Multiscale force sensing in development

Mechanosensing by the nucleus: From pathways to scaling relationships

(2017) Sangkyun Cho et al.   JOURNAL OF CELL BIOLOGY

Force Feedback Controls Motor Activity and Mechanical Properties of Self-Assembling Branched Actin Networks

(2016) Peter Bieling et al.   CELL

Mechanosensing via cell-matrix adhesions in 3D microenvironments

(2016) Andrew D. Doyle et al.   EXPERIMENTAL CELL RESEARCH

Asymmetric division of contractile domains couples cell positioning and fate specification

(2016) Jean-Léon Maître et al.   NATURE

Epithelial tricellular junctions act as interphase cell shape sensors to orient mitosis

(2016) Floris Bosveld et al.   NATURE

Transcription upregulation via force-induced direct stretching of chromatin

(2016) Arash Tajik et al.   NATURE MATERIALS

In vivo quantification of spatially varying mechanical properties in developing tissues

(2016) Friedhelm Serwane et al.   NATURE METHODS

Mechanosensing is critical for axon growth in the developing brain

(2016) David E Koser et al.   NATURE NEUROSCIENCE

A ligand-independent integrin β1 mechanosensory complex guides spindle orientation

(2016) Nicoletta I. Petridou et al.   Nature Communications

Oscillatory Flow Modulates Mechanosensitive klf2a Expression through trpv4 and trpp2 during Heart Valve Development

(2015) Emilie Heckel et al.   CURRENT BIOLOGY

Direct Microtubule-Binding by Myosin-10 Orients Centrosomes toward Retraction Fibers and Subcortical Actin Clouds

(2015) Mijung Kwon et al.   DEVELOPMENTAL CELL

Multiscale mechanobiology: computational models for integrating molecules to multicellular systems

(2015) Michael Mak et al.   Integrative Biology

Measurement of surface and interfacial tension using pendant drop tensiometry

(2015) Joseph D. Berry et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Cell mixing induced by myc is required for competitive tissue invasion and destruction

(2015) Romain Levayer et al.   NATURE

E-cadherin junctions as active mechanical integrators in tissue dynamics

(2015) Thomas Lecuit et al.   NATURE CELL BIOLOGY

Integrin-Linked Kinase links Dynactin-1/Dynactin-2 with cortical Integrin receptors to orient the mitotic spindle relative to the substratum

(2015) Edward James Morris et al.   Scientific Reports

Cadherin Adhesion and Mechanotransduction

(2014) D.E. Leckband et al.   Annual Review of Cell and Developmental Biology

Cytoskeletal Tension Inhibits Hippo Signaling through an Ajuba-Warts Complex

(2014) Cordelia Rauskolb et al.   CELL

How to Measure Molecular Forces in Cells: A Guide to Evaluating Genetically-Encoded FRET-Based Tension Sensors

(2014) Anna-Lena Cost et al.   Cellular and Molecular Bioengineering

The interaction between uPAR and vitronectin triggers ligand-independent adhesion signalling by integrins

(2014) G. M. S. Ferraris et al.   EMBO JOURNAL

SLK-dependent activation of ERMs controls LGN–NuMA localization and spindle orientation

(2014) Mickael Machicoane et al.   JOURNAL OF CELL BIOLOGY

A method to recapitulate early embryonic spatial patterning in human embryonic stem cells

(2014) Aryeh Warmflash et al.   NATURE METHODS

Mechanotransduction and extracellular matrix homeostasis

(2014) Jay D. Humphrey et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Appreciating force and shape — the rise of mechanotransduction in cell biology

(2014) Thomas Iskratsch et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Piezo channels: from structure to function

(2014) Linda Volkers et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

FAK transduces extracellular forces that orient the mitotic spindle and control tissue morphogenesis

(2014) Nicoletta I. Petridou et al.   Nature Communications

Resolving the molecular mechanism of cadherin catch bond formation

(2014) Kristine Manibog et al.   Nature Communications

Forces in Tissue Morphogenesis and Patterning

(2013) Carl-Philipp Heisenberg et al.   CELL

Molecular pathways regulating mitotic spindle orientation in animal cells

(2013) M. S. Lu et al.   DEVELOPMENT

A global pattern of mechanical stress polarizes cell divisions and cell shape in the growing Drosophila wing disc

(2013) Loïc LeGoff et al.   DEVELOPMENT

Differential proliferation rates generate patterns of mechanical tension that orient tissue growth

(2013) Yanlan Mao et al.   EMBO JOURNAL

Cyclic Mechanical Reinforcement of Integrin–Ligand Interactions

(2013) Fang Kong et al.   MOLECULAR CELL

Tension-oriented cell divisions limit anisotropic tissue tension in epithelial spreading during zebrafish epiboly

(2013) Pedro Campinho et al.   NATURE CELL BIOLOGY

F- and G-actin homeostasis regulates mechanosensitive actin nucleation by formins

(2013) Chiharu Higashida et al.   NATURE CELL BIOLOGY

Molecular mechanisms of cellular mechanosensing

(2013) Tianzhi Luo et al.   NATURE MATERIALS

Quantifying cell-generated mechanical forces within living embryonic tissues

(2013) Otger Campàs et al.   NATURE METHODS

Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation

(2013) J. Swift et al.   SCIENCE

Evolutionary conservation of early mesoderm specification by mechanotransduction in Bilateria

(2013) Thibaut Brunet et al.   Nature Communications

Mechanical Stress Acts via Katanin to Amplify Differences in Growth Rate between Adjacent Cells in Arabidopsis

(2012) Magalie Uyttewaal et al.   CELL

Planar Polarity Specification through Asymmetric Subcellular Localization of Fat and Dachsous

(2012) Amy Brittle et al.   CURRENT BIOLOGY

Integrating force-sensing and signaling pathways in a model for the regulation of wing imaginal disc size

(2012) T. Aegerter-Wilmsen et al.   DEVELOPMENT

Spindle Position in Symmetric Cell Divisions during Epiboly Is Controlled by Opposing and Dynamic Apicobasal Forces

(2012) Sarah Woolner et al.   DEVELOPMENTAL CELL

Cell detachment activates the Hippo pathway via cytoskeleton reorganization to induce anoikis

(2012) B. Zhao et al.   GENES & DEVELOPMENT

α-Catenin and Vinculin Cooperate to Promote High E-cadherin-based Adhesion Strength

(2012) William A. Thomas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Substrate stiffness regulates cadherin-dependent collective migration through myosin-II contractility

(2012) Mei Rosa Ng et al.   JOURNAL OF CELL BIOLOGY

Observing force-regulated conformational changes and ligand dissociation from a single integrin on cells

(2012) Wei Chen et al.   JOURNAL OF CELL BIOLOGY

Crowding induces live cell extrusion to maintain homeostatic cell numbers in epithelia

(2012) George T. Eisenhoffer et al.   NATURE

Live-cell delamination counterbalances epithelial growth to limit tissue overcrowding

(2012) Eliana Marinari et al.   NATURE

Mechanical force regulates integrin turnover in Drosophila in vivo

(2012) Mary Pines et al.   NATURE CELL BIOLOGY

External push and internal pull forces recruit curvature-sensing N-BAR domain proteins to the plasma membrane

(2012) Milos Galic et al.   NATURE CELL BIOLOGY

Ideal, catch, and slip bonds in cadherin adhesion

(2012) S. Rakshit et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adhesion Functions in Cell Sorting by Mechanically Coupling the Cortices of Adhering Cells

(2012) J.-L. Maitre et al.   SCIENCE

Generation of Leaf Shape Through Early Patterns of Growth and Tissue Polarity

(2012) E. E. Kuchen et al.   SCIENCE

Use the force: membrane tension as an organizer of cell shape and motility

(2012) Alba Diz-Muñoz et al.   TRENDS IN CELL BIOLOGY

The Development and Application of Optogenetics

(2011) Lief Fenno et al.   Annual Review of Neuroscience

A blood flow-dependent klf2a-NO signaling cascade is required for stabilization of hematopoietic stem cell programming in zebrafish embryos

(2011) L. Wang et al.   BLOOD

Cells Respond to Mechanical Stress by Rapid Disassembly of Caveolae

(2011) Bidisha Sinha et al.   CELL

Modeling new conceptual interpretations of development

(2011) J. Vermot et al.   DEVELOPMENT

Microtubule-induced nuclear envelope fluctuations control chromatin dynamics in Drosophila embryos

(2011) Bernhard Hampoelz et al.   DEVELOPMENT

Actin-Capping Protein and the Hippo pathway regulate F-actin and tissue growth in Drosophila

(2011) B. G. Fernandez et al.   DEVELOPMENT

Hippo pathway regulation by cell morphology and stress fibers

(2011) K.-I. Wada et al.   DEVELOPMENT

Mechanochemical Control of Mesenchymal Condensation and Embryonic Tooth Organ Formation

(2011) Tadanori Mammoto et al.   DEVELOPMENTAL CELL

A Mechanoresponsive Cadherin-Keratin Complex Directs Polarized Protrusive Behavior and Collective Cell Migration

(2011) Gregory F. Weber et al.   DEVELOPMENTAL CELL

Modulating F-actin organization induces organ growth by affecting the Hippo pathway

(2011) Leticia Sansores-Garcia et al.   EMBO JOURNAL

Planar polarization of the atypical myosin Dachs orients cell divisions in Drosophila

(2011) Y. Mao et al.   GENES & DEVELOPMENT

Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein

(2011) B. Zhao et al.   GENES & DEVELOPMENT

A tension-induced mechanotransduction pathway promotes epithelial morphogenesis

(2011) Huimin Zhang et al.   NATURE

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

External forces control mitotic spindle positioning

(2011) Jenny Fink et al.   NATURE CELL BIOLOGY

Strength Dependence of Cadherin-Mediated Adhesions

(2010) Benoit Ladoux et al.   BIOPHYSICAL JOURNAL

Vinculin potentiates E-cadherin mechanosensing and is recruited to actin-anchored sites within adherens junctions in a myosin II–dependent manner

(2010) Quint le Duc et al.   JOURNAL OF CELL BIOLOGY

α-Catenin as a tension transducer that induces adherens junction development

(2010) Shigenobu Yonemura et al.   NATURE CELL BIOLOGY

Aspiration of Biological Viscoelastic Drops

(2010) Karine Guevorkian et al.   PHYSICAL REVIEW LETTERS

Mechanical tugging force regulates the size of cell-cell junctions

(2010) Z. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integrins and Extracellular Matrix in Mechanotransduction

(2010) M. A. Schwartz   Cold Spring Harbor Perspectives in Biology

Cell Traction Forces Direct Fibronectin Matrix Assembly

(2009) Christopher A. Lemmon et al.   BIOPHYSICAL JOURNAL

Hematopoietic Stem Cell Development Is Dependent on Blood Flow

(2009) Trista E. North et al.   CELL

Muscle Contraction Is Necessary to Maintain Joint Progenitor Cell Fate

(2009) Joy Kahn et al.   DEVELOPMENTAL CELL

Myosin II Dynamics Are Regulated by Tension in Intercalating Cells

(2009) Rodrigo Fernandez-Gonzalez et al.   DEVELOPMENTAL CELL

Cadherin Adhesion, Tissue Tension, and Noncanonical Wnt Signaling Regulate Fibronectin Matrix Organization

(2009) Bette J. Dzamba et al.   DEVELOPMENTAL CELL

Demonstration of catch bonds between an integrin and its ligand

(2009) Fang Kong et al.   JOURNAL OF CELL BIOLOGY

Mechanosensing in actin stress fibers revealed by a close correlation between force and protein localization

(2009) J. Colombelli et al.   JOURNAL OF CELL SCIENCE

Determination of mechanical stress distribution in Drosophila wing discs using photoelasticity

(2009) Ulrike Nienhaus et al.   MECHANISMS OF DEVELOPMENT

Biomechanical forces promote embryonic haematopoiesis

(2009) Luigi Adamo et al.   NATURE

Cell shape changes indicate a role for extrinsic tensile forces in Drosophila germ-band extension

(2009) Lucy C. Butler et al.   NATURE CELL BIOLOGY

Stretching Single Talin Rod Molecules Activates Vinculin Binding

(2009) A. del Rio et al.   SCIENCE

Mechanically Activated Integrin Switch Controls  5 1 Function

(2009) J. C. Friedland et al.   SCIENCE

Cell adhesion receptors in mechanotransduction

(2008) Martin A Schwartz et al.   CURRENT OPINION IN CELL BIOLOGY

Morphogen Control of Wing Growth through the Fat Signaling Pathway

(2008) Dragana Rogulja et al.   DEVELOPMENTAL CELL

Tissue Deformation Modulates Twist Expression to Determine Anterior Midgut Differentiation in Drosophila Embryos

(2008) Nicolas Desprat et al.   DEVELOPMENTAL CELL

Mechanotransduction in development: a growing role for contractility

(2008) Michele A. Wozniak et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanotransduction gone awry

(2008) Diana E. Jaalouk et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Rapid signal transduction in living cells is a unique feature of mechanotransduction

(2008) S. Na et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Developmental Patterning by Mechanical Signals in Arabidopsis

(2008) O. Hamant et al.   SCIENCE