Uncoupling FoxO3A mitochondrial and nuclear functions in cancer cells undergoing metabolic stress and chemotherapy

Targeting mitochondrial oxidative phosphorylation eradicates therapy-resistant chronic myeloid leukemia stem cells

(2017) Elodie M Kuntz et al.   NATURE MEDICINE

Mitochondria and Cancer

(2016) Wei-Xing Zong et al.   MOLECULAR CELL

Proteogenomics connects somatic mutations to signalling in breast cancer

(2016) Philipp Mertins et al.   NATURE

Fundamentals of cancer metabolism

(2016) R. J. DeBerardinis et al.   Science Advances

A SMYD3 Small-Molecule Inhibitor Impairing Cancer Cell Growth

(2015) Alessia Peserico et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Targeting mitochondria metabolism for cancer therapy

(2015) Samuel E Weinberg et al.   Nature Chemical Biology

The dynamics of mitochondrial DNA heteroplasmy: implications for human health and disease

(2015) James B. Stewart et al.   NATURE REVIEWS GENETICS

Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria

(2014) Hannah R. Bridges et al.   BIOCHEMICAL JOURNAL

Ischemia in Tumors Induces Early and Sustained Phosphorylation Changes in Stress Kinase Pathways but Does Not Affect Global Protein Levels

(2014) Philipp Mertins et al.   MOLECULAR & CELLULAR PROTEOMICS

The clinical development of MEK inhibitors

(2014) Yujie Zhao et al.   Nature Reviews Clinical Oncology

Quantitative phosphoproteomic analysis reveals system-wide signaling pathways downstream of SDF-1/CXCR4 in breast cancer stem cells

(2014) T. Yi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p38α MAPK pathway: A key factor in colorectal cancer therapy and chemoresistance

(2014) Valentina Grossi   WORLD JOURNAL OF GASTROENTEROLOGY

Ultradeep Human Phosphoproteome Reveals a Distinct Regulatory Nature of Tyr and Ser/Thr-Based Signaling

(2014) Kirti Sharma et al.   Cell Reports

Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis

(2014) William W Wheaton et al.   eLife

Targeted therapy against chemoresistant colorectal cancers: Inhibition of p38α modulates the effect of cisplatin in vitro and in vivo through the tumor suppressor FoxO3A

(2013) Aldo Germani et al.   CANCER LETTERS

A novel AMPK-dependent FoxO3A-SIRT3 intramitochondrial complex sensing glucose levels

(2013) Alessia Peserico et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Efficient Repopulation of Genetically Derived Rho Zero Cells with Exogenous Mitochondria

(2013) Sandra Heller et al.   PLoS One

IKK-β mediates chemoresistance by sequestering FOXO3; A critical factor for cell survival and death

(2012) Tugsan Tezil et al.   CELLULAR SIGNALLING

Phosphosignature Predicts Dasatinib Response in Non-small Cell Lung Cancer

(2012) Martin Klammer et al.   MOLECULAR & CELLULAR PROTEOMICS

FoxO family members in cancer

(2011) Yuqing Zhang et al.   CANCER BIOLOGY & THERAPY

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Resist or die: FOXO transcription factors determine the cellular response to chemotherapy

(2011) Ana R. Gomes et al.   CELL CYCLE

The AMPK-FoxO3A axis as a target for cancer treatment

(2010) Fulvio Chiacchiera et al.   CELL CYCLE

Quantitative Phosphoproteomics Reveals Widespread Full Phosphorylation Site Occupancy During Mitosis

(2010) J. V. Olsen et al.   Science Signaling

Inhibition of p38α unveils an AMPK-FoxO3A axis linking autophagy to cancer-specific metabolism

(2009) Fulvio Chiacchiera et al.   Autophagy

Importing Mitochondrial Proteins: Machineries and Mechanisms

(2009) Agnieszka Chacinska et al.   CELL

p38α blockade inhibits colorectal cancer growth in vivo by inducing a switch from HIF1α- to FoxO-dependent transcription

(2009) F Chiacchiera et al.   CELL DEATH AND DIFFERENTIATION

Global Effects of Kinase Inhibitors on Signaling Networks Revealed by Quantitative Phosphoproteomics

(2009) Cuiping Pan et al.   MOLECULAR & CELLULAR PROTEOMICS

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Evaluating the glucose tolerance test in mice

(2008) Sofianos Andrikopoulos et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

FOXO3a mediates the cytotoxic effects of cisplatin in colon cancer cells

(2008) Silvia Fernández de Mattos et al.   MOLECULAR CANCER THERAPEUTICS

ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation

(2008) Jer-Yen Yang et al.   NATURE CELL BIOLOGY

A brief introduction to FOXOlogy

(2008) B M Th Burgering   ONCOGENE

The FoxO code

(2008) D R Calnan et al.   ONCOGENE

FOXOs, cancer and regulation of apoptosis

(2008) Z Fu et al.   ONCOGENE