Ubiquitin-specific peptidase 7 (USP7)-mediated deubiquitination of the histone deacetylase SIRT7 regulates gluconeogenesis

SIRT7-dependent deacetylation of CDK9 activates RNA polymerase II transcription

(2017) Maximilian F. Blank et al.   NUCLEIC ACIDS RESEARCH

Quantitative proteome-based systematic identification of SIRT7 substrates

(2017) Chaohua Zhang et al.   PROTEOMICS

Downregulation of SIRT7 by 5-fluorouracil induces radiosensitivity in human colorectal cancer

(2017) Ming Tang et al.   Theranostics

Regulation of Serine-Threonine Kinase Akt Activation by NAD + -Dependent Deacetylase SIRT7

(2017) Jia Yu et al.   Cell Reports

C/EBPα negatively regulates SIRT7 expression via recruiting HDAC3 to the upstream-promoter of hepatocellular carcinoma cells

(2016) Gui-fen Liu et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

HDAC4 mediates IFN-γ induced disruption of energy expenditure-related gene expression by repressing SIRT1 transcription in skeletal muscle cells

(2016) Mingming Fang et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Sirtuins, Cell Senescence, and Vascular Aging

(2016) Yujiro Kida et al.   CANADIAN JOURNAL OF CARDIOLOGY

SIRT7 promotes genome integrity and modulates non‐homologous end joining DNA repair

(2016) Berta N Vazquez et al.   EMBO JOURNAL

Acetylation of PGK1 promotes liver cancer cell proliferation and tumorigenesis

(2016) Hongli Hu et al.   HEPATOLOGY

SIRT1 and SIRT7 expression in adipose tissues of obese and normal-weight individuals is regulated by microRNAs but not by methylation status

(2016) A Kurylowicz et al.   INTERNATIONAL JOURNAL OF OBESITY

Regulation of energy homeostasis by the ubiquitin-independent REGγ proteasome

(2016) Lianhui Sun et al.   Nature Communications

SIRT7-dependent deacetylation of the U3-55k protein controls pre-rRNA processing

(2016) Sifan Chen et al.   Nature Communications

SIRT7 is a histone desuccinylase that functionally links to chromatin compaction and genome stability

(2016) Lei Li et al.   Nature Communications

Sirtuin regulation in aging and injury

(2015) Ninu Poulose et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Sirtuin 7 in cell proliferation, stress and disease: Rise of the Seventh Sirtuin!

(2015) Shashi Kiran et al.   CELLULAR SIGNALLING

Sirtuin 7 promotes cellular survival following genomic stress by attenuation of DNA damage, SAPK activation and p53 response

(2015) Shashi Kiran et al.   EXPERIMENTAL CELL RESEARCH

A mitochondrial UPR-mediated metabolic checkpoint regulates hematopoietic stem cell aging

(2015) M. Mohrin et al.   SCIENCE

SIRT7 inactivation reverses metastatic phenotypes in epithelial and mesenchymal tumors

(2015) Shivani Malik et al.   Scientific Reports

MiR-93 Controls Adiposity via Inhibition of Sirt7 and Tbx3

(2015) Michele Cioffi et al.   Cell Reports

USP7 controls Chk1 protein stability by direct deubiquitination

(2014) Ignacio Alonso-de Vega et al.   CELL CYCLE

A SIRT7-Dependent Acetylation Switch of GABPβ1 Controls Mitochondrial Function

(2014) Dongryeol Ryu et al.   Cell Metabolism

SIRT7 Controls Hepatic Lipid Metabolism by Regulating the Ubiquitin-Proteasome Pathway

(2014) Tatsuya Yoshizawa et al.   Cell Metabolism

Overexpression of Sirt7 Exhibits Oncogenic Property and Serves as a Prognostic Factor in Colorectal Cancer

(2014) H. Yu et al.   CLINICAL CANCER RESEARCH

Molecular Pathways: Emerging Roles of Mammalian Sirtuin SIRT7 in Cancer

(2014) S. Paredes et al.   CLINICAL CANCER RESEARCH

USP7 Attenuates Hepatic Gluconeogenesis Through Modulation of FoxO1 Gene Promoter Occupancy

(2014) Jessica A. Hall et al.   MOLECULAR ENDOCRINOLOGY

Tumor suppressor p53 cooperates with SIRT6 to regulate gluconeogenesis by promoting FoxO1 nuclear exclusion

(2014) P. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparative interactomes of SIRT6 and SIRT7: Implication of functional links to aging

(2014) Namgyu Lee et al.   PROTEOMICS

Modelling the structure of full-length Epstein–Barr virus nuclear antigen 1

(2014) Mushtaq Hussain et al.   VIRUS GENES

Inhibition of H3K18 deacetylation of Sirt7 by Myb-binding protein 1a (Mybbp1a)

(2013) Md. Fazlul Karim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hsa-miR-125b suppresses bladder cancer development by down-regulating oncogene SIRT7 and oncogenic long non-coding RNA MALAT1

(2013) Yonghua Han et al.   FEBS LETTERS

Sirtuin-7 Inhibits the Activity of Hypoxia-inducible Factors

(2013) Maimon E. Hubbi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A High-Confidence Interaction Map Identifies SIRT1 as a Mediator of Acetylation of USP22 and the SAGA Coactivator Complex

(2013) S. M. Armour et al.   MOLECULAR AND CELLULAR BIOLOGY

Deubiquitination of Tip60 by USP7 Determines the Activity of the p53-Dependent Apoptotic Pathway

(2013) Ashraf Dar et al.   MOLECULAR AND CELLULAR BIOLOGY

Repression of RNA Polymerase I upon Stress Is Caused by Inhibition of RNA-Dependent Deacetylation of PAF53 by SIRT7

(2013) Sifan Chen et al.   MOLECULAR CELL

FOXO flips the longevity SWItch

(2013) Ashley E. Webb et al.   NATURE CELL BIOLOGY

USP10 Antagonizes c-Myc Transcriptional Activation through SIRT6 Stabilization to Suppress Tumor Formation

(2013) Zhenghong Lin et al.   Cell Reports

SIRT7 Represses Myc Activity to Suppress ER Stress and Prevent Fatty Liver Disease

(2013) Jiyung Shin et al.   Cell Reports

The controversial role of Sirtuins in tumorigenesis — SIRT7 joins the debate

(2012) Ling Li et al.   CELL RESEARCH

Sirtuin7 oncogenic potential in human hepatocellular carcinoma and its regulation by the tumor suppressors MiR-125a-5p and MiR-125b

(2012) Jeong Kyu Kim et al.   HEPATOLOGY

USP22 Antagonizes p53 Transcriptional Activation by Deubiquitinating Sirt1 to Suppress Cell Apoptosis and Is Required for Mouse Embryonic Development

(2012) Zhenghong Lin et al.   MOLECULAR CELL

The Deacetylase Sirt6 Activates the Acetyltransferase GCN5 and Suppresses Hepatic Gluconeogenesis

(2012) John E. Dominy et al.   MOLECULAR CELL

Sirtuins mediate mammalian metabolic responses to nutrient availability

(2012) Angeliki Chalkiadaki et al.   Nature Reviews Endocrinology

Sirtuins as regulators of metabolism and healthspan

(2012) Riekelt H. Houtkooper et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

M phase phosphorylation of the epigenetic regulator UHRF1 regulates its physical association with the deubiquitylase USP7 and stability

(2012) H. Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

K63-Linked Ubiquitination in Kinase Activation and Cancer

(2012) Guocan Wang et al.   Frontiers in Oncology

The Multifaceted Roles of USP7: New Therapeutic Opportunities

(2011) Benjamin Nicholson et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

The Differential Modulation of USP Activity by Internal Regulatory Domains, Interactors and Eight Ubiquitin Chain Types

(2011) Alex C. Faesen et al.   CHEMISTRY & BIOLOGY

The HDAC inhibitor depsipeptide transactivates the p53/p21 pathway by inducing DNA damage

(2011) Haiying Wang et al.   DNA REPAIR

Lys-63-specific Deubiquitination of SDS3 by USP17 Regulates HDAC Activity

(2011) Suresh Ramakrishna et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The USP7/Dnmt1 complex stimulates the DNA methylation activity of Dnmt1 and regulates the stability of UHRF1

(2011) Max Felle et al.   NUCLEIC ACIDS RESEARCH

Ubiquitin: Same Molecule, Different Degradation Pathways

(2010) Michael J. Clague et al.   CELL

Hormonal regulation of gluconeogenic gene transcription in the liver

(2010) Nirmala Yabaluri et al.   JOURNAL OF BIOSCIENCES

Usp7 and Uhrf1 control ubiquitination and stability of the maintenance DNA methyltransferase Dnmt1

(2010) Weihua Qin et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Ten years of NAD-dependent SIR2 family deacetylases: implications for metabolic diseases

(2010) Shin-ichiro Imai et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Involvement of SIRT7 in resumption of rDNA transcription at the exit from mitosis

(2009) A. Grob et al.   JOURNAL OF CELL SCIENCE

Recent progress in the biology and physiology of sirtuins

(2009) Toren Finkel et al.   NATURE

Inactivation of HAUSP in vivo modulates p53 function

(2009) N Kon et al.   ONCOGENE

Atypical ubiquitin chains: new molecular signals. ‘Protein Modifications: Beyond the Usual Suspects’ Review Series

(2008) Fumiyo Ikeda et al.   EMBO REPORTS

Quantitative Analysis of global Ubiquitination in HeLa Cells by Mass Spectrometry

(2008) David Meierhofer et al.   JOURNAL OF PROTEOME RESEARCH

A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange

(2008) Yi Liu et al.   NATURE

The deubiquitinylation and localization of PTEN are regulated by a HAUSP–PML network

(2008) Min Sup Song et al.   NATURE