Article
Pharmacology & Pharmacy
Kai Zhuang, Xiyu Jiang, Renbin Liu, Cunsi Ye, Yumei Wang, Yunhan Wang, Shijian Quan, Heqing Huang
Summary: The study demonstrated that FMN can improve diabetic renal fibrosis and oxidative stress by activating the Nrf2/ARE signaling pathway and increasing Sirt1 protein levels.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Guanyu Yang, Qingde Li, Jing Peng, Lin Jin, Xiaoyu Zhu, Dongxiao Zheng, Yingxia Zhang, Rong Wang, Yanting Song, Wenting Hu, Xi Xie
Summary: The study demonstrated that fucoxanthin activates the Sirt1/Nrf2 signaling pathway to reduce oxidative stress caused by DN, improving renal function and slowing glomerulosclerosis.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Duojun Qiu, Shan Song, Yuhan Wang, Yawei Bian, Ming Wu, Haijiang Wu, Yonghong Shi, Huijun Duan
Summary: The study demonstrates that NQO1 plays a protective role against oxidative stress and apoptosis in diabetic nephropathy by regulating Sirt1 and increasing intracellular NAD+/NADH levels.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Lina Xing, Hengjiang Guo, Sixuan Meng, Bingbing Zhu, Ji Fang, Jiebo Huang, Junliang Chen, Yunman Wang, Li Wang, Xingmei Yao, Hao Wang
Summary: Klotho activates the Nrf2 signaling pathway to inhibit oxidative stress and apoptosis induced by high glucose, thus protecting podocytes. This protective effect may be targeted by activating Nrf2 for the treatment of diabetic nephropathy (DN).
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Food Science & Technology
Jozaa Z. ALTamimi, Nora A. AlFaris, Ghedeir M. Alshammari, Reham Alagal, Dalal H. Aljabryn, Hussain Aldera, Bahauddeen M. Alrfaei, Mahmoud A. Alkhateeb, Mohammed A. Yahya
Summary: The study showed that EA can improve diabetic nephropathy in rats through antioxidant and anti-inflammatory effects. In STZ-induced diabetic rats, EA prevented renal damage, oxidative stress, inflammation, and apoptosis.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Chemistry, Medicinal
Leyi Ma, Fan Wu, Qingqing Shao, Guang Chen, Lijun Xu, Fuer Lu
Summary: This study demonstrated that baicalin can treat diabetic nephropathy (DN) by alleviating oxidative stress and inflammation, and its underlying mechanisms are associated with the activation of Nrf2-mediated antioxidant signaling pathway and the inhibition of MAPK-mediated inflammatory signaling pathway.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Food Science & Technology
Ge Chenxu, Zhong Shaoyu, Lai Lili, Xianling Dai, Qin Kuang, Li Qiang, Hu Linfeng, Lou Deshuai, Tan Jun, Xu Minxuan
Summary: The study showed that plant-derived betacyanins (BCN) could alleviate diabetic nephropathy (DN) by reducing fibrosis and oxidative stress, mainly through improving the Nrf2 signaling pathway, subsequently improving renal function.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Biochemistry & Molecular Biology
Lu Yang, Dong-Xia Li, Bu-Qing Cao, Shu-Juan Liu, Dan-Hong Xu, Xiao-Yan Zhu, Yu-Jian Liu
Summary: Exercise training can protect the kidneys from diabetic nephropathy by regulating endogenous hydrogen sulfide production, reducing renal injury and apoptosis, increasing SIRT1 expression, inhibiting the p53-mediated apoptotic pathway, and improving diabetic nephropathy.
Article
Biochemistry & Molecular Biology
Shanshan Li, Haiming Xiao, Xiaohong Sun, Zhiquan Chen, Zeyuan Lin, Chuting Li, Jingran Zeng, Zhanchi Xu, Yuanyuan Cheng, Heqing Huang
Summary: This study found that Cx32 alleviated DN by activating the Sirt1/Foxo3a antioxidant pathway. The specific mechanism was that Cx32 upregulated the expression of Sirt1 by inhibiting Smurf1 and reducing the ubiquitination of Lys(335) of Sirt1.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Article
Physiology
Wenmin Dong, Huiqian Zhang, Cheng Zhao, Yun Luo, Ying Chen
Summary: The study revealed that silencing miR-150-5p played a protective role in the kidneys of DN mice by targeting SIRT1, leading to activation of AMPK-dependent autophagy.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yiran Liang, Hong Liu, Jiaming Zhu, Nana Song, Zhihui Lu, Yi Fang, Jie Teng, Yan Dai, Xiaoqiang Ding
Summary: The study demonstrates that miR-34a activates the p53 signaling pathway to directly inhibit SIRT1, forming a positive feedback loop that contributes to podocyte injury in diabetic nephropathy. This plays a critical role in the pathogenesis of diabetic kidney disease.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Endocrinology & Metabolism
Shanshan Li, Zeyuan Lin, Haiming Xiao, Zhanchi Xu, Chuting Li, Jingran Zeng, Xi Xie, Li Deng, Heqing Huang
Summary: This study investigated the role of Fyn in diabetic nephropathy and its regulatory mechanism. The results showed that Fyn was up-regulated under high glucose conditions and its knockdown reduced oxidative stress, improving diabetic renal fibrosis. On the other hand, Fyn overexpression increased oxidative stress and led to renal damage. Mechanistically, Fyn facilitated the degradation of Sirt1 by promoting its ubiquitination, impairing the antioxidant effects of Foxo3a.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2023)
Article
Pharmacology & Pharmacy
Rui Chen, Jingran Zeng, Chuting Li, Haiming Xiao, Shanshan Li, Zeyuan Lin, Kaipeng Huang, Juan Shen, Heqing Huang
Summary: Diabetic nephropathy (DN) is a major cause of end-stage renal disease (ESRD) in diabetic patients. Research has shown that using Fraxin (Fr) can alleviate renal fibrosis by regulating Connexin43 (Cx43) and activating the Nrf2/ARE pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Anees Ahmed Syed, Mohammad Irshad Reza, Richa Garg, Umesh K. Goand, Jiaur R. Gayen
Summary: In this study, it was found that the ethanolic extract of Cissus quadrangularis significantly attenuated insulin resistance, abnormal lipid metabolism, and elevated creatinine levels caused by high blood sugar, restored albuminuria, glomerular filtration rate, and creatinine clearance in diabetic nephropathy rats. Additionally, it increased levels of SOD 1 and 3 to prevent oxidative damage and renal inflammation, and protected against renal fibrosis by downregulating TGF beta, Smad2/3, and coil/3 expression.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2021)
Article
Nutrition & Dietetics
Guangping Lu, Qingbo Liu, Ting Gao, Jiahao Li, Jingjing Zhang, Ou Chen, Cong Cao, Min Mao, Mengjie Xiao, Xiaohui Zhang, Jie Wang, Yuanfang Guo, Yufeng Tang, Junlian Gu
Summary: This study aimed to explore the therapeutic potential and underlying mechanisms of the co-treatment of resveratrol (RES) and fibroblast growth factor 1 (FGF1) in a doxorubicin (DOX)-treated model. The results showed that RES could reduce the growth-promoting activity of FGF1 and exhibited a more powerful antioxidative capacity in a DOX-treated model, with cardioprotective action mediated through the SIRT1/NRF2 pathway.
Article
Biochemistry & Molecular Biology
Hao Wu, Lili Kong, Yanli Cheng, Zhiguo Zhang, Yangwei Wang, Manyu Luo, Yi Tan, Xiangmei Chen, Lining Miao, Lu Cai
FREE RADICAL BIOLOGY AND MEDICINE
(2015)
Article
Cell Biology
Yonggang Wang, Hao Wu, Ying Xin, Yang Bai, Lili Kong, Yi Tan, Feng Liu, Lu Cai
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2017)
Article
Endocrinology & Metabolism
Hao Wu, Junduo Wu, Shengzhu Zhou, Wenlin Huang, Ying Li, Huan Zhang, Junnan Wang, Ye Jia
JOURNAL OF ENDOCRINOLOGY
(2018)
Article
Genetics & Heredity
Dan Jiao, Huan Zhang, Ziping Jiang, Wenlin Huang, Zhuo Liu, Zhaohui Wang, Yonggang Wang, Hao Wu
JOURNAL OF MOLECULAR MEDICINE-JMM
(2018)
Review
Endocrinology & Metabolism
Hao Wu, Lili Kong, Shanshan Zhou, Wenpeng Cui, Feng Xu, Manyu Luo, Xiangqi Li, Yi Tan, Lining Miao
JOURNAL OF DIABETES RESEARCH
(2014)
Article
Cell Biology
Junduo Wu, Wenzhao Liang, Yueli Tian, Fuzhe Ma, Wenlin Huang, Ye Jia, Ziping Jiang, Hao Wu
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2019)
Review
Cell Biology
Junduo Wu, Xiaodan Sun, Ziping Jiang, Jun Jiang, Linlin Xu, Ao Tian, Xuechun Sun, Huali Meng, Ying Li, Wenlin Huang, Ye Jia, Hao Wu
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2020)
Article
Agriculture, Multidisciplinary
Lei Du, Yi-Ming Hao, Yu-Hong Yang, Yan Zheng, Zi-Jian Wu, Meng-Qing Zhou, Bao-Zhen Wang, Yu-Ming Wang, Hao Wu, Guo-Hai Su
Summary: DHA-PL and EPA-PL maintain intestinal barrier integrity by balancing apoptosis and autophagy in intestinal epithelial cells, and alleviate LPS-induced intestinal barrier injury by inhibiting NF-κB and MAPKs pathways activation and activating Nrf2 antioxidant pathway.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Nutrition & Dietetics
Xuechun Sun, Xiaodan Sun, Huali Meng, Junduo Wu, Xin Guo, Lei Du, Hao Wu
Summary: This study investigated the preventive effect of krill oil (KO) on diabetic cardiomyopathy (DCM). The results showed that KO could prevent cardiac fibrosis, cardiomyocyte apoptosis, and inflammatory cell infiltration, and reverse the cardiac inflammation and oxidative stress induced by diabetes. Further investigation revealed that KO upregulated the expression of SIRT3 and PGC-1α and inhibited the activation of NLRP3 inflammasome. This study provides molecular targets for KO in the treatment of DCM.
Article
Agriculture, Multidisciplinary
Xuechun Sun, Yu Yang, Xiaodan Sun, Huali Meng, Wenhao Hao, Jialin Yin, Fuzhe Ma, Xin Guo, Lei Du, Lei Sun, Hao Wu
Summary: The current study investigated the preventive effect of krill oil (KO) on diabetic nephropathy (DN) and found that it can prevent DN by suppressing the TGF-beta 1 signaling pathway.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Lei Du, Yan Zheng, Yu-Hong Yang, Yu-Jie Huang, Yi-Ming Hao, Chen Chen, Bao-Zhen Wang, Xin Guo, Hao Wu, Guo-Hai Su
Summary: Krill oil (KO) has a protective effect against lipopolysaccharide (LPS)-evoked acute liver injury by inhibiting oxidative stress and inflammation.
Article
Biochemistry & Molecular Biology
G. F. Senguel, R. Mishra, E. Candiello, P. Schu
Summary: AP2 forms AP2 CCV with clathrin and other coat proteins, and synapses contain different types of CCV. The stability and composition of CCV are regulated by various factors, including Hsc70 and phosphorylation patterns. The knockout of the AP1/O1B complex disrupts synaptic vesicle recycling and endosomal protein sorting, leading to upregulation of endocytosis. Stable CCV, termed stCCV, have distinct characteristics and specialized functions in synaptic plasticity. The phosphorylation of Hsc70 and the levels of kinases play a crucial role in regulating the stability and disassembly of clathrin in CCV.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Martin Fluck, Colline Sanchez, Vincent Jacquemond, Christine Berthier, Marie-Noelle Giraud, Daniel Jacko, Kathe Bersiner, Sebastian Gehlert, Guus Baan, Richard T. Jaspers
Summary: Enhancing CaMKII signaling improves fatigue resistance and contractile characteristics of skeletal muscle by enhancing calcium release.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Letter
Biochemistry & Molecular Biology
Federica Coppola, Sara Monaci, Alessandro Falsini, Carlo Aldinucci, Irene Filippi, Daniela Rossi, Fabio Carraro, Antonella Naldini
Summary: The adaptor protein p62 plays a crucial role in maintaining the survival of dendritic cells (DCs) under hypoxic conditions by preserving Erk1/2 phosphorylation and reducing AMPK activation, thus extending their lifespan to ensure their functions in hypoxic microenvironments.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Jenifer Pendiuk Goncalves, Jorvani Cruz Villarreal, Sierra A. Walker, Xuan Ning Sharon Tan, Chad Borges, Joy Wolfram
Summary: This study used a mass spectrometry-based approach to assess the differences in glycan features between extracellular vesicles (EVs) and originating cells. The results showed that EVs selectively enriched specific glycan features, particularly those associated with binding to the extracellular matrix. The study also found differences in EV glycan sorting between different metastatic cell lines and mouse models, indicating a potential role of glycan diversity in the metastatic process.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
De-ao Gong, Peng Zhou, Wen-yi Chang, Jia-yao Yang, Yan-lai Zhang, Ai-long Huang, Ni Tang, Kai Wang
Summary: Liver cancer, ranked sixth globally, is a major contributor to cancer-related mortality. Metastasis is the main cause of treatment failure and deaths in liver cancer. The SPOP-CREB5-MET axis plays a significant role in liver cancer metastasis.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Ning Huang, Jun Tang, Xiaoyao Yi, Maoxin Zhang, Bin Li, Yuan Cheng, Jin Chen
Summary: This study reveals that glioma-derived S100A9 can induce microglial M2 polarization, inhibit CD8+ T lymphocytes, and promote immunosuppression. The mechanism is related to the interaction with alpha v133 integrin and subsequent activation of AKT1 in microglia. The expression of S100A9 is positively associated with CD206 expression and negatively correlated with CD8+ T lymphocyte accumulation in the TME, suggesting a potential role of S100A9 in regulating the tumor microenvironment and immune evasion in glioma.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Yomna S. Abd El-Aziz, Matthew J. McKay, Mark P. Molloy, Betty McDowell, Elizabeth Moon, Loretta Sioson, Amy Sheen, Angela Chou, Anthony J. Gill, Patric J. Jansson, Sumit Sahni
Summary: This study identified a novel combination of autophagy inhibitors that can effectively inhibit the proliferation of oral squamous cell carcinoma (OSCC) cells, including both chemosensitive and chemoresistant cells. This research is important for the development of new therapies for advanced OSCC tumors.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Luojia Liu, Xiaoqiang Liu, Ying Chen, Meng Kong, Jinghong Zhang, Min Jiang, Hongling Zhou, Jinrui Yang, Xu Chen, Ze Zhang, Chao Wu, Xupin Jiang, Jiaping Zhang
Summary: Our study revealed that the Paxillin/HDAC6 signaling pathway regulates microtubule acetylation in electric field-guided keratinocyte migration.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Julia Weikum, Jeroen F. van Dyck, Saranya Subramani, David P. Klebl, Merete Storflor, Stephen P. Muench, Soren Abel, Frank Sobott, J. Preben Morth
Summary: The study reveals the complex interaction between bacterial magnesium transporter A (MgtA) and cardiolipin 18:1 and cardiolipin 16:0, highlighting the importance of lipid environment in protein activity and stability. Further understanding of Mg2+ homeostasis in bacteria will provide insights into bacterial infections.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Sumit Kinger, Yuvraj Anandrao Jagtap, Ankur Rakesh Dubey, Prashant Kumar, Akash Choudhary, Rohan Dhiman, Vijay Kumar Prajapati, Deepak Chitkara, Krishna Mohan Poluri, Amit Mishra
Summary: Efficient protein synthesis and quality control mechanisms are crucial for maintaining proteostasis and preventing neurodegeneration. This study demonstrates that treating cells with Lanosterol can enhance the proteolytic activity of Proteasome and promote the removal of misfolded proteins, suggesting a potential therapeutic approach for abnormal protein accumulation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Karolina Stepien, Adrianna Skoneczna, Monika Kula-Maximenko, Lukasz Jurczyk, Mateusz Molon
Summary: The replication of DNA requires a complex machinery called the replisome, which is highly conserved across species. One crucial component of the replisome is the CMG helicase complex, which unwinds DNA and coordinates the assembly and function of other replisome components. In this study, the impact of the absence of one copy of the CMG complex genes on the physiology and aging of yeast cells was investigated. The findings showed disruptions in the cell cycle, extended doubling times, and alterations in the biochemical profile of these cells. Importantly, it was found that heterozygous cells for CMG helicase genes exhibited increased reproductive potential and delayed aging. The study also highlighted potential therapeutic targets for cancer treatment using yeast.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Nishadh Rathod, Guadalupe Guerrero-Serna, Howard S. Young, L. Michel Espinoza-Fonseca
Summary: This study reveals that replacing Lys27 with Asn enhances the inhibitory potency of MLN without affecting SERCA's affinity for Ca2+. The findings suggest that the SERCA site modulating Ca2+ affinity also functions as a catalytic activity switch.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Can Jiang, Chunyang Zhang, Min Dai, Fuyan Wang, Sa Xu, Dan Han, Yanyan Wang, Yajie Cao, Yanyan Liang, Ziyu Zhang, Lina Yan, Yujun Shen, Kewu He, Yuxian Shen, Jun Liu
Summary: The phosphorylation of p65 and the expression of SUMO1 are increased in cancer tissues of HCC patients, and there is a positive correlation between SUMO1 and phosphorylated p65. SUMOylation of p65 by SUMO1 promotes p65 nuclear import and enhances NF-xB activity. Both SUMOylation and phosphorylation of p65 increase the viability and invasion of hepatoma cells, and decrease cell apoptosis.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Ming-Fo Hsu, Yoshihiro Ito, Jai Prakash Singh, Shu-Fang Hsu, Alan Wells, Kuang-Yu Jen, Tzu-Ching Meng, Fawaz G. Haj
Summary: This study identified alpha-actinin4 as a novel substrate of PTP1B in podocytes and demonstrated their interaction in regulating podocyte function. Targeting PTP1B and alpha-actinin4 could be a potential therapeutic approach for podocyte injury.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Paulo F. V. Bizerra, Eduardo H. Gilglioni, Hang Lam Li, Simei Go, Ronald P. J. Oude Elferink, Arthur J. Verhoeven, Jung -Chin Chang
Summary: This study investigates the role of cyclic AMP (cAMP) in glycogen metabolism and reveals that cAMP regulates glycogenolysis in opposite directions depending on its site of synthesis within cells and downstream effectors. The canonical tmAC-cAMP-PKA signaling promotes glycogenolysis, while the non-canonical sAC-cAMP-Epac1 signaling suppresses glycogenolysis. This highlights the importance of cAMP microdomain organization for distinct metabolic regulation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)