SIRT2 mediates NADH-induced increases in Nrf2, GCL, and glutathione by modulating Akt phosphorylation in PC12 cells

Investigating the Sensitivity of NAD+-dependent Sirtuin Deacylation Activities to NADH

(2016) Andreas S. Madsen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metformin-induced protection against oxidative stress is associated with AKT/mTOR restoration in PC12 cells

(2016) Behzad Khallaghi et al.   LIFE SCIENCES

Nrf2–ARE pathway: An emerging target against oxidative stress and neuroinflammation in neurodegenerative diseases

(2016) Izaskun Buendia et al.   PHARMACOLOGY & THERAPEUTICS

Examining the neuroprotective effects of protocatechuic acid and chrysin on in vitro and in vivo models of Parkinson disease

(2015) Zaijun Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

In vivo NAD assay reveals the intracellular NAD contents and redox state in healthy human brain and their age dependences

(2015) Xiao-Hong Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neurological morphofunctional differentiation induced by REAC technology in PC12. A neuro protective model for Parkinson’s disease

(2015) Margherita Maioli et al.   Scientific Reports

The Sirtuin-2 Inhibitor AK7 Is Neuroprotective in Models of Parkinson’s Disease but Not Amyotrophic Lateral Sclerosis and Cerebral Ischemia

(2015) Xiqun Chen et al.   PLoS One

SIRT1 protects against cigarette smoke-induced lung oxidative stress via a FOXO3-dependent mechanism

(2014) Hongwei Yao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The Discovery of a Highly Selective 5,6,7,8-Tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one SIRT2 Inhibitor that is Neuroprotective in an in vitro Parkinson’s Disease Model

(2014) Paolo Di Fruscia et al.   ChemMedChem

Decreased SIRT2 activity leads to altered microtubule dynamics in oxidatively-stressed neuronal cells: Implications for Parkinson's disease

(2014) Vivek P. Patel et al.   EXPERIMENTAL NEUROLOGY

SIRT2 mediates oxidative stress-induced apoptosis of differentiated PC12 cells

(2014) Hui Nie et al.   NEUROREPORT

Saponins fromAralia taibaiensisAttenuate D-Galactose-Induced Aging in Rats by Activating FOXO3a and Nrf2 Pathways

(2014) Ying-Na Li et al.   Oxidative Medicine and Cellular Longevity

Essential role of PH domain and leucine-rich repeat protein phosphatase 2 in Nrf2 suppression via modulation of Akt/GSK3β/Fyn kinase axis during oxidative hepatocellular toxicity

(2014) F Rizvi et al.   Cell Death & Disease

Posttranslational regulation of Akt in human cancer

(2014) Chia-Hsin Chan et al.   Cell and Bioscience

SIRT2 enhances 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced nigrostriatal damage via apoptotic pathway

(2014) Lei Liu et al.   Frontiers in Aging Neuroscience

Hydrogen peroxide sensing, signaling and regulation of transcription factors

(2014) H. Susana Marinho et al.   Redox Biology

Phenethyl isothiocyanate induces calcium mobilization and mitochondrial cell death pathway in cholangiocarcinoma KKU-M214 cells

(2013) Ornanong Tusskorn et al.   BMC CANCER

Sirtuin deacetylases in neurodegenerative diseases of aging

(2013) Adrianna Z Herskovits et al.   CELL RESEARCH

Glutathione metabolism and Parkinson's disease

(2013) Michelle Smeyne et al.   FREE RADICAL BIOLOGY AND MEDICINE

Neurodegeneration in Parkinson's Disease: Interactions of Oxidative Stress, Tryptophan Catabolites and Depression with Mitochondria and Sirtuins

(2013) George Anderson et al.   MOLECULAR NEUROBIOLOGY

Sulforaphane and phenylethyl isothiocyanate protect human skin against UVR-induced oxidative stress and apoptosis: Role of Nrf2-dependent gene expression and antioxidant enzymes

(2013) Konrad Kleszczyński et al.   PHARMACOLOGICAL RESEARCH

Sirtuin-2 Activity is Required for Glioma Stem Cell Proliferation Arrest but not Necrosis Induced by Resveratrol

(2013) Salwa Sayd et al.   Stem Cell Reviews and Reports

NAD+ Metabolism and NAD+-Dependent Enzymes: Promising Therapeutic Targets for Neurological Diseases

(2012) Yingxin Ma et al.   CURRENT DRUG TARGETS

Sirtuin 2 (SIRT2) Enhances 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Nigrostriatal Damage via Deacetylating Forkhead Box O3a (Foxo3a) and Activating Bim Protein

(2012) Lei Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Redox imbalance influence in the myocardial Akt activation in aged rats treated with DHEA

(2010) Maria Helena Vianna Metello Jacob et al.   EXPERIMENTAL GERONTOLOGY

Hyperoxia Exposure Alters Hepatic Eicosanoid Metabolism in Newborn Mice

(2010) Lynette K Rogers et al.   PEDIATRIC RESEARCH

Hydrogen peroxide-induced Akt phosphorylation regulates Bax activation

(2009) Mahdieh Sadidi et al.   BIOCHIMIE

Nrf2:INrf2 (Keap1) signaling in oxidative stress

(2009) James W. Kaspar et al.   FREE RADICAL BIOLOGY AND MEDICINE

Regulation of H2O2-induced necrosis by PKC and AMP-activated kinase signaling in primary cultured hepatocytes

(2008) Behnam Saberi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Foxo3a Inhibits Cardiomyocyte Hypertrophy through Transactivating Catalase

(2008) Wei-Qi Tan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bromocriptine activates NQO1 via Nrf2-PI3K/Akt signaling: Novel cytoprotective mechanism against oxidative damage

(2008) Ju Hee Lim et al.   PHARMACOLOGICAL RESEARCH

NAD+/NADH and NADP+/NADPH in Cellular Functions and Cell Death: Regulation and Biological Consequences

(2007) Weihai Ying   ANTIOXIDANTS & REDOX SIGNALING

The Nrf2–Keap1 defence pathway: Role in protection against drug-induced toxicity

(2007) Ian M. Copple et al.   TOXICOLOGY