR CANCER RESEARCH

Circulating Tumor Cells from Patients with Advanced Prostate and Breast Cancer Display Both Epithelial and Mesenchymal Markers

(2011) A. J. Armstrong et al.   MOLECULAR CANCER RESEARCH

Interactions between cancer stem cells and their niche govern metastatic colonization

(2011) Ilaria Malanchi et al.   NATURE

Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs

(2011) Thordur Oskarsson et al.   NATURE MEDICINE

Metastatic Growth from Dormant Cells Induced by a Col-I-Enriched Fibrotic Environment

(2010) D. Barkan et al.   CANCER RESEARCH

α-Catenin as a tension transducer that induces adherens junction development

(2010) Shigenobu Yonemura et al.   NATURE CELL BIOLOGY

Linking actin dynamics and gene transcription to drive cellular motile functions

(2010) Eric N. Olson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Hypoxia-Induced Lysyl Oxidase Is a Critical Mediator of Bone Marrow Cell Recruitment to Form the Premetastatic Niche

(2009) Janine T. Erler et al.   CANCER CELL

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

TGF-β-induced epithelial to mesenchymal transition

(2009) Jian Xu et al.   CELL RESEARCH

Cell-Cycle Control by Physiological Matrix Elasticity and In Vivo Tissue Stiffening

(2009) Eric A. Klein et al.   CURRENT BIOLOGY

Matrix density-induced mechanoregulation of breast cell phenotype, signaling and gene expression through a FAK–ERK linkage

(2009) P P Provenzano et al.   ONCOGENE

Differential Matrix Rigidity Response in Breast Cancer Cell Lines Correlates with the Tissue Tropism

(2009) Ana Kostic et al.   PLoS One

Integrin  1-focal adhesion kinase signaling directs the proliferation of metastatic cancer cells disseminated in the lungs

(2009) T. Shibue et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of Metastatic Outgrowth from Single Dormant Tumor Cells by Targeting the Cytoskeleton

(2008) D. Barkan et al.   CANCER RESEARCH

SREBP Activity Is Regulated by mTORC1 and Contributes to Akt-Dependent Cell Growth

(2008) Thomas Porstmann et al.   Cell Metabolism

TEAD mediates YAP-dependent gene induction and growth control

(2008) B. Zhao et al.   GENES & DEVELOPMENT

TAZ Promotes Cell Proliferation and Epithelial-Mesenchymal Transition and Is Inhibited by the Hippo Pathway

(2008) Q.-Y. Lei et al.   MOLECULAR AND CELLULAR BIOLOGY