Succinylation-dependent mitochondrial translocation of PKM2 promotes cell survival in response to nutritional stress

PKM2 methylation by CARM1 activates aerobic glycolysis to promote tumorigenesis

(2017) Fabao Liu et al.   NATURE CELL BIOLOGY

SIRT5 Desuccinylates and Activates Pyruvate Kinase M2 to Block Macrophage IL-1β Production and to Prevent DSS-Induced Colitis in Mice

(2017) Fang Wang et al.   Cell Reports

Role of cysteines in mammalian VDAC isoforms' function

(2016) Vito De Pinto et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitochondrial PKM2 regulates oxidative stress-induced apoptosis by stabilizing Bcl2

(2016) Ji Liang et al.   CELL RESEARCH

Germline loss of PKM2 promotes metabolic distress and hepatocellular carcinoma

(2016) Talya L. Dayton et al.   GENES & DEVELOPMENT

VDAC3 as a sensor of oxidative state of the intermembrane space of mitochondria: the putative role of cysteine residue modifications

(2016) Simona Reina et al.   Oncotarget

Desuccinylation of pyruvate kinase M2 by SIRT5 contributes to antioxidant response and tumor growth

(2016) Ye Xiangyun et al.   Oncotarget

Pyruvate kinase M2 at a glance

(2015) W. Yang et al.   JOURNAL OF CELL SCIENCE

SAICAR Induces Protein Kinase Activity of PKM2 that Is Necessary for Sustained Proliferative Signaling of Cancer Cells

(2014) Kirstie E. Keller et al.   MOLECULAR CELL

Regulation and function of pyruvate kinase M2 in cancer

(2013) Weiwei Yang et al.   CANCER LETTERS

Mitogenic and Oncogenic Stimulation of K433 Acetylation Promotes PKM2 Protein Kinase Activity and Nuclear Localization

(2013) Lei Lv et al.   MOLECULAR CELL

SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways

(2013) Jeongsoon Park et al.   MOLECULAR CELL

M2 pyruvate kinase provides a mechanism for nutrient sensing and regulation of cell proliferation

(2013) H. P. Morgan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Allosteric Regulation of PKM2 Allows Cellular Adaptation to Different Physiological States

(2013) D. Y. Gui et al.   Science Signaling

PKM2 Phosphorylates Histone H3 and Promotes Gene Transcription and Tumorigenesis

(2012) Weiwei Yang et al.   CELL

PKM2 functions as a histone kinase

(2012) Zhimin Lu   CELL CYCLE

Pyruvate Kinase M2: Multiple Faces for Conferring Benefits on Cancer Cells

(2012) M. Tamada et al.   CLINICAL CANCER RESEARCH

Voltage-dependent Anion Channels (VDACs) Recruit Parkin to Defective Mitochondria to Promote Mitochondrial Autophagy

(2012) Yu Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pyruvate Kinase M2 Regulates Gene Transcription by Acting as a Protein Kinase

(2012) Xueliang Gao et al.   MOLECULAR CELL

ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect

(2012) Weiwei Yang et al.   NATURE CELL BIOLOGY

SAICAR Stimulates Pyruvate Kinase Isoform M2 and Promotes Cancer Cell Survival in Glucose-Limited Conditions

(2012) K. E. Keller et al.   SCIENCE

Rocking cell metabolism: revised functions of the key glycolytic regulator PKM2 in cancer

(2012) Barbara Chaneton et al.   TRENDS IN BIOCHEMICAL SCIENCES

PGC-1α, a Key Modulator of p53, Promotes Cell Survival upon Metabolic Stress

(2011) Nirmalya Sen et al.   MOLECULAR CELL

Acetylation Targets the M2 Isoform of Pyruvate Kinase for Degradation through Chaperone-Mediated Autophagy and Promotes Tumor Growth

(2011) Lei Lv et al.   MOLECULAR CELL

Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation

(2011) Weiwei Yang et al.   NATURE

Shikonin and its analogs inhibit cancer cell glycolysis by targeting tumor pyruvate kinase-M2

(2011) J Chen et al.   ONCOGENE

Sirt5 Is a NAD-Dependent Protein Lysine Demalonylase and Desuccinylase

(2011) J. Du et al.   SCIENCE

VDAC, a multi-functional mitochondrial protein regulating cell life and death

(2010) Varda Shoshan-Barmatz et al.   MOLECULAR ASPECTS OF MEDICINE

Identification of small molecule inhibitors of pyruvate kinase M2

(2009) Matthew G. Vander Heiden et al.   BIOCHEMICAL PHARMACOLOGY

Disulfide Formation in the ER and Mitochondria: Two Solutions to a Common Process

(2009) J. Riemer et al.   SCIENCE

Tumor Cell Metabolism: Cancer's Achilles' Heel

(2008) Guido Kroemer et al.   CANCER CELL

Pyruvate kinase M2 is a phosphotyrosine-binding protein

(2008) Heather R. Christofk et al.   NATURE

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

(2008) Heather R. Christofk et al.   NATURE